HRP20120044T1 - Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-octene kiseline - Google Patents
Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-octene kiseline Download PDFInfo
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- HRP20120044T1 HRP20120044T1 HR20120044T HRP20120044T HRP20120044T1 HR P20120044 T1 HRP20120044 T1 HR P20120044T1 HR 20120044 T HR20120044 T HR 20120044T HR P20120044 T HRP20120044 T HR P20120044T HR P20120044 T1 HRP20120044 T1 HR P20120044T1
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- Prior art keywords
- tetrahydro
- acetic acid
- carbazol
- fluoro
- phenyl
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- CVQXAMOXLNWPLS-UHFFFAOYSA-N 2-(3-amino-1,2,3,4-tetrahydrocarbazol-9-yl)acetic acid Chemical class C12=CC=CC=C2N(CC(O)=O)C2=C1CC(N)CC2 CVQXAMOXLNWPLS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 27
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 125000003118 aryl group Chemical group 0.000 claims abstract 14
- 229910052736 halogen Inorganic materials 0.000 claims abstract 11
- 150000002367 halogens Chemical class 0.000 claims abstract 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 8
- 239000001257 hydrogen Substances 0.000 claims abstract 8
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims abstract 6
- 150000002431 hydrogen Chemical class 0.000 claims abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 6
- -1 halo-C1-6-alkoxy Chemical group 0.000 claims abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims abstract 3
- 125000005222 heteroarylaminocarbonyl group Chemical group 0.000 claims abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 208000010668 atopic eczema Diseases 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- KNCIZOBSNQKDEY-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[3-(3-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 KNCIZOBSNQKDEY-KRWDZBQOSA-N 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- QTDFBFKZHBTIHE-QGZVFWFLSA-N 2-[(3r)-3-(2-phenylethylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)NCCC1=CC=CC=C1 QTDFBFKZHBTIHE-QGZVFWFLSA-N 0.000 claims 1
- BRHKEKFHBZMPRE-GOSISDBHSA-N 2-[(3r)-3-(2-phenylmethoxyethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)OCCOCC1=CC=CC=C1 BRHKEKFHBZMPRE-GOSISDBHSA-N 0.000 claims 1
- ZNMCHXMOHLWBCZ-MRXNPFEDSA-N 2-[(3r)-3-(3-cyclopentylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CCC1CCCC1 ZNMCHXMOHLWBCZ-MRXNPFEDSA-N 0.000 claims 1
- HUSFWFBIHWPVJK-QGZVFWFLSA-N 2-[(3r)-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 HUSFWFBIHWPVJK-QGZVFWFLSA-N 0.000 claims 1
- CYKWQSYYVGBAAC-MRXNPFEDSA-N 2-[(3r)-3-(benzylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 CYKWQSYYVGBAAC-MRXNPFEDSA-N 0.000 claims 1
- RUTKNRXILLQJAJ-MRXNPFEDSA-N 2-[(3r)-3-(benzylcarbamoylamino)-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 RUTKNRXILLQJAJ-MRXNPFEDSA-N 0.000 claims 1
- RLKNXLJVWBFETI-OAHLLOKOSA-N 2-[(3r)-3-(benzylcarbamoylamino)-8-chloro-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 RLKNXLJVWBFETI-OAHLLOKOSA-N 0.000 claims 1
- NUFQMDLPHDSAIV-MRXNPFEDSA-N 2-[(3r)-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 NUFQMDLPHDSAIV-MRXNPFEDSA-N 0.000 claims 1
- KGLFYMSCHQAQKD-MRXNPFEDSA-N 2-[(3r)-3-(phenylmethoxycarbonylamino)-6-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(C=C3C=2C1)C(F)(F)F)CC(=O)O)C(=O)OCC1=CC=CC=C1 KGLFYMSCHQAQKD-MRXNPFEDSA-N 0.000 claims 1
- KYMUFTDMFQWTJD-OAHLLOKOSA-N 2-[(3r)-3-[(2-phenoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1 KYMUFTDMFQWTJD-OAHLLOKOSA-N 0.000 claims 1
- AKENPVSFYWPJSR-MRXNPFEDSA-N 2-[(3r)-3-[(2-phenylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CC=C1 AKENPVSFYWPJSR-MRXNPFEDSA-N 0.000 claims 1
- HCHBFDQPITXATR-QGZVFWFLSA-N 2-[(3r)-3-[(2-phenylmethoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)COCC1=CC=CC=C1 HCHBFDQPITXATR-QGZVFWFLSA-N 0.000 claims 1
- QHPMTYNKBKCMSY-CYBMUJFWSA-N 2-[(3r)-3-[(2-thiophen-2-ylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CS1 QHPMTYNKBKCMSY-CYBMUJFWSA-N 0.000 claims 1
- QUBKOYICJPPWHN-OAHLLOKOSA-N 2-[(3r)-3-[3-(1,3-benzodioxol-5-yl)propanoylamino]-8-chloro-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=C2OCOC2=CC(CCC(=O)N[C@@H]2CCC=3N(C4=C(Cl)C=C(F)C=C4C=3C2)CC(=O)O)=C1 QUBKOYICJPPWHN-OAHLLOKOSA-N 0.000 claims 1
- UEVYOTDJVHBFCA-MRXNPFEDSA-N 2-[(3r)-3-[3-(2-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1Cl UEVYOTDJVHBFCA-MRXNPFEDSA-N 0.000 claims 1
- QYNXPJZVVMJFJI-QGZVFWFLSA-N 2-[(3r)-3-[3-(3-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(Cl)=C1 QYNXPJZVVMJFJI-QGZVFWFLSA-N 0.000 claims 1
- BKYBZEAPVRJARQ-QGZVFWFLSA-N 2-[(3r)-3-[3-(4-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(Cl)C=C1 BKYBZEAPVRJARQ-QGZVFWFLSA-N 0.000 claims 1
- YRDMGRGMCFBSKS-CQSZACIVSA-N 2-[(3r)-3-[[2-(2-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1Cl YRDMGRGMCFBSKS-CQSZACIVSA-N 0.000 claims 1
- QWIGFIHTWHVLDT-CQSZACIVSA-N 2-[(3r)-3-[[2-(3,4-dichlorophenyl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=C(Cl)C(Cl)=C1 QWIGFIHTWHVLDT-CQSZACIVSA-N 0.000 claims 1
- SKWHTNUBDBVPJP-OAHLLOKOSA-N 2-[(3r)-3-[[2-(3-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC(Cl)=C1 SKWHTNUBDBVPJP-OAHLLOKOSA-N 0.000 claims 1
- YLKYUKSMKBLBAW-MRXNPFEDSA-N 2-[(3r)-3-[[2-(3-chlorophenyl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CC(Cl)=C1 YLKYUKSMKBLBAW-MRXNPFEDSA-N 0.000 claims 1
- HAUKDABBJZKIFZ-OAHLLOKOSA-N 2-[(3r)-3-[[2-(4-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=C(Cl)C=C1 HAUKDABBJZKIFZ-OAHLLOKOSA-N 0.000 claims 1
- LOWRDCZTZOJFMM-MRXNPFEDSA-N 2-[(3r)-3-[[2-(4-chlorophenyl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=C(Cl)C=C1 LOWRDCZTZOJFMM-MRXNPFEDSA-N 0.000 claims 1
- YZDSMIBTWNOZBX-QGZVFWFLSA-N 2-[(3r)-6-fluoro-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 YZDSMIBTWNOZBX-QGZVFWFLSA-N 0.000 claims 1
- CVNQXZNCQBZHQQ-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 CVNQXZNCQBZHQQ-MRXNPFEDSA-N 0.000 claims 1
- ZZCSIDSIPSVOTB-OAHLLOKOSA-N 2-[(3r)-6-fluoro-3-[(2-phenoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1 ZZCSIDSIPSVOTB-OAHLLOKOSA-N 0.000 claims 1
- IITNLJJMIZOVJT-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-[(2-phenylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CC=C1 IITNLJJMIZOVJT-MRXNPFEDSA-N 0.000 claims 1
- QESJVXHCHVZWSL-GOSISDBHSA-N 2-[(3r)-6-fluoro-3-[3-(2-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1CCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 QESJVXHCHVZWSL-GOSISDBHSA-N 0.000 claims 1
- KNCIZOBSNQKDEY-QGZVFWFLSA-N 2-[(3r)-6-fluoro-3-[3-(3-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N[C@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 KNCIZOBSNQKDEY-QGZVFWFLSA-N 0.000 claims 1
- XEQFDFSAOZUDQL-GOSISDBHSA-N 2-[(3r)-6-fluoro-3-[3-(3-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC(CCC(=O)N[C@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 XEQFDFSAOZUDQL-GOSISDBHSA-N 0.000 claims 1
- QSFQXABKBPGZGV-QGZVFWFLSA-N 2-[(3r)-6-fluoro-3-[3-(4-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(OC)=CC=C1CCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 QSFQXABKBPGZGV-QGZVFWFLSA-N 0.000 claims 1
- SDPVRHNZMAKVEJ-GOSISDBHSA-N 2-[(3r)-6-fluoro-3-[3-(4-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C)=CC=C1CCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 SDPVRHNZMAKVEJ-GOSISDBHSA-N 0.000 claims 1
- OJZGKILYSGVUNU-OAHLLOKOSA-N 2-[(3r)-6-fluoro-3-[[2-(2-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1OCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 OJZGKILYSGVUNU-OAHLLOKOSA-N 0.000 claims 1
- JDGNSQJSUGAHNB-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-[[2-(2-methylphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1OCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 JDGNSQJSUGAHNB-MRXNPFEDSA-N 0.000 claims 1
- KZDFEZYJNFTSJL-OAHLLOKOSA-N 2-[(3r)-6-fluoro-3-[[2-(3-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(OCC(=O)N[C@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 KZDFEZYJNFTSJL-OAHLLOKOSA-N 0.000 claims 1
- ULWOBADMFAOAEE-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-[[2-(4-methoxyphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(OC)=CC=C1CC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 ULWOBADMFAOAEE-MRXNPFEDSA-N 0.000 claims 1
- YLUFSOYLYBPCJY-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-[[2-(4-methylphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C)=CC=C1OCC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 YLUFSOYLYBPCJY-MRXNPFEDSA-N 0.000 claims 1
- CMZRMVKKKVQSOE-QGZVFWFLSA-N 2-[(3r)-6-fluoro-3-[[2-(4-methylphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C)=CC=C1CC(=O)N[C@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 CMZRMVKKKVQSOE-QGZVFWFLSA-N 0.000 claims 1
- NDYSRJCSIRKNGU-MRXNPFEDSA-N 2-[(3r)-6-fluoro-3-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=C(C(F)(F)F)C=C1 NDYSRJCSIRKNGU-MRXNPFEDSA-N 0.000 claims 1
- RNHFDAHZNYPFCC-MRXNPFEDSA-N 2-[(3r)-6-fluoro-8-methylsulfonyl-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CC=2C=3C=C(F)C=C(C=3N(CC(O)=O)C=2CC1)S(=O)(=O)C)C(=O)OCC1=CC=CC=C1 RNHFDAHZNYPFCC-MRXNPFEDSA-N 0.000 claims 1
- YIMVVAXDWTXMFI-OAHLLOKOSA-N 2-[(3r)-8-bromo-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Br)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 YIMVVAXDWTXMFI-OAHLLOKOSA-N 0.000 claims 1
- UIAAKWRNAHSSCO-OAHLLOKOSA-N 2-[(3r)-8-chloro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=CC=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 UIAAKWRNAHSSCO-OAHLLOKOSA-N 0.000 claims 1
- VEVBNMQMKNUQBE-OAHLLOKOSA-N 2-[(3r)-8-chloro-3-[3-(2-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1Cl VEVBNMQMKNUQBE-OAHLLOKOSA-N 0.000 claims 1
- AUCGEXZGIWVZAV-MRXNPFEDSA-N 2-[(3r)-8-chloro-3-[3-(3-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(Cl)=C1 AUCGEXZGIWVZAV-MRXNPFEDSA-N 0.000 claims 1
- MSYCJUGAAZPCIR-GOSISDBHSA-N 2-[(3r)-8-chloro-3-[[2-(2,3-dihydro-1h-inden-2-yl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1C2=CC=CC=C2CC1CC(=O)N[C@@H]1CCC(N(C2=C(Cl)C=C(F)C=C22)CC(=O)O)=C2C1 MSYCJUGAAZPCIR-GOSISDBHSA-N 0.000 claims 1
- KXAJHTCBBHHWQM-CYBMUJFWSA-N 2-[(3r)-8-chloro-3-[[2-(2-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1Cl KXAJHTCBBHHWQM-CYBMUJFWSA-N 0.000 claims 1
- HTLPJCQXWDAGIU-CQSZACIVSA-N 2-[(3r)-8-chloro-3-[[2-(3-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC(Cl)=C1 HTLPJCQXWDAGIU-CQSZACIVSA-N 0.000 claims 1
- MEVAIXUENBUIRH-CQSZACIVSA-N 2-[(3r)-8-chloro-5-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=CC(F)=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 MEVAIXUENBUIRH-CQSZACIVSA-N 0.000 claims 1
- ZJYFDOBQLVLOHC-MRXNPFEDSA-N 2-[(3r)-8-chloro-6-fluoro-3-(2-phenylethylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCCC1=CC=CC=C1 ZJYFDOBQLVLOHC-MRXNPFEDSA-N 0.000 claims 1
- NXARZSZYEVNKFM-MRXNPFEDSA-N 2-[(3r)-8-chloro-6-fluoro-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 NXARZSZYEVNKFM-MRXNPFEDSA-N 0.000 claims 1
- UVVOSQSXPOQGQG-OAHLLOKOSA-N 2-[(3r)-8-chloro-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 UVVOSQSXPOQGQG-OAHLLOKOSA-N 0.000 claims 1
- KOWSFFLPMVSNGL-MRXNPFEDSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(1h-indol-3-yl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=C2C(CCC(=O)N[C@@H]3CCC=4N(C5=C(Cl)C=C(F)C=C5C=4C3)CC(=O)O)=CNC2=C1 KOWSFFLPMVSNGL-MRXNPFEDSA-N 0.000 claims 1
- NHRKZAMOKHIBNB-OAHLLOKOSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(2-hydroxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1O NHRKZAMOKHIBNB-OAHLLOKOSA-N 0.000 claims 1
- VSUNNIXMVWPJQS-MRXNPFEDSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(2-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CCC(=O)N[C@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 VSUNNIXMVWPJQS-MRXNPFEDSA-N 0.000 claims 1
- BYUYLSZDDFFYCW-QGZVFWFLSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(2-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1CCC(=O)N[C@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 BYUYLSZDDFFYCW-QGZVFWFLSA-N 0.000 claims 1
- YCNHPYPXFLOZHR-OAHLLOKOSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(3-hydroxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(O)=C1 YCNHPYPXFLOZHR-OAHLLOKOSA-N 0.000 claims 1
- VIRWCTONIDIPKI-MRXNPFEDSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(3-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N[C@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 VIRWCTONIDIPKI-MRXNPFEDSA-N 0.000 claims 1
- QIERSVBYOHBKTJ-QGZVFWFLSA-N 2-[(3r)-8-chloro-6-fluoro-3-[3-(3-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC(CCC(=O)N[C@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 QIERSVBYOHBKTJ-QGZVFWFLSA-N 0.000 claims 1
- OTCHTOKDJDNPJR-CQSZACIVSA-N 2-[(3r)-8-chloro-6-fluoro-3-[[2-(2-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1OCC(=O)N[C@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 OTCHTOKDJDNPJR-CQSZACIVSA-N 0.000 claims 1
- VELIHXXMWOMMIK-OAHLLOKOSA-N 2-[(3r)-8-chloro-6-fluoro-3-[[2-(2-methylphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1OCC(=O)N[C@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 VELIHXXMWOMMIK-OAHLLOKOSA-N 0.000 claims 1
- PHYLVLJBONLYJP-CQSZACIVSA-N 2-[(3r)-8-chloro-6-fluoro-3-[[2-(3-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(OCC(=O)N[C@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 PHYLVLJBONLYJP-CQSZACIVSA-N 0.000 claims 1
- LZCOGUGKMCRMNG-GOSISDBHSA-N 2-[(3r)-8-ethenyl-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CCC=2N(C3=C(C=C)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 LZCOGUGKMCRMNG-GOSISDBHSA-N 0.000 claims 1
- XRMOJCZBOGDVSE-NQCNTLBGSA-N 2-[(3s)-3-(2,3-diphenylpropanoylamino)-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)C(C=1C=CC=CC=1)CC1=CC=CC=C1 XRMOJCZBOGDVSE-NQCNTLBGSA-N 0.000 claims 1
- QTDFBFKZHBTIHE-KRWDZBQOSA-N 2-[(3s)-3-(2-phenylethylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)NCCC1=CC=CC=C1 QTDFBFKZHBTIHE-KRWDZBQOSA-N 0.000 claims 1
- BRHKEKFHBZMPRE-SFHVURJKSA-N 2-[(3s)-3-(2-phenylmethoxyethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)OCCOCC1=CC=CC=C1 BRHKEKFHBZMPRE-SFHVURJKSA-N 0.000 claims 1
- ALBKAOWBUCIGIR-QFIPXVFZSA-N 2-[(3s)-3-(3,3-diphenylpropanoylamino)-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC(C=1C=CC=CC=1)C1=CC=CC=C1 ALBKAOWBUCIGIR-QFIPXVFZSA-N 0.000 claims 1
- ZNMCHXMOHLWBCZ-INIZCTEOSA-N 2-[(3s)-3-(3-cyclopentylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CCC1CCCC1 ZNMCHXMOHLWBCZ-INIZCTEOSA-N 0.000 claims 1
- HUSFWFBIHWPVJK-KRWDZBQOSA-N 2-[(3s)-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 HUSFWFBIHWPVJK-KRWDZBQOSA-N 0.000 claims 1
- CYKWQSYYVGBAAC-INIZCTEOSA-N 2-[(3s)-3-(benzylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 CYKWQSYYVGBAAC-INIZCTEOSA-N 0.000 claims 1
- RUTKNRXILLQJAJ-INIZCTEOSA-N 2-[(3s)-3-(benzylcarbamoylamino)-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 RUTKNRXILLQJAJ-INIZCTEOSA-N 0.000 claims 1
- RLKNXLJVWBFETI-HNNXBMFYSA-N 2-[(3s)-3-(benzylcarbamoylamino)-8-chloro-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 RLKNXLJVWBFETI-HNNXBMFYSA-N 0.000 claims 1
- NUFQMDLPHDSAIV-INIZCTEOSA-N 2-[(3s)-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 NUFQMDLPHDSAIV-INIZCTEOSA-N 0.000 claims 1
- KGLFYMSCHQAQKD-INIZCTEOSA-N 2-[(3s)-3-(phenylmethoxycarbonylamino)-6-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(C=C3C=2C1)C(F)(F)F)CC(=O)O)C(=O)OCC1=CC=CC=C1 KGLFYMSCHQAQKD-INIZCTEOSA-N 0.000 claims 1
- CDXCIPRYWGXGNB-SFHVURJKSA-N 2-[(3s)-3-[(2,2-dimethyl-3-phenylpropanoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)C(C)(C)CC1=CC=CC=C1 CDXCIPRYWGXGNB-SFHVURJKSA-N 0.000 claims 1
- LIGRFRFFUCRVOE-YDNXMHBPSA-N 2-[(3s)-3-[(2-benzyl-3,3-dimethylbutanoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)C(C(C)(C)C)CC1=CC=CC=C1 LIGRFRFFUCRVOE-YDNXMHBPSA-N 0.000 claims 1
- OWPRKMLXAFQJMD-INIZCTEOSA-N 2-[(3s)-3-[(2-chlorophenyl)methoxycarbonyl-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)OCC1=CC=CC=C1Cl OWPRKMLXAFQJMD-INIZCTEOSA-N 0.000 claims 1
- JWLFNLXYKJSOML-INIZCTEOSA-N 2-[(3s)-3-[(2-chlorophenyl)methylcarbamoyl-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)NCC1=CC=CC=C1Cl JWLFNLXYKJSOML-INIZCTEOSA-N 0.000 claims 1
- KYMUFTDMFQWTJD-HNNXBMFYSA-N 2-[(3s)-3-[(2-phenoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1 KYMUFTDMFQWTJD-HNNXBMFYSA-N 0.000 claims 1
- AKENPVSFYWPJSR-INIZCTEOSA-N 2-[(3s)-3-[(2-phenylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CC=C1 AKENPVSFYWPJSR-INIZCTEOSA-N 0.000 claims 1
- HCHBFDQPITXATR-KRWDZBQOSA-N 2-[(3s)-3-[(2-phenylmethoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)COCC1=CC=CC=C1 HCHBFDQPITXATR-KRWDZBQOSA-N 0.000 claims 1
- QHPMTYNKBKCMSY-ZDUSSCGKSA-N 2-[(3s)-3-[(2-thiophen-2-ylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=CC=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CS1 QHPMTYNKBKCMSY-ZDUSSCGKSA-N 0.000 claims 1
- ZIWYCDKHZFXRSK-VWLOTQADSA-N 2-[(3s)-3-[3,3-diphenylpropanoyl(2-methoxyethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC(C=1C=CC=CC=1)C1=CC=CC=C1 ZIWYCDKHZFXRSK-VWLOTQADSA-N 0.000 claims 1
- QBLPTHUOWFUGHK-QHCPKHFHSA-N 2-[(3s)-3-[3,3-diphenylpropanoyl(methyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC(C=1C=CC=CC=1)C1=CC=CC=C1 QBLPTHUOWFUGHK-QHCPKHFHSA-N 0.000 claims 1
- OUQXCKLQFVVVKC-YTTGMZPUSA-N 2-[(3s)-3-[3,3-diphenylpropanoyl(naphthalen-1-ylmethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CN([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC(C=1C=CC=CC=1)C1=CC=CC=C1 OUQXCKLQFVVVKC-YTTGMZPUSA-N 0.000 claims 1
- SNBXEFIPSIMCRH-INIZCTEOSA-N 2-[(3s)-3-[3-(1,3-benzodioxol-5-yl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=C2OCOC2=CC(CCC(=O)N[C@H]2CCC=3N(C4=CC=C(F)C=C4C=3C2)CC(=O)O)=C1 SNBXEFIPSIMCRH-INIZCTEOSA-N 0.000 claims 1
- QUBKOYICJPPWHN-HNNXBMFYSA-N 2-[(3s)-3-[3-(1,3-benzodioxol-5-yl)propanoylamino]-8-chloro-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=C2OCOC2=CC(CCC(=O)N[C@H]2CCC=3N(C4=C(Cl)C=C(F)C=C4C=3C2)CC(=O)O)=C1 QUBKOYICJPPWHN-HNNXBMFYSA-N 0.000 claims 1
- XVUNELJEQAKWOC-HNNXBMFYSA-N 2-[(3s)-3-[3-(1h-benzimidazol-2-yl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=C2NC(CCC(=O)N[C@H]3CCC=4N(C5=CC=C(F)C=C5C=4C3)CC(=O)O)=NC2=C1 XVUNELJEQAKWOC-HNNXBMFYSA-N 0.000 claims 1
- YCVUEOZEIFVQLL-KRWDZBQOSA-N 2-[(3s)-3-[3-(2,3-dimethoxyphenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1OC YCVUEOZEIFVQLL-KRWDZBQOSA-N 0.000 claims 1
- YZRQVZNFYNZEIN-INIZCTEOSA-N 2-[(3s)-3-[3-(2,4-dichlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(Cl)C=C1Cl YZRQVZNFYNZEIN-INIZCTEOSA-N 0.000 claims 1
- QZFMAFIZWDGLMY-KRWDZBQOSA-N 2-[(3s)-3-[3-(2,4-dimethoxyphenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC(OC)=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 QZFMAFIZWDGLMY-KRWDZBQOSA-N 0.000 claims 1
- XYLQWNZKEYHRLS-IBGZPJMESA-N 2-[(3s)-3-[3-(2,4-dimethylphenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC(C)=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 XYLQWNZKEYHRLS-IBGZPJMESA-N 0.000 claims 1
- VZNXKZZLCWOJEU-KRWDZBQOSA-N 2-[(3s)-3-[3-(2,5-dimethoxyphenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=C(OC)C(CCC(=O)N[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 VZNXKZZLCWOJEU-KRWDZBQOSA-N 0.000 claims 1
- SRLXVMOGLOHCHV-AWEZNQCLSA-N 2-[(3s)-3-[3-(2,6-dichlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=C(Cl)C=CC=C1Cl SRLXVMOGLOHCHV-AWEZNQCLSA-N 0.000 claims 1
- RFXDYKAIASFHHS-INIZCTEOSA-N 2-[(3s)-3-[3-(2-bromophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1Br RFXDYKAIASFHHS-INIZCTEOSA-N 0.000 claims 1
- UEVYOTDJVHBFCA-INIZCTEOSA-N 2-[(3s)-3-[3-(2-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1Cl UEVYOTDJVHBFCA-INIZCTEOSA-N 0.000 claims 1
- KFEQYTROFAYPAY-HNNXBMFYSA-N 2-[(3s)-3-[3-(3,4-difluorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(F)C(F)=C1 KFEQYTROFAYPAY-HNNXBMFYSA-N 0.000 claims 1
- RRQUWDDNWSHKOH-KRWDZBQOSA-N 2-[(3s)-3-[3-(3-bromophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(Br)=C1 RRQUWDDNWSHKOH-KRWDZBQOSA-N 0.000 claims 1
- ZYZCOLNEBXDQHD-LBPRGKRZSA-N 2-[(3s)-3-[3-(3-chloro-1,2-oxazol-5-yl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC(Cl)=NO1 ZYZCOLNEBXDQHD-LBPRGKRZSA-N 0.000 claims 1
- QYNXPJZVVMJFJI-KRWDZBQOSA-N 2-[(3s)-3-[3-(3-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(Cl)=C1 QYNXPJZVVMJFJI-KRWDZBQOSA-N 0.000 claims 1
- BKYBZEAPVRJARQ-KRWDZBQOSA-N 2-[(3s)-3-[3-(4-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(Cl)C=C1 BKYBZEAPVRJARQ-KRWDZBQOSA-N 0.000 claims 1
- WODSFWRHEVCHEV-IBGZPJMESA-N 2-[(3s)-3-[3-(4-ethylphenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(CC)=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 WODSFWRHEVCHEV-IBGZPJMESA-N 0.000 claims 1
- SZOAYRZNMJBFDK-INIZCTEOSA-N 2-[(3s)-3-[3-[2,5-bis(trifluoromethyl)phenyl]propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC(C(F)(F)F)=CC=C1C(F)(F)F SZOAYRZNMJBFDK-INIZCTEOSA-N 0.000 claims 1
- ZJRFSJAAMDWXMD-KRWDZBQOSA-N 2-[(3s)-3-[3-[3,5-bis(trifluoromethyl)phenyl]propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ZJRFSJAAMDWXMD-KRWDZBQOSA-N 0.000 claims 1
- UCOOXEIDFVQPNC-FQEVSTJZSA-N 2-[(3s)-3-[[2-(2,3-dihydro-1h-inden-2-yl)acetyl]-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1C2=CC=CC=C2CC1CC(=O)N(C)[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 UCOOXEIDFVQPNC-FQEVSTJZSA-N 0.000 claims 1
- MUGDSDBYIAQJEI-IBGZPJMESA-N 2-[(3s)-3-[[2-(2,3-dihydro-1h-inden-2-yl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1C2=CC=CC=C2CC1CC(=O)N[C@H]1CCC(N(C2=CC=C(F)C=C22)CC(=O)O)=C2C1 MUGDSDBYIAQJEI-IBGZPJMESA-N 0.000 claims 1
- RIELICTURSLDJI-HNNXBMFYSA-N 2-[(3s)-3-[[2-(2-chlorophenoxy)acetyl]-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)COC1=CC=CC=C1Cl RIELICTURSLDJI-HNNXBMFYSA-N 0.000 claims 1
- WNTPAVDVQSQMCX-SFHVURJKSA-N 2-[(3s)-3-[[2-(3-chlorophenoxy)acetyl]-(2-methoxyethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)COC1=CC=CC(Cl)=C1 WNTPAVDVQSQMCX-SFHVURJKSA-N 0.000 claims 1
- CNNDNZMNNJOWEA-IBGZPJMESA-N 2-[(3s)-3-[[2-(3-chlorophenoxy)acetyl]-(cyclopropylmethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC(Cl)=CC=1OCC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CC1 CNNDNZMNNJOWEA-IBGZPJMESA-N 0.000 claims 1
- UVXDVAHOOCCELV-KRWDZBQOSA-N 2-[(3s)-3-[[2-(3-chlorophenyl)acetyl]-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=CC(Cl)=C1 UVXDVAHOOCCELV-KRWDZBQOSA-N 0.000 claims 1
- SUZFJNIOUCNFOQ-INIZCTEOSA-N 2-[(3s)-3-[[2-(4-chlorophenoxy)acetyl]-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)COC1=CC=C(Cl)C=C1 SUZFJNIOUCNFOQ-INIZCTEOSA-N 0.000 claims 1
- HAUKDABBJZKIFZ-HNNXBMFYSA-N 2-[(3s)-3-[[2-(4-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=C(Cl)C=C1 HAUKDABBJZKIFZ-HNNXBMFYSA-N 0.000 claims 1
- UGMIDZIYCDFXNX-SFHVURJKSA-N 2-[(3s)-3-[[2-(4-chlorophenyl)acetyl]-ethylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=C(Cl)C=C1 UGMIDZIYCDFXNX-SFHVURJKSA-N 0.000 claims 1
- AUYVFXKAPMIIMM-KRWDZBQOSA-N 2-[(3s)-3-[[2-(4-chlorophenyl)acetyl]-methylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=C(Cl)C=C1 AUYVFXKAPMIIMM-KRWDZBQOSA-N 0.000 claims 1
- BTHMDCJJWSCWIU-IBGZPJMESA-N 2-[(3s)-3-[[2-(4-chlorophenyl)acetyl]-propylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=C(Cl)C=C1 BTHMDCJJWSCWIU-IBGZPJMESA-N 0.000 claims 1
- LOWRDCZTZOJFMM-INIZCTEOSA-N 2-[(3s)-3-[[2-(4-chlorophenyl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=C(Cl)C=C1 LOWRDCZTZOJFMM-INIZCTEOSA-N 0.000 claims 1
- FLQKXHHPLILRHS-IBGZPJMESA-N 2-[(3s)-3-[[2-(4-tert-butylphenyl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1CC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 FLQKXHHPLILRHS-IBGZPJMESA-N 0.000 claims 1
- IGCGPTATJWRJAQ-YNMFNDETSA-N 2-[(3s)-3-[[2-benzyl-3-(2-methylphenyl)propanoyl]-carbamoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1CC(C(=O)N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(N)=O)CC1=CC=CC=C1 IGCGPTATJWRJAQ-YNMFNDETSA-N 0.000 claims 1
- TUWRLGBSSIESSC-JWIMYKKASA-N 2-[(3s)-3-[[2-benzyl-4-(4-chloroanilino)-4-oxobutanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)C(CC=1C=CC=CC=1)CC(=O)NC1=CC=C(Cl)C=C1 TUWRLGBSSIESSC-JWIMYKKASA-N 0.000 claims 1
- IHTVDCRFQKVFGA-JWIMYKKASA-N 2-[(3s)-3-[[2-benzyl-4-(4-fluoroanilino)-4-oxobutanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)C(CC=1C=CC=CC=1)CC(=O)NC1=CC=C(F)C=C1 IHTVDCRFQKVFGA-JWIMYKKASA-N 0.000 claims 1
- JTCCDFVSOOBVLR-TUXUZCGSSA-N 2-[(3s)-3-[[2-benzyl-4-[(4-fluorophenyl)methylamino]-4-oxobutanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)C(CC=1C=CC=CC=1)CC(=O)NCC1=CC=C(F)C=C1 JTCCDFVSOOBVLR-TUXUZCGSSA-N 0.000 claims 1
- YGMVFHWHZULUOI-QWAKEFERSA-N 2-[(3s)-3-[[2-benzyl-4-oxo-4-(propylamino)butanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)C(CC(=O)NCCC)CC1=CC=CC=C1 YGMVFHWHZULUOI-QWAKEFERSA-N 0.000 claims 1
- XOQMIQIDNPCMNR-KRWDZBQOSA-N 2-[(3s)-3-[[4-(4-bromophenyl)-4-oxobutanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC(=O)C1=CC=C(Br)C=C1 XOQMIQIDNPCMNR-KRWDZBQOSA-N 0.000 claims 1
- BKOKGDFUWHWJOD-FQEVSTJZSA-N 2-[(3s)-3-[[benzyl(cyclopropylmethyl)carbamoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)N(CC=1C=CC=CC=1)CC1CC1 BKOKGDFUWHWJOD-FQEVSTJZSA-N 0.000 claims 1
- PVADLBUQUFYAHQ-QHCPKHFHSA-N 2-[(3s)-3-[benzyl(benzylcarbamoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC=CC=1CNC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1=CC=CC=C1 PVADLBUQUFYAHQ-QHCPKHFHSA-N 0.000 claims 1
- GMIJPKJUDORAAW-IBGZPJMESA-N 2-[(3s)-3-[benzylcarbamoyl(2-methoxyethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)NCC1=CC=CC=C1 GMIJPKJUDORAAW-IBGZPJMESA-N 0.000 claims 1
- OSKGKUMJFJNUTD-QHCPKHFHSA-N 2-[(3s)-3-[benzylcarbamoyl(cyclohexylmethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC=CC=1CNC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CCCCC1 OSKGKUMJFJNUTD-QHCPKHFHSA-N 0.000 claims 1
- OHLKPMBLEDCNSI-KRWDZBQOSA-N 2-[(3s)-3-[benzylcarbamoyl(methyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)NCC1=CC=CC=C1 OHLKPMBLEDCNSI-KRWDZBQOSA-N 0.000 claims 1
- ZSPACQRLLKUQQI-SANMLTNESA-N 2-[(3s)-3-[benzylcarbamoyl(naphthalen-1-ylmethyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CN([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCC1=CC=CC=C1 ZSPACQRLLKUQQI-SANMLTNESA-N 0.000 claims 1
- ITUXVRXIAYWXLW-DEOSSOPVSA-N 2-[(3s)-3-[cyclohexylmethyl-[3-(2-methoxyphenyl)propanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CCC(=O)N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)CC1CCCCC1 ITUXVRXIAYWXLW-DEOSSOPVSA-N 0.000 claims 1
- BYYYGJLGEYOFEQ-SANMLTNESA-N 2-[(3s)-3-[cyclopropylmethyl(3,3-diphenylpropanoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CC1 BYYYGJLGEYOFEQ-SANMLTNESA-N 0.000 claims 1
- NWOQUJFGHNPAGE-NRFANRHFSA-N 2-[(3s)-3-[cyclopropylmethyl(3-phenylpropanoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC=CC=1CCC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CC1 NWOQUJFGHNPAGE-NRFANRHFSA-N 0.000 claims 1
- YYXXWIWRFTXNBY-FQEVSTJZSA-N 2-[(3s)-3-[cyclopropylmethyl(phenylmethoxycarbonyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC=CC=1COC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CC1 YYXXWIWRFTXNBY-FQEVSTJZSA-N 0.000 claims 1
- FDSSBSRDDCPWFR-QHCPKHFHSA-N 2-[(3s)-3-[cyclopropylmethyl-(2-naphthalen-1-ylacetyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CC1CC1 FDSSBSRDDCPWFR-QHCPKHFHSA-N 0.000 claims 1
- UHBDMFSDJGGSAS-AVRDEDQJSA-N 2-[(3s)-3-[cyclopropylmethyl-[(2s)-2-methyl-3-phenylpropanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C)C(=O)N(CC1CC1)[C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C1=CC=CC=C1 UHBDMFSDJGGSAS-AVRDEDQJSA-N 0.000 claims 1
- KCARJPNLFAMPKI-NRFANRHFSA-N 2-[(3s)-3-[cyclopropylmethyl-[3-(2-methoxyphenyl)propanoyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CCC(=O)N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)CC1CC1 KCARJPNLFAMPKI-NRFANRHFSA-N 0.000 claims 1
- CKTYPBADFQOURO-IBGZPJMESA-N 2-[(3s)-3-[ethyl(3-phenylpropanoyl)amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CCC1=CC=CC=C1 CKTYPBADFQOURO-IBGZPJMESA-N 0.000 claims 1
- AYMPUSODXJSPBT-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-(2-phenylethylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCCC1=CC=CC=C1 AYMPUSODXJSPBT-KRWDZBQOSA-N 0.000 claims 1
- GBLPOQXOFKUCCX-FQEVSTJZSA-N 2-[(3s)-6-fluoro-3-(3-naphthalen-1-ylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=C2C(CCC(=O)N[C@H]3CCC=4N(C5=CC=C(F)C=C5C=4C3)CC(=O)O)=CC=CC2=C1 GBLPOQXOFKUCCX-FQEVSTJZSA-N 0.000 claims 1
- CFAUXOQNFYJNDU-NRFANRHFSA-N 2-[(3s)-6-fluoro-3-(3-naphthalen-2-ylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=CC2=CC(CCC(=O)N[C@H]3CCC=4N(C5=CC=C(F)C=C5C=4C3)CC(=O)O)=CC=C21 CFAUXOQNFYJNDU-NRFANRHFSA-N 0.000 claims 1
- YZDSMIBTWNOZBX-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 YZDSMIBTWNOZBX-KRWDZBQOSA-N 0.000 claims 1
- MNWGGGJKDVEUFT-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-(3-pyridin-3-ylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CN=C1 MNWGGGJKDVEUFT-INIZCTEOSA-N 0.000 claims 1
- QXNWBFJPBATJPT-AWEZNQCLSA-N 2-[(3s)-6-fluoro-3-(3-pyrimidin-2-ylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=NC=CC=N1 QXNWBFJPBATJPT-AWEZNQCLSA-N 0.000 claims 1
- NNIGJATYHVXFQB-AWEZNQCLSA-N 2-[(3s)-6-fluoro-3-(3-thiophen-2-ylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CS1 NNIGJATYHVXFQB-AWEZNQCLSA-N 0.000 claims 1
- MUXGXMGLRSTANQ-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-(4-phenylbutanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCCC1=CC=CC=C1 MUXGXMGLRSTANQ-SFHVURJKSA-N 0.000 claims 1
- CVNQXZNCQBZHQQ-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 CVNQXZNCQBZHQQ-INIZCTEOSA-N 0.000 claims 1
- AUPBPRQVOYSKGO-MHZLTWQESA-N 2-[(3s)-6-fluoro-3-[(2-naphthalen-1-ylacetyl)-(2-phenylethyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CC(=O)N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)CCC1=CC=CC=C1 AUPBPRQVOYSKGO-MHZLTWQESA-N 0.000 claims 1
- ZZCSIDSIPSVOTB-HNNXBMFYSA-N 2-[(3s)-6-fluoro-3-[(2-phenoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1 ZZCSIDSIPSVOTB-HNNXBMFYSA-N 0.000 claims 1
- IOBWZSPYIMOQGT-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[(2-phenylmethoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COCC1=CC=CC=C1 IOBWZSPYIMOQGT-KRWDZBQOSA-N 0.000 claims 1
- FKNYKFRFAMMHGC-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[(3-methyl-3-phenylbutanoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC(C)(C)C1=CC=CC=C1 FKNYKFRFAMMHGC-SFHVURJKSA-N 0.000 claims 1
- MQNWGJQLWAXIAS-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[(4-oxo-4-phenylbutanoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC(=O)C1=CC=CC=C1 MQNWGJQLWAXIAS-KRWDZBQOSA-N 0.000 claims 1
- CSUGTQYZFWOKIU-FQEVSTJZSA-N 2-[(3s)-6-fluoro-3-[2-methoxyethyl(3-phenylpropanoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CCC1=CC=CC=C1 CSUGTQYZFWOKIU-FQEVSTJZSA-N 0.000 claims 1
- YUFTZVJPWUXRII-IBGZPJMESA-N 2-[(3s)-6-fluoro-3-[2-methoxyethyl(phenylmethoxycarbonyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COCCN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)OCC1=CC=CC=C1 YUFTZVJPWUXRII-IBGZPJMESA-N 0.000 claims 1
- NYCZEJIWSVSOLU-QFIPXVFZSA-N 2-[(3s)-6-fluoro-3-[2-methoxyethyl-(2-naphthalen-1-ylacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=C2C(CC(=O)N([C@@H]3CC4=C(N(C5=CC=C(F)C=C54)CC(O)=O)CC3)CCOC)=CC=CC2=C1 NYCZEJIWSVSOLU-QFIPXVFZSA-N 0.000 claims 1
- XJKKYOXPWUNFRX-RXVVDRJESA-N 2-[(3s)-6-fluoro-3-[2-methoxyethyl-[(2s)-2-methyl-3-phenylpropanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C)C(=O)N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)CCOC)C1=CC=CC=C1 XJKKYOXPWUNFRX-RXVVDRJESA-N 0.000 claims 1
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- OEVKAPAEDAETSV-SANMLTNESA-N 2-[(3s)-6-fluoro-3-[3-(2-methoxyphenyl)propanoyl-(3-phenylpropyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CCC(=O)N([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)CCCC1=CC=CC=C1 OEVKAPAEDAETSV-SANMLTNESA-N 0.000 claims 1
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- FTPQDYKVHJWWTA-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[3-(3-methoxyphenyl)propanoyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N(C)[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 FTPQDYKVHJWWTA-SFHVURJKSA-N 0.000 claims 1
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- MTXNYURBTWFQMN-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[3-(4-hydroxy-3-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=C(O)C(OC)=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 MTXNYURBTWFQMN-INIZCTEOSA-N 0.000 claims 1
- NFZUUUQBPAFYDL-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[3-(4-hydroxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(O)C=C1 NFZUUUQBPAFYDL-INIZCTEOSA-N 0.000 claims 1
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- KZNUTDWGXBLKTP-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[3-(4-methylsulfonylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(S(=O)(=O)C)=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 KZNUTDWGXBLKTP-KRWDZBQOSA-N 0.000 claims 1
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- KFURYTPCXCVDLA-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[3-[3-(trifluoromethoxy)phenyl]propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(OC(F)(F)F)=C1 KFURYTPCXCVDLA-INIZCTEOSA-N 0.000 claims 1
- VIPYEFIEFVMALO-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[3-[3-(trifluoromethyl)phenyl]propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(C(F)(F)F)=C1 VIPYEFIEFVMALO-KRWDZBQOSA-N 0.000 claims 1
- ZDSFBWDWRYZTCH-FQEVSTJZSA-N 2-[(3s)-6-fluoro-3-[3-[3-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC(C)(C)OC(=O)NC1=CC=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 ZDSFBWDWRYZTCH-FQEVSTJZSA-N 0.000 claims 1
- WXDVNDCQUVFYQO-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[3-[4-(trifluoromethyl)phenyl]propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=C(C(F)(F)F)C=C1 WXDVNDCQUVFYQO-KRWDZBQOSA-N 0.000 claims 1
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- QEQXXDCRVPYSLM-QAPCUYQASA-N 2-[(3s)-6-fluoro-3-[[(2r)-2-methyl-3-phenylpropanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@@H](C)C(=O)N[C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C1=CC=CC=C1 QEQXXDCRVPYSLM-QAPCUYQASA-N 0.000 claims 1
- PIHGYPRURWQOTL-DHLKQENFSA-N 2-[(3s)-6-fluoro-3-[[(2s)-2-methyl-3-phenylpropanoyl]-(2-phenoxyethyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C)C(=O)N(CCOC=1C=CC=CC=1)[C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C1=CC=CC=C1 PIHGYPRURWQOTL-DHLKQENFSA-N 0.000 claims 1
- RWNPASCZOCXZAJ-NVQXNPDNSA-N 2-[(3s)-6-fluoro-3-[[(2s)-2-methyl-3-phenylpropanoyl]-(2-phenylethyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C)C(=O)N(CCC=1C=CC=CC=1)[C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C1=CC=CC=C1 RWNPASCZOCXZAJ-NVQXNPDNSA-N 0.000 claims 1
- HADVOHKILDGKMB-FIPFOOKPSA-N 2-[(3s)-6-fluoro-3-[[(2s)-2-methyl-3-phenylpropanoyl]-(naphthalen-1-ylmethyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C)C(=O)N(CC=1C2=CC=CC=C2C=CC=1)[C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C1=CC=CC=C1 HADVOHKILDGKMB-FIPFOOKPSA-N 0.000 claims 1
- HTHQQQZGVVIBAK-GOTSBHOMSA-N 2-[(3s)-6-fluoro-3-[[(2s)-3-(4-fluorophenyl)-2-phenylpropanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C([C@H](C(=O)N[C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C=1C=CC=CC=1)C1=CC=C(F)C=C1 HTHQQQZGVVIBAK-GOTSBHOMSA-N 0.000 claims 1
- ADUDPHHJAJIMHZ-UPVQGACJSA-N 2-[(3s)-6-fluoro-3-[[(2s)-3-(4-methoxyphenyl)-2-phenylpropanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(OC)=CC=C1C[C@@H](C=1C=CC=CC=1)C(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 ADUDPHHJAJIMHZ-UPVQGACJSA-N 0.000 claims 1
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- OJZGKILYSGVUNU-HNNXBMFYSA-N 2-[(3s)-6-fluoro-3-[[2-(2-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1OCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 OJZGKILYSGVUNU-HNNXBMFYSA-N 0.000 claims 1
- RAFNBDRYOGRFGN-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[[2-(2-methoxyphenyl)acetyl]-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CC(=O)N(C)[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 RAFNBDRYOGRFGN-KRWDZBQOSA-N 0.000 claims 1
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- YHQXNKBDKSNGNO-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[[2-(3-methoxyphenyl)acetyl]-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CC(=O)N(C)[C@@H]2CC3=C(N(C4=CC=C(F)C=C43)CC(O)=O)CC2)=C1 YHQXNKBDKSNGNO-KRWDZBQOSA-N 0.000 claims 1
- MRLDTAACPNAZCZ-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[[2-(4-methoxyphenyl)acetyl]-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(OC)=CC=C1CC(=O)N(C)[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 MRLDTAACPNAZCZ-KRWDZBQOSA-N 0.000 claims 1
- ULWOBADMFAOAEE-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[[2-(4-methoxyphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(OC)=CC=C1CC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 ULWOBADMFAOAEE-INIZCTEOSA-N 0.000 claims 1
- YLUFSOYLYBPCJY-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[[2-(4-methylphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C)=CC=C1OCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 YLUFSOYLYBPCJY-INIZCTEOSA-N 0.000 claims 1
- CMZRMVKKKVQSOE-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[[2-(4-methylphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(C)=CC=C1CC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 CMZRMVKKKVQSOE-KRWDZBQOSA-N 0.000 claims 1
- HDRMNCAAHMHEOT-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[[2-[3-(trifluoromethyl)phenyl]acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=CC(C(F)(F)F)=C1 HDRMNCAAHMHEOT-INIZCTEOSA-N 0.000 claims 1
- COHJVDQRURAJAP-HNNXBMFYSA-N 2-[(3s)-6-fluoro-3-[[2-[4-(trifluoromethyl)phenoxy]acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=C(C(F)(F)F)C=C1 COHJVDQRURAJAP-HNNXBMFYSA-N 0.000 claims 1
- NDYSRJCSIRKNGU-INIZCTEOSA-N 2-[(3s)-6-fluoro-3-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC1=CC=C(C(F)(F)F)C=C1 NDYSRJCSIRKNGU-INIZCTEOSA-N 0.000 claims 1
- JDODDBIJISBYHA-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[[4-(4-methylsulfonylphenyl)-4-oxobutanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(=O)CCC(=O)N[C@@H]1CC(C=2C(=CC=C(F)C=2)N2CC(O)=O)=C2CC1 JDODDBIJISBYHA-KRWDZBQOSA-N 0.000 claims 1
- DVBLQLNSUFNCCW-NNBQYGFHSA-N 2-[(3s)-6-fluoro-3-[[5-oxo-3-phenyl-5-(1,3,4-thiadiazol-2-ylamino)pentanoyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CC(C=1C=CC=CC=1)CC(=O)NC1=NN=CS1 DVBLQLNSUFNCCW-NNBQYGFHSA-N 0.000 claims 1
- BWGGIZJXAFQCJR-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl(2-phenylethylcarbamoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)NCCC1=CC=CC=C1 BWGGIZJXAFQCJR-SFHVURJKSA-N 0.000 claims 1
- KOQMPLTYKCURRP-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl(3-phenylpropanoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CCC1=CC=CC=C1 KOQMPLTYKCURRP-SFHVURJKSA-N 0.000 claims 1
- GVOGPKIRAZJOQC-KRWDZBQOSA-N 2-[(3s)-6-fluoro-3-[methyl(phenylmethoxycarbonyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)OCC1=CC=CC=C1 GVOGPKIRAZJOQC-KRWDZBQOSA-N 0.000 claims 1
- BSDGYKDITOAEIV-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl-(2-phenylmethoxyacetyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)COCC1=CC=CC=C1 BSDGYKDITOAEIV-SFHVURJKSA-N 0.000 claims 1
- AUCRSBDDZYXUDK-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl-[2-(2-methylphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=CC=C1C AUCRSBDDZYXUDK-SFHVURJKSA-N 0.000 claims 1
- LREVDNKISSLPSL-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl-[2-(3-methylphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=CC(C)=C1 LREVDNKISSLPSL-SFHVURJKSA-N 0.000 claims 1
- ARJWXDMSNDSVQW-SFHVURJKSA-N 2-[(3s)-6-fluoro-3-[methyl-[2-(4-methylphenyl)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CN([C@@H]1CC2=C(N(C3=CC=C(F)C=C32)CC(O)=O)CC1)C(=O)CC1=CC=C(C)C=C1 ARJWXDMSNDSVQW-SFHVURJKSA-N 0.000 claims 1
- WXBYTQRYYSSSRA-MHZLTWQESA-N 2-[(3s)-6-fluoro-3-[naphthalen-1-ylmethyl(3-phenylpropanoyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CN([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 WXBYTQRYYSSSRA-MHZLTWQESA-N 0.000 claims 1
- DRMNIQRLXIHNOO-SANMLTNESA-N 2-[(3s)-6-fluoro-3-[naphthalen-1-ylmethyl(phenylmethoxycarbonyl)amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1CN([C@H]1CCC=2N(C3=CC=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 DRMNIQRLXIHNOO-SANMLTNESA-N 0.000 claims 1
- WWXZJLMEJGHDBG-KRWDZBQOSA-N 2-[(3s)-6-fluoro-8-methyl-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC=2C=3C=C(F)C=C(C=3N(CC(O)=O)C=2CC1)C)C(=O)OCC1=CC=CC=C1 WWXZJLMEJGHDBG-KRWDZBQOSA-N 0.000 claims 1
- RNHFDAHZNYPFCC-INIZCTEOSA-N 2-[(3s)-6-fluoro-8-methylsulfonyl-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@@H]1CC=2C=3C=C(F)C=C(C=3N(CC(O)=O)C=2CC1)S(=O)(=O)C)C(=O)OCC1=CC=CC=C1 RNHFDAHZNYPFCC-INIZCTEOSA-N 0.000 claims 1
- GWXQOOOVUNSGGC-AWEZNQCLSA-N 2-[(3s)-7-chloro-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=CC(Cl)=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 GWXQOOOVUNSGGC-AWEZNQCLSA-N 0.000 claims 1
- YIMVVAXDWTXMFI-HNNXBMFYSA-N 2-[(3s)-8-bromo-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Br)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 YIMVVAXDWTXMFI-HNNXBMFYSA-N 0.000 claims 1
- VEVBNMQMKNUQBE-HNNXBMFYSA-N 2-[(3s)-8-chloro-3-[3-(2-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1Cl VEVBNMQMKNUQBE-HNNXBMFYSA-N 0.000 claims 1
- AUCGEXZGIWVZAV-INIZCTEOSA-N 2-[(3s)-8-chloro-3-[3-(3-chlorophenyl)propanoylamino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(Cl)=C1 AUCGEXZGIWVZAV-INIZCTEOSA-N 0.000 claims 1
- MSYCJUGAAZPCIR-SFHVURJKSA-N 2-[(3s)-8-chloro-3-[[2-(2,3-dihydro-1h-inden-2-yl)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1C2=CC=CC=C2CC1CC(=O)N[C@H]1CCC(N(C2=C(Cl)C=C(F)C=C22)CC(=O)O)=C2C1 MSYCJUGAAZPCIR-SFHVURJKSA-N 0.000 claims 1
- KXAJHTCBBHHWQM-ZDUSSCGKSA-N 2-[(3s)-8-chloro-3-[[2-(2-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC=C1Cl KXAJHTCBBHHWQM-ZDUSSCGKSA-N 0.000 claims 1
- HTLPJCQXWDAGIU-AWEZNQCLSA-N 2-[(3s)-8-chloro-3-[[2-(3-chlorophenoxy)acetyl]amino]-6-fluoro-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)COC1=CC=CC(Cl)=C1 HTLPJCQXWDAGIU-AWEZNQCLSA-N 0.000 claims 1
- MEVAIXUENBUIRH-AWEZNQCLSA-N 2-[(3s)-8-chloro-5-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=CC(F)=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 MEVAIXUENBUIRH-AWEZNQCLSA-N 0.000 claims 1
- ZJYFDOBQLVLOHC-INIZCTEOSA-N 2-[(3s)-8-chloro-6-fluoro-3-(2-phenylethylcarbamoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)NCCC1=CC=CC=C1 ZJYFDOBQLVLOHC-INIZCTEOSA-N 0.000 claims 1
- NXARZSZYEVNKFM-INIZCTEOSA-N 2-[(3s)-8-chloro-6-fluoro-3-(3-phenylpropanoylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1 NXARZSZYEVNKFM-INIZCTEOSA-N 0.000 claims 1
- UVVOSQSXPOQGQG-HNNXBMFYSA-N 2-[(3s)-8-chloro-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 UVVOSQSXPOQGQG-HNNXBMFYSA-N 0.000 claims 1
- KOWSFFLPMVSNGL-INIZCTEOSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(1h-indol-3-yl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound C1=CC=C2C(CCC(=O)N[C@H]3CCC=4N(C5=C(Cl)C=C(F)C=C5C=4C3)CC(=O)O)=CNC2=C1 KOWSFFLPMVSNGL-INIZCTEOSA-N 0.000 claims 1
- NHRKZAMOKHIBNB-HNNXBMFYSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(2-hydroxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC=C1O NHRKZAMOKHIBNB-HNNXBMFYSA-N 0.000 claims 1
- VSUNNIXMVWPJQS-INIZCTEOSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(2-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 VSUNNIXMVWPJQS-INIZCTEOSA-N 0.000 claims 1
- BYUYLSZDDFFYCW-KRWDZBQOSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(2-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1CCC(=O)N[C@@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 BYUYLSZDDFFYCW-KRWDZBQOSA-N 0.000 claims 1
- YCNHPYPXFLOZHR-HNNXBMFYSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(3-hydroxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(Cl)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)CCC1=CC=CC(O)=C1 YCNHPYPXFLOZHR-HNNXBMFYSA-N 0.000 claims 1
- VIRWCTONIDIPKI-INIZCTEOSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(3-methoxyphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 VIRWCTONIDIPKI-INIZCTEOSA-N 0.000 claims 1
- QIERSVBYOHBKTJ-KRWDZBQOSA-N 2-[(3s)-8-chloro-6-fluoro-3-[3-(3-methylphenyl)propanoylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC(CCC(=O)N[C@@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 QIERSVBYOHBKTJ-KRWDZBQOSA-N 0.000 claims 1
- OTCHTOKDJDNPJR-AWEZNQCLSA-N 2-[(3s)-8-chloro-6-fluoro-3-[[2-(2-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC=C1OCC(=O)N[C@@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 OTCHTOKDJDNPJR-AWEZNQCLSA-N 0.000 claims 1
- VELIHXXMWOMMIK-HNNXBMFYSA-N 2-[(3s)-8-chloro-6-fluoro-3-[[2-(2-methylphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound CC1=CC=CC=C1OCC(=O)N[C@@H]1CC(C=2C(=C(Cl)C=C(F)C=2)N2CC(O)=O)=C2CC1 VELIHXXMWOMMIK-HNNXBMFYSA-N 0.000 claims 1
- PHYLVLJBONLYJP-AWEZNQCLSA-N 2-[(3s)-8-chloro-6-fluoro-3-[[2-(3-methoxyphenoxy)acetyl]amino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound COC1=CC=CC(OCC(=O)N[C@@H]2CC3=C(N(C4=C(Cl)C=C(F)C=C43)CC(O)=O)CC2)=C1 PHYLVLJBONLYJP-AWEZNQCLSA-N 0.000 claims 1
- LZCOGUGKMCRMNG-SFHVURJKSA-N 2-[(3s)-8-ethenyl-6-fluoro-3-(phenylmethoxycarbonylamino)-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid Chemical compound N([C@H]1CCC=2N(C3=C(C=C)C=C(F)C=C3C=2C1)CC(=O)O)C(=O)OCC1=CC=CC=C1 LZCOGUGKMCRMNG-SFHVURJKSA-N 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- 208000016557 Acute basophilic leukemia Diseases 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 206010024378 leukocytosis Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000008423 pleurisy Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IB2006052723 | 2006-08-07 | ||
PCT/IB2007/053046 WO2008017989A1 (en) | 2006-08-07 | 2007-08-02 | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
Publications (1)
Publication Number | Publication Date |
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HRP20120044T1 true HRP20120044T1 (hr) | 2012-02-29 |
Family
ID=38805811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20120044T HRP20120044T1 (hr) | 2006-08-07 | 2012-01-13 | Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-octene kiseline |
Country Status (28)
Country | Link |
---|---|
US (1) | US8143304B2 (sl) |
EP (2) | EP2316824A1 (sl) |
JP (1) | JP5220013B2 (sl) |
KR (1) | KR101411820B1 (sl) |
CN (1) | CN101500996B (sl) |
AR (1) | AR062222A1 (sl) |
AT (1) | ATE530523T1 (sl) |
AU (1) | AU2007282949B8 (sl) |
BR (1) | BRPI0715179A2 (sl) |
CA (1) | CA2658986C (sl) |
CL (1) | CL2007002274A1 (sl) |
CY (1) | CY1112276T1 (sl) |
DK (1) | DK2051962T3 (sl) |
ES (1) | ES2374321T3 (sl) |
HK (1) | HK1130062A1 (sl) |
HR (1) | HRP20120044T1 (sl) |
IL (1) | IL196891A (sl) |
MA (1) | MA30696B1 (sl) |
MX (1) | MX2009001105A (sl) |
MY (1) | MY147588A (sl) |
NO (1) | NO20090979L (sl) |
NZ (1) | NZ574705A (sl) |
PL (1) | PL2051962T3 (sl) |
PT (1) | PT2051962E (sl) |
RU (1) | RU2448092C2 (sl) |
SI (1) | SI2051962T1 (sl) |
TW (1) | TWI408126B (sl) |
WO (1) | WO2008017989A1 (sl) |
Families Citing this family (20)
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DK1725553T3 (da) | 2004-03-11 | 2008-08-18 | Actelion Pharmaceuticals Ltd | Tetrahydropyridoindolderivater |
DK1833791T3 (da) | 2004-12-27 | 2011-10-24 | Actelion Pharmaceuticals Ltd | 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister |
KR101235961B1 (ko) | 2008-02-01 | 2013-02-21 | 판미라 파마슈티칼스, 엘엘씨 | 프로스타글란딘 d2 수용체의 n,n-이치환 아미노알킬비페닐 길항제 |
US8497381B2 (en) | 2008-02-25 | 2013-07-30 | Panmira Pharmaceuticals, Llc | Antagonists of prostaglandin D2 receptors |
JP2011526281A (ja) * | 2008-06-24 | 2011-10-06 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のシクロアルカン[b]インドールアンタゴニスト |
GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
GB2465062B (en) * | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
US8394819B2 (en) * | 2009-02-24 | 2013-03-12 | Merck Sharp & Dohme Corp. | Indole derivatives as CRTH2 receptor antagonists |
JP2013500978A (ja) | 2009-07-31 | 2013-01-10 | パンミラ ファーマシューティカルズ,エルエルシー. | Dp2受容体アンタゴニストの眼の医薬組成物 |
US8815917B2 (en) | 2009-08-05 | 2014-08-26 | Panmira Pharmaceuticals, Llc | DP2 antagonist and uses thereof |
TWI562987B (en) | 2010-03-22 | 2016-12-21 | Actelion Pharmaceuticals Ltd | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
EP2697223B1 (en) * | 2011-04-14 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
PL3119779T3 (pl) | 2014-03-17 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Pochodne kwasu azaindolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny d2 |
JP6484644B2 (ja) | 2014-03-18 | 2019-03-13 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | アザインドール酢酸誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
CN104402798B (zh) * | 2014-10-21 | 2016-09-14 | 杭州瑞德化工有限公司 | 一种3-氨基-1,2,3,4-四氢咔唑的拆分方法 |
WO2016133793A1 (en) | 2015-02-16 | 2016-08-25 | Merck Sharp & Dohme Corp. | FACTOR IXa INHIBITORS |
MX2018003202A (es) | 2015-09-15 | 2018-06-08 | Idorsia Pharmaceuticals Ltd | Formas cristalinas. |
CN112094223B (zh) * | 2019-06-18 | 2023-09-15 | 华东师范大学 | 一类脲基四氢咔唑类小分子有机化合物及用途 |
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GB0521275D0 (en) | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
GB0525143D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525141D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525144D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525337D0 (en) | 2005-12-13 | 2006-01-18 | Novartis Ag | Organic compounds |
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2007
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- 2007-08-02 EP EP11000641A patent/EP2316824A1/en not_active Withdrawn
- 2007-08-02 CN CN2007800292169A patent/CN101500996B/zh not_active Expired - Fee Related
- 2007-08-02 AT AT07805287T patent/ATE530523T1/de active
- 2007-08-02 ES ES07805287T patent/ES2374321T3/es active Active
- 2007-08-02 WO PCT/IB2007/053046 patent/WO2008017989A1/en active Application Filing
- 2007-08-02 CA CA2658986A patent/CA2658986C/en not_active Expired - Fee Related
- 2007-08-02 PL PL07805287T patent/PL2051962T3/pl unknown
- 2007-08-02 PT PT07805287T patent/PT2051962E/pt unknown
- 2007-08-02 MX MX2009001105A patent/MX2009001105A/es active IP Right Grant
- 2007-08-02 DK DK07805287.5T patent/DK2051962T3/da active
- 2007-08-02 KR KR1020097004370A patent/KR101411820B1/ko active IP Right Grant
- 2007-08-02 SI SI200730818T patent/SI2051962T1/sl unknown
- 2007-08-02 BR BRPI0715179-9A patent/BRPI0715179A2/pt not_active IP Right Cessation
- 2007-08-02 NZ NZ574705A patent/NZ574705A/en not_active IP Right Cessation
- 2007-08-02 EP EP07805287A patent/EP2051962B1/en active Active
- 2007-08-02 RU RU2009107889/04A patent/RU2448092C2/ru not_active IP Right Cessation
- 2007-08-02 MY MYPI20090462A patent/MY147588A/en unknown
- 2007-08-02 JP JP2009523396A patent/JP5220013B2/ja not_active Expired - Fee Related
- 2007-08-02 US US12/376,932 patent/US8143304B2/en not_active Expired - Fee Related
- 2007-08-06 AR ARP070103462A patent/AR062222A1/es unknown
- 2007-08-06 CL CL200702274A patent/CL2007002274A1/es unknown
- 2007-08-06 TW TW096128871A patent/TWI408126B/zh not_active IP Right Cessation
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2009
- 2009-02-04 IL IL196891A patent/IL196891A/en not_active IP Right Cessation
- 2009-02-17 MA MA31646A patent/MA30696B1/fr unknown
- 2009-03-04 NO NO20090979A patent/NO20090979L/no not_active Application Discontinuation
- 2009-10-28 HK HK09110028.6A patent/HK1130062A1/xx not_active IP Right Cessation
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2012
- 2012-01-13 HR HR20120044T patent/HRP20120044T1/hr unknown
- 2012-01-25 CY CY20121100090T patent/CY1112276T1/el unknown
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