MA27583A1 - Tetrahydro-4h-pyrido [1,2-a] pyrimidines et les composes apparentes utiles comme inhibiteurs de l'integrase du vih. - Google Patents
Tetrahydro-4h-pyrido [1,2-a] pyrimidines et les composes apparentes utiles comme inhibiteurs de l'integrase du vih.Info
- Publication number
- MA27583A1 MA27583A1 MA28407A MA28407A MA27583A1 MA 27583 A1 MA27583 A1 MA 27583A1 MA 28407 A MA28407 A MA 28407A MA 28407 A MA28407 A MA 28407A MA 27583 A1 MA27583 A1 MA 27583A1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- compounds
- pyrido
- pyrimidines
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
EXTRAIT DE LA DESCRIPTION Tétrahydro-4H-pyrido[l,2-a]pyrimidines et les composés apparentés de la Formule I: sont décrits comme inhibiteurs de l'intégrase du VIH et comme inhibiteurs de la réplication du VTH, oé n est un nombre entier égal à zéro, 1 ou 2, et R1, R3, R4, Rl2 et Rl4 sont définis dans ces présentes. Ces composés sont utiles dans la prévention et le traitement d'infection par le VIH et dans la prévention, le retardement du déclenchement, et le traitement du SIDA. Les composés sont utilisés contre l'infection par le VTH et le SIDA comme composés per se ou sous la forme de sels pharmaceutiquement acceptables. Les composés et leurs sels peuvent être utilisés comme ingrédients dans des compositions pharmaceutiques, facultativement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43683002P | 2002-12-27 | 2002-12-27 | |
US52877603P | 2003-12-12 | 2003-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27583A1 true MA27583A1 (fr) | 2005-10-03 |
Family
ID=32685467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28407A MA27583A1 (fr) | 2002-12-27 | 2005-07-21 | Tetrahydro-4h-pyrido [1,2-a] pyrimidines et les composes apparentes utiles comme inhibiteurs de l'integrase du vih. |
Country Status (20)
Country | Link |
---|---|
US (2) | US7414045B2 (fr) |
EP (1) | EP1578748B1 (fr) |
JP (1) | JP4733986B2 (fr) |
KR (1) | KR20050087865A (fr) |
CN (1) | CN100343253C (fr) |
AT (1) | ATE481401T1 (fr) |
AU (2) | AU2003292437A1 (fr) |
BR (1) | BR0317749A (fr) |
CA (1) | CA2509554C (fr) |
DE (1) | DE60334248D1 (fr) |
EC (1) | ECSP055890A (fr) |
HR (1) | HRP20050593A2 (fr) |
IS (1) | IS7892A (fr) |
MA (1) | MA27583A1 (fr) |
MX (1) | MXPA05007010A (fr) |
NO (1) | NO20053624L (fr) |
NZ (1) | NZ540729A (fr) |
PL (1) | PL377354A1 (fr) |
RU (1) | RU2329265C2 (fr) |
WO (2) | WO2004058756A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2004062613A2 (fr) * | 2003-01-13 | 2004-07-29 | Bristol-Myers Squibb Company | Inhibiteurs d'integrase hiv |
US7435735B2 (en) | 2003-10-20 | 2008-10-14 | Merck & Co., Inc. | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors |
AR046938A1 (es) * | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
TW200526635A (en) * | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
US7273859B2 (en) * | 2004-05-12 | 2007-09-25 | Bristol-Myers Squibb Company | HIV integrase inhibitors: cyclic pyrimidinone compounds |
US7115601B2 (en) | 2004-05-18 | 2006-10-03 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US7176196B2 (en) | 2004-05-28 | 2007-02-13 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
US7173022B2 (en) | 2004-05-28 | 2007-02-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
US7192948B2 (en) * | 2004-05-28 | 2007-03-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
US7157447B2 (en) | 2004-05-28 | 2007-01-02 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
WO2006060225A2 (fr) * | 2004-11-23 | 2006-06-08 | Merck & Co., Inc. | Processus destine a la synthese asymetrique d'hexahydropyrimido[1,2-a] azepine-2-carboxamides et de composes correspondants |
KR20070085702A (ko) * | 2004-12-03 | 2007-08-27 | 머크 앤드 캄파니 인코포레이티드 | Ugt1a1에 의해 대사된 약물의 약력학을 개선시키기위한 아타자나비르의 용도 |
UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
BRPI0518781A2 (pt) * | 2004-12-03 | 2008-12-09 | Merck & Co Inc | formulaÇço farmacÊutica, processo para preparar uma formulaÇço farmacÊutica, e, uso de um composto |
EP1819323B2 (fr) | 2004-12-03 | 2023-03-22 | Merck Sharp & Dohme Corp. | Composition pharmaceutique renfermant un agent d'anti-nucleation |
ATE516026T1 (de) * | 2005-02-21 | 2011-07-15 | Shionogi & Co | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
CN101146811B (zh) * | 2005-03-31 | 2012-01-11 | P.安杰莱蒂分子生物学研究所 | Hiv整合酶抑制剂 |
PL3045206T3 (pl) | 2005-04-28 | 2018-08-31 | Viiv Healthcare Company | Wielopierścieniowe pochodne karbamoilopirydonu wykazujące aktywność inhibitorową wobec integrazy HIV |
AU2006266167A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation |
US7494984B2 (en) * | 2005-08-31 | 2009-02-24 | Bristol-Myers Squibb Company | Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors |
JP5094725B2 (ja) * | 2005-10-04 | 2012-12-12 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | Hivインテグラーゼ阻害剤 |
TW200800988A (en) | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
EP1942736A2 (fr) * | 2005-10-27 | 2008-07-16 | Merck & Co., Inc. | Inhibiteurs de l'integrase du vih |
WO2007059125A2 (fr) * | 2005-11-15 | 2007-05-24 | Bristol-Myers Squibb Company | Inhibiteurs de l'integrase du vih |
WO2007058646A1 (fr) * | 2005-11-15 | 2007-05-24 | Bristol-Myers Squibb Company | Inhibiteurs d’integrase du vih : composes cycliques de la pyrimidinone |
US7902182B2 (en) * | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US8039458B2 (en) * | 2005-11-17 | 2011-10-18 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2007064316A1 (fr) * | 2005-11-30 | 2007-06-07 | Bristol-Myers Squibb Company | Heterocycles bicycliques en tant qu'inhibiteurs de l'integrase du vih |
US20070129379A1 (en) * | 2005-12-01 | 2007-06-07 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
US20090136570A1 (en) * | 2006-01-20 | 2009-05-28 | Bhagwant Rege | Taste-Masked Tablets and Granules |
WO2007143446A1 (fr) * | 2006-05-30 | 2007-12-13 | Bristol-Myers Squibb Company | Composés hétérotricycliques spiro-condensés utilisés en tant qu'inhibiteurs de la vih intégrase |
US7893055B2 (en) * | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2010042392A2 (fr) * | 2008-10-06 | 2010-04-15 | Merck & Co., Inc. | Inhibiteurs de l'intégrase du vih |
US8624023B2 (en) * | 2008-12-11 | 2014-01-07 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
CA2766909C (fr) * | 2009-07-02 | 2018-06-05 | Sanofi | Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one,leur preparation et leur utilisation pharmaceutique |
AU2010305805B2 (en) | 2009-10-13 | 2014-04-03 | Elanco Animal Health Ireland Limited | Macrocyclic integrase inhibitors |
US8383639B2 (en) | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
AU2010313571B2 (en) | 2009-10-26 | 2014-07-31 | Merck Sharp & Dohme Llc | Solid pharmaceutical compositions containing an integrase inhibitor |
JP5739517B2 (ja) | 2010-04-02 | 2015-06-24 | ヤンセン・アールアンドデイ・アイルランド | 大環状インテグラーゼ阻害剤 |
UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
EA029473B1 (ru) | 2011-12-15 | 2018-03-30 | Новартис Аг | Применение ингибиторов pi3k для лечения острой и церебральной малярии |
US9714243B2 (en) | 2012-12-17 | 2017-07-25 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as HIV integrase inhibitors |
WO2014172188A2 (fr) | 2013-04-16 | 2014-10-23 | Merck Sharp & Dohme Corp. | Composés dérivés de 4-pyridone et leurs utilisations en tant qu'inhibiteurs de la vih intégrase |
SI2997033T1 (en) | 2013-05-17 | 2018-04-30 | Merck Sharp & Dohme Corp. | FUZYCLE TRICYCLE HETEROCYCLIC COMPOUNDS AS HIV INTEGRATED INHIBITORS |
EP3008044B1 (fr) | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih |
ES2768658T3 (es) | 2013-09-27 | 2020-06-23 | Merck Sharp & Dohme | Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del VIH |
WO2016187788A1 (fr) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih |
WO2017087257A1 (fr) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Dérivés de pyridotriazine amido-substitués utiles en tant qu'inhibiteurs de l'intégrase du vih |
US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
WO2017113288A1 (fr) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
RU2749043C2 (ru) | 2016-12-02 | 2021-06-03 | Мерк Шарп И Доум Корп. | Трициклические гетероциклические соединения, полезные в качестве ингибиторов интегразы вич |
JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
WO2018140368A1 (fr) | 2017-01-26 | 2018-08-02 | Merck Sharp & Dohme Corp. | Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'intégrase du vih |
KR20210015922A (ko) | 2018-05-31 | 2021-02-10 | 시오노기 앤드 컴파니, 리미티드 | 다환성 카바모일피리돈 유도체 |
MX2020012185A (es) | 2018-05-31 | 2021-01-29 | Shionogi & Co | Derivado policiclico de piridona. |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306891B1 (en) | 1998-06-03 | 2001-10-23 | Merck & Co., Inc. | HIV integrase inhibitors |
US6380249B1 (en) | 1998-06-03 | 2002-04-30 | Merck & Co., Inc. | HIV integrase inhibitors |
US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
EP1196384A4 (fr) | 1999-06-25 | 2002-10-23 | Merck & Co Inc | 1,3-propanediones-1-(aromatiques ou heteroaromatiques substitutees)-3-(heteroaromatiques substituees) et leur utilisation |
JP2003535865A (ja) | 2000-06-07 | 2003-12-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびその使用 |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
CA2321348A1 (fr) * | 2000-09-27 | 2002-03-27 | Blaise Magloire N'zemba | Derives aromatiques ayant des proprietes inhibant l'integrase de l'hiv |
CA2425067A1 (fr) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza- et polyaza-naphtalenyl cetones utiles en tant qu'inhibiteurs de l'integrase du vih |
CA2425625A1 (fr) | 2000-10-12 | 2002-07-18 | Merck & Co., Inc. | Aza- et polyaza-naphthalenyl carboxamides convenant comme inhibiteurs de l'integrase du vih |
ES2287170T3 (es) | 2000-10-12 | 2007-12-16 | MERCK & CO., INC. | Aza- y poliaza-naftalenil-carboxamidas utilies como inhibidores de la vih integrasa. |
DE60138635D1 (de) | 2000-10-12 | 2009-06-18 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
KR20100087209A (ko) | 2001-08-10 | 2010-08-03 | 시오노기세이야쿠가부시키가이샤 | 항바이러스제 |
RS51542B (sr) | 2001-10-26 | 2011-06-30 | Istituto Di Ricerche Di Biologia Molecolare P.Angeletti Spa. | N-supstituisani hidroksipirimidinon karboksamidni inhibitori hiv integraze |
WO2003035076A1 (fr) | 2001-10-26 | 2003-05-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Inhibiteurs de l'integrase du vih a base de dihydroxypyrimidine carboxamide |
DE60315796T2 (de) | 2002-01-17 | 2008-06-05 | Merck & Co., Inc. | Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen |
AU2003248872A1 (en) | 2002-07-09 | 2004-01-23 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
WO2004062613A2 (fr) | 2003-01-13 | 2004-07-29 | Bristol-Myers Squibb Company | Inhibiteurs d'integrase hiv |
US7037908B2 (en) | 2003-04-24 | 2006-05-02 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
AR046938A1 (es) * | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
-
2003
- 2003-12-18 MX MXPA05007010A patent/MXPA05007010A/es active IP Right Grant
- 2003-12-18 AT AT03768014T patent/ATE481401T1/de not_active IP Right Cessation
- 2003-12-18 CN CNB2003801099211A patent/CN100343253C/zh not_active Expired - Fee Related
- 2003-12-18 JP JP2004563339A patent/JP4733986B2/ja not_active Expired - Fee Related
- 2003-12-18 AU AU2003292437A patent/AU2003292437A1/en not_active Abandoned
- 2003-12-18 WO PCT/GB2003/005536 patent/WO2004058756A1/fr active Application Filing
- 2003-12-18 US US10/540,449 patent/US7414045B2/en active Active
- 2003-12-18 PL PL377354A patent/PL377354A1/pl not_active Application Discontinuation
- 2003-12-18 WO PCT/GB2003/005543 patent/WO2004058757A1/fr not_active Application Discontinuation
- 2003-12-18 EP EP03768014A patent/EP1578748B1/fr not_active Expired - Lifetime
- 2003-12-18 RU RU2005123807/04A patent/RU2329265C2/ru not_active IP Right Cessation
- 2003-12-18 CA CA2509554A patent/CA2509554C/fr not_active Expired - Fee Related
- 2003-12-18 KR KR1020057012028A patent/KR20050087865A/ko not_active Application Discontinuation
- 2003-12-18 AU AU2003292436A patent/AU2003292436B2/en not_active Ceased
- 2003-12-18 NZ NZ540729A patent/NZ540729A/en unknown
- 2003-12-18 BR BR0317749-1A patent/BR0317749A/pt not_active IP Right Cessation
- 2003-12-18 DE DE60334248T patent/DE60334248D1/de not_active Expired - Lifetime
-
2005
- 2005-06-13 IS IS7892A patent/IS7892A/is unknown
- 2005-06-23 EC EC2005005890A patent/ECSP055890A/es unknown
- 2005-06-24 HR HR20050593A patent/HRP20050593A2/hr not_active Application Discontinuation
- 2005-07-21 MA MA28407A patent/MA27583A1/fr unknown
- 2005-07-26 NO NO20053624A patent/NO20053624L/no not_active Application Discontinuation
-
2008
- 2008-03-12 US US12/075,514 patent/US7968553B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003292436A1 (en) | 2004-07-22 |
ATE481401T1 (de) | 2010-10-15 |
CA2509554C (fr) | 2011-02-01 |
HRP20050593A2 (en) | 2006-03-31 |
CA2509554A1 (fr) | 2004-07-15 |
ECSP055890A (es) | 2005-09-20 |
AU2003292437A1 (en) | 2004-07-22 |
DE60334248D1 (de) | 2010-10-28 |
US7968553B2 (en) | 2011-06-28 |
CN1753892A (zh) | 2006-03-29 |
MXPA05007010A (es) | 2005-08-18 |
EP1578748A1 (fr) | 2005-09-28 |
WO2004058756A1 (fr) | 2004-07-15 |
RU2329265C2 (ru) | 2008-07-20 |
PL377354A1 (pl) | 2006-01-23 |
JP4733986B2 (ja) | 2011-07-27 |
NO20053624D0 (no) | 2005-07-26 |
AU2003292436B2 (en) | 2009-07-30 |
RU2005123807A (ru) | 2006-01-20 |
US20060046985A1 (en) | 2006-03-02 |
NZ540729A (en) | 2008-03-28 |
EP1578748B1 (fr) | 2010-09-15 |
IS7892A (is) | 2005-06-13 |
US7414045B2 (en) | 2008-08-19 |
CN100343253C (zh) | 2007-10-17 |
BR0317749A (pt) | 2005-11-22 |
KR20050087865A (ko) | 2005-08-31 |
JP2006513200A (ja) | 2006-04-20 |
NO20053624L (no) | 2005-09-26 |
US20080176869A1 (en) | 2008-07-24 |
WO2004058757A1 (fr) | 2004-07-15 |
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