HRP20040371B1 - Thiopene- amd thiazolesulfonamides as antineoplastic agents - Google Patents
Thiopene- amd thiazolesulfonamides as antineoplastic agentsInfo
- Publication number
- HRP20040371B1 HRP20040371B1 HRP20040371AA HRP20040371A HRP20040371B1 HR P20040371 B1 HRP20040371 B1 HR P20040371B1 HR P20040371A A HRP20040371A A HR P20040371AA HR P20040371 A HRP20040371 A HR P20040371A HR P20040371 B1 HRP20040371 B1 HR P20040371B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- halogen
- thiazolesulfonamides
- thiopene
- amd
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35201201P | 2001-10-25 | 2001-10-25 | |
PCT/US2002/031568 WO2003035629A1 (en) | 2001-10-25 | 2002-10-15 | Thiopene- amd thiazolesulfonamides as antineoplastic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20040371A2 HRP20040371A2 (en) | 2004-08-31 |
HRP20040371B1 true HRP20040371B1 (en) | 2012-07-31 |
Family
ID=23383421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20040371AA HRP20040371B1 (en) | 2001-10-25 | 2004-04-26 | Thiopene- amd thiazolesulfonamides as antineoplastic agents |
Country Status (34)
Country | Link |
---|---|
US (2) | US7084170B2 (ru) |
EP (1) | EP1442030B1 (ru) |
JP (1) | JP4464681B2 (ru) |
KR (1) | KR100913471B1 (ru) |
CN (1) | CN1298709C (ru) |
AR (1) | AR037248A1 (ru) |
AT (1) | ATE338033T1 (ru) |
AU (1) | AU2002334817B2 (ru) |
BR (1) | BR0212386A (ru) |
CA (1) | CA2463300C (ru) |
CY (1) | CY1106247T1 (ru) |
DE (1) | DE60214413T2 (ru) |
DK (1) | DK1442030T3 (ru) |
EA (1) | EA006081B1 (ru) |
EC (1) | ECSP045078A (ru) |
EG (1) | EG26021A (ru) |
ES (1) | ES2269816T3 (ru) |
HK (1) | HK1068337A1 (ru) |
HR (1) | HRP20040371B1 (ru) |
HU (1) | HUP0401638A3 (ru) |
IL (2) | IL160851A0 (ru) |
MX (1) | MXPA04003886A (ru) |
MY (1) | MY130718A (ru) |
NO (1) | NO20041316L (ru) |
NZ (1) | NZ531136A (ru) |
PE (1) | PE20030574A1 (ru) |
PL (1) | PL208083B1 (ru) |
PT (1) | PT1442030E (ru) |
SI (1) | SI1442030T1 (ru) |
SV (1) | SV2004001367A (ru) |
TW (1) | TWI281916B (ru) |
UA (1) | UA75716C2 (ru) |
WO (1) | WO2003035629A1 (ru) |
ZA (1) | ZA200403089B (ru) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100900304B1 (ko) * | 2001-06-11 | 2009-06-02 | 바이로켐 파마 인코포레이티드 | 플라비 바이러스 감염용 항바이러스제로서의 티오펜 유도체 |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
JP2005531608A (ja) * | 2002-06-06 | 2005-10-20 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
ES2345438T3 (es) * | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
WO2006030947A1 (ja) * | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
JPWO2006090928A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の血管新生阻害物質との新規併用 |
WO2006090927A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の摂食亢進作用 |
JPWO2006090930A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規併用 |
CN101218224B (zh) | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
US7208506B2 (en) | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
US7625896B2 (en) * | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
WO2007123274A1 (ja) | 2006-04-20 | 2007-11-01 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の新規感受性マーカー |
US7939532B2 (en) | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
JP5290186B2 (ja) | 2006-11-15 | 2013-09-18 | ヴァイロケム ファーマ インコーポレイテッド | フラビウイルス感染症の治療または予防用のチオフェン類似体 |
WO2008138594A1 (en) | 2007-05-16 | 2008-11-20 | F. Hoffmann-La Roche Ag | Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
CN101899008B (zh) * | 2010-05-20 | 2012-10-17 | 中国人民解放军第二军医大学 | N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途 |
CN103450149B (zh) * | 2012-06-01 | 2015-10-14 | 中国科学院上海有机化学研究所 | 苯基噻吩磺酰胺类化合物及其制备方法和用途 |
JP6364967B2 (ja) * | 2014-05-30 | 2018-08-01 | 東ソー株式会社 | ジチエノベンゾジチオフェンの製造方法 |
CN106588868A (zh) * | 2016-11-16 | 2017-04-26 | 武汉理工大学 | 一种2‑溴‑3‑噻吩甲酸中间体的合成方法 |
CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
CN110835345A (zh) * | 2018-08-17 | 2020-02-25 | 中国科学院上海药物研究所 | 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途 |
CN109265437A (zh) * | 2018-10-19 | 2019-01-25 | 凯莱英医药集团(天津)股份有限公司 | 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
EP0560554A2 (en) * | 1992-03-13 | 1993-09-15 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
US5302724A (en) * | 1990-07-17 | 1994-04-12 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
WO1998014440A1 (en) * | 1996-10-04 | 1998-04-09 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA813332B (en) * | 1980-06-21 | 1982-05-26 | Pfizer | Larvicides and isecticides |
DE69734734D1 (de) * | 1996-07-05 | 2005-12-29 | Us Gov Health & Human Serv | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
JP4316787B2 (ja) | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
-
2002
- 2002-10-11 TW TW091123452A patent/TWI281916B/zh not_active IP Right Cessation
- 2002-10-15 AU AU2002334817A patent/AU2002334817B2/en not_active Ceased
- 2002-10-15 CA CA2463300A patent/CA2463300C/en not_active Expired - Fee Related
- 2002-10-15 ES ES02802117T patent/ES2269816T3/es not_active Expired - Lifetime
- 2002-10-15 JP JP2003538145A patent/JP4464681B2/ja not_active Expired - Fee Related
- 2002-10-15 WO PCT/US2002/031568 patent/WO2003035629A1/en active IP Right Grant
- 2002-10-15 DK DK02802117T patent/DK1442030T3/da active
- 2002-10-15 EP EP02802117A patent/EP1442030B1/en not_active Expired - Lifetime
- 2002-10-15 EA EA200400582A patent/EA006081B1/ru not_active IP Right Cessation
- 2002-10-15 HU HU0401638A patent/HUP0401638A3/hu unknown
- 2002-10-15 PT PT02802117T patent/PT1442030E/pt unknown
- 2002-10-15 MX MXPA04003886A patent/MXPA04003886A/es active IP Right Grant
- 2002-10-15 BR BR0212386-0A patent/BR0212386A/pt not_active IP Right Cessation
- 2002-10-15 PL PL368234A patent/PL208083B1/pl not_active IP Right Cessation
- 2002-10-15 NZ NZ531136A patent/NZ531136A/en not_active IP Right Cessation
- 2002-10-15 AT AT02802117T patent/ATE338033T1/de active
- 2002-10-15 IL IL16085102A patent/IL160851A0/xx unknown
- 2002-10-15 CN CNB028212150A patent/CN1298709C/zh not_active Expired - Fee Related
- 2002-10-15 DE DE60214413T patent/DE60214413T2/de not_active Expired - Lifetime
- 2002-10-15 UA UA20040403046A patent/UA75716C2/uk unknown
- 2002-10-15 KR KR1020047006058A patent/KR100913471B1/ko not_active IP Right Cessation
- 2002-10-15 US US10/490,935 patent/US7084170B2/en not_active Expired - Fee Related
- 2002-10-15 SI SI200230399T patent/SI1442030T1/sl unknown
- 2002-10-21 EG EG2002101152A patent/EG26021A/en active
- 2002-10-23 AR ARP020104007A patent/AR037248A1/es active IP Right Grant
- 2002-10-23 MY MYPI20023959A patent/MY130718A/en unknown
- 2002-10-24 SV SV2002001367A patent/SV2004001367A/es unknown
- 2002-10-25 PE PE2002001051A patent/PE20030574A1/es not_active Application Discontinuation
-
2004
- 2004-03-11 IL IL160851A patent/IL160851A/en not_active IP Right Cessation
- 2004-03-30 NO NO20041316A patent/NO20041316L/no not_active Application Discontinuation
- 2004-04-22 ZA ZA200403089A patent/ZA200403089B/en unknown
- 2004-04-23 EC EC2004005078A patent/ECSP045078A/es unknown
- 2004-04-26 HR HRP20040371AA patent/HRP20040371B1/xx not_active IP Right Cessation
-
2005
- 2005-01-14 HK HK05100403A patent/HK1068337A1/xx not_active IP Right Cessation
-
2006
- 2006-06-06 US US11/447,457 patent/US7250430B2/en not_active Expired - Fee Related
- 2006-11-16 CY CY20061101669T patent/CY1106247T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302724A (en) * | 1990-07-17 | 1994-04-12 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
EP0560554A2 (en) * | 1992-03-13 | 1993-09-15 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
WO1998014440A1 (en) * | 1996-10-04 | 1998-04-09 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
Also Published As
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ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
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B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20121011 Year of fee payment: 11 |
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Effective date: 20131015 |