AR081154A1 - Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y metodos de uso - Google Patents

Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y metodos de uso

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Publication number
AR081154A1
AR081154A1 ARP110100821A AR081154A1 AR 081154 A1 AR081154 A1 AR 081154A1 AR P110100821 A ARP110100821 A AR P110100821A AR 081154 A1 AR081154 A1 AR 081154A1
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AR
Argentina
Prior art keywords
alkyl
independently
alkynyl
oxo
alkenyl
Prior art date
Application number
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English (en)
Inventor
Matthew Weiss
Ted Judd
Ana Elena Minatti
Patricia Lopez
Thomas Dineen
Isaac Marx
Michele Potashman
Timothy Powers
Wenyuan Qian
Nick A Paras
Yuan Cheng
Wenge Zhong
Jian J Chen
Oleg Epstein
Jonathan Low
Bryant Yang
Ryan White
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR081154A1 publication Critical patent/AR081154A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente comprende una clase de compuestos para la modulación de actividad de enzima beta-secretasa y para el tratamiento de enfermedades mediadas por beta-secretasa, incluyendo enfermedad de Alzheimer (AD) y afecciones relacionadas. También incluye el uso de estos compuestos en las composiciones farmacéuticas para tratamiento, profiláctico o terapéutico, de trastornos y afecciones relacionadas con la actividad de proteína beta-secretasa. Tales trastornos incluyen, por ejemplo, enfermedad de Alzheimer, déficits cognitivos, deterioro cognitivo, esquizofrenia y otras afecciones del sistema nervioso central relacionadas a y/o causadas por la formación y/o deposición de placa en el cerebro. También comprende además modalidades de la fórmula (1), intermediarios y procesos útiles para la preparación de compuestos de la fórmula (1). Reivindicación 1: Un compuesto de la fórmula (1), o un estereoisómero, tautómero, hidrato, solvato o sal farmacéuticamente aceptable del mismo, caracterizado porque: A1 es CR6 o N; A2 es CR5 o N; A3 es CR4 o N; A4 es CR3 o N; A5 es CR1 o N; A6 es CR8 o N, con la condición de que no más de uno de A1, A2, A3, A4, A5 y A6 es N; cada uno de R1, R4, R5 y R8, independientemente, es H, F, Cl, Br, CF3, OCF3, -alquilo C1-6, CN, OH, -O-alquilo C1-6-, -S(O)o-alquilo C1-6, -NH-alquilo C1-6 o -C(O)-alquilo C1-6, en donde el -alquilo C1-6 y porción -alquilo C1-6 de -O-alquilo C1-6-, -S(O)o-alquilo C1-6, -NH-alquilo C1-6 y -C(O)-alquilo C1-6 se sustituyen opcionalmente con 1 - 3 sustituyentes de F, oxo u OH; cada uno de R2 y R7, independientemente, es F, Cl, Br, l, haloalquilo, haloalcoxilo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, CN, -O-alquilo C1-6, -S-alquilo C1-6, -NH-alquilo C1-6, -N(alquilo C1-3)2, -NH-fenilo, -NH-bencilo, -Si(CH3)3 o un anillo seleccionado del grupo que consiste de fenilo, piridilo, pirimidilo, pirazinilo, piridazinilo, triazinilo, tienilo, pirazolilo, imidazolilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, diazolilo, triazolilo, tetrazolilo, piranilo, dihidropiranilo, tetrahidropiranilo, furanilo, dihidrofuranilo, tetrahidrofuranilo, pirrolilo, dihidropirrolilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, azetidinilo, 8-oxo-3-aza-biciclo[3.2.1]oct-3-ilo, aza-biciclo[2.2.1]hept-5-ilo, 2-oxo-7-aza-[3,5]-espironon-7-ilo, ciclopropilo, ciclobutilo, ciclopentilo y ciclohexilo, en donde el alquilo C1-6, alquenilo C2-4, alquinilo C2-4, -O-alquilo C1-6, -S-alquilo C1-6, -NH-alquilo C1-6, -N(alquilo C1-3)2, -NH-fenilo, -NH-bencilo y un anillo están opcionalmente sustituidos, independientemente, con 1 - 3 sustituyentes de R9; cada uno de R3 y R6, independientemente, es H, halo, haloalquilo, haloalcoxilo, -alquilo C1-6, CN, OH, O-alquilo C1-6. S(O)o-alquilo C1-6, NH-alquilo C1-6 o C(O)-alquilo C1-6; cada R9, independientemente, es halo, haloalquilo, haloalcoxilo, CN, OH, NO2, NH2, acetilo, -C(O)NHCH3, oxo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilamino C1-6-, dialquilamino C1-6-, alcoxilo C1-6, tioalcoxilo C1-6, morfolinilo, pirazolilo, isoxazolilo, dihidropiranilo, pirrolidinilo, piperazinilo, oxetanilo o dioxolilo, en donde cada uno del alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, alquilamino C1-6-, dialquilamino C1-6-, alcoxilo C1-6, tioalcoxilo C1-6, morfolinilo, pirazolilo, isoxazolilo, dihidropiranilo, pirrolidinilo, oxetanilo o dioxolilo, está opcionalmente sustituido independientemente con 1 - 5 sustituyentes de F, Cl, CN, NO2, NH2, OH, oxo, metilo, metoxilo, etilo, etoxilo, propilo, propoxilo, isopropilo, isopropoxilo, ciclopropilo, ciclopropilmetoxilo, butilo, butoxilo, isobutoxilo, tert-butoxilo, isobutilo, sec-butilo, tert-butilo, alquilamino C1-3-, dialquilamino C1-3, tioalcoxilo C1-3, u oxetanilo; X es -CR10R10-, -O- ó -S-, en donde cada R10, independientemente, es H, halo, haloalquilo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6 o un anillo seleccionado del grupo que consiste de morfolinilo, piperidinilo, piperizinilo, tetrahidrofuranilo, furanilo, tienilo, fenilo, piridinilo, pirimidinilo, piridazinilo, pirazinilo, piranilo, dihidropiranilo, tetrahidropiranilo, pirrolilo, dihidropirrolilo, tetrahidropirrolilo y oxetanilo; Y es -O-, -S- o -CH2-, con la condición de que (i) cuando X es -O- ó -S-, entonces Y es -CH2-, o (ii) cuando X es -CR10R10-, entonces Y es -O- ó -S-; y Z es CH2, CHF, CF2, CH(CH3), C(CH3)2 o CH(CF3).
ARP110100821 2010-03-15 2011-03-15 Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y metodos de uso AR081154A1 (es)

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US31402410P 2010-03-15 2010-03-15

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AR081154A1 true AR081154A1 (es) 2012-07-04

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US (2) US8497264B2 (es)
EP (1) EP2547686B1 (es)
JP (1) JP5584352B2 (es)
AR (1) AR081154A1 (es)
AU (1) AU2011227501B9 (es)
CA (1) CA2791389C (es)
ES (1) ES2450568T3 (es)
MX (1) MX2012010657A (es)
TW (1) TW201144323A (es)
UY (1) UY33276A (es)
WO (1) WO2011115928A1 (es)

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