HRP20110414T1 - Indoli i njihova uporaba u liječenju - Google Patents
Indoli i njihova uporaba u liječenju Download PDFInfo
- Publication number
- HRP20110414T1 HRP20110414T1 HR20110414T HRP20110414T HRP20110414T1 HR P20110414 T1 HRP20110414 T1 HR P20110414T1 HR 20110414 T HR20110414 T HR 20110414T HR P20110414 T HRP20110414 T HR P20110414T HR P20110414 T1 HRP20110414 T1 HR P20110414T1
- Authority
- HR
- Croatia
- Prior art keywords
- fluoro
- alkyl
- chloro
- phenyl
- optionally substituted
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- WSVPXEFZKKQPQS-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-3-[(3-pyridin-2-ylsulfonylthiophen-2-yl)methyl]indol-1-yl]acetic acid Chemical compound C12=CC(F)=CC=C2N(CC(O)=O)C(C)=C1CC=1SC=CC=1S(=O)(=O)C1=CC=CC=N1 WSVPXEFZKKQPQS-UHFFFAOYSA-N 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000028004 allergic respiratory disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 6
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 2
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 102000009389 Prostaglandin D receptors Human genes 0.000 abstract 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0724429A GB0724429D0 (en) | 2007-12-14 | 2007-12-14 | Compounds |
| GB0806083A GB0806083D0 (en) | 2008-04-03 | 2008-04-03 | Compounds |
| GB0814910A GB0814910D0 (en) | 2008-08-14 | 2008-08-14 | Compounds |
| PCT/GB2008/004107 WO2009077728A1 (fr) | 2007-12-14 | 2008-12-12 | Indoles et leur utilisation thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110414T1 true HRP20110414T1 (hr) | 2011-08-31 |
Family
ID=40328483
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110414T HRP20110414T1 (hr) | 2007-12-14 | 2011-06-03 | Indoli i njihova uporaba u liječenju |
| HRP20120554AT HRP20120554T1 (hr) | 2007-12-14 | 2012-07-06 | Indoli i njihova terapijska uporaba |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120554AT HRP20120554T1 (hr) | 2007-12-14 | 2012-07-06 | Indoli i njihova terapijska uporaba |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8394836B2 (fr) |
| EP (2) | EP2327693B9 (fr) |
| JP (1) | JP5327762B2 (fr) |
| CN (1) | CN101970405A (fr) |
| AT (1) | ATE502920T1 (fr) |
| AU (1) | AU2008337342B2 (fr) |
| BR (1) | BRPI0820872A2 (fr) |
| CA (1) | CA2707785C (fr) |
| CY (2) | CY1111585T1 (fr) |
| DE (1) | DE602008005796D1 (fr) |
| DK (2) | DK2229358T3 (fr) |
| EA (1) | EA017573B1 (fr) |
| ES (1) | ES2386340T3 (fr) |
| HR (2) | HRP20110414T1 (fr) |
| IL (1) | IL206087A (fr) |
| MX (1) | MX2010006341A (fr) |
| NZ (1) | NZ585888A (fr) |
| PL (2) | PL2229358T3 (fr) |
| PT (2) | PT2327693E (fr) |
| SI (2) | SI2327693T1 (fr) |
| WO (1) | WO2009077728A1 (fr) |
| ZA (1) | ZA201003872B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
| RU2458918C2 (ru) | 2006-07-22 | 2012-08-20 | Оксаген Лимитед | Соединения, обладающие антагонистической активностью по отношению к crth2 |
| RU2503672C2 (ru) * | 2008-01-18 | 2014-01-10 | Оксаген Лимитед | Соединения, обладающие активностью антагонистов crth2 |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| WO2009093029A1 (fr) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Composés présentant une activité antagoniste de crth2 |
| SI2558447T1 (sl) | 2010-03-22 | 2015-01-30 | Actelion Pharmaceuticals Ltd. | Derivati 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-karbazola in njihova uporaba kot modulatorji prostaglandinskega receptorja d2 |
| WO2012009134A1 (fr) * | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Modulateurs de crth2 |
| BR112013026283A8 (pt) | 2011-04-14 | 2018-01-30 | Actelion Pharmaceuticals Ltd | derivados de ácido 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indol acético e seu uso como moduladores do receptor d2 de prostaglandina |
| SI2781508T1 (sl) * | 2011-11-17 | 2019-03-29 | Kbp Biosciences Co., Ltd. | Zlite obročne spojine, ki vsebujejo dušik za uporabo kot antagonisti CRTH2 |
| US20140328861A1 (en) * | 2011-12-16 | 2014-11-06 | Atopix Therapeutics Limited | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis |
| US9797903B2 (en) | 2012-10-24 | 2017-10-24 | Winthrop-University Hospital | Non-invasive biomarker to identify subject at risk of preterm delivery |
| GB201322273D0 (en) * | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| AR099767A1 (es) | 2014-03-17 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados del ácido acético azaindol y su uso como moduladores del receptor de prostaglandina d2 |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| EP3159339B1 (fr) | 2014-06-09 | 2020-11-25 | Sumitomo Chemical Company, Limited | Procédé de production d'un composé pyridinique |
| US10351560B2 (en) | 2015-09-15 | 2019-07-16 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
| TWI726968B (zh) | 2016-01-07 | 2021-05-11 | 開曼群島商Ｃｓ醫藥技術公司 | Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑 |
| WO2017119732A1 (fr) | 2016-01-08 | 2017-07-13 | Samsung Electronics Co., Ltd. | Dispositif électronique, et son procédé de fonctionnement |
| JP7112957B2 (ja) | 2016-03-09 | 2022-08-04 | ベイジン パーカンズ オンコロジー カンパニー リミテッド | 腫瘍細胞懸濁培養及び関連方法 |
| AU2017298256B2 (en) * | 2016-07-21 | 2020-11-26 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indole derivative used as CRTH2 inhibitor |
| EP3682250A4 (fr) | 2017-09-13 | 2021-03-03 | Progenity, Inc. | Biomarqueurs de pré-éclampsie ainsi que systèmes et procédés associés |
| CN109096186B (zh) * | 2018-09-29 | 2020-08-04 | 中南大学 | 一种2-芳磺酰基喹啉衍生物的合成方法 |
| EP4070113A4 (fr) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié |
| CN113425714B (zh) * | 2021-08-04 | 2022-04-26 | 华南师范大学 | 吲哚乙酸在制备防治慢性阻塞性肺病药物中的应用 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842195A1 (fr) | 1995-07-06 | 1998-05-20 | Zeneca Limited | Inhibiteurs peptidiques de la fibronectine |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| YU25500A (sh) | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| JP2001163899A (ja) | 1999-12-09 | 2001-06-19 | Natl Inst Of Sericultural & Entomological Science | 機能性絹フィブロインの製造方法とその利用 |
| GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| EP1241176A1 (fr) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Dérivés de purine pour le traitement de l'ischémie |
| JP4292402B2 (ja) | 2001-09-07 | 2009-07-08 | 小野薬品工業株式会社 | インドール誘導体化合物、それらの製造方法およびそれらを有効成分として含有する薬剤 |
| ES2271365T3 (es) | 2001-12-20 | 2007-04-16 | Bayer Healthcare Ag | Derivados de 1,4-dihidro-1,4-difenilpiridina. |
| SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| AU2003231513A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Pgd2 receptor antagonist |
| AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| US7504508B2 (en) | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| JP2006508077A (ja) | 2002-10-04 | 2006-03-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 炎症疾患を治療するためのｐｇｄ２レセプタアンタゴニスト |
| AU2003269327A1 (en) | 2002-10-21 | 2004-05-04 | Warner-Lambert Company Llc | Tetrahydroquinoline derivatives as crth2 antagonists |
| EP1413306A1 (fr) | 2002-10-21 | 2004-04-28 | Warner-Lambert Company LLC | Dérivé de la tétrahydroquinoline en tant qu'antagonistes de CRTH2 |
| JP4457017B2 (ja) | 2002-12-20 | 2010-04-28 | アムジエン・インコーポレーテツド | 喘息及びアレルギー性炎症モジュレーター |
| EP1435356A1 (fr) | 2003-01-06 | 2004-07-07 | Warner-Lambert Company LLC | Dérivés de la quinoléine en tant qu'antagonistes de CRTH2 |
| EP1600440A1 (fr) | 2003-03-06 | 2005-11-30 | Ono Pharmaceutical Co., Ltd. | Composes a base de derives d'indole et medicaments contenant lesdits composes en tant que principe actif |
| SE0301009D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| WO2005007094A2 (fr) | 2003-07-09 | 2005-01-27 | Tularik Inc. | Modulateurs d'asthme et d'inflammations allergiques |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| WO2005040114A1 (fr) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Composes presentant une activite antagoniste de crth2 |
| WO2005040112A1 (fr) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Composes a activite antagoniste de pgd2 |
| GB2407318A (en) | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
| CN1929834B (zh) | 2004-03-11 | 2010-12-08 | 埃科特莱茵药品有限公司 | 吲哚-1-基乙酸衍生物 |
| KR20070002085A (ko) | 2004-04-07 | 2007-01-04 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질병을 치료하기 위한 ｐｇｄ２ 수용체 길항제 |
| US20050242153A1 (en) | 2004-04-20 | 2005-11-03 | Acco Brands, Inc. | Stapler |
| GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
| WO2005115382A1 (fr) | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Ligands des recepteurs crth2 a usages medicaux |
| WO2006034419A2 (fr) | 2004-09-21 | 2006-03-30 | Athersys, Inc. | Acides indole acetiques antagonistes du recepteur crth2 et ses utilisations |
| WO2006056752A1 (fr) | 2004-11-23 | 2006-06-01 | Astrazeneca Ab | Derives d'acide phenoxyacetique utiles pour le traitement des maladies respiratoires |
| GB0427381D0 (en) | 2004-12-14 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| CA2598133A1 (fr) | 2005-02-24 | 2006-08-31 | Millennium Pharmaceuticals, Inc. | Antagonistes de recepteur de pgd2 pour le traitement des maladies inflammatoires |
| GB0505048D0 (en) * | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0510585D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0512944D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Indolizine compounds |
| GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| EA015358B1 (ru) | 2005-09-30 | 2011-06-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Хинолины и их терапевтическое применение |
| GB0521275D0 (en) | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
| WO2007062678A1 (fr) | 2005-11-29 | 2007-06-07 | 7Tm Pharma A/S | Derives d'acide phenoxyacetique comme ligands du recepteur crth2 |
| GB0524428D0 (en) | 2005-11-30 | 2006-01-11 | 7Tm Pharma As | Medicinal use of receptor ligands |
| GB0525141D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP2125722A2 (fr) * | 2006-05-26 | 2009-12-02 | AstraZeneca AB | Indoles substitues par biaryl ou aryl-heteroaryl |
| GB0611695D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| RU2458918C2 (ru) | 2006-07-22 | 2012-08-20 | Оксаген Лимитед | Соединения, обладающие антагонистической активностью по отношению к crth2 |
| EP2094266A1 (fr) | 2006-12-21 | 2009-09-02 | Argenta Discovery Limited | Antagonistes de crth2 |
| JP2010522149A (ja) | 2007-03-21 | 2010-07-01 | アージェンタ オーラル セラピューティクス リミテッド | Ｃｒｔｈ２アンタゴニストとしてのインドリジン酢酸誘導体 |
| ATE544751T1 (de) | 2007-03-29 | 2012-02-15 | Pulmagen Therapeutics Asthma Ltd | Chinolinderivate als crth2-rezeptorliganden |
| US8173812B2 (en) | 2007-04-04 | 2012-05-08 | Pulmagen Therapeutics (Asthma) Limited | Quinolines and their therapeutic use |
| GB0722203D0 (en) * | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
-
2008
- 2008-12-12 DK DK08862784.9T patent/DK2229358T3/da active
- 2008-12-12 EP EP10193389A patent/EP2327693B9/fr not_active Not-in-force
- 2008-12-12 WO PCT/GB2008/004107 patent/WO2009077728A1/fr active Application Filing
- 2008-12-12 SI SI200830693T patent/SI2327693T1/sl unknown
- 2008-12-12 CN CN2008801267027A patent/CN101970405A/zh active Pending
- 2008-12-12 CA CA2707785A patent/CA2707785C/fr not_active Expired - Fee Related
- 2008-12-12 ES ES10193389T patent/ES2386340T3/es active Active
- 2008-12-12 BR BRPI0820872-7A patent/BRPI0820872A2/pt not_active Application Discontinuation
- 2008-12-12 AU AU2008337342A patent/AU2008337342B2/en not_active Ceased
- 2008-12-12 PT PT10193389T patent/PT2327693E/pt unknown
- 2008-12-12 SI SI200830260T patent/SI2229358T1/sl unknown
- 2008-12-12 DE DE602008005796T patent/DE602008005796D1/de active Active
- 2008-12-12 PL PL08862784T patent/PL2229358T3/pl unknown
- 2008-12-12 EP EP08862784A patent/EP2229358B1/fr not_active Not-in-force
- 2008-12-12 JP JP2010537514A patent/JP5327762B2/ja not_active Expired - Fee Related
- 2008-12-12 DK DK10193389.3T patent/DK2327693T3/da active
- 2008-12-12 AT AT08862784T patent/ATE502920T1/de active
- 2008-12-12 EA EA201070731A patent/EA017573B1/ru not_active IP Right Cessation
- 2008-12-12 US US12/746,104 patent/US8394836B2/en not_active Expired - Fee Related
- 2008-12-12 MX MX2010006341A patent/MX2010006341A/es active IP Right Grant
- 2008-12-12 PT PT08862784T patent/PT2229358E/pt unknown
- 2008-12-12 PL PL10193389T patent/PL2327693T3/pl unknown
- 2008-12-12 NZ NZ585888A patent/NZ585888A/en not_active IP Right Cessation
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2010
- 2010-05-31 ZA ZA2010/03872A patent/ZA201003872B/en unknown
- 2010-05-31 IL IL206087A patent/IL206087A/en active IP Right Grant
-
2011
- 2011-06-03 HR HR20110414T patent/HRP20110414T1/hr unknown
- 2011-06-23 CY CY20111100597T patent/CY1111585T1/el unknown
-
2012
- 2012-07-04 CY CY20121100592T patent/CY1113179T1/el unknown
- 2012-07-06 HR HRP20120554AT patent/HRP20120554T1/hr unknown
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2013
- 2013-01-31 US US13/755,727 patent/US20130225617A1/en not_active Abandoned
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