HRP20080542T3 - Acetamidni derivati epipodofilotoksina, postupak njihove priprave i njihova terapijska primjena kaoantikancerogena sredstva - Google Patents
Acetamidni derivati epipodofilotoksina, postupak njihove priprave i njihova terapijska primjena kaoantikancerogena sredstvaInfo
- Publication number
- HRP20080542T3 HRP20080542T3 HR20080542T HRP20080542T HRP20080542T3 HR P20080542 T3 HRP20080542 T3 HR P20080542T3 HR 20080542 T HR20080542 T HR 20080542T HR P20080542 T HRP20080542 T HR P20080542T HR P20080542 T3 HRP20080542 T3 HR P20080542T3
- Authority
- HR
- Croatia
- Prior art keywords
- radical
- hydrogen atom
- group
- alkyl radical
- independently
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical class NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 title 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 5
- 150000003254 radicals Chemical class 0.000 abstract 5
- -1 hydrogen atom C1-C4 alkyl radical Chemical class 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Spojevi opće formule (I) (I) naznačeni time daR1i R2 neovisno jedan od drugog predstavljaju atom vodika ili metilni radikal, R3 i A zajedno tvore C3-C8 prsten, iliR3 predstavlja radikal odabran iz sljedeće skupine: atom vodika C1-C4 alkilni radikal i benzilni radikal te A predstavlja radikal odabran iz sljedeće skupine: atom vodika C1-C4 alkilniradikal i benzilni radikal te skupina formule (II) (II) u kojoja varira od 2 do 5, R4 i B zajedno tvore C3-C8 prsteniliR4 predstavlja radikal odabran iz sljedeće skupine: atom vodika C1-C4 alkilni radikal i benzilni radikal, moguće je da su R3 i R4spojeni alkilenskim lancem koji sadrži 2 ili 3 atoma ugljika, a B predstavlja radikal odabran iz sljedeće skupine: - atom vodika, - C1-C4 alkilni radikal, - benzilni radikal, - skupina formule (III)(III) u kojoj b i c variraju neovisno jedan od drugog od 2 do 5, a R5 do R7 neovisno jedan od drugog predstavljaju radikal odabran od sljedećih: atomvodika C1-C4 alkilni radikal i benzilni radikal, a moguće je da R4 i R5 i/ili R5 i R6 i/ili R6 i R7budu spojeni alkilenskim lancem koji sadrži 2 do 3 atom ugljika, - te skupina formule (IV) (IV) u kojoj c varira od 2 do 5, a R8 do R9 neovisno jedan od drugog predstavljaju atom vodika ili C1-C5 alkilni radikal, a moguće je da R4 i R8 budu spojenialkilenskim lancem koji sadrži 2 do 3 atom ugljika, ili R8 i R9 zajedno tvore C3-C8 prsten, ili njihove farmaceutski prihvatljive soli, posebno soli nastale adicijom anorganskih ili organskih kiselina. Patent sadrži još 13 patentnih zahtjeva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0404053A FR2869035B1 (fr) | 2004-04-16 | 2004-04-16 | Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux |
| PCT/IB2005/001268 WO2005100363A1 (en) | 2004-04-16 | 2005-04-14 | (poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080542T3 true HRP20080542T3 (hr) | 2008-12-31 |
Family
ID=34944659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080542T HRP20080542T3 (hr) | 2004-04-16 | 2008-10-24 | Acetamidni derivati epipodofilotoksina, postupak njihove priprave i njihova terapijska primjena kaoantikancerogena sredstva |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7846926B2 (hr) |
| EP (1) | EP1742952B1 (hr) |
| JP (1) | JP4876070B2 (hr) |
| CN (1) | CN1946727B (hr) |
| AR (1) | AR048607A1 (hr) |
| AT (1) | ATE402938T1 (hr) |
| AU (1) | AU2005233382C1 (hr) |
| BR (1) | BRPI0509912B8 (hr) |
| CA (1) | CA2562617C (hr) |
| CY (1) | CY1108444T1 (hr) |
| DE (1) | DE602005008578D1 (hr) |
| DK (1) | DK1742952T3 (hr) |
| ES (1) | ES2311985T3 (hr) |
| FR (1) | FR2869035B1 (hr) |
| HK (1) | HK1095812A1 (hr) |
| HR (1) | HRP20080542T3 (hr) |
| MX (1) | MXPA06011886A (hr) |
| MY (1) | MY137712A (hr) |
| PL (1) | PL1742952T3 (hr) |
| PT (1) | PT1742952E (hr) |
| RS (1) | RS50628B (hr) |
| SI (1) | SI1742952T1 (hr) |
| TW (1) | TWI350288B (hr) |
| WO (1) | WO2005100363A1 (hr) |
| ZA (1) | ZA200609055B (hr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2888849B1 (fr) | 2005-07-19 | 2007-10-05 | Pierre Fabre Medicament Sa | Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine |
| FR2919287B1 (fr) * | 2007-07-26 | 2012-10-12 | Pf Medicament | Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses. |
| FR2921369B1 (fr) * | 2007-09-25 | 2014-07-11 | Pf Medicament | Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux. |
| FR2921368B1 (fr) * | 2007-09-25 | 2012-10-12 | Pf Medicament | Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine. |
| FR2935143B1 (fr) * | 2008-08-19 | 2010-12-03 | Pf Medicament | Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux |
| US8507717B2 (en) | 2008-12-31 | 2013-08-13 | Dow Global Technologies Llc | Production of substituted phenylene aromatic diesters |
| BRPI0918698A8 (pt) | 2008-12-31 | 2017-09-19 | Grace W R & Co | Composição de procatalisador e processo para produzir um polímero baseado em olefina |
| MX2012006370A (es) * | 2009-12-02 | 2012-09-07 | Dow Global Technologies Llc | Compuestos de dicarbonato puenteados por dos atomos como donadores internos en catalizadores para la fabricacion de polipropileno. |
| WO2011068775A1 (en) | 2009-12-02 | 2011-06-09 | Dow Global Technologies Inc. | Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture |
| CN102234283B (zh) | 2010-04-23 | 2013-06-12 | 湖北工业大学 | 4′-去甲基表鬼臼毒素衍生物及其合成方法和应用 |
| WO2012063250A1 (en) * | 2010-11-11 | 2012-05-18 | Council Of Scientific And Industrial Research | Substituted 4-beta-acrylamidopodophyllotoxin congeners as antitumour antibiotics and the process for preparation thereof |
| FR2967675B1 (fr) | 2010-11-24 | 2015-02-27 | Pf Medicament | Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic |
| CN105037379B (zh) * | 2014-04-25 | 2017-12-19 | 上海医药工业研究院 | 鬼臼毒素衍生物、其制备方法、药物组合物及应用 |
| CN104926841A (zh) * | 2015-06-30 | 2015-09-23 | 遵义医学院 | 青蒿琥酯与鬼臼毒素偶联物在抗白血病药物中的应用及制备方法 |
| WO2018234574A1 (en) | 2017-06-22 | 2018-12-27 | Ygm Consult Sas | COMBINATORY THERAPY FOR THE TREATMENT OF CANCER |
| CN113801129A (zh) * | 2021-09-30 | 2021-12-17 | 大连民族大学 | 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6323884A (ja) * | 1986-07-17 | 1988-02-01 | Nippon Kayaku Co Ltd | 新規ポドフイロトキシン誘導体 |
| US5300500A (en) * | 1989-02-23 | 1994-04-05 | The University Of North Carolina At Chapel Hill | 4 beta-amino podophyllotoxin analog compounds and methods |
| US5332811A (en) * | 1989-09-12 | 1994-07-26 | The University Of North Carolina At Chapel Hill | Etopside analogs |
| CN1068330A (zh) * | 1991-07-03 | 1993-01-27 | 国家医药管理局上海医药工业研究院 | 4-氮取代-4-脱氧-4′-去甲表鬼臼毒素衍生物及其合成方法 |
| FR2725990B1 (fr) * | 1994-10-21 | 1997-01-10 | Pf Medicament | Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux |
| FR2742439B1 (fr) * | 1995-12-14 | 1998-03-06 | Pf Medicament | Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine |
| FR2810321B1 (fr) * | 2000-06-20 | 2002-07-26 | Adir | Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE60205470T2 (de) | 2002-03-28 | 2006-05-24 | Council Of Scientific And Industrial Research | Analoge von 4-beta-1''-[(2''-(substitutierte-benzoyl)anilin]-podophyllotoxin zur verwendung als antikrebs-agentia 4-beta-1"-∫2"-(substituted benzoyl) anilino∫ podophyllotoxin analogues useful as anticancer agents |
| US6566393B1 (en) * | 2002-06-21 | 2003-05-20 | The University Of North Carolina At Chapel Hill | Etoposide analogs and methods of use thereof |
| EP1603474B1 (en) | 2003-02-14 | 2013-09-11 | The Board Of Trustees Of The Leland Stanford Junior University | Electrosurgical system with uniformly enhanced electric field and minimal collateral damage |
| WO2004073375A2 (en) | 2003-02-18 | 2004-09-02 | Ranbaxy Laboratories Limited | Podophyllotoxin derivatives as antitumor agents |
-
2004
- 2004-04-16 FR FR0404053A patent/FR2869035B1/fr not_active Expired - Fee Related
-
2005
- 2005-04-09 MY MYPI20051581A patent/MY137712A/en unknown
- 2005-04-14 RS RSP-2008/0494A patent/RS50628B/sr unknown
- 2005-04-14 CA CA2562617A patent/CA2562617C/en not_active Expired - Fee Related
- 2005-04-14 JP JP2007507869A patent/JP4876070B2/ja not_active Expired - Fee Related
- 2005-04-14 AU AU2005233382A patent/AU2005233382C1/en not_active Ceased
- 2005-04-14 DK DK05734896T patent/DK1742952T3/da active
- 2005-04-14 EP EP05734896A patent/EP1742952B1/en active Active
- 2005-04-14 PL PL05734896T patent/PL1742952T3/pl unknown
- 2005-04-14 PT PT05734896T patent/PT1742952E/pt unknown
- 2005-04-14 WO PCT/IB2005/001268 patent/WO2005100363A1/en active Application Filing
- 2005-04-14 US US11/578,266 patent/US7846926B2/en not_active Expired - Fee Related
- 2005-04-14 MX MXPA06011886A patent/MXPA06011886A/es active IP Right Grant
- 2005-04-14 CN CN2005800123034A patent/CN1946727B/zh not_active Expired - Fee Related
- 2005-04-14 BR BRPI0509912A patent/BRPI0509912B8/pt not_active IP Right Cessation
- 2005-04-14 SI SI200530369T patent/SI1742952T1/sl unknown
- 2005-04-14 ES ES05734896T patent/ES2311985T3/es active Active
- 2005-04-14 AT AT05734896T patent/ATE402938T1/de active
- 2005-04-14 DE DE602005008578T patent/DE602005008578D1/de active Active
- 2005-04-15 TW TW094111918A patent/TWI350288B/zh not_active IP Right Cessation
- 2005-04-15 AR ARP050101486A patent/AR048607A1/es active IP Right Grant
-
2006
- 2006-10-31 ZA ZA200609055A patent/ZA200609055B/en unknown
-
2007
- 2007-03-13 HK HK07102687A patent/HK1095812A1/xx not_active IP Right Cessation
-
2008
- 2008-10-20 CY CY20081101164T patent/CY1108444T1/el unknown
- 2008-10-24 HR HR20080542T patent/HRP20080542T3/hr unknown
-
2010
- 2010-11-10 US US12/943,804 patent/US9216989B2/en not_active Expired - Fee Related
-
2015
- 2015-09-01 US US14/842,068 patent/US9403840B2/en active Active
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