HRP20100572T1 - 6-heteroarilpiridoindolonski derivati, njihovo dobivanje i terapijska upotreba - Google Patents
6-heteroarilpiridoindolonski derivati, njihovo dobivanje i terapijska upotreba Download PDFInfo
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- HRP20100572T1 HRP20100572T1 HR20100572T HRP20100572T HRP20100572T1 HR P20100572 T1 HRP20100572 T1 HR P20100572T1 HR 20100572 T HR20100572 T HR 20100572T HR P20100572 T HRP20100572 T HR P20100572T HR P20100572 T1 HRP20100572 T1 HR P20100572T1
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- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 59
- -1 -SO2-R12 Chemical group 0.000 claims abstract 52
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 43
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 31
- 239000002253 acid Substances 0.000 claims abstract 16
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 239000012453 solvate Substances 0.000 claims abstract 15
- 125000005843 halogen group Chemical group 0.000 claims abstract 13
- 125000001424 substituent group Chemical group 0.000 claims abstract 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 8
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims abstract 4
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract 3
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims abstract 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 3
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 5
- 150000004677 hydrates Chemical class 0.000 claims 5
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 3
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000001359 1,2,3-triazol-4-yl group Chemical group [H]N1N=NC([*])=C1[H] 0.000 claims 1
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- MBIZXFATKUQOOA-UHFFFAOYSA-N 1,3,4-thiadiazole Chemical group C1=NN=CS1 MBIZXFATKUQOOA-UHFFFAOYSA-N 0.000 claims 1
- JTQOJZXQILCGHT-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(1h-pyrazol-5-yl)pyrido[2,3-b]indol-2-one Chemical compound O=C1N(C)C=2N(C)C3=CC=C(C=4NN=CC=4)C=C3C=2C=C1C1=CC=C(Cl)C=C1Cl JTQOJZXQILCGHT-UHFFFAOYSA-N 0.000 claims 1
- CCQJUYFVPVBREI-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(2-methyl-1,3-oxazol-4-yl)pyrido[2,3-b]indol-2-one Chemical compound O1C(C)=NC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C(=CC(Cl)=CC=2)Cl)=C1 CCQJUYFVPVBREI-UHFFFAOYSA-N 0.000 claims 1
- NYDKDRFDXYNZFZ-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(2-methyl-1,3-oxazol-5-yl)pyrido[2,3-b]indol-2-one Chemical compound O1C(C)=NC=C1C1=CC=C(N(C)C2=C3C=C(C(=O)N2C)C=2C(=CC(Cl)=CC=2)Cl)C3=C1 NYDKDRFDXYNZFZ-UHFFFAOYSA-N 0.000 claims 1
- GCZKCOYBRBPHCI-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(2-methyl-1,3-thiazol-4-yl)pyrido[2,3-b]indol-2-one Chemical compound S1C(C)=NC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C(=CC(Cl)=CC=2)Cl)=C1 GCZKCOYBRBPHCI-UHFFFAOYSA-N 0.000 claims 1
- NTNYCYHROWMLKJ-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[1-(2,2-dimethylpropanoyl)-4-methylpyrazol-3-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound CC1=CN(C(=O)C(C)(C)C)N=C1C1=CC=C(N(C)C2=C3C=C(C(=O)N2C)C=2C(=CC(Cl)=CC=2)Cl)C3=C1 NTNYCYHROWMLKJ-UHFFFAOYSA-N 0.000 claims 1
- NWZSDAWYFMMQIJ-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[1-(2,2-dimethylpropanoyl)pyrazol-3-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound O=C1N(C)C=2N(C)C3=CC=C(C4=NN(C=C4)C(=O)C(C)(C)C)C=C3C=2C=C1C1=CC=C(Cl)C=C1Cl NWZSDAWYFMMQIJ-UHFFFAOYSA-N 0.000 claims 1
- QUWTVYLPASCIQS-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[1-(methoxymethyl)pyrazol-3-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound COCN1C=CC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 QUWTVYLPASCIQS-UHFFFAOYSA-N 0.000 claims 1
- SDIYYSGFKAAZHI-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[1-(methoxymethyl)triazol-4-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound N1=NN(COC)C=C1C1=CC=C(N(C)C2=C3C=C(C(=O)N2C)C=2C(=CC(Cl)=CC=2)Cl)C3=C1 SDIYYSGFKAAZHI-UHFFFAOYSA-N 0.000 claims 1
- LUOKWCXJOWPAJS-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[2-(ethoxymethyl)-1,3-thiazol-4-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound S1C(COCC)=NC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C(=CC(Cl)=CC=2)Cl)=C1 LUOKWCXJOWPAJS-UHFFFAOYSA-N 0.000 claims 1
- KQJVRVDEILZHFW-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[2-(hydroxymethyl)-1,3-thiazol-4-yl]-1-methyl-9h-pyrido[2,3-b]indol-2-one Chemical compound O=C1N(C)C=2NC3=CC=C(C=4N=C(CO)SC=4)C=C3C=2C=C1C1=CC=C(Cl)C=C1Cl KQJVRVDEILZHFW-UHFFFAOYSA-N 0.000 claims 1
- JRHOLBXHPIQLLL-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-6-[2-(methoxymethyl)-1,3-thiazol-4-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound S1C(COC)=NC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C(=CC(Cl)=CC=2)Cl)=C1 JRHOLBXHPIQLLL-UHFFFAOYSA-N 0.000 claims 1
- JZDYXYKBWCZEDD-UHFFFAOYSA-N 3-(4-bromophenyl)-6-(1-ethylpyrazol-3-yl)-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound CCN1C=CC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C=CC(Br)=CC=2)=N1 JZDYXYKBWCZEDD-UHFFFAOYSA-N 0.000 claims 1
- FFPOMZICLTZMLU-UHFFFAOYSA-N 3-(4-chlorophenyl)-6-[2-(ethoxymethyl)-1,3-thiazol-4-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound S1C(COCC)=NC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C=CC(Cl)=CC=2)=C1 FFPOMZICLTZMLU-UHFFFAOYSA-N 0.000 claims 1
- ZRVPREUDDRMGLE-UHFFFAOYSA-N 3-(4-fluorophenyl)-6-[1-(methoxymethyl)pyrazol-3-yl]-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound COCN1C=CC(C=2C=C3C=4C=C(C(=O)N(C)C=4N(C)C3=CC=2)C=2C=CC(F)=CC=2)=N1 ZRVPREUDDRMGLE-UHFFFAOYSA-N 0.000 claims 1
- LYTLHZJJCCVEHX-UHFFFAOYSA-N 6-(2-amino-1,3-thiazol-5-yl)-3-(2-chloro-4-fluorophenyl)-1,9-dimethylpyrido[2,3-b]indol-2-one Chemical compound O=C1N(C)C=2N(C)C3=CC=C(C=4SC(N)=NC=4)C=C3C=2C=C1C1=CC=C(F)C=C1Cl LYTLHZJJCCVEHX-UHFFFAOYSA-N 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- GGLQUALFDAXJQF-UHFFFAOYSA-N CCOCC1=CC(=NN1C)C2=CC3=C(C=C2)N(C4=C3C=C(CN4C)C5=C(C=C(C=C5)Cl)Cl)C Chemical compound CCOCC1=CC(=NN1C)C2=CC3=C(C=C2)N(C4=C3C=C(CN4C)C5=C(C=C(C=C5)Cl)Cl)C GGLQUALFDAXJQF-UHFFFAOYSA-N 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010062767 Hypophysitis Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- MJERFLAKVFCILK-UHFFFAOYSA-N [4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxopyrido[2,3-b]indol-6-yl]-1,3-thiazol-2-yl]methyl 2,2-dimethylpropanoate Chemical compound O=C1N(C)C=2N(C)C3=CC=C(C=4N=C(COC(=O)C(C)(C)C)SC=4)C=C3C=2C=C1C1=CC=C(Cl)C=C1Cl MJERFLAKVFCILK-UHFFFAOYSA-N 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 201000000322 choriocarcinoma of ovary Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000001752 female genitalia Anatomy 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 210000003026 hypopharynx Anatomy 0.000 claims 1
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 claims 1
- 125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000000260 male genitalia Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000002418 meninge Anatomy 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 201000005987 myeloid sarcoma Diseases 0.000 claims 1
- DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 210000003300 oropharynx Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000003635 pituitary gland Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 210000001625 seminal vesicle Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 201000010653 vesiculitis Diseases 0.000 claims 1
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical group C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0510730A FR2892416B1 (fr) | 2005-10-20 | 2005-10-20 | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
PCT/FR2006/002330 WO2007045758A1 (fr) | 2005-10-20 | 2006-10-17 | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100572T1 true HRP20100572T1 (hr) | 2011-01-31 |
Family
ID=35953891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100572T HRP20100572T1 (hr) | 2005-10-20 | 2010-10-19 | 6-heteroarilpiridoindolonski derivati, njihovo dobivanje i terapijska upotreba |
Country Status (33)
Country | Link |
---|---|
US (1) | US8063061B2 (ru) |
EP (1) | EP1940840B1 (ru) |
JP (1) | JP2009512666A (ru) |
KR (1) | KR20080057300A (ru) |
CN (1) | CN101312970A (ru) |
AR (1) | AR056874A1 (ru) |
AT (1) | ATE474840T1 (ru) |
AU (1) | AU2006303210A1 (ru) |
BR (1) | BRPI0617684A2 (ru) |
CA (1) | CA2625502C (ru) |
CR (1) | CR9873A (ru) |
CY (1) | CY1110891T1 (ru) |
DE (1) | DE602006015675D1 (ru) |
DK (1) | DK1940840T3 (ru) |
DO (1) | DOP2006000225A (ru) |
EA (1) | EA014873B1 (ru) |
EC (1) | ECSP088370A (ru) |
ES (1) | ES2348745T3 (ru) |
FR (1) | FR2892416B1 (ru) |
GT (1) | GT200600462A (ru) |
HR (1) | HRP20100572T1 (ru) |
IL (1) | IL190519A0 (ru) |
MA (1) | MA29961B1 (ru) |
NO (1) | NO20082226L (ru) |
PE (1) | PE20070591A1 (ru) |
PL (1) | PL1940840T3 (ru) |
PT (1) | PT1940840E (ru) |
SI (1) | SI1940840T1 (ru) |
TN (1) | TNSN08161A1 (ru) |
TW (1) | TW200734336A (ru) |
UY (1) | UY29879A1 (ru) |
WO (1) | WO2007045758A1 (ru) |
ZA (1) | ZA200803445B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2823975B1 (fr) | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
FR2846329B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
FR2869316B1 (fr) | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
BR112014028585B1 (pt) | 2012-05-17 | 2020-12-22 | Genentech , Inc | processo para fabricação de aminoácidos, e seus intermediários |
MX2016006351A (es) | 2013-12-13 | 2016-08-01 | Hoffmann La Roche | Inhibidores de tirosina cinasa de bruton. |
RU2648236C2 (ru) | 2013-12-13 | 2018-03-23 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1268772A (en) | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
US4263304A (en) * | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
SU833971A1 (ru) | 1979-07-10 | 1981-05-30 | Ленинградский Химико-Фармацевтическийинститут | Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ |
FR2595701B1 (fr) * | 1986-03-17 | 1988-07-01 | Sanofi Sa | Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant |
ATE386131T1 (de) * | 1994-04-13 | 2008-03-15 | Univ Rockefeller | Aav-vermittelte überbringung von dna in zellen des nervensystems |
DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
FR2765581B1 (fr) | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique |
FR2765582B1 (fr) | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique |
WO1999051597A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands |
IT1313592B1 (it) | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Derivati di 1h-pirido 3,4-b indol-1-one. |
US20020156016A1 (en) * | 2001-03-30 | 2002-10-24 | Gerald Minuk | Control of cell growth by altering cell membrane potentials |
FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
FR2846329B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
FR2846330B1 (fr) * | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique |
US7456193B2 (en) * | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
FR2869316B1 (fr) * | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
-
2005
- 2005-10-20 FR FR0510730A patent/FR2892416B1/fr not_active Expired - Fee Related
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2006
- 2006-10-05 PE PE2006001217A patent/PE20070591A1/es not_active Application Discontinuation
- 2006-10-16 DO DO2006000225A patent/DOP2006000225A/es unknown
- 2006-10-17 PL PL06830970T patent/PL1940840T3/pl unknown
- 2006-10-17 EP EP06830970A patent/EP1940840B1/fr active Active
- 2006-10-17 WO PCT/FR2006/002330 patent/WO2007045758A1/fr active Application Filing
- 2006-10-17 ES ES06830970T patent/ES2348745T3/es active Active
- 2006-10-17 PT PT06830970T patent/PT1940840E/pt unknown
- 2006-10-17 JP JP2008536081A patent/JP2009512666A/ja not_active Withdrawn
- 2006-10-17 BR BRPI0617684-4A patent/BRPI0617684A2/pt not_active IP Right Cessation
- 2006-10-17 AU AU2006303210A patent/AU2006303210A1/en not_active Abandoned
- 2006-10-17 KR KR1020087009373A patent/KR20080057300A/ko not_active Application Discontinuation
- 2006-10-17 CN CNA2006800433247A patent/CN101312970A/zh active Pending
- 2006-10-17 DK DK06830970.7T patent/DK1940840T3/da active
- 2006-10-17 ZA ZA200803445A patent/ZA200803445B/xx unknown
- 2006-10-17 AT AT06830970T patent/ATE474840T1/de active
- 2006-10-17 SI SI200630800T patent/SI1940840T1/sl unknown
- 2006-10-17 CA CA2625502A patent/CA2625502C/fr not_active Expired - Fee Related
- 2006-10-17 EA EA200801123A patent/EA014873B1/ru not_active IP Right Cessation
- 2006-10-17 DE DE602006015675T patent/DE602006015675D1/de active Active
- 2006-10-17 GT GT200600462A patent/GT200600462A/es unknown
- 2006-10-18 AR ARP060104538A patent/AR056874A1/es unknown
- 2006-10-19 TW TW095138582A patent/TW200734336A/zh unknown
- 2006-10-20 UY UY29879A patent/UY29879A1/es unknown
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2008
- 2008-03-30 IL IL190519A patent/IL190519A0/en unknown
- 2008-04-08 CR CR9873A patent/CR9873A/es not_active Application Discontinuation
- 2008-04-09 US US12/100,079 patent/US8063061B2/en not_active Expired - Fee Related
- 2008-04-10 TN TNP2008000161A patent/TNSN08161A1/en unknown
- 2008-04-15 EC EC2008008370A patent/ECSP088370A/es unknown
- 2008-05-14 NO NO20082226A patent/NO20082226L/no not_active Application Discontinuation
- 2008-05-19 MA MA30945A patent/MA29961B1/fr unknown
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2010
- 2010-10-13 CY CY20101100910T patent/CY1110891T1/el unknown
- 2010-10-19 HR HR20100572T patent/HRP20100572T1/hr unknown
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