AR035117A1 - Procedimiento para la preparacion del acido 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-l-acetico y procedimiento para la preparación 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizina y 2-bencil-4,4-dimetil-1-pirrolina de utilidad en el anterior - Google Patents
Procedimiento para la preparacion del acido 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-l-acetico y procedimiento para la preparación 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizina y 2-bencil-4,4-dimetil-1-pirrolina de utilidad en el anteriorInfo
- Publication number
- AR035117A1 AR035117A1 ARP020103045A ARP020103045A AR035117A1 AR 035117 A1 AR035117 A1 AR 035117A1 AR P020103045 A ARP020103045 A AR P020103045A AR P020103045 A ARP020103045 A AR P020103045A AR 035117 A1 AR035117 A1 AR 035117A1
- Authority
- AR
- Argentina
- Prior art keywords
- dimethyl
- formula
- dihydro
- phenyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un procedimiento para la preparación del ácido 6-(-4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1H-pirrolizin-5-il acético de la fórmula (1), que comprende: a) transformar el compuesto de la fórmula (4) en el compuesto de la fórmula (3) como sigue: a1) se hidrogena catalíticamente el compuesto de la fórmula (4) o a2) se transforma el compuesto de la fórmula (4) en el cetal de la fórmula (5) en donde los restos R, que pueden ser iguales o diferentes, representan alquilo C1-4 o juntos alquileno C2-3, y se hidrogena catalíticamente el cetal, b) transformar el compuesto de la fórmula (3) con w-bromo-4-cloroacetofenona en un compuesto de la fórmula (2) y c) introducir un resto de ácido acético en el compuesto de la fórmula (2). El ML 3000 es una sustancia inhibidora muy prometedora de la ciclooxigenasa y de la 5-lipoxigenasa y es apto por lo tanto para el tratamiento de enfermedades del grupo de las formas reumáticas y para el tratamiento preventivo de enfermedades inducidas alérgicamente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10141285A DE10141285A1 (de) | 2001-08-23 | 2001-08-23 | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035117A1 true AR035117A1 (es) | 2004-04-14 |
Family
ID=7696330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103045A AR035117A1 (es) | 2001-08-23 | 2002-08-13 | Procedimiento para la preparacion del acido 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-l-acetico y procedimiento para la preparación 6-(4-clorofenil)-2,2-dimetil-7-fenil-2,3-dihidro-1h-pirrolizina y 2-bencil-4,4-dimetil-1-pirrolina de utilidad en el anterior |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7078535B2 (es) |
| EP (1) | EP1419160B1 (es) |
| JP (1) | JP4195379B2 (es) |
| KR (1) | KR100687472B1 (es) |
| CN (1) | CN1266152C (es) |
| AR (1) | AR035117A1 (es) |
| AT (1) | ATE417047T1 (es) |
| AU (1) | AU2002331168C1 (es) |
| BR (1) | BR0212009A (es) |
| CA (1) | CA2458339C (es) |
| CO (1) | CO5560556A2 (es) |
| CU (1) | CU23345A3 (es) |
| CY (1) | CY1109089T1 (es) |
| DE (2) | DE10141285A1 (es) |
| DK (1) | DK1419160T3 (es) |
| EA (1) | EA006436B1 (es) |
| ES (1) | ES2319268T3 (es) |
| GE (1) | GEP20063918B (es) |
| HK (1) | HK1060879A1 (es) |
| HR (1) | HRP20040263B1 (es) |
| HU (1) | HU228125B1 (es) |
| IL (2) | IL160047A0 (es) |
| MX (1) | MXPA04001664A (es) |
| NO (1) | NO328299B1 (es) |
| NZ (1) | NZ531113A (es) |
| PL (1) | PL367796A1 (es) |
| PT (1) | PT1419160E (es) |
| RS (1) | RS51877B (es) |
| TW (1) | TWI274755B (es) |
| UA (1) | UA75702C2 (es) |
| WO (1) | WO2003018583A1 (es) |
| ZA (1) | ZA200402209B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
| CZ2007752A3 (cs) * | 2007-10-30 | 2009-05-13 | Zentiva, A. S. | Nový zpusob výroby 2-(6-(4-chlorfenyl)-2,2-dimethyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl)octové kyseliny (licofelonu) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK304185A (da) | 1984-07-27 | 1986-01-28 | Hoffmann La Roche | Fremgangsmaade til fremstilling af furanon |
| DE3915450A1 (de) | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
| DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
| ATE262529T1 (de) | 2000-01-28 | 2004-04-15 | Merckle Gmbh | Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dih dro-1h-pyrrolizin-5- yl-essigsäure |
-
2001
- 2001-08-23 DE DE10141285A patent/DE10141285A1/de not_active Withdrawn
-
2002
- 2002-08-13 AR ARP020103045A patent/AR035117A1/es active IP Right Grant
- 2002-08-21 CN CNB028164490A patent/CN1266152C/zh not_active Expired - Fee Related
- 2002-08-21 US US10/486,911 patent/US7078535B2/en not_active Expired - Fee Related
- 2002-08-21 PL PL02367796A patent/PL367796A1/xx unknown
- 2002-08-21 AT AT02767415T patent/ATE417047T1/de active
- 2002-08-21 EA EA200400344A patent/EA006436B1/ru not_active IP Right Cessation
- 2002-08-21 IL IL16004702A patent/IL160047A0/xx unknown
- 2002-08-21 UA UA2004032036A patent/UA75702C2/uk unknown
- 2002-08-21 KR KR1020047002654A patent/KR100687472B1/ko not_active IP Right Cessation
- 2002-08-21 CA CA002458339A patent/CA2458339C/en not_active Expired - Fee Related
- 2002-08-21 RS YU14604A patent/RS51877B/en unknown
- 2002-08-21 ES ES02767415T patent/ES2319268T3/es not_active Expired - Lifetime
- 2002-08-21 NZ NZ531113A patent/NZ531113A/en not_active IP Right Cessation
- 2002-08-21 EP EP02767415A patent/EP1419160B1/de not_active Expired - Lifetime
- 2002-08-21 JP JP2003523244A patent/JP4195379B2/ja not_active Expired - Fee Related
- 2002-08-21 WO PCT/EP2002/009356 patent/WO2003018583A1/de active IP Right Grant
- 2002-08-21 DK DK02767415T patent/DK1419160T3/da active
- 2002-08-21 PT PT02767415T patent/PT1419160E/pt unknown
- 2002-08-21 HU HU0401440A patent/HU228125B1/hu not_active IP Right Cessation
- 2002-08-21 DE DE50213105T patent/DE50213105D1/de not_active Expired - Lifetime
- 2002-08-21 AU AU2002331168A patent/AU2002331168C1/en not_active Ceased
- 2002-08-21 GE GE5474A patent/GEP20063918B/en unknown
- 2002-08-21 BR BR0212009-7A patent/BR0212009A/pt not_active Application Discontinuation
- 2002-08-21 MX MXPA04001664A patent/MXPA04001664A/es active IP Right Grant
- 2002-08-23 TW TW091119151A patent/TWI274755B/zh not_active IP Right Cessation
-
2004
- 2004-01-26 IL IL160047A patent/IL160047A/en not_active IP Right Cessation
- 2004-01-29 CU CU20040019A patent/CU23345A3/es not_active IP Right Cessation
- 2004-02-19 CO CO04014456A patent/CO5560556A2/es not_active Application Discontinuation
- 2004-03-17 HR HRP20040263AA patent/HRP20040263B1/xx not_active IP Right Cessation
- 2004-03-19 ZA ZA200402209A patent/ZA200402209B/en unknown
- 2004-03-19 NO NO20041178A patent/NO328299B1/no not_active IP Right Cessation
- 2004-05-27 HK HK04103801.9A patent/HK1060879A1/xx not_active IP Right Cessation
-
2009
- 2009-03-06 CY CY20091100258T patent/CY1109089T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |