AR048607A1 - Derivados (poli)aminoalquilaminoacetamida de la epipodofilotoxina, proceso de preparacion de los mismos y sus aplicaciones terapeuticas como agentes anticancerosos - Google Patents
Derivados (poli)aminoalquilaminoacetamida de la epipodofilotoxina, proceso de preparacion de los mismos y sus aplicaciones terapeuticas como agentes anticancerososInfo
- Publication number
- AR048607A1 AR048607A1 ARP050101486A ARP050101486A AR048607A1 AR 048607 A1 AR048607 A1 AR 048607A1 AR P050101486 A ARP050101486 A AR P050101486A AR P050101486 A ARP050101486 A AR P050101486A AR 048607 A1 AR048607 A1 AR 048607A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- group
- atom
- independently
- alkyl radical
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 2
- 102100035472 DNA polymerase iota Human genes 0.000 title 1
- 101001094672 Homo sapiens DNA polymerase iota Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000008569 process Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 C1-4 alkyl radical Chemical class 0.000 abstract 6
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 5
- 125000004429 atom Chemical group 0.000 abstract 5
- 150000003254 radicals Chemical class 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- YJGVMLPVUAXIQN-LGWHJFRWSA-N (5s,5ar,8ar,9r)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-LGWHJFRWSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0404053A FR2869035B1 (fr) | 2004-04-16 | 2004-04-16 | Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048607A1 true AR048607A1 (es) | 2006-05-10 |
Family
ID=34944659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101486A AR048607A1 (es) | 2004-04-16 | 2005-04-15 | Derivados (poli)aminoalquilaminoacetamida de la epipodofilotoxina, proceso de preparacion de los mismos y sus aplicaciones terapeuticas como agentes anticancerosos |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7846926B2 (enExample) |
| EP (1) | EP1742952B1 (enExample) |
| JP (1) | JP4876070B2 (enExample) |
| CN (1) | CN1946727B (enExample) |
| AR (1) | AR048607A1 (enExample) |
| AT (1) | ATE402938T1 (enExample) |
| AU (1) | AU2005233382C1 (enExample) |
| BR (1) | BRPI0509912B8 (enExample) |
| CA (1) | CA2562617C (enExample) |
| CY (1) | CY1108444T1 (enExample) |
| DE (1) | DE602005008578D1 (enExample) |
| DK (1) | DK1742952T3 (enExample) |
| ES (1) | ES2311985T3 (enExample) |
| FR (1) | FR2869035B1 (enExample) |
| HR (1) | HRP20080542T3 (enExample) |
| MX (1) | MXPA06011886A (enExample) |
| MY (1) | MY137712A (enExample) |
| PL (1) | PL1742952T3 (enExample) |
| PT (1) | PT1742952E (enExample) |
| RS (1) | RS50628B (enExample) |
| SI (1) | SI1742952T1 (enExample) |
| TW (1) | TWI350288B (enExample) |
| WO (1) | WO2005100363A1 (enExample) |
| ZA (1) | ZA200609055B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2888849B1 (fr) * | 2005-07-19 | 2007-10-05 | Pierre Fabre Medicament Sa | Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine |
| FR2919287B1 (fr) * | 2007-07-26 | 2012-10-12 | Pf Medicament | Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses. |
| FR2921369B1 (fr) * | 2007-09-25 | 2014-07-11 | Pf Medicament | Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux. |
| FR2921368B1 (fr) * | 2007-09-25 | 2012-10-12 | Pf Medicament | Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine. |
| FR2935143B1 (fr) * | 2008-08-19 | 2010-12-03 | Pf Medicament | Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux |
| US8288585B2 (en) | 2008-12-31 | 2012-10-16 | Dow Global Technologies Llc | Procatalyst composition with substitute 1,2-phenylene aromatic diester internal donor and method |
| CN102741341B (zh) | 2008-12-31 | 2015-08-05 | 陶氏环球技术有限责任公司 | 丙烯抗冲共聚物和方法 |
| US8263520B2 (en) | 2009-12-02 | 2012-09-11 | Dow Global Technologies Llc | Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture |
| CN102712704B (zh) | 2009-12-02 | 2015-01-07 | 陶氏环球技术有限责任公司 | 作为用于聚丙烯制造的催化剂中的内部给体的三个和四个原子桥接的二碳酸酯化合物 |
| CN102234283B (zh) | 2010-04-23 | 2013-06-12 | 湖北工业大学 | 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用 |
| US8673969B2 (en) * | 2010-11-11 | 2014-03-18 | Council Of Scientific & Industrial Research | Substituted 4-β-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof |
| FR2967675B1 (fr) | 2010-11-24 | 2015-02-27 | Pf Medicament | Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic |
| WO2015161745A1 (zh) * | 2014-04-25 | 2015-10-29 | 中国医药工业研究总院 | 鬼臼毒素衍生物、其制备方法、药物组合物及应用 |
| CN104926841A (zh) * | 2015-06-30 | 2015-09-23 | 遵义医学院 | 青蒿琥酯与鬼臼毒素偶联物在抗白血病药物中的应用及制备方法 |
| WO2018234574A1 (en) | 2017-06-22 | 2018-12-27 | Ygm Consult Sas | Combination therapy for the treatment of cancer |
| CN113801129A (zh) * | 2021-09-30 | 2021-12-17 | 大连民族大学 | 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6323884A (ja) * | 1986-07-17 | 1988-02-01 | Nippon Kayaku Co Ltd | 新規ポドフイロトキシン誘導体 |
| US5300500A (en) * | 1989-02-23 | 1994-04-05 | The University Of North Carolina At Chapel Hill | 4 beta-amino podophyllotoxin analog compounds and methods |
| US5332811A (en) * | 1989-09-12 | 1994-07-26 | The University Of North Carolina At Chapel Hill | Etopside analogs |
| CN1068330A (zh) * | 1991-07-03 | 1993-01-27 | 国家医药管理局上海医药工业研究院 | 4-氮取代-4-脱氧-4′-去甲表鬼臼毒素衍生物及其合成方法 |
| FR2725990B1 (fr) * | 1994-10-21 | 1997-01-10 | Pf Medicament | Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux |
| FR2742439B1 (fr) | 1995-12-14 | 1998-03-06 | Pf Medicament | Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine |
| FR2810321B1 (fr) | 2000-06-20 | 2002-07-26 | Adir | Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2002249559A1 (en) | 2002-03-28 | 2003-10-13 | Council Of Scientific And Industrial Research | 4-beta-1''-`(2''-(substituted benzoyl)anilino! podophyllotoxin analogues useful as anticancer agents |
| US6566393B1 (en) | 2002-06-21 | 2003-05-20 | The University Of North Carolina At Chapel Hill | Etoposide analogs and methods of use thereof |
| WO2004073752A2 (en) | 2003-02-14 | 2004-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Electrosurgical system with uniformly enhanced electric field and minimal collateral damage |
| US20070066837A1 (en) | 2003-02-18 | 2007-03-22 | Ahmed Kamal | Podophyllotoxin derivatives as antitumor agents |
-
2004
- 2004-04-16 FR FR0404053A patent/FR2869035B1/fr not_active Expired - Fee Related
-
2005
- 2005-04-09 MY MYPI20051581A patent/MY137712A/en unknown
- 2005-04-14 HR HR20080542T patent/HRP20080542T3/xx unknown
- 2005-04-14 DK DK05734896T patent/DK1742952T3/da active
- 2005-04-14 AU AU2005233382A patent/AU2005233382C1/en not_active Ceased
- 2005-04-14 AT AT05734896T patent/ATE402938T1/de active
- 2005-04-14 CN CN2005800123034A patent/CN1946727B/zh not_active Expired - Fee Related
- 2005-04-14 MX MXPA06011886A patent/MXPA06011886A/es active IP Right Grant
- 2005-04-14 US US11/578,266 patent/US7846926B2/en not_active Expired - Fee Related
- 2005-04-14 CA CA2562617A patent/CA2562617C/en not_active Expired - Fee Related
- 2005-04-14 WO PCT/IB2005/001268 patent/WO2005100363A1/en not_active Ceased
- 2005-04-14 PT PT05734896T patent/PT1742952E/pt unknown
- 2005-04-14 BR BRPI0509912A patent/BRPI0509912B8/pt not_active IP Right Cessation
- 2005-04-14 PL PL05734896T patent/PL1742952T3/pl unknown
- 2005-04-14 JP JP2007507869A patent/JP4876070B2/ja not_active Expired - Fee Related
- 2005-04-14 DE DE602005008578T patent/DE602005008578D1/de not_active Expired - Lifetime
- 2005-04-14 ES ES05734896T patent/ES2311985T3/es not_active Expired - Lifetime
- 2005-04-14 EP EP05734896A patent/EP1742952B1/en not_active Expired - Lifetime
- 2005-04-14 RS RSP-2008/0494A patent/RS50628B/sr unknown
- 2005-04-14 SI SI200530369T patent/SI1742952T1/sl unknown
- 2005-04-15 TW TW094111918A patent/TWI350288B/zh not_active IP Right Cessation
- 2005-04-15 AR ARP050101486A patent/AR048607A1/es active IP Right Grant
-
2006
- 2006-10-31 ZA ZA200609055A patent/ZA200609055B/en unknown
-
2008
- 2008-10-20 CY CY20081101164T patent/CY1108444T1/el unknown
-
2010
- 2010-11-10 US US12/943,804 patent/US9216989B2/en not_active Expired - Fee Related
-
2015
- 2015-09-01 US US14/842,068 patent/US9403840B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |