HRP20070057T3 - 2-substituted pyrimidines - Google Patents

2-substituted pyrimidines

Info

Publication number
HRP20070057T3
HRP20070057T3 HR20070057T HRP20070057T HRP20070057T3 HR P20070057 T3 HRP20070057 T3 HR P20070057T3 HR 20070057 T HR20070057 T HR 20070057T HR P20070057 T HRP20070057 T HR P20070057T HR P20070057 T3 HRP20070057 T3 HR P20070057T3
Authority
HR
Croatia
Prior art keywords
alkyl
cyano
cycloalkyl
alkenyl
alkoxy
Prior art date
Application number
HR20070057T
Other languages
English (en)
Croatian (hr)
Inventor
Schw�gler Anja
Gewehr Markus
Mller Bernd
Grote Thomas
Grammenos Wassilios
Tormo I Blasco Jordi
Gypser Andreas
Rheinheimer Joachim
Blettner Carsten
Sch�fer Peter
Schieweck Frank
Wagner Oliver
Stierl Reinhard
Sch�fl Ulrich
Strathmann Siegfired
Scherer Maria
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HRP20070057T3 publication Critical patent/HRP20070057T3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20070057T 2003-07-24 2007-02-14 2-substituted pyrimidines HRP20070057T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10333857 2003-07-24
DE10357714 2003-12-09
PCT/EP2004/007877 WO2005012261A1 (de) 2003-07-24 2004-07-15 2-substituierte pyrimidine

Publications (1)

Publication Number Publication Date
HRP20070057T3 true HRP20070057T3 (en) 2007-07-31

Family

ID=34117367

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20070057T HRP20070057T3 (en) 2003-07-24 2007-02-14 2-substituted pyrimidines

Country Status (30)

Country Link
US (1) US7375108B2 (pl)
EP (1) EP1651618B1 (pl)
JP (1) JP2006528603A (pl)
KR (1) KR20060052857A (pl)
AP (1) AP2157A (pl)
AR (1) AR045100A1 (pl)
AT (1) ATE350370T1 (pl)
AU (1) AU2004261373B8 (pl)
BR (1) BRPI0412891A (pl)
CA (1) CA2532718A1 (pl)
CO (1) CO5660292A2 (pl)
CR (1) CR8184A (pl)
CY (1) CY1106391T1 (pl)
DE (1) DE502004002570D1 (pl)
DK (1) DK1651618T3 (pl)
EA (1) EA010566B1 (pl)
EC (1) ECSP066278A (pl)
ES (1) ES2279395T3 (pl)
HR (1) HRP20070057T3 (pl)
IL (1) IL172848A0 (pl)
MA (1) MA27949A1 (pl)
MX (1) MXPA06000038A (pl)
NZ (1) NZ545103A (pl)
PE (1) PE20050882A1 (pl)
PL (1) PL1651618T3 (pl)
PT (1) PT1651618E (pl)
SI (1) SI1651618T1 (pl)
TW (1) TW200516075A (pl)
UY (1) UY28436A1 (pl)
WO (1) WO2005012261A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505957A (ja) * 2004-07-14 2008-02-28 ビーエーエスエフ アクチェンゲゼルシャフト 2−置換ピリミジン、その調製方法および有害菌類を防除するためのその使用
CL2007002231A1 (es) * 2006-08-02 2008-04-11 Basf Ag Uso de compuestos derivados de 5-(het) arilpirimidina para combatir hongos daninos; compuestos derivados de 5-(het) arilpirimidina; agente fungicida; y agente farmaceutico.
SG190211A1 (en) * 2010-11-16 2013-06-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
JP6626437B2 (ja) 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. ヒストンデアセチラーゼ阻害剤とHer2阻害剤またはPI3K阻害剤のいずれかの組み合わせ
EP3055299B1 (en) 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
WO2015061684A1 (en) 2013-10-24 2015-04-30 Mayo Foundation For Medical Education And Research Treatment of polycystic diseases with an hdac6 inhibitor
CR20160308A (es) 2013-12-03 2016-11-08 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
EP3166603B1 (en) 2014-07-07 2020-02-12 Acetylon Pharmaceuticals, Inc. Treatment of leukemia with histone deacetylase inhibitors
EP3226903A1 (en) 2014-12-05 2017-10-11 University of Modena and Reggio Emila Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
WO2017184774A1 (en) 2016-04-19 2017-10-26 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030011894A (ko) 2000-06-13 2003-02-11 바스프 악티엔게젤샤프트 5-페닐 치환된 2-(시아노아미노)피리미딘 살균제
CZ20032475A3 (cs) * 2001-03-15 2003-12-17 Basf Aktiengesellschaft 5-Fenylpyrimidiny, způsob jejich přípravy, meziprodukty pro jejich přípravu a jejich použití pro kontrolu škodlivých hub
HUP0402385A3 (en) * 2001-11-19 2005-10-28 Basf Ag 5-phenylpyrimidines, fungicide compositions comprising the same, method for producing and use thereof

Also Published As

Publication number Publication date
AU2004261373B8 (en) 2010-11-04
AR045100A1 (es) 2005-10-12
CY1106391T1 (el) 2011-10-12
WO2005012261A1 (de) 2005-02-10
AP2157A (en) 2010-09-13
EP1651618B1 (de) 2007-01-03
PT1651618E (pt) 2007-03-30
JP2006528603A (ja) 2006-12-21
CR8184A (es) 2006-10-06
DE502004002570D1 (de) 2007-02-15
AU2004261373B2 (en) 2010-08-19
US20070105873A1 (en) 2007-05-10
ES2279395T3 (es) 2007-08-16
TW200516075A (en) 2005-05-16
UY28436A1 (es) 2005-02-28
SI1651618T1 (sl) 2007-06-30
NZ545103A (en) 2008-06-30
KR20060052857A (ko) 2006-05-19
CO5660292A2 (es) 2006-07-31
EP1651618A1 (de) 2006-05-03
AP2006003497A0 (en) 2006-02-28
PE20050882A1 (es) 2005-12-01
ECSP066278A (es) 2006-07-28
EA010566B1 (ru) 2008-10-30
IL172848A0 (en) 2006-06-11
MA27949A1 (fr) 2006-06-01
AU2004261373A1 (en) 2005-02-10
DK1651618T3 (da) 2007-05-14
EA200600212A1 (ru) 2006-08-25
PL1651618T3 (pl) 2007-05-31
BRPI0412891A (pt) 2006-10-03
MXPA06000038A (es) 2006-03-21
CA2532718A1 (en) 2005-02-10
ATE350370T1 (de) 2007-01-15
US7375108B2 (en) 2008-05-20

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