CO5560556A2 - Procedimiento para la preparacion de acido 6-(4-clorofenil)- 2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-acetico - Google Patents
Procedimiento para la preparacion de acido 6-(4-clorofenil)- 2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-aceticoInfo
- Publication number
- CO5560556A2 CO5560556A2 CO04014456A CO04014456A CO5560556A2 CO 5560556 A2 CO5560556 A2 CO 5560556A2 CO 04014456 A CO04014456 A CO 04014456A CO 04014456 A CO04014456 A CO 04014456A CO 5560556 A2 CO5560556 A2 CO 5560556A2
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- compound
- preparation
- acetic
- pirrolizin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
1.- Un procedimiento para la preparación del compuesto de la Fórmula I, en donde:a) se transforma el compuesto de la Fórmula IVen el compuesto de la Fórmula III como sigue:a1) se hidrogena catalíticamente el compuesto de la Fórmula IV oa2) se transforma el compuesto de la Fórmula IV en el cetal de la Fórmula IVa en donde los restos R, que pueden ser iguales o diferentes,representan alquilo-C1-C4 o juntos alquileno-C2-C3, y se hidrogena catalíticamente el cetal, b) se transforma el compuesto de la Fórmula III con ?-bromo4-cloroacetofenona en un compuesto de la Fórmula II yc) se introduce un resto de ácido acético en el compuesto de la Fórmula II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10141285A DE10141285A1 (de) | 2001-08-23 | 2001-08-23 | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5560556A2 true CO5560556A2 (es) | 2005-09-30 |
Family
ID=7696330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04014456A CO5560556A2 (es) | 2001-08-23 | 2004-02-19 | Procedimiento para la preparacion de acido 6-(4-clorofenil)- 2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-il-acetico |
Country Status (32)
Country | Link |
---|---|
US (1) | US7078535B2 (es) |
EP (1) | EP1419160B1 (es) |
JP (1) | JP4195379B2 (es) |
KR (1) | KR100687472B1 (es) |
CN (1) | CN1266152C (es) |
AR (1) | AR035117A1 (es) |
AT (1) | ATE417047T1 (es) |
AU (1) | AU2002331168C1 (es) |
BR (1) | BR0212009A (es) |
CA (1) | CA2458339C (es) |
CO (1) | CO5560556A2 (es) |
CU (1) | CU23345A3 (es) |
CY (1) | CY1109089T1 (es) |
DE (2) | DE10141285A1 (es) |
DK (1) | DK1419160T3 (es) |
EA (1) | EA006436B1 (es) |
ES (1) | ES2319268T3 (es) |
GE (1) | GEP20063918B (es) |
HK (1) | HK1060879A1 (es) |
HR (1) | HRP20040263B1 (es) |
HU (1) | HU228125B1 (es) |
IL (2) | IL160047A0 (es) |
MX (1) | MXPA04001664A (es) |
NO (1) | NO328299B1 (es) |
NZ (1) | NZ531113A (es) |
PL (1) | PL367796A1 (es) |
PT (1) | PT1419160E (es) |
RS (1) | RS51877B (es) |
TW (1) | TWI274755B (es) |
UA (1) | UA75702C2 (es) |
WO (1) | WO2003018583A1 (es) |
ZA (1) | ZA200402209B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
CZ2007752A3 (cs) * | 2007-10-30 | 2009-05-13 | Zentiva, A. S. | Nový zpusob výroby 2-(6-(4-chlorfenyl)-2,2-dimethyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl)octové kyseliny (licofelonu) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0172371A1 (de) | 1984-07-27 | 1986-02-26 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Dehydroxypantolacton |
DE3915450A1 (de) | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
RS50374B (sr) | 2000-01-28 | 2009-11-10 | Merckle Gmbh., | Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline |
-
2001
- 2001-08-23 DE DE10141285A patent/DE10141285A1/de not_active Withdrawn
-
2002
- 2002-08-13 AR ARP020103045A patent/AR035117A1/es active IP Right Grant
- 2002-08-21 CA CA002458339A patent/CA2458339C/en not_active Expired - Fee Related
- 2002-08-21 PL PL02367796A patent/PL367796A1/xx unknown
- 2002-08-21 NZ NZ531113A patent/NZ531113A/en not_active IP Right Cessation
- 2002-08-21 IL IL16004702A patent/IL160047A0/xx unknown
- 2002-08-21 KR KR1020047002654A patent/KR100687472B1/ko not_active IP Right Cessation
- 2002-08-21 ES ES02767415T patent/ES2319268T3/es not_active Expired - Lifetime
- 2002-08-21 EA EA200400344A patent/EA006436B1/ru not_active IP Right Cessation
- 2002-08-21 AT AT02767415T patent/ATE417047T1/de active
- 2002-08-21 PT PT02767415T patent/PT1419160E/pt unknown
- 2002-08-21 US US10/486,911 patent/US7078535B2/en not_active Expired - Fee Related
- 2002-08-21 JP JP2003523244A patent/JP4195379B2/ja not_active Expired - Fee Related
- 2002-08-21 AU AU2002331168A patent/AU2002331168C1/en not_active Ceased
- 2002-08-21 UA UA2004032036A patent/UA75702C2/uk unknown
- 2002-08-21 DE DE50213105T patent/DE50213105D1/de not_active Expired - Lifetime
- 2002-08-21 HU HU0401440A patent/HU228125B1/hu not_active IP Right Cessation
- 2002-08-21 GE GE5474A patent/GEP20063918B/en unknown
- 2002-08-21 WO PCT/EP2002/009356 patent/WO2003018583A1/de active IP Right Grant
- 2002-08-21 CN CNB028164490A patent/CN1266152C/zh not_active Expired - Fee Related
- 2002-08-21 DK DK02767415T patent/DK1419160T3/da active
- 2002-08-21 MX MXPA04001664A patent/MXPA04001664A/es active IP Right Grant
- 2002-08-21 BR BR0212009-7A patent/BR0212009A/pt not_active Application Discontinuation
- 2002-08-21 EP EP02767415A patent/EP1419160B1/de not_active Expired - Lifetime
- 2002-08-21 RS YU14604A patent/RS51877B/en unknown
- 2002-08-23 TW TW091119151A patent/TWI274755B/zh not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160047A patent/IL160047A/en not_active IP Right Cessation
- 2004-01-29 CU CU20040019A patent/CU23345A3/es not_active IP Right Cessation
- 2004-02-19 CO CO04014456A patent/CO5560556A2/es not_active Application Discontinuation
- 2004-03-17 HR HRP20040263AA patent/HRP20040263B1/xx not_active IP Right Cessation
- 2004-03-19 ZA ZA200402209A patent/ZA200402209B/en unknown
- 2004-03-19 NO NO20041178A patent/NO328299B1/no not_active IP Right Cessation
- 2004-05-27 HK HK04103801.9A patent/HK1060879A1/xx not_active IP Right Cessation
-
2009
- 2009-03-06 CY CY20091100258T patent/CY1109089T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted | ||
FD | Application lapsed |