HRP20050278A2 - Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b - Google Patents

Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b

Info

Publication number
HRP20050278A2
HRP20050278A2 HR20050278A HRP20050278A HRP20050278A2 HR P20050278 A2 HRP20050278 A2 HR P20050278A2 HR 20050278 A HR20050278 A HR 20050278A HR P20050278 A HRP20050278 A HR P20050278A HR P20050278 A2 HRP20050278 A2 HR P20050278A2
Authority
HR
Croatia
Prior art keywords
epothilone
isolation
purification
preparation
methods
Prior art date
Application number
HR20050278A
Other languages
English (en)
Inventor
Benigni Daniel
Chiang Shu-Jen
L. Davis Brian
T. Comezoglu Fahri
Eagan Bruce
Galvin Gabriel
Gu Dennis
Hargro Ivan
Hou Hsing
Hou David
Mascari Mark
W. Mcconlogue Cary
Mintzmyer Les
Skankavage Robert
Stein Gregory
P. Tully Thomas
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HRP20050278A2 publication Critical patent/HRP20050278A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20050278A 2002-09-23 2005-03-23 Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b HRP20050278A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41299402P 2002-09-23 2002-09-23
PCT/US2003/029628 WO2004026254A2 (en) 2002-09-23 2003-09-22 Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b

Publications (1)

Publication Number Publication Date
HRP20050278A2 true HRP20050278A2 (en) 2005-10-31

Family

ID=32030950

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050278A HRP20050278A2 (en) 2002-09-23 2005-03-23 Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b

Country Status (23)

Country Link
US (4) US7172884B2 (ko)
EP (3) EP2280014B1 (ko)
JP (2) JP4523843B2 (ko)
KR (2) KR101406635B1 (ko)
CN (2) CN1705662B (ko)
AU (1) AU2003275068B2 (ko)
BR (1) BRPI0314133A8 (ko)
CA (3) CA2499600C (ko)
CO (1) CO5540384A2 (ko)
ES (2) ES2439995T3 (ko)
GE (1) GEP20074017B (ko)
HK (1) HK1113387A1 (ko)
HR (1) HRP20050278A2 (ko)
IL (2) IL222455A0 (ko)
IS (1) IS7768A (ko)
MX (1) MXPA05003006A (ko)
NO (1) NO334167B1 (ko)
PL (1) PL375902A1 (ko)
RS (1) RS20050235A (ko)
RU (1) RU2368661C2 (ko)
TW (1) TWI291464B (ko)
WO (1) WO2004026254A2 (ko)
ZA (1) ZA200501680B (ko)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
AU2003275068B2 (en) * 2002-09-23 2009-09-17 Bristol-Myers Squibb Company Methods for the preparation, isolation and purification of epothilone B, and X-Ray crystal structures of epothilone B
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
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CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
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WO2015024884A1 (en) * 2013-08-19 2015-02-26 Sandoz Ag Method for the purifiction of epothilones via crystallization
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CN106834377B (zh) * 2017-03-07 2020-05-05 鲁南制药集团股份有限公司 一种生产埃博霉素b的方法
CN106905338B (zh) * 2017-03-07 2020-06-23 鲁南制药集团股份有限公司 一种埃博霉素b的提纯方法
CN107827943B (zh) * 2017-11-28 2022-06-10 绍兴厚普生物科技有限责任公司 一种从发酵液中提取胞嘧啶核苷的方法
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法
KR102440644B1 (ko) * 2020-05-28 2022-09-05 공주대학교 산학협력단 파클리탁셀 정제 시 가스 버블을 이용한 분별침전방법
CN112409369B (zh) * 2020-11-30 2023-03-28 湖北宏中药业股份有限公司 一种埃博霉素b的高效提取纯化方法
CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法

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Also Published As

Publication number Publication date
NO334167B1 (no) 2013-12-23
NO20050929L (no) 2005-04-08
RS20050235A (en) 2007-06-04
US20070122891A1 (en) 2007-05-31
US7172884B2 (en) 2007-02-06
CA2695720C (en) 2013-04-02
KR101406635B1 (ko) 2014-06-11
CA2499600C (en) 2012-08-21
IS7768A (is) 2005-03-22
JP2010011873A (ja) 2010-01-21
CN101050445A (zh) 2007-10-10
US20040132146A1 (en) 2004-07-08
KR20120080649A (ko) 2012-07-17
CN101050445B (zh) 2011-08-10
IL166868A (en) 2012-12-31
ES2405753T3 (es) 2013-06-03
WO2004026254A3 (en) 2004-05-27
HK1113387A1 (en) 2008-10-03
WO2004026254A2 (en) 2004-04-01
CA2695720A1 (en) 2004-04-01
EP2287168A2 (en) 2011-02-23
TW200409773A (en) 2004-06-16
AU2003275068A1 (en) 2004-04-08
BRPI0314133A8 (pt) 2017-09-19
CN1705662A (zh) 2005-12-07
JP4523843B2 (ja) 2010-08-11
KR20050053681A (ko) 2005-06-08
BR0314133A (pt) 2005-07-12
US7241899B2 (en) 2007-07-10
CA2695671A1 (en) 2004-04-01
ZA200501680B (en) 2006-05-31
US20060135474A1 (en) 2006-06-22
PL375902A1 (en) 2005-12-12
RU2368661C2 (ru) 2009-09-27
EP2280014A2 (en) 2011-02-02
USRE42191E1 (en) 2011-03-01
TWI291464B (en) 2007-12-21
JP2006500031A (ja) 2006-01-05
EP2280014B1 (en) 2013-10-23
GEP20074017B (en) 2007-01-10
CA2499600A1 (en) 2004-04-01
EP2280014A3 (en) 2011-08-03
RU2005112443A (ru) 2005-10-27
JP5193983B2 (ja) 2013-05-08
CO5540384A2 (es) 2005-07-29
US7767432B2 (en) 2010-08-03
EP2287168B1 (en) 2013-02-13
EP1542998A2 (en) 2005-06-22
AU2003275068B2 (en) 2009-09-17
MXPA05003006A (es) 2005-06-22
ES2439995T3 (es) 2014-01-27
EP1542998A4 (en) 2007-01-31
EP2287168A3 (en) 2011-03-16
CN1705662B (zh) 2011-07-06
IL222455A0 (en) 2012-12-02

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