EA200800615A1 - Производные 5-пиридазинил-1-азабицикло [3.2.1] октана, их получение и применение в терапии - Google Patents
Производные 5-пиридазинил-1-азабицикло [3.2.1] октана, их получение и применение в терапииInfo
- Publication number
- EA200800615A1 EA200800615A1 EA200800615A EA200800615A EA200800615A1 EA 200800615 A1 EA200800615 A1 EA 200800615A1 EA 200800615 A EA200800615 A EA 200800615A EA 200800615 A EA200800615 A EA 200800615A EA 200800615 A1 EA200800615 A1 EA 200800615A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkylamino
- therapy
- pyridazinil
- azabicyclo
- octane
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к соединениям общей формулы (I), в которой R представляет собой атом водорода или галогена; или фенил, замещенный при необходимости одним или несколькими атомами галогенов, одной или несколькими группами, выбранными из (C-C)алкила, (C-C)алкокси, нитро, амино, ди(С-С)алкиламино, трифторметила, трифторметокси, циано, гидрокси, ацетила или метилендиокси; или группу, выбранную из пиридинила, пиразолила, имидазолила, триазолила, тетразолила, оксазолила, тиазолила, оксадиазолила, тиадиазолила, тиенила, фурила, изоксазолила, изотиазолила, пирролила, нафтила, причем такая группа при необходимости может быть замещенной одной или несколькими группами, выбранными из атомов галогенов, (C-С)алкила, (C-C)алкокси, трифторметокси, трифторметила, нитро, циано, гидрокси, амино, (C-C)алкиламино или ди(С-С)алкиламино; в виде основания или кислотно-аддитивной соли, а также в виде гидрата или сольвата. Способ получения и применение в терапии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0508594A FR2889847B1 (fr) | 2005-08-18 | 2005-08-18 | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| PCT/FR2006/001911 WO2007020343A1 (fr) | 2005-08-18 | 2006-08-07 | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200800615A1 true EA200800615A1 (ru) | 2008-06-30 |
| EA013601B1 EA013601B1 (ru) | 2010-06-30 |
Family
ID=36297201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800615A EA013601B1 (ru) | 2005-08-18 | 2006-08-07 | Производные 5-пиридазинил-1-азабицикло[3.2.1]октана, их получение и применение в терапии |
Country Status (40)
| Country | Link |
|---|---|
| US (3) | US7476674B2 (ru) |
| EP (1) | EP1922320B1 (ru) |
| JP (1) | JP5249758B2 (ru) |
| KR (1) | KR101260546B1 (ru) |
| CN (2) | CN102558177A (ru) |
| AR (1) | AR056461A1 (ru) |
| AT (1) | ATE486073T1 (ru) |
| AU (1) | AU2006281340B2 (ru) |
| BR (1) | BRPI0614796A2 (ru) |
| CA (1) | CA2618110C (ru) |
| CR (1) | CR9693A (ru) |
| CY (1) | CY1111101T1 (ru) |
| DE (1) | DE602006017854D1 (ru) |
| DK (1) | DK1922320T3 (ru) |
| DO (1) | DOP2006000191A (ru) |
| EA (1) | EA013601B1 (ru) |
| EC (1) | ECSP088182A (ru) |
| ES (1) | ES2354833T3 (ru) |
| FR (1) | FR2889847B1 (ru) |
| HK (1) | HK1125628A1 (ru) |
| HN (1) | HN2008000276A (ru) |
| HR (1) | HRP20110043T1 (ru) |
| IL (1) | IL189014A0 (ru) |
| JO (1) | JO2680B1 (ru) |
| MA (1) | MA29913B1 (ru) |
| MX (1) | MX2008002276A (ru) |
| MY (1) | MY145923A (ru) |
| NO (1) | NO20081289L (ru) |
| NZ (1) | NZ565537A (ru) |
| PE (1) | PE20070234A1 (ru) |
| PL (1) | PL1922320T3 (ru) |
| PT (1) | PT1922320E (ru) |
| RS (1) | RS51653B (ru) |
| SI (1) | SI1922320T1 (ru) |
| TN (1) | TNSN08026A1 (ru) |
| TW (1) | TWI322808B (ru) |
| UA (1) | UA92360C2 (ru) |
| UY (1) | UY29756A1 (ru) |
| WO (1) | WO2007020343A1 (ru) |
| ZA (1) | ZA200800966B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| US20220347175A1 (en) | 2018-07-19 | 2022-11-03 | Sumitomo Dainippon Pharma Co., Ltd. | Pyridazinone derivative |
| US20230109839A1 (en) | 2020-01-07 | 2023-04-13 | Sumitomo Pharma Co., Ltd. | Therapeutic agent for tauopathies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| ES2223209B1 (es) | 2001-12-11 | 2005-10-01 | Esteve Quimica, S.A. | Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion. |
| JP4312456B2 (ja) | 2000-10-13 | 2009-08-12 | ニューロサーチ、アクティーゼルスカブ | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| US6644511B2 (en) | 2002-01-11 | 2003-11-11 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Container for dispensing a dual phase fluid product |
-
2005
- 2005-08-18 FR FR0508594A patent/FR2889847B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-26 JO JO2006251A patent/JO2680B1/en active
- 2006-08-07 BR BRPI0614796-8A patent/BRPI0614796A2/pt not_active IP Right Cessation
- 2006-08-07 AT AT06794297T patent/ATE486073T1/de active
- 2006-08-07 SI SI200630880T patent/SI1922320T1/sl unknown
- 2006-08-07 CN CN2011104283877A patent/CN102558177A/zh active Pending
- 2006-08-07 DK DK06794297.9T patent/DK1922320T3/da active
- 2006-08-07 NZ NZ565537A patent/NZ565537A/en not_active IP Right Cessation
- 2006-08-07 PT PT06794297T patent/PT1922320E/pt unknown
- 2006-08-07 CA CA2618110A patent/CA2618110C/fr not_active Expired - Fee Related
- 2006-08-07 EP EP06794297A patent/EP1922320B1/fr active Active
- 2006-08-07 DE DE602006017854T patent/DE602006017854D1/de active Active
- 2006-08-07 MX MX2008002276A patent/MX2008002276A/es active IP Right Grant
- 2006-08-07 UA UAA200803421A patent/UA92360C2/ru unknown
- 2006-08-07 RS RS20110011A patent/RS51653B/en unknown
- 2006-08-07 WO PCT/FR2006/001911 patent/WO2007020343A1/fr active Application Filing
- 2006-08-07 PL PL06794297T patent/PL1922320T3/pl unknown
- 2006-08-07 EA EA200800615A patent/EA013601B1/ru not_active IP Right Cessation
- 2006-08-07 JP JP2008526522A patent/JP5249758B2/ja not_active Expired - Fee Related
- 2006-08-07 AU AU2006281340A patent/AU2006281340B2/en not_active Ceased
- 2006-08-07 ES ES06794297T patent/ES2354833T3/es active Active
- 2006-08-07 CN CN2006800297295A patent/CN101291933B/zh not_active Expired - Fee Related
- 2006-08-15 PE PE2006000988A patent/PE20070234A1/es not_active Application Discontinuation
- 2006-08-16 MY MYPI20063961A patent/MY145923A/en unknown
- 2006-08-16 AR ARP060103567A patent/AR056461A1/es unknown
- 2006-08-17 TW TW095130289A patent/TWI322808B/zh not_active IP Right Cessation
- 2006-08-18 DO DO2006000191A patent/DOP2006000191A/es unknown
- 2006-08-18 UY UY29756A patent/UY29756A1/es unknown
-
2008
- 2008-01-18 TN TNP2008000026A patent/TNSN08026A1/en unknown
- 2008-01-24 IL IL189014A patent/IL189014A0/en not_active IP Right Cessation
- 2008-01-25 CR CR9693A patent/CR9693A/es unknown
- 2008-02-11 US US12/029,008 patent/US7476674B2/en not_active Expired - Fee Related
- 2008-02-13 EC EC2008008182A patent/ECSP088182A/es unknown
- 2008-02-15 KR KR1020087003657A patent/KR101260546B1/ko not_active IP Right Cessation
- 2008-02-18 HN HN2008000276A patent/HN2008000276A/es unknown
- 2008-03-07 MA MA30721A patent/MA29913B1/fr unknown
- 2008-03-11 NO NO20081289A patent/NO20081289L/no not_active Application Discontinuation
- 2008-08-07 ZA ZA200800966A patent/ZA200800966B/xx unknown
- 2008-12-05 US US12/328,804 patent/US8076340B2/en not_active Expired - Fee Related
-
2009
- 2009-04-16 HK HK09103512.4A patent/HK1125628A1/xx not_active IP Right Cessation
-
2011
- 2011-01-12 CY CY20111100037T patent/CY1111101T1/el unknown
- 2011-01-20 HR HR20110043T patent/HRP20110043T1/hr unknown
- 2011-11-01 US US13/286,662 patent/US8557819B2/en not_active Expired - Fee Related
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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