HRP20050043A2 - Antibakterijski amidni makrocikli - Google Patents

Antibakterijski amidni makrocikli

Info

Publication number
HRP20050043A2
HRP20050043A2 HR20050043A HRP20050043A HRP20050043A2 HR P20050043 A2 HRP20050043 A2 HR P20050043A2 HR 20050043 A HR20050043 A HR 20050043A HR P20050043 A HRP20050043 A HR P20050043A HR P20050043 A2 HRP20050043 A2 HR P20050043A2
Authority
HR
Croatia
Prior art keywords
hydrogen
alkyl
amino
substituents
cycloalkyl
Prior art date
Application number
HR20050043A
Other languages
English (en)
Croatian (hr)
Inventor
Lampe Thomas
Adelt Isabelle
Beyer Dieter
Brunner Nina
Endermann Rainer
Ehlert Kerstin
Kroll Hein-Peter
Von Nussbaum Franz
Raddatz Siegfried
Rudolph Joachim
Schiffer Guido
Schumacher Andreas
Cancho-Grande Yolanda
Michels Martin
Weigand Stefan
Original Assignee
Aicuris Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co. Kg filed Critical Aicuris Gmbh & Co. Kg
Publication of HRP20050043A2 publication Critical patent/HRP20050043A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20050043A 2002-06-17 2003-06-10 Antibakterijski amidni makrocikli HRP20050043A2 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226921A DE10226921A1 (de) 2002-06-17 2002-06-17 Antibakterielle Amid-Makrozyklen
PCT/EP2003/006078 WO2003106480A1 (de) 2002-06-17 2003-06-10 Antibakterielle amid-makrozyklen

Publications (1)

Publication Number Publication Date
HRP20050043A2 true HRP20050043A2 (hr) 2006-04-30

Family

ID=29594575

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050043A HRP20050043A2 (hr) 2002-06-17 2003-06-10 Antibakterijski amidni makrocikli

Country Status (21)

Country Link
US (1) US20070129288A1 (enExample)
EP (1) EP1515983B1 (enExample)
JP (1) JP4437078B2 (enExample)
KR (1) KR20050010060A (enExample)
CN (1) CN1326870C (enExample)
AT (1) ATE354585T1 (enExample)
AU (1) AU2003245928B2 (enExample)
BR (1) BR0311948A (enExample)
CA (1) CA2489454A1 (enExample)
DE (2) DE10226921A1 (enExample)
EC (1) ECSP045499A (enExample)
ES (1) ES2282643T3 (enExample)
HR (1) HRP20050043A2 (enExample)
MA (1) MA28613B1 (enExample)
MX (1) MXPA04012438A (enExample)
NO (1) NO20050210L (enExample)
PL (1) PL374554A1 (enExample)
PT (1) PT1515983E (enExample)
RU (1) RU2005100954A (enExample)
WO (1) WO2003106480A1 (enExample)
ZA (1) ZA200410006B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004025569D1 (de) 2003-06-18 2010-04-01 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004018405A1 (de) * 2004-04-16 2005-11-03 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen II
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
ZA200805192B (en) 2005-12-29 2009-11-25 Lexicon Pharmaceuticals Inc Multicyclic amino acid derivatives and methods of their use
JP2012510958A (ja) * 2008-12-04 2012-05-17 バイエル ファーマ アクチエンゲゼルシャフト 放射性同位体で標識されたリジン及びオルニチン誘導体、それらの使用及び製造方法
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CA2892027A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
JP5437525B1 (ja) * 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
RU2016146581A (ru) 2014-05-20 2018-06-21 АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК. Макроциклические антибиотики широкого спектра действия
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CR20180232A (es) 2015-10-27 2018-05-31 Hoffmann La Roche Macrociclos peptídicos contra acinetobacter baumannii
EP3377474B1 (en) 2015-11-20 2023-08-16 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
IL295889B2 (en) 2019-05-28 2025-01-01 Hoffmann La Roche Broad-spectrum macrocyclic antibiotic

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
NO20050210L (no) 2005-03-01
MA28613B1 (fr) 2007-06-01
ATE354585T1 (de) 2007-03-15
CA2489454A1 (en) 2004-12-14
HK1083511A1 (zh) 2006-07-07
KR20050010060A (ko) 2005-01-26
DE10226921A1 (de) 2003-12-24
US20070129288A1 (en) 2007-06-07
BR0311948A (pt) 2005-03-29
ECSP045499A (es) 2005-03-10
JP4437078B2 (ja) 2010-03-24
JP2006511446A (ja) 2006-04-06
CN1675236A (zh) 2005-09-28
WO2003106480A1 (de) 2003-12-24
CN1326870C (zh) 2007-07-18
AU2003245928A1 (en) 2003-12-31
PT1515983E (pt) 2007-03-30
AU2003245928B2 (en) 2009-03-05
MXPA04012438A (es) 2005-04-19
ZA200410006B (en) 2006-02-22
DE50306587D1 (de) 2007-04-05
EP1515983B1 (de) 2007-02-21
ES2282643T3 (es) 2007-10-16
EP1515983A1 (de) 2005-03-23
RU2005100954A (ru) 2005-07-10
PL374554A1 (en) 2005-10-31

Similar Documents

Publication Publication Date Title
HRP20050043A2 (hr) Antibakterijski amidni makrocikli
AU2015228898B2 (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics
ZA200400334B (en) Dolastatin 10 derivatives
US20060258571A1 (en) Antibacterial ester macrocycles
US7446102B2 (en) Antibacterial amide macrocycles IV
da Costa et al. Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of L-prolyl-L-leucyl-glycinamide (PLG) modified in the L-proline or L-proline and L-leucine scaffolds
CA2540646A1 (en) Antibacterial amide macrocycles
KR20070116169A (ko) 항박테리아성 아미드-마크로사이클 ｖ
EP1697400A1 (de) Antibakterielle makrozyklen mit substituiertem biphenyl
MX2008013191A (es) Lisobactina amidas.
CA2602743A1 (en) Antibacterial amide macrocycles vi
HK1083511B (en) Antibacterial amide macrocycles
AU2007237433A1 (en) Process for the manufacture of lysobactin derivatives
IL165630A (en) Antibacterial amide macrocycles
HK1240940B (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: AICURIS GMBH & CO. KG, DE

ODRP Renewal fee for the maintenance of a patent

Payment date: 20070606

Year of fee payment: 5

OBST Application withdrawn