HRP20110184T1 - Postupak priprave 5-(haloacetil)-8-(supstituirani oksi)-(1h)-kinolin-2-ona - Google Patents
Postupak priprave 5-(haloacetil)-8-(supstituirani oksi)-(1h)-kinolin-2-ona Download PDFInfo
- Publication number
- HRP20110184T1 HRP20110184T1 HR20110184T HRP20110184T HRP20110184T1 HR P20110184 T1 HRP20110184 T1 HR P20110184T1 HR 20110184 T HR20110184 T HR 20110184T HR P20110184 T HRP20110184 T HR P20110184T HR P20110184 T1 HRP20110184 T1 HR P20110184T1
- Authority
- HR
- Croatia
- Prior art keywords
- quinolin
- hydroxy
- acetyl
- substituted oxy
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45972403P | 2003-04-02 | 2003-04-02 | |
| PCT/EP2004/003479 WO2004087668A1 (en) | 2003-04-02 | 2004-04-01 | A process for the preparation of 5-(haloacetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110184T1 true HRP20110184T1 (hr) | 2011-04-30 |
Family
ID=33131902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110184T HRP20110184T1 (hr) | 2003-04-02 | 2004-04-01 | Postupak priprave 5-(haloacetil)-8-(supstituirani oksi)-(1h)-kinolin-2-ona |
Country Status (34)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| GB0413960D0 (en) * | 2004-06-22 | 2004-07-28 | Novartis Ag | Organic compounds |
| DK2044025T3 (da) | 2006-06-30 | 2013-01-14 | Novartis Ag | Quinolinonderivater samt farmaceutiske sammensætninger deraf |
| WO2013132514A2 (en) * | 2012-03-09 | 2013-09-12 | Rao Davuluri Ramamohan | A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one |
| CN102633717B (zh) * | 2012-03-30 | 2013-11-20 | 西南大学 | N-乙酰-喹啉-2(1h)酮类化合物及其制备方法和应用 |
| CN104379566B (zh) * | 2012-07-11 | 2016-08-24 | 上海威智医药科技有限公司 | 茚达特罗中间体及茚达特罗的合成方法 |
| CZ306252B6 (cs) | 2013-03-15 | 2016-10-26 | Zentiva, K.S. | Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu) |
| PT3092217T (pt) | 2014-01-09 | 2020-09-04 | Ramamohan Rao Davuluri | Processo inovador para preparação de indacaterol ou dos seus sais farmaceuticamente aceitáveis |
| CN105693603B (zh) * | 2014-11-24 | 2019-11-29 | 上海医药工业研究院 | 改良的马来酸茚达特罗制备工艺 |
| CN107531636B (zh) * | 2015-04-09 | 2022-11-25 | 正大天晴药业集团股份有限公司 | 茚达特罗或其盐的制备方法 |
| CN107868045A (zh) * | 2016-09-28 | 2018-04-03 | 四川海思科制药有限公司 | 一种茚达特罗中间体的制备方法 |
| CN108264483A (zh) * | 2016-12-31 | 2018-07-10 | 天津金耀集团有限公司 | 一种马来酸茚达特罗的制备方法 |
| CN109721534B (zh) * | 2018-09-25 | 2022-05-20 | 四川海思科制药有限公司 | 一种马来酸茚达特罗中间体及其制备方法和用途 |
| CN114751857A (zh) * | 2022-04-29 | 2022-07-15 | 梯尔希（南京）药物研发有限公司 | 一种茚达特罗杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539228B2 (enExample) * | 1974-01-31 | 1978-04-04 | ||
| CA1164459A (en) * | 1980-11-11 | 1984-03-27 | Yung-Hsiung Yang | Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives |
| JPS5896022A (ja) * | 1981-11-30 | 1983-06-07 | Otsuka Pharmaceut Co Ltd | 強心剤 |
| ES519384A0 (es) * | 1983-01-28 | 1984-03-16 | Espanola Farma Therapeut | Procedimiento para la obtencion de un compuesto derivado de la 2-quinolinona. |
| ES8605239A1 (es) * | 1985-12-04 | 1986-03-16 | Astur Pharma | Un procedimiento para la preparacion de quinolonas sustitui-das |
| US4894219A (en) * | 1988-03-29 | 1990-01-16 | University Of Florida | Beta-agonist carbostyril derivatives, assay method and pharmacological composition |
| GB9405019D0 (en) * | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| JP2000510865A (ja) * | 1996-05-20 | 2000-08-22 | ダーウィン・ディスカバリー・リミテッド | Ｔｎｆとｐｄｅ―ｉｖのインヒビターとしてのキノリンカルボキサミド |
| GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| US6653323B2 (en) * | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI324150B (en) * | 2003-02-28 | 2010-05-01 | Novartis Ag | Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt |
-
2004
- 2004-03-31 PE PE2004000341A patent/PE20050211A1/es not_active Application Discontinuation
- 2004-03-31 PE PE2010000225A patent/PE20100399A1/es not_active Application Discontinuation
- 2004-03-31 TW TW093108942A patent/TWI324151B/zh not_active IP Right Cessation
- 2004-04-01 PT PT04725035T patent/PT1613599E/pt unknown
- 2004-04-01 MY MYPI20041213A patent/MY141871A/en unknown
- 2004-04-01 ES ES04725035T patent/ES2358193T3/es not_active Expired - Lifetime
- 2004-04-01 DE DE602004030553T patent/DE602004030553D1/de not_active Expired - Lifetime
- 2004-04-01 JP JP2006504953A patent/JP4726778B2/ja not_active Expired - Lifetime
- 2004-04-01 AR ARP040101105A patent/AR043825A1/es not_active Application Discontinuation
- 2004-04-01 AT AT04725035T patent/ATE491690T1/de active
- 2004-04-01 CN CNA2004800089560A patent/CN1774423A/zh active Pending
- 2004-04-01 NZ NZ542623A patent/NZ542623A/en not_active IP Right Cessation
- 2004-04-01 CL CL200400706A patent/CL2004000706A1/es unknown
- 2004-04-01 AU AU2004226212A patent/AU2004226212B2/en not_active Expired
- 2004-04-01 DK DK04725035.2T patent/DK1613599T3/da active
- 2004-04-01 MX MXPA05010616A patent/MXPA05010616A/es active IP Right Grant
- 2004-04-01 BR BRPI0409154-0B1A patent/BRPI0409154B1/pt not_active IP Right Cessation
- 2004-04-01 EP EP04725035A patent/EP1613599B8/en not_active Expired - Lifetime
- 2004-04-01 PL PL04725035T patent/PL1613599T3/pl unknown
- 2004-04-01 US US10/550,621 patent/US7605267B2/en active Active
- 2004-04-01 SI SI200431618T patent/SI1613599T1/sl unknown
- 2004-04-01 CA CA2520990A patent/CA2520990C/en not_active Expired - Lifetime
- 2004-04-01 RU RU2005133664/04A patent/RU2339621C2/ru active
- 2004-04-01 HR HR20110184T patent/HRP20110184T1/hr unknown
- 2004-04-01 WO PCT/EP2004/003479 patent/WO2004087668A1/en not_active Ceased
-
2005
- 2005-09-20 ZA ZA200507603A patent/ZA200507603B/en unknown
- 2005-09-22 IL IL171053A patent/IL171053A/en active IP Right Grant
- 2005-09-29 EC EC2005006059A patent/ECSP056059A/es unknown
- 2005-09-30 TN TNP2005000245A patent/TNSN05245A1/en unknown
- 2005-09-30 KR KR1020057018750A patent/KR101073740B1/ko not_active Expired - Lifetime
- 2005-10-11 MA MA28545A patent/MA27761A1/fr unknown
- 2005-10-12 CO CO05104250A patent/CO5700779A2/es active IP Right Grant
- 2005-10-27 IS IS8095A patent/IS2800B/is unknown
- 2005-11-01 NO NO20055099A patent/NO331980B1/no unknown
-
2011
- 2011-03-14 CY CY20111100284T patent/CY1111515T1/el unknown
-
2016
- 2016-01-25 AR ARP160100188A patent/AR103508A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20110184T1 (hr) | Postupak priprave 5-(haloacetil)-8-(supstituirani oksi)-(1h)-kinolin-2-ona | |
| SU1657064A3 (ru) | Способ получени производных тетрагидро(фуро- или тиено)-[2,3-с]пиридина или их гидрохлоридов или четвертичных солей с метилйодидом | |
| ES2536923T3 (es) | Proceso e intermedios para preparar inhibidores de la integrasa del VIH | |
| US7057067B2 (en) | Process for the preparation of 2-halobenzoic acids | |
| HRP20161369T1 (hr) | Postupak za proizvodnju intermedijera estetrola | |
| US20100081688A1 (en) | Process for the preparation of montelukast, and intermediates therefor | |
| JP2006522055A5 (enExample) | ||
| KR920010571B1 (ko) | 플루오르화 벤조일 화합물 | |
| CN113233974A (zh) | 一种酰基氟化物的合成方法 | |
| TW201833065A (zh) | 製備經環丙基取代之苯乙酮的方法 | |
| ES2400943T3 (es) | Proceso para la preparación de N-alquil-2(hidroxi-4-benzoil)-3-benzofuranos y compuestos intermedios de los mismos | |
| US4785121A (en) | Preparation of halophthalic anhydrides | |
| CN106565626A (zh) | 2‑氨基‑4‑芳基‑5‑甲硫基噻唑类化合物的合成方法 | |
| IE39419L (en) | Bis-(benzyl) acetic acid derivatives. | |
| WO2005063661A1 (ja) | フッ素化剤およびそれを用いる含フッ素化合物の製造方法 | |
| JPH01254659A (ja) | ピロール誘導体 | |
| TH2103000895C3 (th) | อนุพันธ์ของสาร 5,7-ไดไฮดรอกซี-3-เมทอกซี ฟลาโวน (5,7-dihydroxy-3-methoxy flavone) | |
| CN109956968B (zh) | 铽有机膦酸配合物的制备方法及其在水体检测中的应用 | |
| ES8105737A1 (es) | Un procedimiento para la preparacion de un derivado de un acido penicilanico 6b-sustituido | |
| EP0015140B1 (en) | Thermolysis of 2-(3-aryl-isoxazol-5-yl)benzoic acids, salts and halides from 3'-(aryl)-spiro(isobenzofuran-1(3h),5'(4'h)isoxazol)-3-ones | |
| Wojakowska et al. | Phase diagram for the CuBr–CsBr system | |
| GB2149795A (en) | Thio substituted triaryl sulphonium salts | |
| CN104387265B (zh) | 一种4,5-二羟基-2-甲基苯甲酸的制备方法 | |
| IT8222986A1 (it) | Procedimento per la produzione di 2-ammino-4-idrossi-5-alogeno-pirimidine | |
| CN103772340B (zh) | 一种芳基取代萘并吡喃类化合物的改进合成方法 |