HRP20100637T1 - Peptidi koji se mogu vezati na transformirajući čimbenik rasta beta 1 (tgf-beta 1) - Google Patents
Peptidi koji se mogu vezati na transformirajući čimbenik rasta beta 1 (tgf-beta 1) Download PDFInfo
- Publication number
- HRP20100637T1 HRP20100637T1 HR20100637T HRP20100637T HRP20100637T1 HR P20100637 T1 HRP20100637 T1 HR P20100637T1 HR 20100637 T HR20100637 T HR 20100637T HR P20100637 T HRP20100637 T HR P20100637T HR P20100637 T1 HRP20100637 T1 HR P20100637T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- peptide
- tgf
- pharmaceutically acceptable
- fibrosis
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 22
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 5
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 title claims 7
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 title claims 7
- 229940099456 transforming growth factor beta 1 Drugs 0.000 title claims 2
- 230000004071 biological effect Effects 0.000 claims abstract 2
- 206010016654 Fibrosis Diseases 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 230000004761 fibrosis Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 208000002260 Keloid Diseases 0.000 claims 1
- 206010023330 Keloid scar Diseases 0.000 claims 1
- 206010023421 Kidney fibrosis Diseases 0.000 claims 1
- 238000012084 abdominal surgery Methods 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000009618 Transforming Growth Factors Human genes 0.000 abstract 1
- 108010009583 Transforming Growth Factors Proteins 0.000 abstract 1
- 230000002074 deregulated effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000009543 pathological alteration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302020A ES2304069B1 (es) | 2003-08-22 | 2003-08-22 | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
| PCT/ES2004/000320 WO2005019244A1 (es) | 2003-08-22 | 2004-07-05 | Péptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-beta1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100637T1 true HRP20100637T1 (hr) | 2010-12-31 |
Family
ID=34203356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100637T HRP20100637T1 (hr) | 2003-08-22 | 2010-11-24 | Peptidi koji se mogu vezati na transformirajući čimbenik rasta beta 1 (tgf-beta 1) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7666841B2 (ru) |
| EP (1) | EP1669367B1 (ru) |
| JP (1) | JP4902352B2 (ru) |
| CN (1) | CN100424093C (ru) |
| AT (1) | ATE479702T1 (ru) |
| AU (2) | AU2004266856A1 (ru) |
| BR (1) | BRPI0413215A (ru) |
| CA (1) | CA2535807A1 (ru) |
| CY (1) | CY1110885T1 (ru) |
| DE (1) | DE602004028949D1 (ru) |
| DK (1) | DK1669367T3 (ru) |
| ES (2) | ES2304069B1 (ru) |
| HR (1) | HRP20100637T1 (ru) |
| PL (1) | PL1669367T3 (ru) |
| PT (1) | PT1669367E (ru) |
| RU (2) | RU2333917C2 (ru) |
| SI (1) | SI1669367T1 (ru) |
| WO (1) | WO2005019244A1 (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8158589B2 (en) * | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
| AU2005337776B2 (en) * | 2005-10-24 | 2013-01-31 | Proyecto De Biomedicina Cima, S.L. | Use of TGF-Beta1 inhibitor peptides in the preparation of an immune response modulating agent |
| ES2327088B1 (es) * | 2007-08-20 | 2010-07-26 | Proyecto De Biomedicina Cima S.L. | Combinaciones terapeuticas para el tratamiento de las metastasis. |
| ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
| ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
| US20110293557A1 (en) | 2008-06-13 | 2011-12-01 | Proyecto De Biomedicina Cima, S.L. | Conjugates for the administration of biologically active compounds |
| CA2750559A1 (en) * | 2009-02-05 | 2010-08-12 | Digna Biotech, S.L. | Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides |
| BR112012010755A2 (pt) | 2009-11-05 | 2015-09-22 | Proyecto Biomedicina Cima Sl | constructo de gene que permite a expressão hepato-específica induzível de um polinucleotídeo de interesse em resposta a um agente indutor, vetor, genoma viral recombinante, vírion, método in vitro para a expressão de um polinucleotídeo de interesse em uma célula de origem hepática, composição farmacêutica e operador-promotor bi-direcional induzível adequado para a expressão hepato-específica induzível de dois polinucleotídeos de interesse por um agente indutor |
| WO2012001196A2 (es) | 2010-06-28 | 2012-01-05 | Proyecto De Biomedicina Cima, S.L. | Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos |
| KR101029705B1 (ko) * | 2010-06-30 | 2011-04-18 | (주)엔솔테크 | 신규 펩타이드 및 그 용도 |
| EP2407534A1 (en) | 2010-07-14 | 2012-01-18 | Neo Virnatech, S.L. | Methods and reagents for obtaining transcriptionally active virus-like particles and recombinant virions |
| CN104053788A (zh) | 2011-11-28 | 2014-09-17 | 加泰罗尼亚调查和高级研究机构 | 结肠直肠癌的预后方法和试剂盒 |
| WO2013113755A1 (en) | 2012-01-30 | 2013-08-08 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Reagents and methods for the treatment of diseases based on the inhibition of calcineurin - nfat signalling pathway |
| EP2917365B1 (en) | 2012-11-12 | 2020-03-11 | Institució Catalana de Recerca i Estudis Avançats | Methods and kits for the prognosis of colorectal cancer |
| US20140170158A1 (en) * | 2012-12-17 | 2014-06-19 | The Johns Hopkins University | Compositions and methods for treating or preventing lung diseases |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| EP3069732B1 (en) | 2013-11-14 | 2023-07-12 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
| US20170121685A1 (en) | 2015-11-02 | 2017-05-04 | Tigenix S.A.U. | Mesenchymal stem cell-derived exosomes and their uses |
| WO2017110093A1 (ja) | 2015-12-24 | 2017-06-29 | 学校法人同志社 | ＴＧＦ－βシグナルに起因する障害を治療または予防するための医薬およびその応用 |
| GB201707561D0 (en) * | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| WO2019022152A1 (ja) | 2017-07-26 | 2019-01-31 | 学校法人同志社 | ＴＧＦ－βシグナルに起因する障害を治療または予防するための医薬およびその応用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08151396A (ja) * | 1994-11-28 | 1996-06-11 | Teijin Ltd | Ｈｌａ結合性オリゴペプチド及びそれを含有する免疫調節剤 |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| ES2146552B1 (es) * | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
| US6509318B1 (en) * | 2000-09-29 | 2003-01-21 | The Regents Of The University Of California | TGF-B inhibitors and methods |
| CA2504125A1 (en) * | 2002-11-01 | 2004-05-21 | Boys Town National Research Hospital | Inducible ligand for .alpha.1.beta.1 integrin and uses |
-
2003
- 2003-08-22 ES ES200302020A patent/ES2304069B1/es not_active Expired - Fee Related
-
2004
- 2004-07-05 CN CNB200480024201XA patent/CN100424093C/zh not_active Expired - Fee Related
- 2004-07-05 DK DK04742049.2T patent/DK1669367T3/da active
- 2004-07-05 PT PT04742049T patent/PT1669367E/pt unknown
- 2004-07-05 PL PL04742049T patent/PL1669367T3/pl unknown
- 2004-07-05 US US10/569,012 patent/US7666841B2/en not_active Expired - Fee Related
- 2004-07-05 AT AT04742049T patent/ATE479702T1/de active
- 2004-07-05 RU RU2006109011/13A patent/RU2333917C2/ru not_active IP Right Cessation
- 2004-07-05 ES ES04742049T patent/ES2351865T3/es not_active Expired - Lifetime
- 2004-07-05 EP EP04742049A patent/EP1669367B1/en not_active Expired - Lifetime
- 2004-07-05 CA CA002535807A patent/CA2535807A1/en not_active Abandoned
- 2004-07-05 WO PCT/ES2004/000320 patent/WO2005019244A1/es active Application Filing
- 2004-07-05 JP JP2006524375A patent/JP4902352B2/ja not_active Expired - Fee Related
- 2004-07-05 AU AU2004266856A patent/AU2004266856A1/en not_active Abandoned
- 2004-07-05 SI SI200431516T patent/SI1669367T1/sl unknown
- 2004-07-05 DE DE602004028949T patent/DE602004028949D1/de not_active Expired - Lifetime
- 2004-07-05 BR BRPI0413215-7A patent/BRPI0413215A/pt not_active IP Right Cessation
-
2008
- 2008-04-21 RU RU2008115678/10A patent/RU2455358C2/ru not_active IP Right Cessation
-
2010
- 2010-08-20 AU AU2010212466A patent/AU2010212466B2/en not_active Ceased
- 2010-11-12 CY CY20101101024T patent/CY1110885T1/el unknown
- 2010-11-24 HR HR20100637T patent/HRP20100637T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2351865T3 (es) | 2011-02-11 |
| CA2535807A1 (en) | 2005-03-03 |
| AU2010212466A1 (en) | 2010-09-09 |
| RU2333917C2 (ru) | 2008-09-20 |
| RU2006109011A (ru) | 2006-07-27 |
| PT1669367E (pt) | 2010-12-07 |
| ES2304069B1 (es) | 2009-08-12 |
| DK1669367T3 (da) | 2010-11-08 |
| AU2004266856A1 (en) | 2005-03-03 |
| DE602004028949D1 (en) | 2010-10-14 |
| AU2010212466B2 (en) | 2012-07-19 |
| CN100424093C (zh) | 2008-10-08 |
| CN1839149A (zh) | 2006-09-27 |
| US7666841B2 (en) | 2010-02-23 |
| ATE479702T1 (de) | 2010-09-15 |
| WO2005019244A1 (es) | 2005-03-03 |
| EP1669367A1 (en) | 2006-06-14 |
| SI1669367T1 (sl) | 2010-11-30 |
| JP4902352B2 (ja) | 2012-03-21 |
| RU2455358C2 (ru) | 2012-07-10 |
| ES2304069A1 (es) | 2008-09-01 |
| EP1669367B1 (en) | 2010-09-01 |
| JP2007525204A (ja) | 2007-09-06 |
| PL1669367T3 (pl) | 2011-02-28 |
| CY1110885T1 (el) | 2015-06-10 |
| US20070142275A1 (en) | 2007-06-21 |
| BRPI0413215A (pt) | 2007-06-19 |
| RU2008115678A (ru) | 2009-10-27 |
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