HRP20100039T1 - Nosač bioadhezivan za sluznicu za sporo oslobađanje aktivnih elemenata - Google Patents
Nosač bioadhezivan za sluznicu za sporo oslobađanje aktivnih elemenata Download PDFInfo
- Publication number
- HRP20100039T1 HRP20100039T1 HR20100039T HRP20100039T HRP20100039T1 HR P20100039 T1 HRP20100039 T1 HR P20100039T1 HR 20100039 T HR20100039 T HR 20100039T HR P20100039 T HRP20100039 T HR P20100039T HR P20100039 T1 HRP20100039 T1 HR P20100039T1
- Authority
- HR
- Croatia
- Prior art keywords
- agent
- bioadhesive
- carrier
- active element
- oral
- Prior art date
Links
- 239000000227 bioadhesive Substances 0.000 title claims abstract 15
- 239000000203 mixture Substances 0.000 claims abstract 13
- 229920000642 polymer Polymers 0.000 claims abstract 10
- 239000003085 diluting agent Substances 0.000 claims abstract 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- 239000008187 granular material Substances 0.000 claims abstract 4
- 238000002156 mixing Methods 0.000 claims abstract 4
- 239000011230 binding agent Substances 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 210000004877 mucosa Anatomy 0.000 claims abstract 3
- 238000003825 pressing Methods 0.000 claims abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract 2
- -1 alkali metal alkyl sulfate Chemical class 0.000 claims abstract 2
- 238000001035 drying Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 10
- 210000004400 mucous membrane Anatomy 0.000 claims 6
- 239000003443 antiviral agent Substances 0.000 claims 5
- 229960004150 aciclovir Drugs 0.000 claims 4
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000003444 anaesthetic effect Effects 0.000 claims 3
- 230000000202 analgesic effect Effects 0.000 claims 3
- 230000003474 anti-emetic effect Effects 0.000 claims 3
- 239000002111 antiemetic agent Substances 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 239000003429 antifungal agent Substances 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229940124641 pain reliever Drugs 0.000 claims 3
- 210000003296 saliva Anatomy 0.000 claims 3
- 208000001688 Herpes Genitalis Diseases 0.000 claims 2
- 208000009889 Herpes Simplex Diseases 0.000 claims 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 2
- 102000014171 Milk Proteins Human genes 0.000 claims 2
- 108010011756 Milk Proteins Proteins 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000013265 extended release Methods 0.000 claims 2
- 201000004946 genital herpes Diseases 0.000 claims 2
- 229960003943 hypromellose Drugs 0.000 claims 2
- 235000021239 milk protein Nutrition 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 206010013911 Dysgeusia Diseases 0.000 claims 1
- 206010064147 Gastrointestinal inflammation Diseases 0.000 claims 1
- 208000005794 Hairy Leukoplakia Diseases 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 208000005647 Mumps Diseases 0.000 claims 1
- 208000007027 Oral Candidiasis Diseases 0.000 claims 1
- 208000007117 Oral Ulcer Diseases 0.000 claims 1
- 206010031009 Oral pain Diseases 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
- 208000026375 Salivary gland disease Diseases 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims 1
- 208000005946 Xerostomia Diseases 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 206010064097 avian influenza Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 229960002963 ganciclovir Drugs 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
- 208000018925 gastrointestinal mucositis Diseases 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 208000010805 mumps infectious disease Diseases 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 206010030979 oral hairy leukoplakia Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 229940093257 valacyclovir Drugs 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 229960002555 zidovudine Drugs 0.000 claims 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06290480A EP1837020A1 (de) | 2006-03-24 | 2006-03-24 | Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen |
PCT/IB2007/001662 WO2007110778A2 (en) | 2006-03-24 | 2007-03-23 | Mucosal bioadhesive slow release carrier for delivering active principles |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100039T1 true HRP20100039T1 (hr) | 2010-02-28 |
Family
ID=36889131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100039T HRP20100039T1 (hr) | 2006-03-24 | 2010-01-21 | Nosač bioadhezivan za sluznicu za sporo oslobađanje aktivnih elemenata |
Country Status (27)
Country | Link |
---|---|
US (5) | US20090169511A1 (de) |
EP (3) | EP1837020A1 (de) |
JP (1) | JP5242548B2 (de) |
KR (1) | KR101335185B1 (de) |
CN (1) | CN101410092B (de) |
AR (1) | AR060085A1 (de) |
AT (1) | ATE446743T1 (de) |
AU (1) | AU2007231029B2 (de) |
BR (1) | BRPI0709057C1 (de) |
CA (1) | CA2647123C (de) |
CY (1) | CY1109723T1 (de) |
DE (1) | DE602007002996D1 (de) |
DK (1) | DK1998750T3 (de) |
ES (1) | ES2335712T3 (de) |
HK (1) | HK1121692A1 (de) |
HR (1) | HRP20100039T1 (de) |
IL (1) | IL193987A (de) |
ME (1) | ME01180B (de) |
MX (1) | MX2008012186A (de) |
MY (1) | MY150072A (de) |
PL (1) | PL1998750T3 (de) |
PT (1) | PT1998750E (de) |
RS (1) | RS51342B (de) |
RU (1) | RU2420267C2 (de) |
SI (1) | SI1998750T1 (de) |
WO (1) | WO2007110778A2 (de) |
ZA (1) | ZA200807883B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1837020A1 (de) | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen |
EP2165706A1 (de) * | 2008-09-18 | 2010-03-24 | BioAlliance Pharma | Behandlung von Entzündungsschmerzen der Mundhöhlenschleimhäute unter Verwendung von therapeutischen mukosalen, bioadhäsiven Trägern mit verlängerter Abgabe |
EP2509586B1 (de) | 2009-12-09 | 2018-05-02 | Vectans Pharma | Mukoadhäsive bukkale tabletten zur behandlung von orofazialem herpes |
EP2335690A1 (de) | 2009-12-09 | 2011-06-22 | BioAlliance Pharma | Mukoadhäsive bukkale Tabletten zur Behandlung von orofazialem Herpes |
US8592434B2 (en) * | 2009-12-09 | 2013-11-26 | Bioalliance Pharma Sa | Mucoadhesive buccal tablets for the treatment of orofacial herpes |
CA2841851A1 (en) * | 2011-07-15 | 2013-01-24 | Femalon S.P.R.L. | Composition and method for treating hpv |
KR101406106B1 (ko) * | 2011-12-19 | 2014-06-13 | 동국제약 주식회사 | 국소 투여용 지속형 치주염 치료제 조성물 |
CN108904460A (zh) * | 2012-02-19 | 2018-11-30 | 奥拉黑尔斯公司 | 用于口腔粘附圆片的碱化金合欢树胶粘合剂 |
KR20170141774A (ko) * | 2015-04-29 | 2017-12-26 | 포어사이트 바이오쎄라퓨틱스, 인코퍼레이티드 | 항바이러스 및 항염증 치료제의 치료 조합물 |
RU2636173C1 (ru) * | 2016-08-03 | 2017-11-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) | Способ лечения хронического генерализованного пародонтита средней степени тяжести в стадии обострения |
RU2636185C1 (ru) * | 2016-08-03 | 2017-11-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) | Способ лечения хронического генерализованного катарального гингивита в стадии обострения |
BR102018008324A2 (pt) * | 2018-04-25 | 2019-11-05 | Laboratorios Ferring Ltda | composição farmacêutica de uso tópico e processo de fabricação de composição farmacêutica de uso tópico |
CA3099119A1 (en) * | 2018-04-30 | 2019-11-07 | Perfect Day, Inc. | Recombinant milk protein polymers |
WO2020150460A1 (en) * | 2019-01-18 | 2020-07-23 | Milne Iii Donald A | Micronized aspirin formulation |
CN111803468B (zh) * | 2020-06-23 | 2022-12-23 | 黑龙江天龙药业有限公司 | 一种靶向、缓释、成膜抑制病毒、细菌的鼻腔喷膜剂及其制备方法 |
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