HRP20070057T3 - 2-substituted pyrimidines - Google Patents
2-substituted pyrimidinesInfo
- Publication number
- HRP20070057T3 HRP20070057T3 HR20070057T HRP20070057T HRP20070057T3 HR P20070057 T3 HRP20070057 T3 HR P20070057T3 HR 20070057 T HR20070057 T HR 20070057T HR P20070057 T HRP20070057 T HR P20070057T HR P20070057 T3 HRP20070057 T3 HR P20070057T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- cyano
- cycloalkyl
- alkenyl
- alkoxy
- Prior art date
Links
- -1 2-substituted pyrimidines Chemical class 0.000 title abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 abstract 1
- 125000004962 sulfoxyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10333857 | 2003-07-24 | ||
| DE10357714 | 2003-12-09 | ||
| PCT/EP2004/007877 WO2005012261A1 (de) | 2003-07-24 | 2004-07-15 | 2-substituierte pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070057T3 true HRP20070057T3 (en) | 2007-07-31 |
Family
ID=34117367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070057T HRP20070057T3 (en) | 2003-07-24 | 2007-02-14 | 2-substituted pyrimidines |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7375108B2 (xx) |
| EP (1) | EP1651618B1 (xx) |
| JP (1) | JP2006528603A (xx) |
| KR (1) | KR20060052857A (xx) |
| AP (1) | AP2157A (xx) |
| AR (1) | AR045100A1 (xx) |
| AT (1) | ATE350370T1 (xx) |
| AU (1) | AU2004261373B8 (xx) |
| BR (1) | BRPI0412891A (xx) |
| CA (1) | CA2532718A1 (xx) |
| CO (1) | CO5660292A2 (xx) |
| CR (1) | CR8184A (xx) |
| CY (1) | CY1106391T1 (xx) |
| DE (1) | DE502004002570D1 (xx) |
| DK (1) | DK1651618T3 (xx) |
| EA (1) | EA010566B1 (xx) |
| EC (1) | ECSP066278A (xx) |
| ES (1) | ES2279395T3 (xx) |
| HR (1) | HRP20070057T3 (xx) |
| IL (1) | IL172848A0 (xx) |
| MA (1) | MA27949A1 (xx) |
| MX (1) | MXPA06000038A (xx) |
| NZ (1) | NZ545103A (xx) |
| PE (1) | PE20050882A1 (xx) |
| PL (1) | PL1651618T3 (xx) |
| PT (1) | PT1651618E (xx) |
| SI (1) | SI1651618T1 (xx) |
| TW (1) | TW200516075A (xx) |
| UY (1) | UY28436A1 (xx) |
| WO (1) | WO2005012261A1 (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080132522A1 (en) * | 2004-07-14 | 2008-06-05 | Basf Aktiengesellschaft | 2-Substituted Pyrimidines, Method for Their Production and Their Use for Controlling Pathogenic Fungi |
| CL2007002231A1 (es) * | 2006-08-02 | 2008-04-11 | Basf Ag | Uso de compuestos derivados de 5-(het) arilpirimidina para combatir hongos daninos; compuestos derivados de 5-(het) arilpirimidina; agente fungicida; y agente farmaceutico. |
| PT2640709T (pt) * | 2010-11-16 | 2016-07-13 | Acetylon Pharmaceuticals Inc | Compostos de pirimidina hidroxiamida como inibidores de proteína desacetilase e métodos de utilização dos mesmos |
| EP3054952B1 (en) | 2013-10-08 | 2022-10-26 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer |
| US9278963B2 (en) | 2013-10-10 | 2016-03-08 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| EP3060217B1 (en) | 2013-10-24 | 2022-06-08 | Mayo Foundation for Medical Education and Research | Treatment of polycystic diseases with an hdac6 inhibitor |
| CA2932411A1 (en) | 2013-12-03 | 2015-06-11 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase inhibitors and immunomodulatory drugs |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| EP3166603B1 (en) | 2014-07-07 | 2020-02-12 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| CA2969790A1 (en) | 2014-12-05 | 2016-06-09 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| JP2019515909A (ja) | 2016-04-19 | 2019-06-13 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU778913B2 (en) | 2000-06-13 | 2004-12-23 | Basf Aktiengesellschaft | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines |
| JP4361736B2 (ja) * | 2001-03-15 | 2009-11-11 | ビーエーエスエフ ソシエタス・ヨーロピア | ５−フェニルピリミジン、その製造方法、製造のための中間体および有害な菌類を防除するための使用 |
| CN1312134C (zh) | 2001-11-19 | 2007-04-25 | 巴斯福股份公司 | 5－苯基嘧啶化合物、包含它们的组合物、其制备方法及其用途 |
-
2004
- 2004-07-15 DK DK04741053T patent/DK1651618T3/da active
- 2004-07-15 AT AT04741053T patent/ATE350370T1/de not_active IP Right Cessation
- 2004-07-15 BR BRPI0412891-5A patent/BRPI0412891A/pt not_active IP Right Cessation
- 2004-07-15 MX MXPA06000038A patent/MXPA06000038A/es active IP Right Grant
- 2004-07-15 KR KR1020067001493A patent/KR20060052857A/ko not_active Application Discontinuation
- 2004-07-15 PT PT04741053T patent/PT1651618E/pt unknown
- 2004-07-15 SI SI200430228T patent/SI1651618T1/sl unknown
- 2004-07-15 ES ES04741053T patent/ES2279395T3/es not_active Expired - Lifetime
- 2004-07-15 US US10/564,013 patent/US7375108B2/en not_active Expired - Fee Related
- 2004-07-15 PL PL04741053T patent/PL1651618T3/pl unknown
- 2004-07-15 EP EP04741053A patent/EP1651618B1/de not_active Expired - Lifetime
- 2004-07-15 AU AU2004261373A patent/AU2004261373B8/en not_active Ceased
- 2004-07-15 WO PCT/EP2004/007877 patent/WO2005012261A1/de active Application Filing
- 2004-07-15 CA CA002532718A patent/CA2532718A1/en not_active Abandoned
- 2004-07-15 DE DE502004002570T patent/DE502004002570D1/de not_active Expired - Lifetime
- 2004-07-15 EA EA200600212A patent/EA010566B1/ru not_active IP Right Cessation
- 2004-07-15 AP AP2006003497A patent/AP2157A/xx active
- 2004-07-15 NZ NZ545103A patent/NZ545103A/en unknown
- 2004-07-15 JP JP2006520743A patent/JP2006528603A/ja active Pending
- 2004-07-22 PE PE2004000707A patent/PE20050882A1/es not_active Application Discontinuation
- 2004-07-23 TW TW093122163A patent/TW200516075A/zh unknown
- 2004-07-23 UY UY28436A patent/UY28436A1/es unknown
- 2004-07-23 AR ARP040102631A patent/AR045100A1/es active IP Right Grant
-
2005
- 2005-12-27 IL IL172848A patent/IL172848A0/en not_active IP Right Cessation
-
2006
- 2006-01-11 EC EC2006006278A patent/ECSP066278A/es unknown
- 2006-01-11 CR CR8184A patent/CR8184A/es unknown
- 2006-01-24 CO CO06006393A patent/CO5660292A2/es not_active Application Discontinuation
- 2006-02-15 MA MA28806A patent/MA27949A1/fr unknown
-
2007
- 2007-02-14 HR HR20070057T patent/HRP20070057T3/xx unknown
- 2007-03-16 CY CY20071100372T patent/CY1106391T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20070057T3 (en) | 2-substituted pyrimidines | |
| RS51888B (en) | N- (PHENYL (PIPERIDIN-2-IL) METHYL) BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | |
| RS51224B (sr) | Jedinjenja piperazina sa herbicidnim delovanjem | |
| NZ590887A (en) | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| TW200604175A (en) | Ortho substituted aryl or heteroaryl amide compounds | |
| EA200601847A1 (ru) | Замещённые метиларил- или гетероариламидные соединения | |
| RS54638B1 (en) | HCV SERIN PROTEASE INHIBITORS DERIVED FROM MACROCYCLIC PROLINE | |
| NO20065830L (no) | Substituerte 2-kinolyloksazoler som er anvendbare som PDE4-inhibitorer. | |
| WO2005092858A3 (en) | Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist | |
| RS53108B (en) | AMINO-1,3,5-TRIAZINES N-REPLACED BY CHIRAL BICYCLIC RADICALS, THE PROCESS FOR THEIR PREPARATION, THEIR COMPOUNDS AND THEIR APPLICATIONS AS HERBICIDES AND PLANT GROWTH REGULATORS | |
| NZ601967A (en) | Pde10 inhibitors and related compositions and methods | |
| RS53569B1 (en) | NEW COMPOUNDS AND COMPOSITIONS, AND PROCEDURES FOR USE | |
| HUP0402310A2 (hu) | 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények | |
| MXPA05010874A (es) | Compuestos n-heterociclicos condensados y su uso como antagonistas del receptor del factor liberador de corticotropina. | |
| TW200610760A (en) | 2-(pyridin-2-yl)pyrimidines and their use for controlling harmful fungi | |
| JOP20190239A1 (ar) | مركبات مثبطة لـ vmat2 وتركيبات منها | |
| MX2010005283A (es) | Compuestos de piridilmetil-sulfonamida. | |
| RS51190B (sr) | Aminoacilni derivati kao prolekovi i lekovi za lečenje tromboembolijskih bolesti | |
| HRP20070286T3 (en) | Substituted diketopiperazines and their use as oxytocyn antagonists | |
| HK1081194A1 (en) | 6-amino-1h-indazole compounds as phosphodiesterase4 inhibitors, pharmaceutical compositions compris ing the same, and use thereof | |
| ES2139246T3 (es) | Derivados de n-(benciloxi sustituido en orto)imina y su uso como fungicidas, acaricidas o insecticidas. | |
| EA201390374A1 (ru) | Гетероциклические соединения для лечения или профилактики расстройств, вызываемых ослабленной нейротрансмиссией серотонина, норэпинефрина или допамина | |
| RS53965B1 (en) | ACILBENZENA DERIVATIVES | |
| TW200700419A (en) | 5,6-dialkyl-7-aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds | |
| HRP20030797B1 (en) | Fungicide compositions |