DOP2006000225A - Derivados de 6-heteroarilpiridoindolona, su preparación y su aplicación en terapéutica - Google Patents

Derivados de 6-heteroarilpiridoindolona, su preparación y su aplicación en terapéutica

Info

Publication number
DOP2006000225A
DOP2006000225A DO2006000225A DO2006000225A DOP2006000225A DO P2006000225 A DOP2006000225 A DO P2006000225A DO 2006000225 A DO2006000225 A DO 2006000225A DO 2006000225 A DO2006000225 A DO 2006000225A DO P2006000225 A DOP2006000225 A DO P2006000225A
Authority
DO
Dominican Republic
Prior art keywords
preparation
application
heteroarilpiridoindolona
therapeutics
derivatives
Prior art date
Application number
DO2006000225A
Other languages
English (en)
Inventor
Pierre Casellas
Claude Muneaux
Samir Jegham
Bernard Bourrie
Paola Ciapetti
Jean-Marie Derocq
Camille-Georges Wermuth
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of DOP2006000225A publication Critical patent/DOP2006000225A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención tiene por objeto los compuestos que responden a la formula (I): (I) en la que: - R1 representa un atomo de hidrógeno o un grupo alquilo (Cl-C4), CN, CF3 o CHF2; - R2 representa un atomo de hidrógeno o un grupo alquilo (C1-C4) ; - R3 representa un fenilo no sustituido o sustituido; - R4 representa un radical heterociclico; - R5 representa un atomo de hidrógeno, un atomo de halbgeno, un grupo alquilo (C1-C4) o un grupo alcoxi (C1-C4); Proceso de preparación y aplicación en terapeutica.
DO2006000225A 2005-10-20 2006-10-16 Derivados de 6-heteroarilpiridoindolona, su preparación y su aplicación en terapéutica DOP2006000225A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510730A FR2892416B1 (fr) 2005-10-20 2005-10-20 Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DOP2006000225A true DOP2006000225A (es) 2007-08-31

Family

ID=35953891

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2006000225A DOP2006000225A (es) 2005-10-20 2006-10-16 Derivados de 6-heteroarilpiridoindolona, su preparación y su aplicación en terapéutica

Country Status (33)

Country Link
US (1) US8063061B2 (es)
EP (1) EP1940840B1 (es)
JP (1) JP2009512666A (es)
KR (1) KR20080057300A (es)
CN (1) CN101312970A (es)
AR (1) AR056874A1 (es)
AT (1) ATE474840T1 (es)
AU (1) AU2006303210A1 (es)
BR (1) BRPI0617684A2 (es)
CA (1) CA2625502C (es)
CR (1) CR9873A (es)
CY (1) CY1110891T1 (es)
DE (1) DE602006015675D1 (es)
DK (1) DK1940840T3 (es)
DO (1) DOP2006000225A (es)
EA (1) EA014873B1 (es)
EC (1) ECSP088370A (es)
ES (1) ES2348745T3 (es)
FR (1) FR2892416B1 (es)
GT (1) GT200600462A (es)
HR (1) HRP20100572T1 (es)
IL (1) IL190519A0 (es)
MA (1) MA29961B1 (es)
NO (1) NO20082226L (es)
PE (1) PE20070591A1 (es)
PL (1) PL1940840T3 (es)
PT (1) PT1940840E (es)
SI (1) SI1940840T1 (es)
TN (1) TNSN08161A1 (es)
TW (1) TW200734336A (es)
UY (1) UY29879A1 (es)
WO (1) WO2007045758A1 (es)
ZA (1) ZA200803445B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2869316B1 (fr) 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
ES2668477T3 (es) * 2012-05-17 2018-05-18 Genentech, Inc. Proceso de preparación de compuestos de aminoácidos
RU2648236C2 (ru) 2013-12-13 2018-03-23 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
US9802920B2 (en) 2013-12-13 2017-10-31 Hoffman-La Roche Inc. Inhibitors of bruton's tyrosine kinase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268772A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US4263304A (en) 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
SU833971A1 (ru) 1979-07-10 1981-05-30 Ленинградский Химико-Фармацевтическийинститут Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ
FR2595701B1 (fr) 1986-03-17 1988-07-01 Sanofi Sa Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant
CA2187626C (en) 1994-04-13 2009-11-03 Michael G. Kaplitt Aav-mediated delivery of dna to cells of the nervous system
DE19502753A1 (de) 1995-01-23 1996-07-25 Schering Ag Neue 9H-Pyrido[3,4-b]indol-Derivate
FR2765582B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
FR2765581B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
WO1999051597A1 (en) 1998-04-02 1999-10-14 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands
IT1313592B1 (it) 1999-08-03 2002-09-09 Novuspharma Spa Derivati di 1h-pirido 3,4-b indol-1-one.
US20020156016A1 (en) 2001-03-30 2002-10-24 Gerald Minuk Control of cell growth by altering cell membrane potentials
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2846330B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
FR2869316B1 (fr) * 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
DE602006015675D1 (de) 2010-09-02
ES2348745T3 (es) 2010-12-13
ATE474840T1 (de) 2010-08-15
TNSN08161A1 (en) 2009-10-30
US20080262020A1 (en) 2008-10-23
ECSP088370A (es) 2008-05-30
CN101312970A (zh) 2008-11-26
TW200734336A (en) 2007-09-16
ZA200803445B (en) 2010-02-24
EP1940840B1 (fr) 2010-07-21
MA29961B1 (fr) 2008-11-03
UY29879A1 (es) 2007-05-31
CY1110891T1 (el) 2015-06-10
GT200600462A (es) 2007-07-17
FR2892416B1 (fr) 2008-06-27
BRPI0617684A2 (pt) 2011-11-01
PE20070591A1 (es) 2007-08-03
JP2009512666A (ja) 2009-03-26
HRP20100572T1 (hr) 2011-01-31
FR2892416A1 (fr) 2007-04-27
CR9873A (es) 2008-05-05
IL190519A0 (en) 2008-11-03
AU2006303210A1 (en) 2007-04-26
DK1940840T3 (da) 2010-11-22
CA2625502A1 (fr) 2007-04-26
EP1940840A1 (fr) 2008-07-09
SI1940840T1 (sl) 2010-11-30
NO20082226L (no) 2008-07-01
EA200801123A1 (ru) 2009-02-27
PL1940840T3 (pl) 2010-12-31
EA014873B1 (ru) 2011-02-28
AR056874A1 (es) 2007-10-31
US8063061B2 (en) 2011-11-22
KR20080057300A (ko) 2008-06-24
PT1940840E (pt) 2010-10-13
CA2625502C (fr) 2012-01-10
WO2007045758A1 (fr) 2007-04-26

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