HRP20050593A2 - Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors - Google Patents

Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors Download PDF

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Publication number
HRP20050593A2
HRP20050593A2 HR20050593A HRP20050593A HRP20050593A2 HR P20050593 A2 HRP20050593 A2 HR P20050593A2 HR 20050593 A HR20050593 A HR 20050593A HR P20050593 A HRP20050593 A HR P20050593A HR P20050593 A2 HRP20050593 A2 HR P20050593A2
Authority
HR
Croatia
Prior art keywords
oxo
hydroxy
amino
fluorobenzyl
tetrahydro
Prior art date
Application number
HR20050593A
Other languages
English (en)
Croatian (hr)
Inventor
Crescenzi Benedetta
Kinzel Olaf
Muraglia Ester
Orvieto Federica
Pescatore Giovanna
Rowley Michael
Summa Vincenzo
Original Assignee
Instituto di Ricerche di Biologia Molecolare P. An
Geletti S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto di Ricerche di Biologia Molecolare P. An, Geletti S.P.A. filed Critical Instituto di Ricerche di Biologia Molecolare P. An
Publication of HRP20050593A2 publication Critical patent/HRP20050593A2/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20050593A 2002-12-27 2005-06-24 Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors HRP20050593A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43683002P 2002-12-27 2002-12-27
US52877603P 2003-12-12 2003-12-12
PCT/GB2003/005543 WO2004058757A1 (fr) 2002-12-27 2003-12-18 Tetrahydro-4h-pyrido[1,2-a]pyrimidines et composes associes utilises en tant qu'inhibiteurs de l'integrase du vih

Publications (1)

Publication Number Publication Date
HRP20050593A2 true HRP20050593A2 (en) 2006-03-31

Family

ID=32685467

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050593A HRP20050593A2 (en) 2002-12-27 2005-06-24 Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors

Country Status (20)

Country Link
US (2) US7414045B2 (fr)
EP (1) EP1578748B1 (fr)
JP (1) JP4733986B2 (fr)
KR (1) KR20050087865A (fr)
CN (1) CN100343253C (fr)
AT (1) ATE481401T1 (fr)
AU (2) AU2003292436B2 (fr)
BR (1) BR0317749A (fr)
CA (1) CA2509554C (fr)
DE (1) DE60334248D1 (fr)
EC (1) ECSP055890A (fr)
HR (1) HRP20050593A2 (fr)
IS (1) IS7892A (fr)
MA (1) MA27583A1 (fr)
MX (1) MXPA05007010A (fr)
NO (1) NO20053624L (fr)
NZ (1) NZ540729A (fr)
PL (1) PL377354A1 (fr)
RU (1) RU2329265C2 (fr)
WO (2) WO2004058756A1 (fr)

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US7157447B2 (en) 2004-05-28 2007-01-02 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7173022B2 (en) * 2004-05-28 2007-02-06 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
WO2006060225A2 (fr) * 2004-11-23 2006-06-08 Merck & Co., Inc. Processus destine a la synthese asymetrique d'hexahydropyrimido[1,2-a] azepine-2-carboxamides et de composes correspondants
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WO2007005404A1 (fr) 2005-06-30 2007-01-11 Wyeth DÉRIVÉS D'IMIDAZOLONE PORTANT UN GROUPEMENT HÉTÉROARYLE À 6 CHAÎNONS EN POSITION 5 ET UN GROUPEMENT AMINO, ET LEUR EMPLOI DANS LA RÉGULATION DE LA β-SECRÉTASE
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KR20080064182A (ko) * 2005-10-27 2008-07-08 시오노기세야쿠 가부시키가이샤 Hiv 인테그라아제 억제활성을 가지는 다환성카르바모일피리돈 유도체
AU2006306355A1 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
WO2007058646A1 (fr) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Inhibiteurs d’integrase du vih : composes cycliques de la pyrimidinone
WO2007059125A2 (fr) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Inhibiteurs de l'integrase du vih
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
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WO2007064316A1 (fr) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Heterocycles bicycliques en tant qu'inhibiteurs de l'integrase du vih
US20070129379A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
WO2007087188A2 (fr) * 2006-01-20 2007-08-02 Merck & Co., Inc. Comprimes et granules au gout masque
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US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
CA2738814C (fr) * 2008-10-06 2014-01-28 Merck Sharp & Dohme Corp. Inhibiteurs de l'integrase du vih
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US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
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CN102574854B (zh) 2009-10-13 2014-04-16 伊兰科动物健康爱尔兰有限公司 大环整合酶抑制剂
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UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
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WO2014099586A1 (fr) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Dérivés 4-pyridinonetriazines en tant qu'inhibiteurs de l'intégrase du vih
EP2986291B1 (fr) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. Composés dérivés de 4-pyridone et leurs utilisations en tant qu'inhibiteurs de la vih intégrase
RS56701B1 (sr) 2013-05-17 2018-03-30 Merck Sharp & Dohme Fuzionisana triciklična heterociklična jedinjenja kao inhibitori hiv integraze
EP3008044B1 (fr) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih
KR101809392B1 (ko) 2013-09-27 2017-12-14 머크 샤프 앤드 돔 코포레이션 Hiv 인테그라제 억제제로서 유용한 치환된 퀴놀리진 유도체
WO2016187788A1 (fr) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih
US10548910B2 (en) 2015-11-17 2020-02-04 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors
US10544155B2 (en) 2015-12-15 2020-01-28 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors
WO2017113288A1 (fr) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih
CN110062627A (zh) 2016-12-02 2019-07-26 默沙东公司 可用作hiv整合酶抑制剂的三环杂环化合物
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
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Also Published As

Publication number Publication date
NO20053624D0 (no) 2005-07-26
WO2004058756A1 (fr) 2004-07-15
CN100343253C (zh) 2007-10-17
MA27583A1 (fr) 2005-10-03
JP2006513200A (ja) 2006-04-20
CA2509554C (fr) 2011-02-01
WO2004058757A1 (fr) 2004-07-15
AU2003292436A1 (en) 2004-07-22
RU2005123807A (ru) 2006-01-20
CN1753892A (zh) 2006-03-29
US20060046985A1 (en) 2006-03-02
PL377354A1 (pl) 2006-01-23
AU2003292436B2 (en) 2009-07-30
EP1578748A1 (fr) 2005-09-28
CA2509554A1 (fr) 2004-07-15
US7414045B2 (en) 2008-08-19
RU2329265C2 (ru) 2008-07-20
JP4733986B2 (ja) 2011-07-27
MXPA05007010A (es) 2005-08-18
DE60334248D1 (de) 2010-10-28
KR20050087865A (ko) 2005-08-31
ATE481401T1 (de) 2010-10-15
US20080176869A1 (en) 2008-07-24
US7968553B2 (en) 2011-06-28
BR0317749A (pt) 2005-11-22
EP1578748B1 (fr) 2010-09-15
NZ540729A (en) 2008-03-28
ECSP055890A (es) 2005-09-20
IS7892A (is) 2005-06-13
NO20053624L (no) 2005-09-26
AU2003292437A1 (en) 2004-07-22

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