RS50570B - Postupak deacilovanja lipopeptida - Google Patents

Postupak deacilovanja lipopeptida

Info

Publication number
RS50570B
RS50570B RSP-2008/0294A RSP20080294A RS50570B RS 50570 B RS50570 B RS 50570B RS P20080294 A RSP20080294 A RS P20080294A RS 50570 B RS50570 B RS 50570B
Authority
RS
Serbia
Prior art keywords
biomass
lipopeptide
fermentation
nucleus
adhering
Prior art date
Application number
RSP-2008/0294A
Other languages
English (en)
Inventor
Eberhard Ehlers
Heinrich Decker
Sebastian Rissom
Guido Seidel
Reiner Olliger
Original Assignee
Sanofi-Aventis Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh. filed Critical Sanofi-Aventis Deutschland Gmbh.
Publication of RS50570B publication Critical patent/RS50570B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Postupak za enzimsko otkidanje N-acil bočnih lanaca sa lipopeptida uz nastajanje odgovarajućeg nukleusa, pri čemu(a) je lipopeptid proizveden fermentacijom, a pri tome je dobijeni lipopeptid vezan za ćelije biomase i biomasa sa vezanim lipopeptidom se izdvaja,(b) se biomasa sa vezanim lipopeptidom iz stupnja (a) resuspenduje u jednom vodenom sistemu,(c) se pogodna deacilasa u rastvorenom ili čvrstom obliku dodaje u suspenziju biomase iz stupnja (b) i pri tome nastaje odgovarajući nukleus, i(d) nukleus se po želji izdvaja i prečišćava,naznačen time što se u stupnju (a) fermentacijom dobijeni lipopeptid, koji po završetku fermentacije ostaje povezan sa ćelijama biomase, bez daljeg prečišćavanja u stupnju (c) direktno dovodi u reakciju sa jednom deacilazom pri čemu dolazi do otkidanja N-acil lanac povezanog preko peptidne veze. Prijava sadrži 1+11 patentnih zahteva.
RSP-2008/0294A 2004-12-15 2005-12-13 Postupak deacilovanja lipopeptida RS50570B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004060750A DE102004060750A1 (de) 2004-12-15 2004-12-15 Verfahren zur Deacylierung von Lipopeptiden
PCT/EP2005/013336 WO2006063783A1 (de) 2004-12-15 2005-12-13 Verfahren zur deacylierung von lipopeptiden

Publications (1)

Publication Number Publication Date
RS50570B true RS50570B (sr) 2010-05-07

Family

ID=36283779

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2008/0294A RS50570B (sr) 2004-12-15 2005-12-13 Postupak deacilovanja lipopeptida

Country Status (14)

Country Link
US (1) US7785826B2 (sr)
EP (1) EP1828228B1 (sr)
JP (1) JP4922182B2 (sr)
AT (1) ATE394416T1 (sr)
CY (1) CY1108188T1 (sr)
DE (2) DE102004060750A1 (sr)
DK (1) DK1828228T3 (sr)
ES (1) ES2304736T3 (sr)
HR (1) HRP20080290T3 (sr)
PL (1) PL1828228T3 (sr)
PT (1) PT1828228E (sr)
RS (1) RS50570B (sr)
SI (1) SI1828228T1 (sr)
WO (1) WO2006063783A1 (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6000254B2 (ja) * 2010-09-29 2016-09-28 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
US8877777B2 (en) * 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102443560A (zh) * 2010-10-13 2012-05-09 上海医药工业研究院 一种高效转化棘白菌素b的基因工程菌及其制备方法
CN102443561B (zh) * 2010-10-13 2014-08-27 上海医药工业研究院 一种高效转化棘白菌素b的基因工程菌及其制备方法
CN103074403B (zh) * 2011-10-26 2014-07-09 上海医药工业研究院 微生物酶转化棘白菌素b的方法
CN103374593B (zh) * 2012-04-13 2016-04-20 浙江震元制药有限公司 微生物发酵将棘白菌素b转化为棘白菌素b母核的方法
CN103387606B (zh) * 2012-05-11 2015-05-20 浙江震元制药有限公司 制备棘白菌素b母核的方法
IN2015DN01633A (sr) * 2012-09-24 2015-07-03 Dsm Sinochem Pharm Nl Bv
KR101425108B1 (ko) * 2012-09-25 2014-07-31 동국제약 주식회사 탈아실화된 환상 리포펩티드의 제조방법
CN104447961B (zh) * 2013-09-13 2018-05-15 浙江震元制药有限公司 棘白菌素b母核的提取方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
US11248222B2 (en) 2016-02-24 2022-02-15 Amano Enzyme Inc. Method for controlling enzyme productivity of microorganisms
US10606170B2 (en) 2017-09-14 2020-03-31 Canon Kabushiki Kaisha Template for imprint lithography and methods of making and using the same
CN110438012B (zh) * 2019-08-05 2021-10-26 四川大学 一种产花青素的萨氏曲霉h-1及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE886577A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Noyaux peptidiques cycliques et leur preparation
US4293482A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
BE886575A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
US5310873A (en) * 1990-03-12 1994-05-10 Merck & Co., Inc. Cyclohexapeptide compound
CA2043762C (en) * 1990-06-07 2001-05-29 Adam J. Kreuzman Lipopeptide deacylase
TW455591B (en) 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
EP1064299A1 (en) * 1998-03-16 2001-01-03 Fujisawa Pharmaceutical Co., Ltd. Cyclohexapeptide wf14573 or its salt, production thereof and use thereof
IL143563A0 (en) * 1998-12-09 2002-04-21 Lilly Co Eli Purification of echinocandin cyclopeptide compounds
FR2794746B1 (fr) 1999-06-09 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2794747B1 (fr) 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
HUP0202315A2 (en) * 1999-07-15 2002-10-28 Lilly Co Eli Process for deacylation of lipodepsipeptides
US6511962B1 (en) * 2000-07-17 2003-01-28 Micrologix Biotech Inc. Derivatives of laspartomycin and preparation and use thereof

Also Published As

Publication number Publication date
HRP20080290T3 (en) 2008-07-31
JP4922182B2 (ja) 2012-04-25
US20080076149A1 (en) 2008-03-27
ES2304736T3 (es) 2008-10-16
EP1828228B1 (de) 2008-05-07
CY1108188T1 (el) 2014-02-12
DK1828228T3 (da) 2008-09-01
PL1828228T3 (pl) 2008-09-30
EP1828228A1 (de) 2007-09-05
DE102004060750A1 (de) 2006-07-13
US7785826B2 (en) 2010-08-31
JP2008523789A (ja) 2008-07-10
WO2006063783A1 (de) 2006-06-22
DE502005004058D1 (de) 2008-06-19
SI1828228T1 (sl) 2008-08-31
ATE394416T1 (de) 2008-05-15
PT1828228E (pt) 2008-07-04

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