HRP20031068B1 - Klormetilacija tiofena - Google Patents

Klormetilacija tiofena

Info

Publication number
HRP20031068B1
HRP20031068B1 HR20031068A HRP20031068A HRP20031068B1 HR P20031068 B1 HRP20031068 B1 HR P20031068B1 HR 20031068 A HR20031068 A HR 20031068A HR P20031068 A HRP20031068 A HR P20031068A HR P20031068 B1 HRP20031068 B1 HR P20031068B1
Authority
HR
Croatia
Prior art keywords
chloromethylation
thiophene
ketone
compound
formula
Prior art date
Application number
HR20031068A
Other languages
English (en)
Inventor
Aradi M�ty�s
Bakos Ferenc
Dombr�dy Zsolt
Gaj�ry Antal
Gy�ngy�si Istv�n
Kov�cs Ferenc
Major Andrea
M�t�n� T�r�k Erika
P�rk�nyi Zsolt
Schultz L�szl�
Supic Attila
Szab� S�ndor
Szalay Erzs�bet
Ugrics J�zsef
Zsiga J�zsef
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20031068A2 publication Critical patent/HRP20031068A2/xx
Publication of HRP20031068B1 publication Critical patent/HRP20031068B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Charge By Means Of Generators (AREA)

Abstract

Postupak proizvodnje spoja formule (I) (I) Slika 1klormetilacijom tiofena, naznačen time, da se klormetilacija izvodi u prisutnosti jednog ili više spojeva koji sadržavaju ketone. Patent sadrži još 13 patentnih zahtjeva.
HR20031068A 2001-05-22 2003-12-19 Klormetilacija tiofena HRP20031068B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0102118A HU0102118D0 (en) 2001-05-22 2001-05-22 Process for chloromethylation
PCT/HU2002/000042 WO2002094806A1 (en) 2001-05-22 2002-05-16 Chloromethylation of thiophene

Publications (2)

Publication Number Publication Date
HRP20031068A2 HRP20031068A2 (en) 2004-04-30
HRP20031068B1 true HRP20031068B1 (hr) 2011-12-31

Family

ID=89979350

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20031068A HRP20031068B1 (hr) 2001-05-22 2003-12-19 Klormetilacija tiofena

Country Status (20)

Country Link
US (1) US7462725B2 (hr)
EP (1) EP1392672B1 (hr)
JP (1) JP4467890B2 (hr)
KR (1) KR100859386B1 (hr)
CN (1) CN1260224C (hr)
AT (1) ATE294790T1 (hr)
BR (1) BRPI0209874B1 (hr)
CA (1) CA2447440C (hr)
CZ (1) CZ301166B6 (hr)
DE (1) DE60204014T2 (hr)
DK (1) DK1392672T3 (hr)
ES (1) ES2240738T3 (hr)
HR (1) HRP20031068B1 (hr)
HU (1) HU0102118D0 (hr)
MX (1) MXPA03010594A (hr)
PL (1) PL210713B1 (hr)
PT (1) PT1392672E (hr)
SI (1) SI1392672T1 (hr)
SK (1) SK285681B6 (hr)
WO (1) WO2002094806A1 (hr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104513225A (zh) * 2013-10-08 2015-04-15 华东师范大学 2-噻吩乙腈的制备方法
CN103880741A (zh) * 2014-02-28 2014-06-25 安徽国星生物化学有限公司 一种2-氯甲基-3，5-二甲基-4-烷氧基吡啶-n-氧化物的制备方法
CN103992302A (zh) * 2014-06-16 2014-08-20 商丘凯瑞达化工有限公司 2-噻吩乙酸合成工艺
CN104327040A (zh) * 2014-10-11 2015-02-04 华东师范大学 一种2-噻吩乙酸的合成方法
US10450512B2 (en) * 2016-02-10 2019-10-22 Primus Green Energy Inc. Single-loop octane enrichment
CN113896709B (zh) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 一种苯并噻吩-3-乙酸的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527680A (en) * 1945-06-21 1950-10-31 Monsanto Chemicals Alpha thenyl chloride from hydrogen chloride-formaldehyde solution and thiophene
US4501903A (en) * 1983-07-05 1985-02-26 Stauffer Chemical Company Chloromethylation process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB639438A (en) * 1948-02-25 1950-06-28 Ici Ltd Preparation of organic nitriles
FR2608607B1 (fr) * 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
PL158225B1 (en) * 1989-06-09 1992-08-31 Method for manufacturing 2-chlormethylthiopen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527680A (en) * 1945-06-21 1950-10-31 Monsanto Chemicals Alpha thenyl chloride from hydrogen chloride-formaldehyde solution and thiophene
US4501903A (en) * 1983-07-05 1985-02-26 Stauffer Chemical Company Chloromethylation process

Also Published As

Publication number Publication date
EP1392672A1 (en) 2004-03-03
CZ301166B6 (cs) 2009-11-25
ATE294790T1 (de) 2005-05-15
CN1260224C (zh) 2006-06-21
KR100859386B1 (ko) 2008-09-22
CZ20032973A3 (en) 2004-03-17
US20060161008A1 (en) 2006-07-20
MXPA03010594A (es) 2004-04-02
PL210713B1 (pl) 2012-02-29
SK13542003A3 (sk) 2004-07-07
JP2004532247A (ja) 2004-10-21
PL363923A1 (en) 2004-11-29
SK285681B6 (sk) 2007-06-07
DK1392672T3 (da) 2005-08-29
BRPI0209874B1 (pt) 2016-03-22
CA2447440A1 (en) 2002-11-28
HRP20031068A2 (en) 2004-04-30
ES2240738T3 (es) 2005-10-16
EP1392672B1 (en) 2005-05-04
SI1392672T1 (en) 2005-10-31
HU0102118D0 (en) 2001-07-30
KR20040018373A (ko) 2004-03-03
US7462725B2 (en) 2008-12-09
JP4467890B2 (ja) 2010-05-26
CA2447440C (en) 2010-10-19
CN1511148A (zh) 2004-07-07
DE60204014T2 (de) 2006-02-02
PT1392672E (pt) 2005-08-31
BR0209874A (pt) 2004-06-08
WO2002094806A1 (en) 2002-11-28
DE60204014D1 (de) 2005-06-09

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20190401

Year of fee payment: 18

ODRP Renewal fee for the maintenance of a patent

Payment date: 20200331

Year of fee payment: 19

PBON Lapse due to non-payment of renewal fee

Effective date: 20210516