HRP20110784T1 - 3-indazolil-4-piridilizotiazoli - Google Patents
3-indazolil-4-piridilizotiazoli Download PDFInfo
- Publication number
- HRP20110784T1 HRP20110784T1 HR20110784T HRP20110784T HRP20110784T1 HR P20110784 T1 HRP20110784 T1 HR P20110784T1 HR 20110784 T HR20110784 T HR 20110784T HR P20110784 T HRP20110784 T HR P20110784T HR P20110784 T1 HRP20110784 T1 HR P20110784T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- methyl
- alkyl
- Prior art date
Links
- CVVZXBNOQGUOQI-UHFFFAOYSA-N 3-[3-(1h-indazol-3-yl)pyridin-4-yl]-1,2-thiazole Chemical class S1C=CC(C=2C(=CN=CC=2)C=2C3=CC=CC=C3NN=2)=N1 CVVZXBNOQGUOQI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 150000003839 salts Chemical class 0.000 claims abstract 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 5
- -1 1-fluoro-1-methylethyl Chemical group 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Spoj formule, ili njegova farmaceutski prihvatljiva sol, naznačen time štoR1 je H ili C1-C3 alkil; R2 je H, C1-C3 alkil, C3-C5 cikloalkil, C1-C3 fluoralkil, NR4R5, C1-C3 alkoksi ili C1-C3 alkoksimetil; R3 je H ili metil; iR4 i R5 su neovisno H ili C1-C3 alkil. Patent sadrži još 11 patentnih zahtjeva.
Claims (12)
1. Spoj formule, ili njegova farmaceutski prihvatljiva sol,
[image]
naznačen time što
R1 je H ili C1-C3 alkil;
R2 je H, C1-C3 alkil, C3-C5 cikloalkil, C1-C3 fluoralkil, NR4R5, C1-C3 alkoksi ili C1-C3 alkoksimetil;
R3 je H ili metil; i
R4 i R5 su neovisno H ili C1-C3 alkil.
2. Spoj i skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što
R1 je C1-C3 alkil;
R2 je C1-C3 alkil, C3-C5 cikloalkil ili C1-C3 fluoralkil; i
R3 je metil.
3. Spoj i skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što R1 je C1-C3 alkil.
4. Spoj i skladu s patentnim zahtjevom 1 ili 3, ili njegova farmaceutski prihvatljiva sol, naznačen time što R2 je C1-C3 alkil.
5. Spoj i skladu s patentnim zahtjevom 1, 3 ili 4, ili njegova farmaceutski prihvatljiva sol, naznačen time što R3 je metil.
6. Spoj i skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što
R1 je H, metil ili etil;
R2 je H, metil, etil, propil, izopropil, ciklopropil, ciklobutil, ciklopentil, fluormetil, difluormetil, 1-fluor-1-metiletil, metilamino, dimetilamino, metoksi ili metoksimetil; i
R3 je H ili metil.
7. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je [4-(6-etilpiridin-2-il)-3-(2-metil-2H-indazol-5-il)izotiazol-5-il]amid (1R,2R)-2-metilciklopropankarboksilne kiseline, ili njegova farmaceutski prihvatljiva sol.
8. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što je [4-(6-izopropilpiridin-2-il)-3-(2-metil-2H-indazol-5-il)izotiazol-5-il]amid (1R,2R)-2-metilciklopropankarboksilne kiseline, ili njegova farmaceutski prihvatljiva sol.
9. Spoj u skladu s in patentni zahtjev 8, naznečen time što je [4-(6-izopropilpiridin-2-il)-3-(2-metil-2H-indazol-5-il)izotiazol-5-il]amid (1R,2R)-2-metilciklopropankarboksilne kiseline.
10. Farmaceutski pripravak naznačen time što sadrži spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegovu farmaceutski prihvatljivu sol, i farmaceutski prihvatljivu podlogu, razrjeđivač ili pomoćnu tvar.
11. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
12. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 9, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju anksioznosti.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4239408P | 2008-04-04 | 2008-04-04 | |
PCT/US2009/037458 WO2009123855A1 (en) | 2008-04-04 | 2009-03-18 | 3-indazolyl-4-pyridylisothiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110784T1 true HRP20110784T1 (hr) | 2011-11-30 |
Family
ID=40725748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110784T HRP20110784T1 (hr) | 2008-04-04 | 2011-10-26 | 3-indazolil-4-piridilizotiazoli |
Country Status (24)
Country | Link |
---|---|
US (1) | US7932274B2 (hr) |
EP (1) | EP2276759B1 (hr) |
JP (1) | JP5449320B2 (hr) |
KR (1) | KR101247010B1 (hr) |
CN (1) | CN101959883B (hr) |
AR (1) | AR070986A1 (hr) |
AT (1) | ATE529422T1 (hr) |
AU (1) | AU2009232263B2 (hr) |
BR (1) | BRPI0910692A2 (hr) |
CA (1) | CA2720631C (hr) |
CL (1) | CL2009000646A1 (hr) |
CY (1) | CY1112118T1 (hr) |
DK (1) | DK2276759T3 (hr) |
EA (1) | EA018001B1 (hr) |
ES (1) | ES2372677T3 (hr) |
HR (1) | HRP20110784T1 (hr) |
JO (1) | JO2775B1 (hr) |
MX (1) | MX2010010781A (hr) |
PE (1) | PE20091681A1 (hr) |
PL (1) | PL2276759T3 (hr) |
PT (1) | PT2276759E (hr) |
SI (1) | SI2276759T1 (hr) |
TW (1) | TW200944522A (hr) |
WO (1) | WO2009123855A1 (hr) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4075001A (en) | 1976-06-18 | 1978-02-21 | Fmc Corporation | 3-Aminoisothiazole derivatives as herbicides |
IL72091A0 (en) | 1983-06-20 | 1984-10-31 | Lilly Co Eli | N'-substituted(3-aryl 5-isothiazolyl)urea derivatives |
DE4328425A1 (de) | 1993-08-24 | 1995-03-02 | Basf Ag | Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung |
US6413997B1 (en) | 1998-10-23 | 2002-07-02 | Dow Agrosciences Llc | 3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds |
DE60205974T2 (de) * | 2001-04-04 | 2006-06-29 | Pfizer Products Inc., Groton | Neue Benzotriazole mit entzündungshemmender Wirkung |
AU2004228057A1 (en) * | 2003-04-03 | 2004-10-21 | Merck & Co., Inc. | Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
TW200735866A (en) * | 2005-11-18 | 2007-10-01 | Synta Pharmaceuticals Corp | Compounds for the treatment of proliferative disorders |
UA95480C2 (uk) | 2006-06-08 | 2011-08-10 | Елі Ліллі Енд Компані | Заміщені карбоксаміди |
CA2684385A1 (en) * | 2007-04-19 | 2008-10-30 | Glaxo Group Limited | Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (s1p) agonists |
-
2009
- 2009-03-18 CN CN2009801072150A patent/CN101959883B/zh not_active Expired - Fee Related
- 2009-03-18 SI SI200930131T patent/SI2276759T1/sl unknown
- 2009-03-18 KR KR1020107022020A patent/KR101247010B1/ko not_active IP Right Cessation
- 2009-03-18 EA EA201071168A patent/EA018001B1/ru not_active IP Right Cessation
- 2009-03-18 WO PCT/US2009/037458 patent/WO2009123855A1/en active Application Filing
- 2009-03-18 BR BRPI0910692A patent/BRPI0910692A2/pt not_active IP Right Cessation
- 2009-03-18 DK DK09727170.4T patent/DK2276759T3/da active
- 2009-03-18 ES ES09727170T patent/ES2372677T3/es active Active
- 2009-03-18 US US12/406,139 patent/US7932274B2/en not_active Expired - Fee Related
- 2009-03-18 AR ARP090100977A patent/AR070986A1/es not_active Application Discontinuation
- 2009-03-18 PL PL09727170T patent/PL2276759T3/pl unknown
- 2009-03-18 EP EP09727170A patent/EP2276759B1/en not_active Not-in-force
- 2009-03-18 JO JO2009109A patent/JO2775B1/en active
- 2009-03-18 JP JP2011503023A patent/JP5449320B2/ja not_active Expired - Fee Related
- 2009-03-18 TW TW098108812A patent/TW200944522A/zh unknown
- 2009-03-18 AT AT09727170T patent/ATE529422T1/de active
- 2009-03-18 MX MX2010010781A patent/MX2010010781A/es active IP Right Grant
- 2009-03-18 PT PT09727170T patent/PT2276759E/pt unknown
- 2009-03-18 AU AU2009232263A patent/AU2009232263B2/en not_active Ceased
- 2009-03-18 PE PE2009000402A patent/PE20091681A1/es not_active Application Discontinuation
- 2009-03-18 CA CA2720631A patent/CA2720631C/en not_active Expired - Fee Related
- 2009-03-18 CL CL2009000646A patent/CL2009000646A1/es unknown
-
2011
- 2011-10-26 HR HR20110784T patent/HRP20110784T1/hr unknown
- 2011-11-25 CY CY20111101158T patent/CY1112118T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EA201071168A1 (ru) | 2011-04-29 |
CY1112118T1 (el) | 2015-11-04 |
EP2276759A1 (en) | 2011-01-26 |
JP2011516481A (ja) | 2011-05-26 |
PE20091681A1 (es) | 2009-11-04 |
EP2276759B1 (en) | 2011-10-19 |
PT2276759E (pt) | 2011-12-19 |
WO2009123855A1 (en) | 2009-10-08 |
ATE529422T1 (de) | 2011-11-15 |
CN101959883A (zh) | 2011-01-26 |
CN101959883B (zh) | 2013-01-30 |
KR20100118999A (ko) | 2010-11-08 |
KR101247010B1 (ko) | 2013-03-26 |
DK2276759T3 (da) | 2012-01-02 |
JO2775B1 (en) | 2014-03-15 |
AR070986A1 (es) | 2010-05-19 |
AU2009232263B2 (en) | 2013-07-04 |
BRPI0910692A2 (pt) | 2018-03-27 |
US7932274B2 (en) | 2011-04-26 |
SI2276759T1 (sl) | 2012-02-29 |
CA2720631C (en) | 2012-08-28 |
CA2720631A1 (en) | 2009-10-08 |
AU2009232263A1 (en) | 2009-10-08 |
ES2372677T3 (es) | 2012-01-25 |
CL2009000646A1 (es) | 2010-04-09 |
JP5449320B2 (ja) | 2014-03-19 |
TW200944522A (en) | 2009-11-01 |
EA018001B1 (ru) | 2013-04-30 |
US20090253750A1 (en) | 2009-10-08 |
MX2010010781A (es) | 2010-12-14 |
PL2276759T3 (pl) | 2012-03-30 |
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