HRP20040263B1 - Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid - Google Patents
Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acidInfo
- Publication number
- HRP20040263B1 HRP20040263B1 HRP20040263AA HRP20040263A HRP20040263B1 HR P20040263 B1 HRP20040263 B1 HR P20040263B1 HR P20040263A A HRP20040263A A HR P20040263AA HR P20040263 A HRP20040263 A HR P20040263A HR P20040263 B1 HRP20040263 B1 HR P20040263B1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- pyrrolizin
- chlorophenyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10141285A DE10141285A1 (de) | 2001-08-23 | 2001-08-23 | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
PCT/EP2002/009356 WO2003018583A1 (de) | 2001-08-23 | 2002-08-21 | Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20040263A2 HRP20040263A2 (en) | 2004-08-31 |
HRP20040263B1 true HRP20040263B1 (en) | 2012-07-31 |
Family
ID=7696330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20040263AA HRP20040263B1 (en) | 2001-08-23 | 2004-03-17 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid |
Country Status (32)
Country | Link |
---|---|
US (1) | US7078535B2 (xx) |
EP (1) | EP1419160B1 (xx) |
JP (1) | JP4195379B2 (xx) |
KR (1) | KR100687472B1 (xx) |
CN (1) | CN1266152C (xx) |
AR (1) | AR035117A1 (xx) |
AT (1) | ATE417047T1 (xx) |
AU (1) | AU2002331168C1 (xx) |
BR (1) | BR0212009A (xx) |
CA (1) | CA2458339C (xx) |
CO (1) | CO5560556A2 (xx) |
CU (1) | CU23345A3 (xx) |
CY (1) | CY1109089T1 (xx) |
DE (2) | DE10141285A1 (xx) |
DK (1) | DK1419160T3 (xx) |
EA (1) | EA006436B1 (xx) |
ES (1) | ES2319268T3 (xx) |
GE (1) | GEP20063918B (xx) |
HK (1) | HK1060879A1 (xx) |
HR (1) | HRP20040263B1 (xx) |
HU (1) | HU228125B1 (xx) |
IL (2) | IL160047A0 (xx) |
MX (1) | MXPA04001664A (xx) |
NO (1) | NO328299B1 (xx) |
NZ (1) | NZ531113A (xx) |
PL (1) | PL367796A1 (xx) |
PT (1) | PT1419160E (xx) |
RS (1) | RS51877B (xx) |
TW (1) | TWI274755B (xx) |
UA (1) | UA75702C2 (xx) |
WO (1) | WO2003018583A1 (xx) |
ZA (1) | ZA200402209B (xx) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
CZ2007752A3 (cs) * | 2007-10-30 | 2009-05-13 | Zentiva, A. S. | Nový zpusob výroby 2-(6-(4-chlorfenyl)-2,2-dimethyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl)octové kyseliny (licofelonu) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0172371A1 (de) | 1984-07-27 | 1986-02-26 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Dehydroxypantolacton |
DE3915450A1 (de) | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
HUP0300604A3 (en) | 2000-01-28 | 2003-10-28 | Merckle Gmbh | Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid and their polymorphous form and use thereof |
-
2001
- 2001-08-23 DE DE10141285A patent/DE10141285A1/de not_active Withdrawn
-
2002
- 2002-08-13 AR ARP020103045A patent/AR035117A1/es active IP Right Grant
- 2002-08-21 WO PCT/EP2002/009356 patent/WO2003018583A1/de active IP Right Grant
- 2002-08-21 CA CA002458339A patent/CA2458339C/en not_active Expired - Fee Related
- 2002-08-21 EP EP02767415A patent/EP1419160B1/de not_active Expired - Lifetime
- 2002-08-21 DK DK02767415T patent/DK1419160T3/da active
- 2002-08-21 DE DE50213105T patent/DE50213105D1/de not_active Expired - Lifetime
- 2002-08-21 US US10/486,911 patent/US7078535B2/en not_active Expired - Fee Related
- 2002-08-21 GE GE5474A patent/GEP20063918B/en unknown
- 2002-08-21 RS YU14604A patent/RS51877B/en unknown
- 2002-08-21 NZ NZ531113A patent/NZ531113A/en not_active IP Right Cessation
- 2002-08-21 MX MXPA04001664A patent/MXPA04001664A/es active IP Right Grant
- 2002-08-21 CN CNB028164490A patent/CN1266152C/zh not_active Expired - Fee Related
- 2002-08-21 BR BR0212009-7A patent/BR0212009A/pt not_active Application Discontinuation
- 2002-08-21 JP JP2003523244A patent/JP4195379B2/ja not_active Expired - Fee Related
- 2002-08-21 ES ES02767415T patent/ES2319268T3/es not_active Expired - Lifetime
- 2002-08-21 PT PT02767415T patent/PT1419160E/pt unknown
- 2002-08-21 EA EA200400344A patent/EA006436B1/ru not_active IP Right Cessation
- 2002-08-21 HU HU0401440A patent/HU228125B1/hu not_active IP Right Cessation
- 2002-08-21 UA UA2004032036A patent/UA75702C2/uk unknown
- 2002-08-21 KR KR1020047002654A patent/KR100687472B1/ko not_active IP Right Cessation
- 2002-08-21 AT AT02767415T patent/ATE417047T1/de active
- 2002-08-21 IL IL16004702A patent/IL160047A0/xx unknown
- 2002-08-21 PL PL02367796A patent/PL367796A1/xx unknown
- 2002-08-21 AU AU2002331168A patent/AU2002331168C1/en not_active Ceased
- 2002-08-23 TW TW091119151A patent/TWI274755B/zh not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160047A patent/IL160047A/en not_active IP Right Cessation
- 2004-01-29 CU CU20040019A patent/CU23345A3/es not_active IP Right Cessation
- 2004-02-19 CO CO04014456A patent/CO5560556A2/es not_active Application Discontinuation
- 2004-03-17 HR HRP20040263AA patent/HRP20040263B1/xx not_active IP Right Cessation
- 2004-03-19 ZA ZA200402209A patent/ZA200402209B/en unknown
- 2004-03-19 NO NO20041178A patent/NO328299B1/no not_active IP Right Cessation
- 2004-05-27 HK HK04103801.9A patent/HK1060879A1/xx not_active IP Right Cessation
-
2009
- 2009-03-06 CY CY20091100258T patent/CY1109089T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS62242663A (ja) | 1−デオキシノジリマイシンおよびそれのn−誘導体を製造する方法 | |
Ma et al. | A modified Curtius reaction: an efficient and simple method for direct isolation of free amine | |
CN105377819A (zh) | 制备苯并咪唑衍生物的方法 | |
HRP20120219T1 (hr) | Postupak za pripremu trans-2,3-disupstituiranih naftokinona | |
TW200631988A (en) | Method of preparing polycarbonate resin | |
BRPI0314238B1 (pt) | Processo para a fabricação de um composto, intermediário e uso de um composto | |
HRP20040263B1 (en) | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | |
CN105418502B (zh) | 一种用于合成帕罗西汀的中间体及其制备方法和用途 | |
CN107522584A (zh) | 一种α‑三氟甲基酮化合物及其制备方法 | |
Lee et al. | Chiral acetylenic sulfoxide in alkaloid synthesis. Total synthesis of (R)-(+)-carnegine. | |
WO2016189542A1 (en) | Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin | |
DE602007002486D1 (de) | Verfahren zur herstellung von 1-halogen-2,7-naphthyridinylderivaten | |
CN112409275B (zh) | 一种光催化的3-酰基喹喔啉酮化合物的制备方法 | |
CN104045661A (zh) | 醇促进下芳香胺硼化反应生成芳基硼酸和芳基硼酸酯的方法 | |
ZA200600598B (en) | Method for production of $g(alpha),$g(beta)-unsaturated amide compounds | |
CN106083553A (zh) | Dl‑樟脑醌的合成新工艺 | |
CN111253334A (zh) | 一种温和的c2醚取代2h-苯并噻唑衍生物的光催化合成方法 | |
EP0946537B1 (en) | Process for the stereoselective production of nitro-enamine compounds | |
TW200736218A (en) | Method for producing tertiary amines | |
CN101863815A (zh) | 顺式3-苯基取代脯氨酸衍生物的合成方法 | |
CN101671297B (zh) | 4-(3-碘-2-吡啶基)哌嗪类化合物的合成方法 | |
ATE414053T1 (de) | Verfahren zur herstellung einer kosmetisch aktiven verbindung | |
CN106967079B (zh) | 一种罗丹明6g异羟肟酸的合成方法 | |
CN117466757A (zh) | 一种多取代α-芳基三氟乙醇类衍生物的合成方法 | |
CN105503925A (zh) | 一种双(频哪醇合)二硼烷的活化方法及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20120816 Year of fee payment: 11 |
|
PBON | Lapse due to non-payment of renewal fee |
Effective date: 20130821 |