CY1111585T1 - Ινδολια και θεραπευτικη χρηση αυτων - Google Patents
Ινδολια και θεραπευτικη χρηση αυτωνInfo
- Publication number
- CY1111585T1 CY1111585T1 CY20111100597T CY111100597T CY1111585T1 CY 1111585 T1 CY1111585 T1 CY 1111585T1 CY 20111100597 T CY20111100597 T CY 20111100597T CY 111100597 T CY111100597 T CY 111100597T CY 1111585 T1 CY1111585 T1 CY 1111585T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fluoro
- alkyl
- chloro
- phenyl
- optionally substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ενώσεις του τύπου (I) είναι συνδετήρες του υποδοχέα CRTH2, χρήσιμες μεταξύ άλλων για θεραπεία φλεγμονωδών καταστάσεων. Όπου το Χ είναι -SO2- ή *-SO2NR3- όπου ο δεσμός που σημειώνεται με έναν αστερίσκο συνδέεται προς Ar1, το R1 είναι υδρογόνο, φθόρο, χλώρο, CN ή CF3, το R2 είναι υδρογόνο, φθόρο ή χλώρο, το R3 είναι υδρογόνο, C1-C8αλκύλ ή C3- C7κυκλοαλκύλ, το Ar1 είναι φαινύλ ή 5-μελής ή 6-μελής ετεροαρύλ ομάδα επιλεγόμενη από φουρανύλ, θειενύλ, οξαζολύλ, θειαζολύλ, ιμιδαζολύλ, πυραζολύλ, ισοξαζολύλ, ισοθειαζολύλ, πυριδινύλ, πυριδαζινύλ, πυριμιδινύλ και πιπεραζινύλ, όπου οι φαινύλ ή ετεροαρύλ ομάδες προαιρετικά είναι υποκατεστημένες με έναν ή περισσότερους υποκατάστατες ανεξαρτήτως επιλεγόμενους από φθόρο, χλώρο, CN, C3-C7κυκλοαλκύλ, -Ο(C1-C4αλκύλ) ή C1-C6αλκύλ, οι τελευταίες δε δύο ομάδες προαιρετικά είναι υποκατεστημένες με ένα ή περισσότερα φθόρο άτομα και το Ar2 είναι φαινύλ ή 5-μελής ή 6-μελής ετεροαρύλ ομάδα, επιλεγόμενη από πυρρολύλ, φουρανύλ, θειενύλ, οξαζολύλ, θειαζολύλ, ιμιδαζολύλ, πυραζολύλ, ισοξαζολύλ, ισοθειαζολύλ, πυριδινύλ, πυριδαζινύλ, πυριμιδινύλ και πιπεραζινύλ, όπου οι φαινύλ ή ετεροαρύλ ομάδες προαιρετικά είναι υποκατεστημένες με έναν ή περισσότερους υποκατάστατες ανεξαρτήτως επιλεγόμενους από φθόρο, χλώρο, CN, C3-C3-C7κυκλοαλκύλ, -Ο(C1-C4αλκύλ) ή C1-C6αλκύλ, οι τελευταίες δε δύο ομάδες προαιρετικά είναι υποκατεστημένες με ένα ή περισσότερα φθόρο άτομα.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0724429A GB0724429D0 (en) | 2007-12-14 | 2007-12-14 | Compounds |
GB0806083A GB0806083D0 (en) | 2008-04-03 | 2008-04-03 | Compounds |
GB0814910A GB0814910D0 (en) | 2008-08-14 | 2008-08-14 | Compounds |
EP08862784A EP2229358B1 (en) | 2007-12-14 | 2008-12-12 | Indoles and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111585T1 true CY1111585T1 (el) | 2015-10-07 |
Family
ID=40328483
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100597T CY1111585T1 (el) | 2007-12-14 | 2011-06-23 | Ινδολια και θεραπευτικη χρηση αυτων |
CY20121100592T CY1113179T1 (el) | 2007-12-14 | 2012-07-04 | Ινδολια και θεραπευτικη χρηση αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100592T CY1113179T1 (el) | 2007-12-14 | 2012-07-04 | Ινδολια και θεραπευτικη χρηση αυτων |
Country Status (22)
Country | Link |
---|---|
US (2) | US8394836B2 (el) |
EP (2) | EP2327693B9 (el) |
JP (1) | JP5327762B2 (el) |
CN (1) | CN101970405A (el) |
AT (1) | ATE502920T1 (el) |
AU (1) | AU2008337342B2 (el) |
BR (1) | BRPI0820872A2 (el) |
CA (1) | CA2707785C (el) |
CY (2) | CY1111585T1 (el) |
DE (1) | DE602008005796D1 (el) |
DK (2) | DK2229358T3 (el) |
EA (1) | EA017573B1 (el) |
ES (1) | ES2386340T3 (el) |
HR (2) | HRP20110414T1 (el) |
IL (1) | IL206087A (el) |
MX (1) | MX2010006341A (el) |
NZ (1) | NZ585888A (el) |
PL (2) | PL2327693T3 (el) |
PT (2) | PT2229358E (el) |
SI (2) | SI2327693T1 (el) |
WO (1) | WO2009077728A1 (el) |
ZA (1) | ZA201003872B (el) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
KR20090042808A (ko) | 2006-07-22 | 2009-04-30 | 옥사겐 리미티드 | 씨알티에이치2 길항제 활성을 갖는 화합물 |
US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
EP2250161B1 (en) * | 2008-01-18 | 2013-10-16 | Atopix Therapeutics Limited | Compounds having crth2 antagonist activity |
EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
AR080703A1 (es) | 2010-03-22 | 2012-05-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-carbazol, moduladores de receptores de prostaglandina d2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos alergicos o inmunitarios tales como asma. |
WO2012009134A1 (en) * | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
EP2697223B1 (en) | 2011-04-14 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
EP2781508B9 (en) * | 2011-11-17 | 2019-08-21 | KBP Biosciences Co., Ltd. | Nitrogen-containing fused ring compounds for use as crth2 antagonists |
BR112014014558A8 (pt) * | 2011-12-16 | 2017-07-04 | Atopix Therapeutics Ltd | composição farmacêutica, uso de um antagonista de crth2 e de um inibidor de bomba de prótons, e, kit para o tratamento de esofagite eosinofílica |
WO2014066568A1 (en) | 2012-10-24 | 2014-05-01 | Winthrop-University Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
GB201322273D0 (en) * | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
PL3119779T3 (pl) | 2014-03-17 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Pochodne kwasu azaindolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny d2 |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
JPWO2015190316A1 (ja) * | 2014-06-09 | 2017-04-20 | 住友化学株式会社 | ピリジン化合物の製造方法 |
KR20180053345A (ko) | 2015-09-15 | 2018-05-21 | 이도르시아 파마슈티컬스 리미티드 | 결정질 형태 |
US10435388B2 (en) | 2016-01-07 | 2019-10-08 | Cs Pharmatech Limited | Selective inhibitors of clinically important mutants of the EGFR tyrosine kinase |
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US11753626B2 (en) | 2016-03-09 | 2023-09-12 | Beijing Percans Oncology Co., Ltd. | Tumor cell suspension cultures and related methods |
US10800765B2 (en) * | 2016-07-21 | 2020-10-13 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indole derivative used as CRTH2 inhibitor |
WO2019055661A1 (en) | 2017-09-13 | 2019-03-21 | Progenity, Inc. | PRE-ÉCLAMPSIE BIOMARKERS AND ASSOCIATED SYSTEMS AND METHODS |
CN109096186B (zh) * | 2018-09-29 | 2020-08-04 | 中南大学 | 一种2-芳磺酰基喹啉衍生物的合成方法 |
EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
CN113425714B (zh) * | 2021-08-04 | 2022-04-26 | 华南师范大学 | 吲哚乙酸在制备防治慢性阻塞性肺病药物中的应用 |
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GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
GB0510585D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0512944D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Indolizine compounds |
GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
ES2399061T3 (es) | 2005-09-30 | 2013-03-25 | Pulmagen Therapeutics (Asthma) Limited | Quinolinas y su uso terapéutico |
GB0521275D0 (en) | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
WO2007062678A1 (en) | 2005-11-29 | 2007-06-07 | 7Tm Pharma A/S | Phenoxyacetic acid derivatives as crth2 receptor ligands |
GB0524428D0 (en) | 2005-11-30 | 2006-01-11 | 7Tm Pharma As | Medicinal use of receptor ligands |
GB0525141D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
CN102558021A (zh) | 2006-05-26 | 2012-07-11 | 阿斯利康(瑞典)有限公司 | 联芳基或芳基-杂芳基取代的吲哚类化合物 |
GB0611695D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
KR20090042808A (ko) * | 2006-07-22 | 2009-04-30 | 옥사겐 리미티드 | 씨알티에이치2 길항제 활성을 갖는 화합물 |
EA200970590A1 (ru) | 2006-12-21 | 2009-12-30 | Арджента Дискавери Лимитед | Антагонисты crth2 |
AU2007349641A1 (en) | 2007-03-21 | 2008-09-25 | Argenta Oral Therapeutics Limited | Indolizine acetic acid derivatives as CRTH2 antagonists |
MX2009010376A (es) | 2007-03-29 | 2010-01-20 | Argenta Oral Therapeutics Ltd | Derivados de quinolina como ligandos del receptor crth2. |
ES2375588T3 (es) | 2007-04-04 | 2012-03-02 | Pulmagen Therapeutics (Asthma) Limited | Quinolinas y su uso terapéutico. |
GB0722203D0 (en) * | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
-
2008
- 2008-12-12 AU AU2008337342A patent/AU2008337342B2/en not_active Ceased
- 2008-12-12 EA EA201070731A patent/EA017573B1/ru not_active IP Right Cessation
- 2008-12-12 WO PCT/GB2008/004107 patent/WO2009077728A1/en active Application Filing
- 2008-12-12 PT PT08862784T patent/PT2229358E/pt unknown
- 2008-12-12 US US12/746,104 patent/US8394836B2/en not_active Expired - Fee Related
- 2008-12-12 PL PL10193389T patent/PL2327693T3/pl unknown
- 2008-12-12 BR BRPI0820872-7A patent/BRPI0820872A2/pt not_active Application Discontinuation
- 2008-12-12 JP JP2010537514A patent/JP5327762B2/ja not_active Expired - Fee Related
- 2008-12-12 SI SI200830693T patent/SI2327693T1/sl unknown
- 2008-12-12 CA CA2707785A patent/CA2707785C/en not_active Expired - Fee Related
- 2008-12-12 SI SI200830260T patent/SI2229358T1/sl unknown
- 2008-12-12 ES ES10193389T patent/ES2386340T3/es active Active
- 2008-12-12 EP EP10193389A patent/EP2327693B9/en not_active Not-in-force
- 2008-12-12 PT PT10193389T patent/PT2327693E/pt unknown
- 2008-12-12 DE DE602008005796T patent/DE602008005796D1/de active Active
- 2008-12-12 EP EP08862784A patent/EP2229358B1/en not_active Not-in-force
- 2008-12-12 CN CN2008801267027A patent/CN101970405A/zh active Pending
- 2008-12-12 NZ NZ585888A patent/NZ585888A/en not_active IP Right Cessation
- 2008-12-12 DK DK08862784.9T patent/DK2229358T3/da active
- 2008-12-12 DK DK10193389.3T patent/DK2327693T3/da active
- 2008-12-12 AT AT08862784T patent/ATE502920T1/de active
- 2008-12-12 PL PL08862784T patent/PL2229358T3/pl unknown
- 2008-12-12 MX MX2010006341A patent/MX2010006341A/es active IP Right Grant
-
2010
- 2010-05-31 IL IL206087A patent/IL206087A/en active IP Right Grant
- 2010-05-31 ZA ZA2010/03872A patent/ZA201003872B/en unknown
-
2011
- 2011-06-03 HR HR20110414T patent/HRP20110414T1/hr unknown
- 2011-06-23 CY CY20111100597T patent/CY1111585T1/el unknown
-
2012
- 2012-07-04 CY CY20121100592T patent/CY1113179T1/el unknown
- 2012-07-06 HR HRP20120554AT patent/HRP20120554T1/hr unknown
-
2013
- 2013-01-31 US US13/755,727 patent/US20130225617A1/en not_active Abandoned
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