GT200600462A - Derivados de 6-heteroarilpiridoindolona, su preparacion y su aplicacion terapeutica - Google Patents

Derivados de 6-heteroarilpiridoindolona, su preparacion y su aplicacion terapeutica

Info

Publication number
GT200600462A
GT200600462A GT200600462A GT200600462A GT200600462A GT 200600462 A GT200600462 A GT 200600462A GT 200600462 A GT200600462 A GT 200600462A GT 200600462 A GT200600462 A GT 200600462A GT 200600462 A GT200600462 A GT 200600462A
Authority
GT
Guatemala
Prior art keywords
heteroarilpiridoindolona
derivatives
preparation
therapeutic application
compounds
Prior art date
Application number
GT200600462A
Other languages
English (en)
Inventor
Yvette Muneaux
Samir Jegham
Bernard Bourrie
Pierre Casellas
Paola Ciapetti
Jean-Marie Derocq
Camille-Georges Wermuth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200600462A publication Critical patent/GT200600462A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN LA QUE R1,R2,R3,R4,R5, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS TIENEN AFINIDAD POR LOS SITIOS MODULADORES OMEGA ASOCIADOS A LOS RECEPTORES GABA A POR LO QUE SON DE UTILIDAD EN EL TRATAMIENTO DE AFECCIONES ASOCIADAS A TRASTORNOS DE LA TRANSMISION GABAERGICA TALES COMO ANSIEDAD, TRASTORNOS DEL SUEÑO, EPILEPSIA.
GT200600462A 2005-10-20 2006-10-17 Derivados de 6-heteroarilpiridoindolona, su preparacion y su aplicacion terapeutica GT200600462A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510730A FR2892416B1 (fr) 2005-10-20 2005-10-20 Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
GT200600462A true GT200600462A (es) 2007-07-17

Family

ID=35953891

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600462A GT200600462A (es) 2005-10-20 2006-10-17 Derivados de 6-heteroarilpiridoindolona, su preparacion y su aplicacion terapeutica

Country Status (33)

Country Link
US (1) US8063061B2 (es)
EP (1) EP1940840B1 (es)
JP (1) JP2009512666A (es)
KR (1) KR20080057300A (es)
CN (1) CN101312970A (es)
AR (1) AR056874A1 (es)
AT (1) ATE474840T1 (es)
AU (1) AU2006303210A1 (es)
BR (1) BRPI0617684A2 (es)
CA (1) CA2625502C (es)
CR (1) CR9873A (es)
CY (1) CY1110891T1 (es)
DE (1) DE602006015675D1 (es)
DK (1) DK1940840T3 (es)
DO (1) DOP2006000225A (es)
EA (1) EA014873B1 (es)
EC (1) ECSP088370A (es)
ES (1) ES2348745T3 (es)
FR (1) FR2892416B1 (es)
GT (1) GT200600462A (es)
HR (1) HRP20100572T1 (es)
IL (1) IL190519A0 (es)
MA (1) MA29961B1 (es)
NO (1) NO20082226L (es)
PE (1) PE20070591A1 (es)
PL (1) PL1940840T3 (es)
PT (1) PT1940840E (es)
SI (1) SI1940840T1 (es)
TN (1) TNSN08161A1 (es)
TW (1) TW200734336A (es)
UY (1) UY29879A1 (es)
WO (1) WO2007045758A1 (es)
ZA (1) ZA200803445B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (fr) 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2869316B1 (fr) 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.
ES2668477T3 (es) * 2012-05-17 2018-05-18 Genentech, Inc. Proceso de preparación de compuestos de aminoácidos
RU2648236C2 (ru) 2013-12-13 2018-03-23 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
US9802920B2 (en) 2013-12-13 2017-10-31 Hoffman-La Roche Inc. Inhibitors of bruton's tyrosine kinase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268772A (en) 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
US4263304A (en) 1978-06-05 1981-04-21 Sumitomo Chemical Company, Limited 7 H-indolo[2,3-c]isoquinolines
SU833971A1 (ru) 1979-07-10 1981-05-30 Ленинградский Химико-Фармацевтическийинститут Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ
FR2595701B1 (fr) 1986-03-17 1988-07-01 Sanofi Sa Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant
CA2187626C (en) 1994-04-13 2009-11-03 Michael G. Kaplitt Aav-mediated delivery of dna to cells of the nervous system
DE19502753A1 (de) 1995-01-23 1996-07-25 Schering Ag Neue 9H-Pyrido[3,4-b]indol-Derivate
FR2765582B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
FR2765581B1 (fr) 1997-07-03 1999-08-06 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
WO1999051597A1 (en) 1998-04-02 1999-10-14 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands
IT1313592B1 (it) 1999-08-03 2002-09-09 Novuspharma Spa Derivati di 1h-pirido 3,4-b indol-1-one.
US20020156016A1 (en) 2001-03-30 2002-10-24 Gerald Minuk Control of cell growth by altering cell membrane potentials
FR2823975B1 (fr) 2001-04-27 2003-05-30 Sanofi Synthelabo Nouvelle utilisation de pyridoindolone
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique
FR2846330B1 (fr) * 2002-10-23 2004-12-03 Sanofi Synthelabo Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique
FR2869316B1 (fr) * 2004-04-21 2006-06-02 Sanofi Synthelabo Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
DE602006015675D1 (de) 2010-09-02
ES2348745T3 (es) 2010-12-13
ATE474840T1 (de) 2010-08-15
TNSN08161A1 (en) 2009-10-30
US20080262020A1 (en) 2008-10-23
ECSP088370A (es) 2008-05-30
CN101312970A (zh) 2008-11-26
TW200734336A (en) 2007-09-16
ZA200803445B (en) 2010-02-24
EP1940840B1 (fr) 2010-07-21
MA29961B1 (fr) 2008-11-03
UY29879A1 (es) 2007-05-31
CY1110891T1 (el) 2015-06-10
FR2892416B1 (fr) 2008-06-27
BRPI0617684A2 (pt) 2011-11-01
PE20070591A1 (es) 2007-08-03
JP2009512666A (ja) 2009-03-26
HRP20100572T1 (hr) 2011-01-31
FR2892416A1 (fr) 2007-04-27
CR9873A (es) 2008-05-05
DOP2006000225A (es) 2007-08-31
IL190519A0 (en) 2008-11-03
AU2006303210A1 (en) 2007-04-26
DK1940840T3 (da) 2010-11-22
CA2625502A1 (fr) 2007-04-26
EP1940840A1 (fr) 2008-07-09
SI1940840T1 (sl) 2010-11-30
NO20082226L (no) 2008-07-01
EA200801123A1 (ru) 2009-02-27
PL1940840T3 (pl) 2010-12-31
EA014873B1 (ru) 2011-02-28
AR056874A1 (es) 2007-10-31
US8063061B2 (en) 2011-11-22
KR20080057300A (ko) 2008-06-24
PT1940840E (pt) 2010-10-13
CA2625502C (fr) 2012-01-10
WO2007045758A1 (fr) 2007-04-26

Similar Documents

Publication Publication Date Title
GT200600462A (es) Derivados de 6-heteroarilpiridoindolona, su preparacion y su aplicacion terapeutica
NI201000013A (es) Sulfonamidas como moduladores del trpm8
ECSP077275A (es) Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos
CU20110142A6 (es) Procedimiento para tratar enfermedades inflamatorias o alérgicas
CL2008002246A1 (es) Uso de compuestos derivados de benzamida para tratar trastornos del sistema nervioso central seleccionados entre depresion, ansiedad trastornos psicoticos, trastornos neurologicos, epilepsia, trastornos cardiovasculares, diabetes, dislipidemias, entre otros; compuestos derivados de benzamida; composicion farmaceutica; y uso de la composicion.
GT200500208A (es) Indazoles ùtiles para tratar enfermedades cardiovasculares
CO6270312A2 (es) Moduladores de gpr40 bifenilo-sustituidos
CR10243A (es) "bencimidazoles 2-sustituidos como modulares de receptor de androgeno selectivos"
CR8992A (es) Analogos de biaril piperazinilpiridina sustituida
UY32888A (es) Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparación y uso de las mismas
CL2008002744A1 (es) Compuestos derivados de 1,3-disustituidos-4-fenil-1h-piridin-2-ona, moduladores alostericos del receptor glutamatérgico mglur2; composición farmacéutica y uso de los compuestos en el tratamiento de afecciones neurológicas y siquiatricas mediadas por mglur2.
GT200800033A (es) Antagonistas de los receptores 2 de dopamina de rapida disociacion
CL2013001073A1 (es) Compuestos derivados de 6-amino-nicotinamidas sustituidas, como moduladores de kcnq2/3; composicion farmaceutica que los comprende, util para el tratamiento y/o profilaxis de trastornos y/o enfermedades seleccionadas de dolor, epilepsia, ansiedad, enfermedades cognitivas, entre otras.
UY30572A1 (es) N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2
UY31622A1 (es) Antagonistas de aminoalquilbifenilo n,n-disubstituidos de receptores de prostaglandina d2
CL2011002209A1 (es) Compuestos derivados de 2-mercaptoquinolin-3-carboxamida; medicamento que los comprende; y uso para tratar el dolor, epilepsia, incontinencia urinaria, ansiedad, dependencia manias, transtornos bipolares, migraña, enfermedades cognitivas, discinesia asociada a la distonia y/o incontinencia urinaria.
GT200500049A (es) Derivados de 1,6-naftiridina y 1,8-naftiridina y su uso para tratar la diabetes y trastornos relacionados
ECSP088807A (es) Tetrahidro-pirimidoazepinas como moduladores del potencial transitorio de receptor vaillinoide 1 (trpv1)
CL2012001031A1 (es) Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros.
CR11843A (es) Derivados de 4,5-dihidro-oxazol-2-ilo
EA200900330A1 (ru) Аналоги 2-феноксипиримидинона
UY33323A (es) Análogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119
ECSP109961A (es) Derivados de indol-2-ona disustituidos en 3, su preparación y su aplicación en terapéutica
CO6390059A2 (es) Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, su preparación y su uso terapéutico
CR9733A (es) Derivados de azinil-3-sulfonilindazol como ligandos de 5-hidroxitriptamina-6