HRP20090453T1 - Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora - Google Patents
Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora Download PDFInfo
- Publication number
- HRP20090453T1 HRP20090453T1 HR20090453T HRP20090453T HRP20090453T1 HR P20090453 T1 HRP20090453 T1 HR P20090453T1 HR 20090453 T HR20090453 T HR 20090453T HR P20090453 T HRP20090453 T HR P20090453T HR P20090453 T1 HRP20090453 T1 HR P20090453T1
- Authority
- HR
- Croatia
- Prior art keywords
- benzoimidazol
- phenyl
- disorder
- pyridin
- ylmethyl
- Prior art date
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- 102000027484 GABAA receptors Human genes 0.000 title claims 2
- 108091008681 GABAA receptors Proteins 0.000 title claims 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 7
- 239000001257 hydrogen Substances 0.000 claims abstract 7
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 150000001204 N-oxides Chemical class 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 4
- 150000002431 hydrogen Chemical class 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract 3
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 3
- 125000001424 substituent group Chemical group 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 claims abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- -1 trifluoromethoxy, hydrazino Chemical group 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 6
- 206010047700 Vomiting Diseases 0.000 claims 4
- 230000008673 vomiting Effects 0.000 claims 4
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000008811 Agoraphobia Diseases 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- WJGWWTHPHXQRTA-UHFFFAOYSA-N 1-[1-(3-pyrazin-2-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CN=CC=N1 WJGWWTHPHXQRTA-UHFFFAOYSA-N 0.000 claims 1
- IWPABMQRXNLQAO-UHFFFAOYSA-N 1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1 IWPABMQRXNLQAO-UHFFFAOYSA-N 0.000 claims 1
- IITIYOZAQGTVPC-UHFFFAOYSA-N 1-[1-(3-pyrimidin-5-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CN=CN=C1 IITIYOZAQGTVPC-UHFFFAOYSA-N 0.000 claims 1
- MMVFDEGKHUCZNU-UHFFFAOYSA-N 1-[1-[3-(2,4-dimethoxypyrimidin-5-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound COC1=NC(OC)=NC=C1C1=CC=CC(N2C3=CC=C(C=C3N=C2)C(C)N)=C1 MMVFDEGKHUCZNU-UHFFFAOYSA-N 0.000 claims 1
- NBPXEHLTPRERML-UHFFFAOYSA-N 1-[1-[3-(2-fluoropyridin-3-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1F NBPXEHLTPRERML-UHFFFAOYSA-N 0.000 claims 1
- VARISCAAVFWAFZ-UHFFFAOYSA-N 1-[1-[3-(2-methoxypyridin-3-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound COC1=NC=CC=C1C1=CC=CC(N2C3=CC=C(C=C3N=C2)C(C)N)=C1 VARISCAAVFWAFZ-UHFFFAOYSA-N 0.000 claims 1
- JMLWUZSYPSJZGT-UHFFFAOYSA-N 1-[1-[3-(5-chloro-1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=NC=C(Cl)S1 JMLWUZSYPSJZGT-UHFFFAOYSA-N 0.000 claims 1
- VTSVDTAXNRKQFF-UHFFFAOYSA-N 1-[1-[3-(6-fluoropyridin-3-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=C(F)N=C1 VTSVDTAXNRKQFF-UHFFFAOYSA-N 0.000 claims 1
- ZOVKSGHMLZHIIZ-UHFFFAOYSA-N 1-[1-[3-(6-hydrazinylpyridin-3-yl)phenyl]benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(N)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=C(NN)N=C1 ZOVKSGHMLZHIIZ-UHFFFAOYSA-N 0.000 claims 1
- UKYUDSJMQZYWIA-UHFFFAOYSA-N 1-phenyl-n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]methanamine Chemical compound C=1C=CC=CC=1CNCC(C=C1N=C2)=CC=C1N2C(C=1)=CC=CC=1C1=NC=CS1 UKYUDSJMQZYWIA-UHFFFAOYSA-N 0.000 claims 1
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- 241000124008 Mammalia Species 0.000 claims 1
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- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 206010033892 Paraplegia Diseases 0.000 claims 1
- 208000031649 Postoperative Nausea and Vomiting Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010066962 Procedural nausea Diseases 0.000 claims 1
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- 208000031674 Traumatic Acute Stress disease Diseases 0.000 claims 1
- NIAGYMSBCDVDRM-UHFFFAOYSA-N [1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methanamine Chemical compound C1=NC2=CC(CN)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 NIAGYMSBCDVDRM-UHFFFAOYSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000026345 acute stress disease Diseases 0.000 claims 1
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- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 208000025748 atypical depressive disease Diseases 0.000 claims 1
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- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 208000026725 cyclothymic disease Diseases 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 230000003001 depressive effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 208000024732 dysthymic disease Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- 201000003152 motion sickness Diseases 0.000 claims 1
- ARZIWYMXKAJNHC-UHFFFAOYSA-N n,n-dibenzyl-1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C=1C=C2N(C=3C=C(C=CC=3)C=3C=NC=CC=3)C=NC2=CC=1C(C)N(CC=1C=CC=CC=1)CC1=CC=CC=C1 ARZIWYMXKAJNHC-UHFFFAOYSA-N 0.000 claims 1
- FOOUCLZBBJESCC-UHFFFAOYSA-N n,n-dimethyl-1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]methanamine Chemical compound C1=NC2=CC(CN(C)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1 FOOUCLZBBJESCC-UHFFFAOYSA-N 0.000 claims 1
- XKHUFZZVVIQKAQ-UHFFFAOYSA-N n,n-dimethyl-1-[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methanamine Chemical compound C1=NC2=CC(CN(C)C)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 XKHUFZZVVIQKAQ-UHFFFAOYSA-N 0.000 claims 1
- BEZWQFDHNMAXGX-UHFFFAOYSA-N n-[1-[1-[3-(2,4-dimethoxypyrimidin-5-yl)phenyl]benzimidazol-5-yl]ethyl]formamide Chemical compound COC1=NC(OC)=NC=C1C1=CC=CC(N2C3=CC=C(C=C3N=C2)C(C)NC=O)=C1 BEZWQFDHNMAXGX-UHFFFAOYSA-N 0.000 claims 1
- IIDSYIHWNFIJKJ-UHFFFAOYSA-N n-[1-[1-[3-(2-fluoropyridin-3-yl)phenyl]benzimidazol-5-yl]ethyl]formamide Chemical compound C1=NC2=CC(C(NC=O)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1F IIDSYIHWNFIJKJ-UHFFFAOYSA-N 0.000 claims 1
- NRZYATBXGSHEST-UHFFFAOYSA-N n-[1-[1-[3-(2-methoxypyridin-3-yl)phenyl]benzimidazol-5-yl]ethyl]formamide Chemical compound COC1=NC=CC=C1C1=CC=CC(N2C3=CC=C(C=C3N=C2)C(C)NC=O)=C1 NRZYATBXGSHEST-UHFFFAOYSA-N 0.000 claims 1
- UURCMGBEZFJDOZ-UHFFFAOYSA-N n-[[1-(3-pyridin-2-ylphenyl)benzimidazol-5-yl]methyl]acetamide Chemical compound C1=NC2=CC(CNC(=O)C)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CC=N1 UURCMGBEZFJDOZ-UHFFFAOYSA-N 0.000 claims 1
- WWWRMEOJCUCABV-UHFFFAOYSA-N n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]acetamide Chemical compound C1=NC2=CC(CNC(=O)C)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 WWWRMEOJCUCABV-UHFFFAOYSA-N 0.000 claims 1
- GWXALXVNVINHIP-UHFFFAOYSA-N n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]ethanamine Chemical compound C1=NC2=CC(CNCC)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 GWXALXVNVINHIP-UHFFFAOYSA-N 0.000 claims 1
- FGKPWAWZFDUSDZ-UHFFFAOYSA-N n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]formamide Chemical compound C1=NC2=CC(CNC=O)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 FGKPWAWZFDUSDZ-UHFFFAOYSA-N 0.000 claims 1
- WBFXCSSYQVCGJV-UHFFFAOYSA-N n-benzyl-1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C=1C=C2N(C=3C=C(C=CC=3)C=3C=NC=CC=3)C=NC2=CC=1C(C)NCC1=CC=CC=C1 WBFXCSSYQVCGJV-UHFFFAOYSA-N 0.000 claims 1
- IZJJSDXPAYRTEX-UHFFFAOYSA-N n-benzyl-1-phenyl-n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]methanamine Chemical compound C=1C=CC=CC=1CN(CC=1C=C2N=CN(C2=CC=1)C=1C=C(C=CC=1)C=1SC=CN=1)CC1=CC=CC=C1 IZJJSDXPAYRTEX-UHFFFAOYSA-N 0.000 claims 1
- BVTLCOAEDRZKEN-UHFFFAOYSA-N n-ethyl-n-[[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methyl]ethanamine Chemical compound C1=NC2=CC(CN(CC)CC)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 BVTLCOAEDRZKEN-UHFFFAOYSA-N 0.000 claims 1
- WSERYBZHBJHRSL-UHFFFAOYSA-N n-methoxy-1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]ethanamine Chemical compound C1=NC2=CC(C(C)NOC)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1 WSERYBZHBJHRSL-UHFFFAOYSA-N 0.000 claims 1
- KAQZSDGTCKZAPH-UHFFFAOYSA-N n-methyl-1-[1-(3-pyridin-3-ylphenyl)benzimidazol-5-yl]methanamine Chemical compound C1=NC2=CC(CNC)=CC=C2N1C(C=1)=CC=CC=1C1=CC=CN=C1 KAQZSDGTCKZAPH-UHFFFAOYSA-N 0.000 claims 1
- CKLMMAQWWYMBIE-UHFFFAOYSA-N n-methyl-1-[1-[3-(1,3-thiazol-2-yl)phenyl]benzimidazol-5-yl]methanamine Chemical compound C1=NC2=CC(CNC)=CC=C2N1C(C=1)=CC=CC=1C1=NC=CS1 CKLMMAQWWYMBIE-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67064705P | 2005-04-13 | 2005-04-13 | |
| DKPA200500530 | 2005-04-13 | ||
| PCT/EP2006/061417 WO2006108800A1 (en) | 2005-04-13 | 2006-04-07 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090453T1 true HRP20090453T1 (hr) | 2009-10-31 |
Family
ID=36658703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090453T HRP20090453T1 (hr) | 2005-04-13 | 2009-08-21 | Derivati benzimidazola i njihova uporaba za modulaciju gabaa receptora |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7851490B2 (no) |
| EP (1) | EP1877052B1 (no) |
| JP (1) | JP2008535891A (no) |
| KR (1) | KR20070119691A (no) |
| AU (1) | AU2006233894A1 (no) |
| CA (1) | CA2604516A1 (no) |
| CO (1) | CO6241194A2 (no) |
| DE (1) | DE602006007976D1 (no) |
| DK (1) | DK1877052T3 (no) |
| ES (1) | ES2330468T3 (no) |
| HR (1) | HRP20090453T1 (no) |
| IL (1) | IL185371A0 (no) |
| MX (1) | MX2007012624A (no) |
| NO (1) | NO20075793L (no) |
| NZ (1) | NZ560939A (no) |
| PL (1) | PL1877052T3 (no) |
| PT (1) | PT1877052E (no) |
| RU (1) | RU2405779C2 (no) |
| WO (1) | WO2006108800A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006324046A1 (en) | 2005-12-05 | 2007-06-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
| WO2010055126A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| WO2010055124A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| WO2010055125A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| RU2452486C1 (ru) * | 2011-04-13 | 2012-06-10 | Общество с ограниченной ответственностью "Лечебно-реабилитационный научный центр "Феникс" | Способ фармакотерапии панического расстройства |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK40192D0 (da) | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| DE69617665T2 (de) | 1995-04-21 | 2002-05-08 | Neurosearch As Ballerup | Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes |
| US6218547B1 (en) * | 1996-10-21 | 2001-04-17 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators |
| AU742172B2 (en) | 1997-10-10 | 2001-12-20 | Neurosearch A/S | Benzimidazole compounds, pharmaceutical compositions containing the comp ounds and their use |
| RU2243226C2 (ru) | 1999-06-22 | 2004-12-27 | НьюроСёрч А/С | Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции |
| AU2002221566A1 (en) | 2000-12-20 | 2002-07-01 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
| DE602004011914T2 (de) | 2003-04-03 | 2008-06-12 | Neurosearch A/S | Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren |
| AU2004226179A1 (en) * | 2003-04-03 | 2004-10-14 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABA-a receptor complex |
| KR20060121818A (ko) * | 2003-08-21 | 2006-11-29 | 오에스아이 파마슈티컬스, 인코포레이티드 | Ｎ-치환된 벤즈이미다졸릴 ｃ-ｋｉｔ 억제제 |
| EP1678144A1 (en) | 2003-10-23 | 2006-07-12 | Akzo Nobel N.V. | 1,5,7-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-a RECEPTOR COMPLEX |
| CN101193867A (zh) | 2004-12-01 | 2008-06-04 | Osi医药有限公司 | N取代的苯并咪唑基c-Kit抑制剂和苯并咪唑组合库 |
| TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
-
2006
- 2006-04-07 WO PCT/EP2006/061417 patent/WO2006108800A1/en active Application Filing
- 2006-04-07 DK DK06725630T patent/DK1877052T3/da active
- 2006-04-07 PT PT06725630T patent/PT1877052E/pt unknown
- 2006-04-07 MX MX2007012624A patent/MX2007012624A/es active IP Right Grant
- 2006-04-07 ES ES06725630T patent/ES2330468T3/es active Active
- 2006-04-07 NZ NZ560939A patent/NZ560939A/en not_active IP Right Cessation
- 2006-04-07 US US11/887,780 patent/US7851490B2/en not_active Expired - Fee Related
- 2006-04-07 CA CA002604516A patent/CA2604516A1/en not_active Abandoned
- 2006-04-07 DE DE602006007976T patent/DE602006007976D1/de active Active
- 2006-04-07 PL PL06725630T patent/PL1877052T3/pl unknown
- 2006-04-07 KR KR1020077023521A patent/KR20070119691A/ko not_active Application Discontinuation
- 2006-04-07 RU RU2007137096/04A patent/RU2405779C2/ru not_active IP Right Cessation
- 2006-04-07 JP JP2008505868A patent/JP2008535891A/ja not_active Abandoned
- 2006-04-07 EP EP06725630A patent/EP1877052B1/en active Active
- 2006-04-07 AU AU2006233894A patent/AU2006233894A1/en not_active Abandoned
-
2007
- 2007-08-20 IL IL185371A patent/IL185371A0/en unknown
- 2007-10-09 CO CO07105966A patent/CO6241194A2/es not_active Application Discontinuation
- 2007-11-12 NO NO20075793A patent/NO20075793L/no not_active Application Discontinuation
-
2009
- 2009-08-21 HR HR20090453T patent/HRP20090453T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6241194A2 (es) | 2011-01-20 |
| US7851490B2 (en) | 2010-12-14 |
| RU2405779C2 (ru) | 2010-12-10 |
| ES2330468T3 (es) | 2009-12-10 |
| KR20070119691A (ko) | 2007-12-20 |
| JP2008535891A (ja) | 2008-09-04 |
| EP1877052A1 (en) | 2008-01-16 |
| NO20075793L (no) | 2008-01-14 |
| WO2006108800A1 (en) | 2006-10-19 |
| NZ560939A (en) | 2010-07-30 |
| IL185371A0 (en) | 2008-02-09 |
| US20090036493A1 (en) | 2009-02-05 |
| CA2604516A1 (en) | 2006-10-19 |
| RU2007137096A (ru) | 2009-05-20 |
| AU2006233894A1 (en) | 2006-10-19 |
| EP1877052B1 (en) | 2009-07-22 |
| PL1877052T3 (pl) | 2010-01-29 |
| DK1877052T3 (da) | 2009-10-12 |
| DE602006007976D1 (de) | 2009-09-03 |
| MX2007012624A (es) | 2008-01-11 |
| PT1877052E (pt) | 2009-08-25 |
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