HRP20080542T3 - (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents - Google Patents

(poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents

Info

Publication number
HRP20080542T3
HRP20080542T3 HR20080542T HRP20080542T HRP20080542T3 HR P20080542 T3 HRP20080542 T3 HR P20080542T3 HR 20080542 T HR20080542 T HR 20080542T HR P20080542 T HRP20080542 T HR P20080542T HR P20080542 T3 HRP20080542 T3 HR P20080542T3
Authority
HR
Croatia
Prior art keywords
radical
hydrogen atom
group
alkyl radical
independently
Prior art date
Application number
HR20080542T
Other languages
English (en)
Croatian (hr)
Inventor
Imbert Thierry
Guminski Yves
Barret Jean-Marc
Kruczinski Anna
Original Assignee
Pierre Fabre Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament filed Critical Pierre Fabre Medicament
Publication of HRP20080542T3 publication Critical patent/HRP20080542T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20080542T 2004-04-16 2005-04-14 (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents HRP20080542T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404053A FR2869035B1 (fr) 2004-04-16 2004-04-16 Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
PCT/IB2005/001268 WO2005100363A1 (en) 2004-04-16 2005-04-14 (poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents

Publications (1)

Publication Number Publication Date
HRP20080542T3 true HRP20080542T3 (en) 2008-12-31

Family

ID=34944659

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080542T HRP20080542T3 (en) 2004-04-16 2005-04-14 (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents

Country Status (24)

Country Link
US (3) US7846926B2 (enExample)
EP (1) EP1742952B1 (enExample)
JP (1) JP4876070B2 (enExample)
CN (1) CN1946727B (enExample)
AR (1) AR048607A1 (enExample)
AT (1) ATE402938T1 (enExample)
AU (1) AU2005233382C1 (enExample)
BR (1) BRPI0509912B8 (enExample)
CA (1) CA2562617C (enExample)
CY (1) CY1108444T1 (enExample)
DE (1) DE602005008578D1 (enExample)
DK (1) DK1742952T3 (enExample)
ES (1) ES2311985T3 (enExample)
FR (1) FR2869035B1 (enExample)
HR (1) HRP20080542T3 (enExample)
MX (1) MXPA06011886A (enExample)
MY (1) MY137712A (enExample)
PL (1) PL1742952T3 (enExample)
PT (1) PT1742952E (enExample)
RS (1) RS50628B (enExample)
SI (1) SI1742952T1 (enExample)
TW (1) TWI350288B (enExample)
WO (1) WO2005100363A1 (enExample)
ZA (1) ZA200609055B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2919287B1 (fr) * 2007-07-26 2012-10-12 Pf Medicament Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses.
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.
FR2921368B1 (fr) * 2007-09-25 2012-10-12 Pf Medicament Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR2935143B1 (fr) * 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
US8288585B2 (en) 2008-12-31 2012-10-16 Dow Global Technologies Llc Procatalyst composition with substitute 1,2-phenylene aromatic diester internal donor and method
CN102741341B (zh) 2008-12-31 2015-08-05 陶氏环球技术有限责任公司 丙烯抗冲共聚物和方法
US8263520B2 (en) 2009-12-02 2012-09-11 Dow Global Technologies Llc Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture
CN102712704B (zh) 2009-12-02 2015-01-07 陶氏环球技术有限责任公司 作为用于聚丙烯制造的催化剂中的内部给体的三个和四个原子桥接的二碳酸酯化合物
CN102234283B (zh) 2010-04-23 2013-06-12 湖北工业大学 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用
US8673969B2 (en) * 2010-11-11 2014-03-18 Council Of Scientific & Industrial Research Substituted 4-β-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof
FR2967675B1 (fr) 2010-11-24 2015-02-27 Pf Medicament Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic
WO2015161745A1 (zh) * 2014-04-25 2015-10-29 中国医药工业研究总院 鬼臼毒素衍生物、其制备方法、药物组合物及应用
CN104926841A (zh) * 2015-06-30 2015-09-23 遵义医学院 青蒿琥酯与鬼臼毒素偶联物在抗白血病药物中的应用及制备方法
WO2018234574A1 (en) 2017-06-22 2018-12-27 Ygm Consult Sas Combination therapy for the treatment of cancer
CN113801129A (zh) * 2021-09-30 2021-12-17 大连民族大学 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323884A (ja) * 1986-07-17 1988-02-01 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
US5332811A (en) * 1989-09-12 1994-07-26 The University Of North Carolina At Chapel Hill Etopside analogs
CN1068330A (zh) * 1991-07-03 1993-01-27 国家医药管理局上海医药工业研究院 4-氮取代-4-脱氧-4′-去甲表鬼臼毒素衍生物及其合成方法
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
FR2742439B1 (fr) 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
FR2810321B1 (fr) 2000-06-20 2002-07-26 Adir Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002249559A1 (en) 2002-03-28 2003-10-13 Council Of Scientific And Industrial Research 4-beta-1''-`(2''-(substituted benzoyl)anilino! podophyllotoxin analogues useful as anticancer agents
US6566393B1 (en) 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
WO2004073752A2 (en) 2003-02-14 2004-09-02 The Board Of Trustees Of The Leland Stanford Junior University Electrosurgical system with uniformly enhanced electric field and minimal collateral damage
US20070066837A1 (en) 2003-02-18 2007-03-22 Ahmed Kamal Podophyllotoxin derivatives as antitumor agents

Also Published As

Publication number Publication date
AU2005233382C1 (en) 2010-02-04
RS50628B (sr) 2010-06-30
CY1108444T1 (el) 2014-04-09
SI1742952T1 (sl) 2008-12-31
AR048607A1 (es) 2006-05-10
US20150368258A1 (en) 2015-12-24
CA2562617A1 (en) 2005-10-27
MXPA06011886A (es) 2006-12-14
BRPI0509912B1 (pt) 2019-08-27
ES2311985T3 (es) 2009-02-16
WO2005100363A8 (en) 2006-10-26
ATE402938T1 (de) 2008-08-15
PL1742952T3 (pl) 2009-01-30
DE602005008578D1 (de) 2008-09-11
TW200604191A (en) 2006-02-01
WO2005100363A1 (en) 2005-10-27
AU2005233382B2 (en) 2009-07-16
CN1946727A (zh) 2007-04-11
EP1742952B1 (en) 2008-07-30
EP1742952A1 (en) 2007-01-17
US9216989B2 (en) 2015-12-22
FR2869035B1 (fr) 2006-07-14
PT1742952E (pt) 2008-10-27
DK1742952T3 (da) 2008-10-27
US7846926B2 (en) 2010-12-07
CA2562617C (en) 2013-06-11
BRPI0509912B8 (pt) 2021-05-25
MY137712A (en) 2009-02-27
US20090170843A1 (en) 2009-07-02
US9403840B2 (en) 2016-08-02
CN1946727B (zh) 2010-08-11
FR2869035A1 (fr) 2005-10-21
AU2005233382A1 (en) 2005-10-27
US20110053967A1 (en) 2011-03-03
BRPI0509912A (pt) 2007-09-18
ZA200609055B (en) 2008-06-25
HK1095812A1 (en) 2007-05-18
TWI350288B (en) 2011-10-11
JP4876070B2 (ja) 2012-02-15
JP2007532628A (ja) 2007-11-15

Similar Documents

Publication Publication Date Title
HRP20080542T3 (en) (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents
PE20060285A1 (es) Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
TW200745034A (en) New compounds
CY1117132T1 (el) Παραγωγο θειαζολιου
HRP20110498T1 (hr) Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
RU2010116253A (ru) Производные n-гидроксилсульфонамида как новые физиологически применимые доноры нитроксила
MY140528A (en) Spiroketal derivatives and their use as therapeutic agents for diabetes
BRPI0409938A (pt) derivados de azetidinacarboxamida e seu uso em terapia
AR048669A1 (es) Derivados biciclicos de bisamida
WO2003064404A1 (en) 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
TW200745058A (en) MMP-13 selective inhibitors
ECSP077402A (es) Derivados de 2-amido-4-feniltiazol, su preparación y su aplicación en terapéutica
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
EA201171328A1 (ru) Производное замещенного изохинолина
MY160942A (en) Melanin production inhibitor
ECSP045420A (es) Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos
TW200612920A (en) Novel imidazolidine derivatives
CY1111748T1 (el) Παραγωγα 7-αλκυνυλο-1.8-ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη
CO5601030A2 (es) Derivados de quinolinona/benzoxazinona y usos de los mismos
DK1204662T3 (da) Azaindoler med serotoninreceptoraffinitet
CR7249A (es) Derivados de diamina, proceso para producir los derivados de diamina, y funguicidas que contienen los derivados de diamina como ingrediente activo
CO5700763A2 (es) Derivados de 1-bencil-5-piperazin-1-il-3,4-dihidro-1h-quinazolin-2-ona y el respexctivo 1h-benzo (1,2,6)tiadiazin-2,2-dioxido y derivados de 1,4-dihidro-benzo (d) (1,3) oxazin-2-ona como moduladores del receptor 5-hidroxitriptamina (5-ht) para el tra
AR073037A1 (es) Derivados de enfumafungina, utiles en la inhibicionde (1,3)-beta-d-glucano sintasa
TW200612931A (en) Substituted biphenyl derivatives
MXPA05012096A (es) Derivados de amina ciclica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.