HRP20080290T3 - Postupak deacilacije lipopeptida - Google Patents

Postupak deacilacije lipopeptida

Info

Publication number
HRP20080290T3
HRP20080290T3 HR20080290T HRP20080290T HRP20080290T3 HR P20080290 T3 HRP20080290 T3 HR P20080290T3 HR 20080290 T HR20080290 T HR 20080290T HR P20080290 T HRP20080290 T HR P20080290T HR P20080290 T3 HRP20080290 T3 HR P20080290T3
Authority
HR
Croatia
Prior art keywords
biomass
lipopeptide
fermentation
nucleus
lipopeptides
Prior art date
Application number
HR20080290T
Other languages
English (en)
Inventor
Ehlers Eberhard
Decker Heinrich
Rissom Sebastian
Seidel Guido
Olliger Reiner
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of HRP20080290T3 publication Critical patent/HRP20080290T3/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Postupak enzimatskog cijepanja N-acil postranog lanca lipopeptida da se dobije odgovarajuća jezgra,gdje: a) lipopeptid se pripravlja fermentacijom, lipopeptid je vezan na stanice biomase, te se biomasa ukloni s adheziranim lipopeptidom, b) biomasa s adheziranim lipopeptidom iz koraka a) se resuspendira u vodenom sistemu, c) prikladna deacilaza sedoda u otopljenom ili krutom obliku u suspenziju biomase iz koraka b), te se dobije odgovarajuća jezgra, ted) jezgra se eventualno izolira i pročisti, gdje lipopeptid dobiven fermentacijom u koraku a) reagira nakon završetka fermentacije kao biomasas vezanim stanicama bez daljnjeg pročišćavanja u koraku c) direktno s deacilazom, čime se N-acil lanac vezan preko amidne veze cijepa. Patent sadrži još 11 patentnih zahtjeva.
HR20080290T 2004-12-15 2008-06-23 Postupak deacilacije lipopeptida HRP20080290T3 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004060750A DE102004060750A1 (de) 2004-12-15 2004-12-15 Verfahren zur Deacylierung von Lipopeptiden
PCT/EP2005/013336 WO2006063783A1 (de) 2004-12-15 2005-12-13 Verfahren zur deacylierung von lipopeptiden

Publications (1)

Publication Number Publication Date
HRP20080290T3 true HRP20080290T3 (hr) 2008-07-31

Family

ID=36283779

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080290T HRP20080290T3 (hr) 2004-12-15 2008-06-23 Postupak deacilacije lipopeptida

Country Status (14)

Country Link
US (1) US7785826B2 (hr)
EP (1) EP1828228B1 (hr)
JP (1) JP4922182B2 (hr)
AT (1) ATE394416T1 (hr)
CY (1) CY1108188T1 (hr)
DE (2) DE102004060750A1 (hr)
DK (1) DK1828228T3 (hr)
ES (1) ES2304736T3 (hr)
HR (1) HRP20080290T3 (hr)
PL (1) PL1828228T3 (hr)
PT (1) PT1828228E (hr)
RS (1) RS50570B (hr)
SI (1) SI1828228T1 (hr)
WO (1) WO2006063783A1 (hr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2813330A1 (en) * 2010-09-29 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
US8877777B2 (en) * 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102443560A (zh) * 2010-10-13 2012-05-09 上海医药工业研究院 一种高效转化棘白菌素b的基因工程菌及其制备方法
CN102443561B (zh) * 2010-10-13 2014-08-27 上海医药工业研究院 一种高效转化棘白菌素b的基因工程菌及其制备方法
CN103074403B (zh) * 2011-10-26 2014-07-09 上海医药工业研究院 微生物酶转化棘白菌素b的方法
CN103374593B (zh) * 2012-04-13 2016-04-20 浙江震元制药有限公司 微生物发酵将棘白菌素b转化为棘白菌素b母核的方法
CN103387606B (zh) * 2012-05-11 2015-05-20 浙江震元制药有限公司 制备棘白菌素b母核的方法
US20150218221A1 (en) * 2012-09-24 2015-08-06 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for producing a cyclic peptide
KR101425108B1 (ko) * 2012-09-25 2014-07-31 동국제약 주식회사 탈아실화된 환상 리포펩티드의 제조방법
CN104447961B (zh) * 2013-09-13 2018-05-15 浙江震元制药有限公司 棘白菌素b母核的提取方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
WO2017146009A1 (ja) 2016-02-24 2017-08-31 天野エンザイム株式会社 微生物の酵素生産性を制御する方法
US10606170B2 (en) 2017-09-14 2020-03-31 Canon Kabushiki Kaisha Template for imprint lithography and methods of making and using the same
CN110438012B (zh) * 2019-08-05 2021-10-26 四川大学 一种产花青素的萨氏曲霉h-1及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE886577A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Noyaux peptidiques cycliques et leur preparation
BE886575A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
US4293482A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US5310873A (en) * 1990-03-12 1994-05-10 Merck & Co., Inc. Cyclohexapeptide compound
ES2089133T3 (es) 1990-06-07 1996-10-01 Lilly Co Eli Desacilasa de lipopeptidos.
TW455591B (en) 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
EP1064299A1 (en) * 1998-03-16 2001-01-03 Fujisawa Pharmaceutical Co., Ltd. Cyclohexapeptide wf14573 or its salt, production thereof and use thereof
PT1137663E (pt) * 1998-12-09 2006-12-29 Lilly Co Eli Purificação de compostos ciclopéptidos equinocandina
FR2794746B1 (fr) 1999-06-09 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2794747B1 (fr) 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
HUP0202315A2 (en) * 1999-07-15 2002-10-28 Lilly Co Eli Process for deacylation of lipodepsipeptides
US6511962B1 (en) * 2000-07-17 2003-01-28 Micrologix Biotech Inc. Derivatives of laspartomycin and preparation and use thereof

Also Published As

Publication number Publication date
US7785826B2 (en) 2010-08-31
CY1108188T1 (el) 2014-02-12
PL1828228T3 (pl) 2008-09-30
DK1828228T3 (da) 2008-09-01
EP1828228B1 (de) 2008-05-07
DE102004060750A1 (de) 2006-07-13
ATE394416T1 (de) 2008-05-15
EP1828228A1 (de) 2007-09-05
JP2008523789A (ja) 2008-07-10
JP4922182B2 (ja) 2012-04-25
RS50570B (sr) 2010-05-07
WO2006063783A1 (de) 2006-06-22
DE502005004058D1 (de) 2008-06-19
SI1828228T1 (sl) 2008-08-31
PT1828228E (pt) 2008-07-04
ES2304736T3 (es) 2008-10-16
US20080076149A1 (en) 2008-03-27

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