AR056461A1 - Derivados de 5-piridazinil-1-azabiciclo(3.2.1)octano, su preparacion y su aplicacion en terapéutica - Google Patents
Derivados de 5-piridazinil-1-azabiciclo(3.2.1)octano, su preparacion y su aplicacion en terapéuticaInfo
- Publication number
- AR056461A1 AR056461A1 ARP060103567A ARP060103567A AR056461A1 AR 056461 A1 AR056461 A1 AR 056461A1 AR P060103567 A ARP060103567 A AR P060103567A AR P060103567 A ARP060103567 A AR P060103567A AR 056461 A1 AR056461 A1 AR 056461A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- groups
- trifluoromethoxy
- dialkyl
- cyano
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que los contienen y usos en trastornos asociados a disfuncion de receptores nicotinicos a nivel del sistema nervioso central. REIVINDICACION 1.- Compuesto que responde a la formula (I): en la que: R representa - bien un átomo de hidrogeno o de halogeno; - bien un grupo fenilo opcionalmente sustituido con uno o varios átomos de halogeno, con uno o varios grupos elegidos entre los grupos alquilo (C1-C6), alcoxi (C1-C6), nitro, amino, dialquil (C1-C3)-amino, trifluorometilo, trifluorometoxi, ciano, hidroxi, acetilo o metilendioxi; - o bien un grupo elegido entre un piridinilo, pirazolilo, imidazolilo, triazolilo, tetrazolilo, oxazolilo, tiazolilo, oxadiazolilo, tiadiazolilo, tienilo, furilo, isoxazolilo, isotiazolilo, pirrolilo, naftilo, pudiendo este grupo estar opcionalmente sustituido con uno o varios grupos elegidos entre los átomos de halogeno, los grupos alquilo (C1-C6), alcoxi (C1-C6), trifluorometoxi, nitro, ciano, hidroxi, amino, alquil (C1-C6)-amino o dialquil (C1-C6)-amino. en el estado de base o de sal de adicion a un ácido, así como en el estado de hidrato o de solvato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0508594A FR2889847B1 (fr) | 2005-08-18 | 2005-08-18 | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056461A1 true AR056461A1 (es) | 2007-10-10 |
Family
ID=36297201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103567A AR056461A1 (es) | 2005-08-18 | 2006-08-16 | Derivados de 5-piridazinil-1-azabiciclo(3.2.1)octano, su preparacion y su aplicacion en terapéutica |
Country Status (40)
| Country | Link |
|---|---|
| US (3) | US7476674B2 (es) |
| EP (1) | EP1922320B1 (es) |
| JP (1) | JP5249758B2 (es) |
| KR (1) | KR101260546B1 (es) |
| CN (2) | CN102558177A (es) |
| AR (1) | AR056461A1 (es) |
| AT (1) | ATE486073T1 (es) |
| AU (1) | AU2006281340B2 (es) |
| BR (1) | BRPI0614796A2 (es) |
| CA (1) | CA2618110C (es) |
| CR (1) | CR9693A (es) |
| CY (1) | CY1111101T1 (es) |
| DE (1) | DE602006017854D1 (es) |
| DK (1) | DK1922320T3 (es) |
| DO (1) | DOP2006000191A (es) |
| EA (1) | EA013601B1 (es) |
| EC (1) | ECSP088182A (es) |
| ES (1) | ES2354833T3 (es) |
| FR (1) | FR2889847B1 (es) |
| HK (1) | HK1125628A1 (es) |
| HN (1) | HN2008000276A (es) |
| HR (1) | HRP20110043T1 (es) |
| IL (1) | IL189014A0 (es) |
| JO (1) | JO2680B1 (es) |
| MA (1) | MA29913B1 (es) |
| MX (1) | MX2008002276A (es) |
| MY (1) | MY145923A (es) |
| NO (1) | NO20081289L (es) |
| NZ (1) | NZ565537A (es) |
| PE (1) | PE20070234A1 (es) |
| PL (1) | PL1922320T3 (es) |
| PT (1) | PT1922320E (es) |
| RS (1) | RS51653B (es) |
| SI (1) | SI1922320T1 (es) |
| TN (1) | TNSN08026A1 (es) |
| TW (1) | TWI322808B (es) |
| UA (1) | UA92360C2 (es) |
| UY (1) | UY29756A1 (es) |
| WO (1) | WO2007020343A1 (es) |
| ZA (1) | ZA200800966B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
| US20220347175A1 (en) | 2018-07-19 | 2022-11-03 | Sumitomo Dainippon Pharma Co., Ltd. | Pyridazinone derivative |
| US20230109839A1 (en) | 2020-01-07 | 2023-04-13 | Sumitomo Pharma Co., Ltd. | Therapeutic agent for tauopathies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786770B1 (fr) * | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| ES2223209B1 (es) | 2001-12-11 | 2005-10-01 | Esteve Quimica, S.A. | Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion. |
| JP4312456B2 (ja) | 2000-10-13 | 2009-08-12 | ニューロサーチ、アクティーゼルスカブ | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| US6644511B2 (en) | 2002-01-11 | 2003-11-11 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Container for dispensing a dual phase fluid product |
-
2005
- 2005-08-18 FR FR0508594A patent/FR2889847B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-26 JO JO2006251A patent/JO2680B1/en active
- 2006-08-07 BR BRPI0614796-8A patent/BRPI0614796A2/pt not_active IP Right Cessation
- 2006-08-07 AT AT06794297T patent/ATE486073T1/de active
- 2006-08-07 SI SI200630880T patent/SI1922320T1/sl unknown
- 2006-08-07 CN CN2011104283877A patent/CN102558177A/zh active Pending
- 2006-08-07 DK DK06794297.9T patent/DK1922320T3/da active
- 2006-08-07 NZ NZ565537A patent/NZ565537A/en not_active IP Right Cessation
- 2006-08-07 PT PT06794297T patent/PT1922320E/pt unknown
- 2006-08-07 CA CA2618110A patent/CA2618110C/fr not_active Expired - Fee Related
- 2006-08-07 EP EP06794297A patent/EP1922320B1/fr active Active
- 2006-08-07 DE DE602006017854T patent/DE602006017854D1/de active Active
- 2006-08-07 MX MX2008002276A patent/MX2008002276A/es active IP Right Grant
- 2006-08-07 UA UAA200803421A patent/UA92360C2/ru unknown
- 2006-08-07 RS RS20110011A patent/RS51653B/en unknown
- 2006-08-07 WO PCT/FR2006/001911 patent/WO2007020343A1/fr active Application Filing
- 2006-08-07 PL PL06794297T patent/PL1922320T3/pl unknown
- 2006-08-07 EA EA200800615A patent/EA013601B1/ru not_active IP Right Cessation
- 2006-08-07 JP JP2008526522A patent/JP5249758B2/ja not_active Expired - Fee Related
- 2006-08-07 AU AU2006281340A patent/AU2006281340B2/en not_active Ceased
- 2006-08-07 ES ES06794297T patent/ES2354833T3/es active Active
- 2006-08-07 CN CN2006800297295A patent/CN101291933B/zh not_active Expired - Fee Related
- 2006-08-15 PE PE2006000988A patent/PE20070234A1/es not_active Application Discontinuation
- 2006-08-16 MY MYPI20063961A patent/MY145923A/en unknown
- 2006-08-16 AR ARP060103567A patent/AR056461A1/es unknown
- 2006-08-17 TW TW095130289A patent/TWI322808B/zh not_active IP Right Cessation
- 2006-08-18 DO DO2006000191A patent/DOP2006000191A/es unknown
- 2006-08-18 UY UY29756A patent/UY29756A1/es unknown
-
2008
- 2008-01-18 TN TNP2008000026A patent/TNSN08026A1/en unknown
- 2008-01-24 IL IL189014A patent/IL189014A0/en not_active IP Right Cessation
- 2008-01-25 CR CR9693A patent/CR9693A/es unknown
- 2008-02-11 US US12/029,008 patent/US7476674B2/en not_active Expired - Fee Related
- 2008-02-13 EC EC2008008182A patent/ECSP088182A/es unknown
- 2008-02-15 KR KR1020087003657A patent/KR101260546B1/ko not_active IP Right Cessation
- 2008-02-18 HN HN2008000276A patent/HN2008000276A/es unknown
- 2008-03-07 MA MA30721A patent/MA29913B1/fr unknown
- 2008-03-11 NO NO20081289A patent/NO20081289L/no not_active Application Discontinuation
- 2008-08-07 ZA ZA200800966A patent/ZA200800966B/xx unknown
- 2008-12-05 US US12/328,804 patent/US8076340B2/en not_active Expired - Fee Related
-
2009
- 2009-04-16 HK HK09103512.4A patent/HK1125628A1/xx not_active IP Right Cessation
-
2011
- 2011-01-12 CY CY20111100037T patent/CY1111101T1/el unknown
- 2011-01-20 HR HR20110043T patent/HRP20110043T1/hr unknown
- 2011-11-01 US US13/286,662 patent/US8557819B2/en not_active Expired - Fee Related
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| TH86642B (th) | อนุพันธ์ของ 5-พิริดิล-1-อะซาไบไซโคล[3.2.1]ออกเทน การเตรียมสารนั้นและการใช้สารนั้นรักษาโรค | |
| AR071581A1 (es) | Derivados de oxima |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |