BRPI0709057B8 - veículo mucoso bioadesivo de lenta liberação, método para preparar um veículo mucoso bioadesivo de lenta liberação, e, uso do veículo mucoso bioadesivo de lenta liberação - Google Patents

veículo mucoso bioadesivo de lenta liberação, método para preparar um veículo mucoso bioadesivo de lenta liberação, e, uso do veículo mucoso bioadesivo de lenta liberação

Info

Publication number
BRPI0709057B8
BRPI0709057B8 BRPI0709057A BRPI0709057A BRPI0709057B8 BR PI0709057 B8 BRPI0709057 B8 BR PI0709057B8 BR PI0709057 A BRPI0709057 A BR PI0709057A BR PI0709057 A BRPI0709057 A BR PI0709057A BR PI0709057 B8 BRPI0709057 B8 BR PI0709057B8
Authority
BR
Brazil
Prior art keywords
vehicle
slow
mucous
bioadhesive
release
Prior art date
Application number
BRPI0709057A
Other languages
English (en)
Inventor
Lemarchand Caroline
Costantini Dominique
Original Assignee
Bioalliance Pharma
Onxeo S A
Vectans Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Pharma, Onxeo S A, Vectans Pharma filed Critical Bioalliance Pharma
Publication of BRPI0709057A2 publication Critical patent/BRPI0709057A2/pt
Publication of BRPI0709057B1 publication Critical patent/BRPI0709057B1/pt
Publication of BRPI0709057B8 publication Critical patent/BRPI0709057B8/pt
Publication of BRPI0709057C1 publication Critical patent/BRPI0709057C1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4468Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2063Proteins, e.g. gelatin

Abstract

veículo mucoso bioadesivo de lenta liberação, método para preparar um veículo mucoso bioadesivo de lenta liberação, e, uso do veículo mucoso bioadesivo de lenta liberação. um veículo de liberação lenta bioadesivo mucoso, compreendendo um princípio ativo e desprovido de amido, lactose, que pode liberar o princípio ativo por uma duração de mais do que 20 horas. este veículo bioadesivo contém um diluente, um alquilsulfato de metal alcalino, um agente de aglutinação, pelo menos um polímero bioadesivo e pelo menos um polímero de liberação prolongada, bem como um método para sua preparação.
BRPI0709057A 2006-03-24 2007-03-23 veículo mucoso bioadesivo de lenta liberação, método para preparar um veículo mucoso bioadesivo de lenta liberação, e, uso do veículo mucoso bioadesivo de lenta liberação BRPI0709057C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06290480A EP1837020A1 (en) 2006-03-24 2006-03-24 Mucosal bioadhesive slow release carrier for delivering active principles
EP06290480.0 2006-03-24
PCT/IB2007/001662 WO2007110778A2 (en) 2006-03-24 2007-03-23 Mucosal bioadhesive slow release carrier for delivering active principles

Publications (4)

Publication Number Publication Date
BRPI0709057A2 BRPI0709057A2 (pt) 2011-06-28
BRPI0709057B1 BRPI0709057B1 (pt) 2020-06-30
BRPI0709057B8 true BRPI0709057B8 (pt) 2021-02-23
BRPI0709057C1 BRPI0709057C1 (pt) 2021-05-25

Family

ID=36889131

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0709057A BRPI0709057C1 (pt) 2006-03-24 2007-03-23 veículo mucoso bioadesivo de lenta liberação, método para preparar um veículo mucoso bioadesivo de lenta liberação, e, uso do veículo mucoso bioadesivo de lenta liberação

Country Status (27)

Country Link
US (5) US20090169511A1 (pt)
EP (3) EP1837020A1 (pt)
JP (1) JP5242548B2 (pt)
KR (1) KR101335185B1 (pt)
CN (1) CN101410092B (pt)
AR (1) AR060085A1 (pt)
AT (1) ATE446743T1 (pt)
AU (1) AU2007231029B2 (pt)
BR (1) BRPI0709057C1 (pt)
CA (1) CA2647123C (pt)
CY (1) CY1109723T1 (pt)
DE (1) DE602007002996D1 (pt)
DK (1) DK1998750T3 (pt)
ES (1) ES2335712T3 (pt)
HK (1) HK1121692A1 (pt)
HR (1) HRP20100039T1 (pt)
IL (1) IL193987A (pt)
ME (1) ME01180B (pt)
MX (1) MX2008012186A (pt)
MY (1) MY150072A (pt)
PL (1) PL1998750T3 (pt)
PT (1) PT1998750E (pt)
RS (1) RS51342B (pt)
RU (1) RU2420267C2 (pt)
SI (1) SI1998750T1 (pt)
WO (1) WO2007110778A2 (pt)
ZA (1) ZA200807883B (pt)

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EP1837020A1 (en) 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
EP2165706A1 (en) * 2008-09-18 2010-03-24 BioAlliance Pharma Treating Inflammatory Pain in Mucosa of the Oral Cavity Using Mucosal Prolonged Release Bioadhesive Therapeutic Carriers.
EP2509586B1 (en) 2009-12-09 2018-05-02 Vectans Pharma Mucoadhesive buccal tablets for the treatment of orofacial herpes
EP2335690A1 (en) 2009-12-09 2011-06-22 BioAlliance Pharma Mucoadhesive buccal tablets for the treatment of orofacial herpes
US8592434B2 (en) * 2009-12-09 2013-11-26 Bioalliance Pharma Sa Mucoadhesive buccal tablets for the treatment of orofacial herpes
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CN108904460A (zh) * 2012-02-19 2018-11-30 奥拉黑尔斯公司 用于口腔粘附圆片的碱化金合欢树胶粘合剂
KR20170141774A (ko) * 2015-04-29 2017-12-26 포어사이트 바이오쎄라퓨틱스, 인코퍼레이티드 항바이러스 및 항염증 치료제의 치료 조합물
RU2636173C1 (ru) * 2016-08-03 2017-11-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) Способ лечения хронического генерализованного пародонтита средней степени тяжести в стадии обострения
RU2636185C1 (ru) * 2016-08-03 2017-11-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) Способ лечения хронического генерализованного катарального гингивита в стадии обострения
BR102018008324A2 (pt) * 2018-04-25 2019-11-05 Laboratorios Ferring Ltda composição farmacêutica de uso tópico e processo de fabricação de composição farmacêutica de uso tópico
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CN111803468B (zh) * 2020-06-23 2022-12-23 黑龙江天龙药业有限公司 一种靶向、缓释、成膜抑制病毒、细菌的鼻腔喷膜剂及其制备方法
CN115463102B (zh) * 2022-09-26 2023-11-24 湖北科益药业股份有限公司 一种阿昔洛韦片剂及其制备方法

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Also Published As

Publication number Publication date
DE602007002996D1 (de) 2009-12-10
AR060085A1 (es) 2008-05-21
ES2335712T3 (es) 2010-03-31
JP5242548B2 (ja) 2013-07-24
WO2007110778A3 (en) 2008-04-24
US20120329817A1 (en) 2012-12-27
AU2007231029A1 (en) 2007-10-04
EP1998750B1 (en) 2009-10-28
JP2009531411A (ja) 2009-09-03
US8747896B2 (en) 2014-06-10
ME01180B (me) 2013-03-20
US8211466B2 (en) 2012-07-03
WO2007110778A2 (en) 2007-10-04
CY1109723T1 (el) 2014-08-13
MX2008012186A (es) 2009-01-16
CN101410092B (zh) 2012-05-23
ATE446743T1 (de) 2009-11-15
RU2008139869A (ru) 2010-04-27
EP2216017A1 (en) 2010-08-11
EP1998750A2 (en) 2008-12-10
DK1998750T3 (da) 2010-01-25
BRPI0709057C1 (pt) 2021-05-25
KR20090010958A (ko) 2009-01-30
US20100266667A1 (en) 2010-10-21
HK1121692A1 (en) 2009-04-30
ZA200807883B (en) 2011-02-23
IL193987A0 (en) 2009-09-22
US20130303556A1 (en) 2013-11-14
CN101410092A (zh) 2009-04-15
US20090169511A1 (en) 2009-07-02
BRPI0709057A2 (pt) 2011-06-28
US20120326350A1 (en) 2012-12-27
EP1837020A1 (en) 2007-09-26
RS51342B (en) 2011-02-28
MY150072A (en) 2013-11-29
AU2007231029B2 (en) 2012-02-02
HRP20100039T1 (hr) 2010-02-28
PL1998750T3 (pl) 2010-03-31
BRPI0709057B1 (pt) 2020-06-30
KR101335185B1 (ko) 2013-12-02
US8791127B2 (en) 2014-07-29
RU2420267C2 (ru) 2011-06-10
CA2647123A1 (en) 2007-10-04
PT1998750E (pt) 2010-01-08
SI1998750T1 (sl) 2010-02-26
IL193987A (en) 2012-06-28
CA2647123C (en) 2013-08-06

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