TWI350288B - (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, a process for their preparation, and their applications in therapeutics as anti-cancer agents - Google Patents

(poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, a process for their preparation, and their applications in therapeutics as anti-cancer agents

Info

Publication number
TWI350288B
TWI350288B TW094111918A TW94111918A TWI350288B TW I350288 B TWI350288 B TW I350288B TW 094111918 A TW094111918 A TW 094111918A TW 94111918 A TW94111918 A TW 94111918A TW I350288 B TWI350288 B TW I350288B
Authority
TW
Taiwan
Prior art keywords
aminoalkylaminoacetamide
epipodophyllotoxin
therapeutics
poly
compounds
Prior art date
Application number
TW094111918A
Other languages
English (en)
Chinese (zh)
Other versions
TW200604191A (en
Inventor
Thierry Imbert
Yves Guminski
Jean-Marc Barret
Anna Kruczynski
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of TW200604191A publication Critical patent/TW200604191A/zh
Application granted granted Critical
Publication of TWI350288B publication Critical patent/TWI350288B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW094111918A 2004-04-16 2005-04-15 (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, a process for their preparation, and their applications in therapeutics as anti-cancer agents TWI350288B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0404053A FR2869035B1 (fr) 2004-04-16 2004-04-16 Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux

Publications (2)

Publication Number Publication Date
TW200604191A TW200604191A (en) 2006-02-01
TWI350288B true TWI350288B (en) 2011-10-11

Family

ID=34944659

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094111918A TWI350288B (en) 2004-04-16 2005-04-15 (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, a process for their preparation, and their applications in therapeutics as anti-cancer agents

Country Status (24)

Country Link
US (3) US7846926B2 (enExample)
EP (1) EP1742952B1 (enExample)
JP (1) JP4876070B2 (enExample)
CN (1) CN1946727B (enExample)
AR (1) AR048607A1 (enExample)
AT (1) ATE402938T1 (enExample)
AU (1) AU2005233382C1 (enExample)
BR (1) BRPI0509912B8 (enExample)
CA (1) CA2562617C (enExample)
CY (1) CY1108444T1 (enExample)
DE (1) DE602005008578D1 (enExample)
DK (1) DK1742952T3 (enExample)
ES (1) ES2311985T3 (enExample)
FR (1) FR2869035B1 (enExample)
HR (1) HRP20080542T3 (enExample)
MX (1) MXPA06011886A (enExample)
MY (1) MY137712A (enExample)
PL (1) PL1742952T3 (enExample)
PT (1) PT1742952E (enExample)
RS (1) RS50628B (enExample)
SI (1) SI1742952T1 (enExample)
TW (1) TWI350288B (enExample)
WO (1) WO2005100363A1 (enExample)
ZA (1) ZA200609055B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2919287B1 (fr) * 2007-07-26 2012-10-12 Pf Medicament Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses.
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.
FR2921368B1 (fr) * 2007-09-25 2012-10-12 Pf Medicament Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR2935143B1 (fr) * 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
US8288585B2 (en) 2008-12-31 2012-10-16 Dow Global Technologies Llc Procatalyst composition with substitute 1,2-phenylene aromatic diester internal donor and method
CN102741341B (zh) 2008-12-31 2015-08-05 陶氏环球技术有限责任公司 丙烯抗冲共聚物和方法
US8263520B2 (en) 2009-12-02 2012-09-11 Dow Global Technologies Llc Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture
CN102712704B (zh) 2009-12-02 2015-01-07 陶氏环球技术有限责任公司 作为用于聚丙烯制造的催化剂中的内部给体的三个和四个原子桥接的二碳酸酯化合物
CN102234283B (zh) 2010-04-23 2013-06-12 湖北工业大学 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用
US8673969B2 (en) * 2010-11-11 2014-03-18 Council Of Scientific & Industrial Research Substituted 4-β-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof
FR2967675B1 (fr) 2010-11-24 2015-02-27 Pf Medicament Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic
WO2015161745A1 (zh) * 2014-04-25 2015-10-29 中国医药工业研究总院 鬼臼毒素衍生物、其制备方法、药物组合物及应用
CN104926841A (zh) * 2015-06-30 2015-09-23 遵义医学院 青蒿琥酯与鬼臼毒素偶联物在抗白血病药物中的应用及制备方法
WO2018234574A1 (en) 2017-06-22 2018-12-27 Ygm Consult Sas Combination therapy for the treatment of cancer
CN113801129A (zh) * 2021-09-30 2021-12-17 大连民族大学 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323884A (ja) * 1986-07-17 1988-02-01 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
US5332811A (en) * 1989-09-12 1994-07-26 The University Of North Carolina At Chapel Hill Etopside analogs
CN1068330A (zh) * 1991-07-03 1993-01-27 国家医药管理局上海医药工业研究院 4-氮取代-4-脱氧-4′-去甲表鬼臼毒素衍生物及其合成方法
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
FR2742439B1 (fr) 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
FR2810321B1 (fr) 2000-06-20 2002-07-26 Adir Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002249559A1 (en) 2002-03-28 2003-10-13 Council Of Scientific And Industrial Research 4-beta-1''-`(2''-(substituted benzoyl)anilino! podophyllotoxin analogues useful as anticancer agents
US6566393B1 (en) 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
WO2004073752A2 (en) 2003-02-14 2004-09-02 The Board Of Trustees Of The Leland Stanford Junior University Electrosurgical system with uniformly enhanced electric field and minimal collateral damage
US20070066837A1 (en) 2003-02-18 2007-03-22 Ahmed Kamal Podophyllotoxin derivatives as antitumor agents

Also Published As

Publication number Publication date
AU2005233382C1 (en) 2010-02-04
RS50628B (sr) 2010-06-30
CY1108444T1 (el) 2014-04-09
SI1742952T1 (sl) 2008-12-31
AR048607A1 (es) 2006-05-10
US20150368258A1 (en) 2015-12-24
CA2562617A1 (en) 2005-10-27
MXPA06011886A (es) 2006-12-14
BRPI0509912B1 (pt) 2019-08-27
ES2311985T3 (es) 2009-02-16
WO2005100363A8 (en) 2006-10-26
ATE402938T1 (de) 2008-08-15
PL1742952T3 (pl) 2009-01-30
DE602005008578D1 (de) 2008-09-11
TW200604191A (en) 2006-02-01
WO2005100363A1 (en) 2005-10-27
AU2005233382B2 (en) 2009-07-16
HRP20080542T3 (en) 2008-12-31
CN1946727A (zh) 2007-04-11
EP1742952B1 (en) 2008-07-30
EP1742952A1 (en) 2007-01-17
US9216989B2 (en) 2015-12-22
FR2869035B1 (fr) 2006-07-14
PT1742952E (pt) 2008-10-27
DK1742952T3 (da) 2008-10-27
US7846926B2 (en) 2010-12-07
CA2562617C (en) 2013-06-11
BRPI0509912B8 (pt) 2021-05-25
MY137712A (en) 2009-02-27
US20090170843A1 (en) 2009-07-02
US9403840B2 (en) 2016-08-02
CN1946727B (zh) 2010-08-11
FR2869035A1 (fr) 2005-10-21
AU2005233382A1 (en) 2005-10-27
US20110053967A1 (en) 2011-03-03
BRPI0509912A (pt) 2007-09-18
ZA200609055B (en) 2008-06-25
HK1095812A1 (en) 2007-05-18
JP4876070B2 (ja) 2012-02-15
JP2007532628A (ja) 2007-11-15

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