HRP20110043T1 - Derivati 5-piridazinil-1-azabiciklo[3.2.1]oktana, njihovo dobivanje i njihova upotreba u terapiji - Google Patents
Derivati 5-piridazinil-1-azabiciklo[3.2.1]oktana, njihovo dobivanje i njihova upotreba u terapiji Download PDFInfo
- Publication number
- HRP20110043T1 HRP20110043T1 HR20110043T HRP20110043T HRP20110043T1 HR P20110043 T1 HRP20110043 T1 HR P20110043T1 HR 20110043 T HR20110043 T HR 20110043T HR P20110043 T HRP20110043 T HR P20110043T HR P20110043 T1 HRP20110043 T1 HR P20110043T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- azabicyclo
- octane
- pyridazin
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 13
- 238000002360 preparation method Methods 0.000 title claims 13
- DSXZGIRPYFTAGF-UHFFFAOYSA-N 5-pyridazin-3-yl-1-azabicyclo[3.2.1]octane Chemical class C1N(CCC2)CCC21C1=CC=CN=N1 DSXZGIRPYFTAGF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 37
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 10
- 125000005843 halogen group Chemical group 0.000 claims abstract 10
- -1 nitro, amino Chemical group 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 6
- 239000012453 solvate Substances 0.000 claims abstract 6
- 239000002253 acid Substances 0.000 claims abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims abstract 4
- 125000002541 furyl group Chemical group 0.000 claims abstract 4
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 4
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract 4
- 125000001544 thienyl group Chemical group 0.000 claims abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 4
- 125000001786 isothiazolyl group Chemical group 0.000 claims abstract 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims abstract 3
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims abstract 3
- 125000002971 oxazolyl group Chemical group 0.000 claims abstract 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims abstract 3
- 125000001113 thiadiazolyl group Chemical group 0.000 claims abstract 3
- 125000000335 thiazolyl group Chemical group 0.000 claims abstract 3
- 125000001425 triazolyl group Chemical group 0.000 claims abstract 3
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims 12
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 6
- PBIUDEUWYGBHDW-UHFFFAOYSA-N 2-chloro-1-pyridin-3-ylethanone;hydrochloride Chemical compound Cl.ClCC(=O)C1=CC=CN=C1 PBIUDEUWYGBHDW-UHFFFAOYSA-N 0.000 claims 5
- 230000032683 aging Effects 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 210000003141 lower extremity Anatomy 0.000 claims 4
- 230000007170 pathology Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 3
- 229910052763 palladium Inorganic materials 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 208000006264 Korsakoff syndrome Diseases 0.000 claims 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 241000208125 Nicotiana Species 0.000 claims 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 206010039580 Scar Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 208000000558 Varicose Ulcer Diseases 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 208000029650 alcohol withdrawal Diseases 0.000 claims 2
- 230000001476 alcoholic effect Effects 0.000 claims 2
- 206010003230 arteritis Diseases 0.000 claims 2
- 230000009901 attention process Effects 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 230000001146 hypoxic effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 210000003625 skull Anatomy 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 201000002282 venous insufficiency Diseases 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0508594A FR2889847B1 (fr) | 2005-08-18 | 2005-08-18 | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
PCT/FR2006/001911 WO2007020343A1 (fr) | 2005-08-18 | 2006-08-07 | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110043T1 true HRP20110043T1 (hr) | 2011-02-28 |
Family
ID=36297201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110043T HRP20110043T1 (hr) | 2005-08-18 | 2011-01-20 | Derivati 5-piridazinil-1-azabiciklo[3.2.1]oktana, njihovo dobivanje i njihova upotreba u terapiji |
Country Status (40)
Country | Link |
---|---|
US (3) | US7476674B2 (es) |
EP (1) | EP1922320B1 (es) |
JP (1) | JP5249758B2 (es) |
KR (1) | KR101260546B1 (es) |
CN (2) | CN102558177A (es) |
AR (1) | AR056461A1 (es) |
AT (1) | ATE486073T1 (es) |
AU (1) | AU2006281340B2 (es) |
BR (1) | BRPI0614796A2 (es) |
CA (1) | CA2618110C (es) |
CR (1) | CR9693A (es) |
CY (1) | CY1111101T1 (es) |
DE (1) | DE602006017854D1 (es) |
DK (1) | DK1922320T3 (es) |
DO (1) | DOP2006000191A (es) |
EA (1) | EA013601B1 (es) |
EC (1) | ECSP088182A (es) |
ES (1) | ES2354833T3 (es) |
FR (1) | FR2889847B1 (es) |
HK (1) | HK1125628A1 (es) |
HN (1) | HN2008000276A (es) |
HR (1) | HRP20110043T1 (es) |
IL (1) | IL189014A0 (es) |
JO (1) | JO2680B1 (es) |
MA (1) | MA29913B1 (es) |
MX (1) | MX2008002276A (es) |
MY (1) | MY145923A (es) |
NO (1) | NO20081289L (es) |
NZ (1) | NZ565537A (es) |
PE (1) | PE20070234A1 (es) |
PL (1) | PL1922320T3 (es) |
PT (1) | PT1922320E (es) |
RS (1) | RS51653B (es) |
SI (1) | SI1922320T1 (es) |
TN (1) | TNSN08026A1 (es) |
TW (1) | TWI322808B (es) |
UA (1) | UA92360C2 (es) |
UY (1) | UY29756A1 (es) |
WO (1) | WO2007020343A1 (es) |
ZA (1) | ZA200800966B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
US20220347175A1 (en) | 2018-07-19 | 2022-11-03 | Sumitomo Dainippon Pharma Co., Ltd. | Pyridazinone derivative |
US20230109839A1 (en) | 2020-01-07 | 2023-04-13 | Sumitomo Pharma Co., Ltd. | Therapeutic agent for tauopathies |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
ES2223209B1 (es) | 2001-12-11 | 2005-10-01 | Esteve Quimica, S.A. | Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion. |
JP4312456B2 (ja) | 2000-10-13 | 2009-08-12 | ニューロサーチ、アクティーゼルスカブ | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
US6644511B2 (en) | 2002-01-11 | 2003-11-11 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Container for dispensing a dual phase fluid product |
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2005
- 2005-08-18 FR FR0508594A patent/FR2889847B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-26 JO JO2006251A patent/JO2680B1/en active
- 2006-08-07 BR BRPI0614796-8A patent/BRPI0614796A2/pt not_active IP Right Cessation
- 2006-08-07 AT AT06794297T patent/ATE486073T1/de active
- 2006-08-07 SI SI200630880T patent/SI1922320T1/sl unknown
- 2006-08-07 CN CN2011104283877A patent/CN102558177A/zh active Pending
- 2006-08-07 DK DK06794297.9T patent/DK1922320T3/da active
- 2006-08-07 NZ NZ565537A patent/NZ565537A/en not_active IP Right Cessation
- 2006-08-07 PT PT06794297T patent/PT1922320E/pt unknown
- 2006-08-07 CA CA2618110A patent/CA2618110C/fr not_active Expired - Fee Related
- 2006-08-07 EP EP06794297A patent/EP1922320B1/fr active Active
- 2006-08-07 DE DE602006017854T patent/DE602006017854D1/de active Active
- 2006-08-07 MX MX2008002276A patent/MX2008002276A/es active IP Right Grant
- 2006-08-07 UA UAA200803421A patent/UA92360C2/ru unknown
- 2006-08-07 RS RS20110011A patent/RS51653B/en unknown
- 2006-08-07 WO PCT/FR2006/001911 patent/WO2007020343A1/fr active Application Filing
- 2006-08-07 PL PL06794297T patent/PL1922320T3/pl unknown
- 2006-08-07 EA EA200800615A patent/EA013601B1/ru not_active IP Right Cessation
- 2006-08-07 JP JP2008526522A patent/JP5249758B2/ja not_active Expired - Fee Related
- 2006-08-07 AU AU2006281340A patent/AU2006281340B2/en not_active Ceased
- 2006-08-07 ES ES06794297T patent/ES2354833T3/es active Active
- 2006-08-07 CN CN2006800297295A patent/CN101291933B/zh not_active Expired - Fee Related
- 2006-08-15 PE PE2006000988A patent/PE20070234A1/es not_active Application Discontinuation
- 2006-08-16 MY MYPI20063961A patent/MY145923A/en unknown
- 2006-08-16 AR ARP060103567A patent/AR056461A1/es unknown
- 2006-08-17 TW TW095130289A patent/TWI322808B/zh not_active IP Right Cessation
- 2006-08-18 DO DO2006000191A patent/DOP2006000191A/es unknown
- 2006-08-18 UY UY29756A patent/UY29756A1/es unknown
-
2008
- 2008-01-18 TN TNP2008000026A patent/TNSN08026A1/en unknown
- 2008-01-24 IL IL189014A patent/IL189014A0/en not_active IP Right Cessation
- 2008-01-25 CR CR9693A patent/CR9693A/es unknown
- 2008-02-11 US US12/029,008 patent/US7476674B2/en not_active Expired - Fee Related
- 2008-02-13 EC EC2008008182A patent/ECSP088182A/es unknown
- 2008-02-15 KR KR1020087003657A patent/KR101260546B1/ko not_active IP Right Cessation
- 2008-02-18 HN HN2008000276A patent/HN2008000276A/es unknown
- 2008-03-07 MA MA30721A patent/MA29913B1/fr unknown
- 2008-03-11 NO NO20081289A patent/NO20081289L/no not_active Application Discontinuation
- 2008-08-07 ZA ZA200800966A patent/ZA200800966B/xx unknown
- 2008-12-05 US US12/328,804 patent/US8076340B2/en not_active Expired - Fee Related
-
2009
- 2009-04-16 HK HK09103512.4A patent/HK1125628A1/xx not_active IP Right Cessation
-
2011
- 2011-01-12 CY CY20111100037T patent/CY1111101T1/el unknown
- 2011-01-20 HR HR20110043T patent/HRP20110043T1/hr unknown
- 2011-11-01 US US13/286,662 patent/US8557819B2/en not_active Expired - Fee Related
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