MXPA03010594A - Clorometilacion de tiofeno. - Google Patents

Clorometilacion de tiofeno.

Info

Publication number
MXPA03010594A
MXPA03010594A MXPA03010594A MXPA03010594A MXPA03010594A MX PA03010594 A MXPA03010594 A MX PA03010594A MX PA03010594 A MXPA03010594 A MX PA03010594A MX PA03010594 A MXPA03010594 A MX PA03010594A MX PA03010594 A MXPA03010594 A MX PA03010594A
Authority
MX
Mexico
Prior art keywords
thiophene
formula
chloromethylation
compounds
transforme
Prior art date
Application number
MXPA03010594A
Other languages
English (en)
Inventor
Aradi Matyas
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of MXPA03010594A publication Critical patent/MXPA03010594A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Charge By Means Of Generators (AREA)

Abstract

El proceso de acuerdo a la invencion se refiere a la preparacion de 2-clorometil-tiofeno de la formula (I). Durante este proceso, el tiofeno es clorometilado en presencia de uno o mas compuestos que contienen grupo ceto y opcionalmente este es transformado en el compuesto de la formula (II). Los compuestos de la formula (I) y (II) son productos intermedios de diversos ingredientes farmaceuticamente activos.
MXPA03010594A 2001-05-22 2002-05-16 Clorometilacion de tiofeno. MXPA03010594A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0102118A HU0102118D0 (en) 2001-05-22 2001-05-22 Process for chloromethylation
PCT/HU2002/000042 WO2002094806A1 (en) 2001-05-22 2002-05-16 Chloromethylation of thiophene

Publications (1)

Publication Number Publication Date
MXPA03010594A true MXPA03010594A (es) 2004-04-02

Family

ID=89979350

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010594A MXPA03010594A (es) 2001-05-22 2002-05-16 Clorometilacion de tiofeno.

Country Status (20)

Country Link
US (1) US7462725B2 (es)
EP (1) EP1392672B1 (es)
JP (1) JP4467890B2 (es)
KR (1) KR100859386B1 (es)
CN (1) CN1260224C (es)
AT (1) ATE294790T1 (es)
BR (1) BRPI0209874B1 (es)
CA (1) CA2447440C (es)
CZ (1) CZ301166B6 (es)
DE (1) DE60204014T2 (es)
DK (1) DK1392672T3 (es)
ES (1) ES2240738T3 (es)
HR (1) HRP20031068B1 (es)
HU (1) HU0102118D0 (es)
MX (1) MXPA03010594A (es)
PL (1) PL210713B1 (es)
PT (1) PT1392672E (es)
SI (1) SI1392672T1 (es)
SK (1) SK285681B6 (es)
WO (1) WO2002094806A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104513225A (zh) * 2013-10-08 2015-04-15 华东师范大学 2-噻吩乙腈的制备方法
CN103880741A (zh) * 2014-02-28 2014-06-25 安徽国星生物化学有限公司 一种2-氯甲基-3，5-二甲基-4-烷氧基吡啶-n-氧化物的制备方法
CN103992302A (zh) * 2014-06-16 2014-08-20 商丘凯瑞达化工有限公司 2-噻吩乙酸合成工艺
CN104327040A (zh) * 2014-10-11 2015-02-04 华东师范大学 一种2-噻吩乙酸的合成方法
US10450512B2 (en) * 2016-02-10 2019-10-22 Primus Green Energy Inc. Single-loop octane enrichment
CN113896709B (zh) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 一种苯并噻吩-3-乙酸的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527680A (en) 1945-06-21 1950-10-31 Monsanto Chemicals Alpha thenyl chloride from hydrogen chloride-formaldehyde solution and thiophene
GB639438A (en) * 1948-02-25 1950-06-28 Ici Ltd Preparation of organic nitriles
US4501903A (en) 1983-07-05 1985-02-26 Stauffer Chemical Company Chloromethylation process
FR2608607B1 (fr) * 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
PL158225B1 (en) * 1989-06-09 1992-08-31 Method for manufacturing 2-chlormethylthiopen

Also Published As

Publication number Publication date
BR0209874A (pt) 2004-06-08
HRP20031068A2 (en) 2004-04-30
SI1392672T1 (en) 2005-10-31
HU0102118D0 (en) 2001-07-30
CN1260224C (zh) 2006-06-21
PT1392672E (pt) 2005-08-31
CN1511148A (zh) 2004-07-07
HRP20031068B1 (en) 2011-12-31
KR20040018373A (ko) 2004-03-03
WO2002094806A1 (en) 2002-11-28
JP2004532247A (ja) 2004-10-21
ES2240738T3 (es) 2005-10-16
EP1392672B1 (en) 2005-05-04
SK13542003A3 (sk) 2004-07-07
CZ20032973A3 (en) 2004-03-17
SK285681B6 (sk) 2007-06-07
DE60204014T2 (de) 2006-02-02
CA2447440A1 (en) 2002-11-28
PL363923A1 (en) 2004-11-29
CA2447440C (en) 2010-10-19
DE60204014D1 (de) 2005-06-09
DK1392672T3 (da) 2005-08-29
ATE294790T1 (de) 2005-05-15
CZ301166B6 (cs) 2009-11-25
BRPI0209874B1 (pt) 2016-03-22
US7462725B2 (en) 2008-12-09
EP1392672A1 (en) 2004-03-03
PL210713B1 (pl) 2012-02-29
KR100859386B1 (ko) 2008-09-22
JP4467890B2 (ja) 2010-05-26
US20060161008A1 (en) 2006-07-20

Similar Documents

Publication Publication Date Title
BG66103B1 (bg) Кондензирани пиролокарбазоли
CA2416867A1 (en) Cyclopentanoindoles, compositions containing such compounds and methods of treatment
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
MXPA02012033A (es) Derivados de 2-aminocarbonil-9h-purina.
NZ514711A (en) Compounds useful as anti-inflammatory agents
AU9092501A (en) Compositions and methods for inhibition of hiv-1 infection
IL157816A0 (en) Steroids as agonists for fxr
EP1252325A4 (en) COMPOSITIONS AND METHODS FOR INHIBITING HIV-1 INFECTION
MXPA02007942A (es) Derivados de pirrolopirimidinona, procesos de preparacion y uso.
GB9929552D0 (en) Compounds
DE60025848D1 (en) Pyrimidin-derivate als selective inhibitoren von cox-2
GB0114185D0 (en) Compounds
ATE451123T1 (de) Vaginal verabreichbare zusammensetzung zur behandlung von uteriner dysrhythmie
DE60207877D1 (de) Mischung enthaltend procyanidine zur verminderung des appetits bei säugetieren
IL156967A0 (en) Camptothecin derivatives
AU2001290480A1 (en) Cyclized benzamide neurokinin antagonists for use in therapy
MXPA03010594A (es) Clorometilacion de tiofeno.
AU2002218337A1 (en) Method for inducing cognition enhancement by use of trimethyl-bicyclo(2.2.1)heptane derivatives
DE50205466D1 (de) Substituierte 2,5-diamidoindole als ece-inhibitoren zur behandlung von kardiovaskulären erkrankungen
IL156768A0 (en) Process for preparing (+/-) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
GB9806409D0 (en) Processes for preparing intermediates
MXPA04004980A (es) Antagonistas del receptor ccr-3.
CA2309485A1 (en) New 4-arylpiperidine derivatives for the treatment of pruritus
WO2001083423A3 (en) 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof
GB9923951D0 (en) Treatment of gas mixture

Legal Events

Date Code Title Description
HC Change of company name or juridical status
FG Grant or registration