HRP20030778B1 - Lipid lowering biphenylcarboxamides - Google Patents
Lipid lowering biphenylcarboxamidesInfo
- Publication number
- HRP20030778B1 HRP20030778B1 HR20030778A HRP20030778A HRP20030778B1 HR P20030778 B1 HRP20030778 B1 HR P20030778B1 HR 20030778 A HR20030778 A HR 20030778A HR P20030778 A HRP20030778 A HR P20030778A HR P20030778 B1 HRP20030778 B1 HR P20030778B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- 4alkyl
- phenyl
- formula
- hydrogen
- Prior art date
Links
- GTKIGDZXPDCIKR-UHFFFAOYSA-N 2-phenylbenzamide Chemical class NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GTKIGDZXPDCIKR-UHFFFAOYSA-N 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 101100422770 Caenorhabditis elegans sup-1 gene Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 hydroxy, mercapto Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201270 | 2001-04-06 | ||
| PCT/EP2002/003491 WO2002081460A1 (fr) | 2001-04-06 | 2002-03-27 | Biphenylcarboxamides hypolipidemiants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030778A2 HRP20030778A2 (en) | 2005-06-30 |
| HRP20030778B1 true HRP20030778B1 (en) | 2007-04-30 |
Family
ID=8180113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030778A HRP20030778B1 (en) | 2001-04-06 | 2003-09-26 | Lipid lowering biphenylcarboxamides |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7642378B2 (fr) |
| EP (1) | EP1379515B1 (fr) |
| JP (1) | JP2004525176A (fr) |
| KR (1) | KR20030094293A (fr) |
| CN (1) | CN1312140C (fr) |
| AR (1) | AR035814A1 (fr) |
| AT (1) | ATE349436T1 (fr) |
| AU (1) | AU2002253171B2 (fr) |
| BG (1) | BG108219A (fr) |
| BR (1) | BR0208688A (fr) |
| CA (1) | CA2441398C (fr) |
| CZ (1) | CZ20032640A3 (fr) |
| DE (1) | DE60217089T2 (fr) |
| DK (1) | DK1379515T3 (fr) |
| EA (1) | EA006385B1 (fr) |
| EE (1) | EE200300488A (fr) |
| ES (1) | ES2278914T3 (fr) |
| HR (1) | HRP20030778B1 (fr) |
| HU (1) | HUP0303736A2 (fr) |
| IL (2) | IL158252A0 (fr) |
| IS (1) | IS6951A (fr) |
| JO (1) | JO2390B1 (fr) |
| MX (1) | MXPA03009089A (fr) |
| MY (1) | MY136267A (fr) |
| NO (1) | NO20034474L (fr) |
| NZ (1) | NZ528445A (fr) |
| PA (1) | PA8542601A1 (fr) |
| PL (1) | PL213504B1 (fr) |
| PT (1) | PT1379515E (fr) |
| SI (1) | SI1379515T1 (fr) |
| SK (1) | SK12152003A3 (fr) |
| UA (1) | UA76739C2 (fr) |
| WO (1) | WO2002081460A1 (fr) |
| ZA (1) | ZA200307714B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| AU2003211617C1 (en) | 2002-02-28 | 2008-03-06 | Japan Tobacco Inc. | Ester compound and medicinal use thereof |
| UA79300C2 (en) | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| GB0230024D0 (en) * | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
| JP4832897B2 (ja) | 2003-08-29 | 2011-12-07 | 日本たばこ産業株式会社 | エステル誘導体及びその医薬用途 |
| AR045496A1 (es) | 2003-08-29 | 2005-11-02 | Schering Corp | Analolgos de benzimidazolpiperidinas 2- substiyuidas como antagonistas de los receptores de la hormona que concentra melanina selectivos para el tratamiento de la obesidad y trastornos relacionados |
| UA83510C2 (en) * | 2003-12-09 | 2008-07-25 | Янссен Фармацевтика Н.В. | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b |
| US8101774B2 (en) | 2004-10-18 | 2012-01-24 | Japan Tobacco Inc. | Ester derivatives and medicinal use thereof |
| US8183239B2 (en) | 2005-10-31 | 2012-05-22 | Janssen Pharmaceutica Nv | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor |
| CA2640091A1 (fr) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Derives de vinyl-phenyl utilises dans le traitement et la prevention de troubles inflammatoires et immuns |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| AU2008258560C1 (en) | 2007-06-08 | 2014-04-10 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| EP2152271B1 (fr) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Dérivés de piperidine/piperazine |
| EP2152270B1 (fr) | 2007-06-08 | 2015-03-04 | Janssen Pharmaceutica, N.V. | Dérivés de piperidine/piperazine |
| ES2617619T3 (es) | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
| DK2435406T3 (da) | 2009-05-29 | 2013-05-13 | Janssen Pharmaceutica Nv | Opløsning af (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETAT |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| US4647576A (en) | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
| US4602023A (en) * | 1985-06-03 | 1986-07-22 | Warner-Lambert Company | Diphenic acid monoamides |
| US5041432A (en) | 1987-01-30 | 1991-08-20 | E. I. Du Pont De Nemours And Company | Steroid derivatives useful as hypocholesterolemics |
| US5064856A (en) | 1989-07-31 | 1991-11-12 | Merck & Co., Inc. | Novel hmg-coa synthase inhibitors |
| US5120729A (en) | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
| US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| WO1993011782A1 (fr) | 1991-12-19 | 1993-06-24 | Southwest Foundation For Biomedical Research | Polypeptide inhibant la proteine de transfert aux esters de cholesteryl, anticorps contre le polypeptide synthetique et traitements prophylactiques et therapeutiques anti-atherosclerose |
| CA2091102C (fr) | 1992-03-06 | 2009-05-26 | John R. Ii Wetterau | Proteine de transfert de triglycerides microsomaux |
| SG48855A1 (en) | 1992-04-20 | 1998-05-18 | Takeda Chemical Industries Ltd | 4,1-benzoxazepin derivatives and their use |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| AU678503B2 (en) | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| JPH10510512A (ja) | 1994-10-04 | 1998-10-13 | 藤沢薬品工業株式会社 | 尿素誘導体とａｃａｔ阻害剤としての用途 |
| US5510379A (en) | 1994-12-19 | 1996-04-23 | Warner-Lambert Company | Sulfonate ACAT inhibitors |
| GB9504066D0 (en) | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Phosphate derivatives of ureas and thioureas |
| WO1996040640A1 (fr) | 1995-06-07 | 1996-12-19 | Pfizer Inc. | DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B) |
| SK283408B6 (sk) * | 1995-06-07 | 2003-07-01 | Pfizer Inc. | Amidy a farmaceutické prostriedky na ich báze |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| AU5513298A (en) | 1996-12-20 | 1998-07-17 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of microsomal triglyceride transfer protein and method |
| FR2763334A1 (fr) | 1997-05-13 | 1998-11-20 | Lipha | Derives anthraniliques |
| GB9826412D0 (en) * | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
| DE19933926A1 (de) | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Pharma | Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| GB0013378D0 (en) | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Use of therapeutic benzamide derivatives |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
-
2002
- 2002-03-17 JO JO200224A patent/JO2390B1/en active
- 2002-03-27 DE DE60217089T patent/DE60217089T2/de not_active Expired - Lifetime
- 2002-03-27 KR KR10-2003-7012392A patent/KR20030094293A/ko not_active Application Discontinuation
- 2002-03-27 CN CNB028078667A patent/CN1312140C/zh not_active Expired - Fee Related
- 2002-03-27 CA CA2441398A patent/CA2441398C/fr not_active Expired - Fee Related
- 2002-03-27 PL PL363805A patent/PL213504B1/pl unknown
- 2002-03-27 UA UA2003098593A patent/UA76739C2/uk unknown
- 2002-03-27 HU HU0303736A patent/HUP0303736A2/hu unknown
- 2002-03-27 EP EP02722278A patent/EP1379515B1/fr not_active Expired - Lifetime
- 2002-03-27 SK SK1215-2003A patent/SK12152003A3/sk not_active Application Discontinuation
- 2002-03-27 EE EEP200300488A patent/EE200300488A/xx unknown
- 2002-03-27 EA EA200301095A patent/EA006385B1/ru not_active IP Right Cessation
- 2002-03-27 WO PCT/EP2002/003491 patent/WO2002081460A1/fr active IP Right Grant
- 2002-03-27 AT AT02722278T patent/ATE349436T1/de not_active IP Right Cessation
- 2002-03-27 AU AU2002253171A patent/AU2002253171B2/en not_active Ceased
- 2002-03-27 JP JP2002579448A patent/JP2004525176A/ja active Pending
- 2002-03-27 PT PT02722278T patent/PT1379515E/pt unknown
- 2002-03-27 MX MXPA03009089A patent/MXPA03009089A/es active IP Right Grant
- 2002-03-27 DK DK02722278T patent/DK1379515T3/da active
- 2002-03-27 BR BR0208688-3A patent/BR0208688A/pt not_active IP Right Cessation
- 2002-03-27 CZ CZ20032640A patent/CZ20032640A3/cs unknown
- 2002-03-27 ES ES02722278T patent/ES2278914T3/es not_active Expired - Lifetime
- 2002-03-27 NZ NZ528445A patent/NZ528445A/en unknown
- 2002-03-27 IL IL15825202A patent/IL158252A0/xx active IP Right Grant
- 2002-03-27 US US10/474,281 patent/US7642378B2/en not_active Expired - Fee Related
- 2002-03-27 SI SI200230501T patent/SI1379515T1/sl unknown
- 2002-04-02 PA PA20028542601A patent/PA8542601A1/es unknown
- 2002-04-04 MY MYPI20021225A patent/MY136267A/en unknown
- 2002-04-05 AR ARP020101267A patent/AR035814A1/es not_active Application Discontinuation
-
2003
- 2003-09-12 IS IS6951A patent/IS6951A/is unknown
- 2003-09-26 HR HR20030778A patent/HRP20030778B1/xx not_active IP Right Cessation
- 2003-10-01 BG BG108219A patent/BG108219A/bg unknown
- 2003-10-02 IL IL158252A patent/IL158252A/en not_active IP Right Cessation
- 2003-10-02 ZA ZA200307714A patent/ZA200307714B/en unknown
- 2003-10-06 NO NO20034474A patent/NO20034474L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20030778B1 (en) | Lipid lowering biphenylcarboxamides | |
| PL377501A1 (pl) | Adamantyloacetamidy jako inhibitory dehydrogenazy 11-beta hydroksysteroidowej | |
| YU79200A (sh) | Terapeutski biaril derivati | |
| TW200732284A (en) | Amine compound and pharmaceutical use thereof | |
| MY116761A (en) | Novel spiroazabicyclic heterocyclic compounds. | |
| TW200612920A (en) | Novel imidazolidine derivatives | |
| TW200607808A (en) | Pyrido-pyrimidine derivatives, preparation thereof and application thereof | |
| CA2475432A1 (fr) | Derives de 2,4,6-triamino-1,3,5-triazine | |
| HUP0100601A2 (hu) | N-tartalmú biciklusos vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CA2545427A1 (fr) | Inhibiteurs selectifs de kinases | |
| MX2009011212A (es) | Derivados de triazolopiridina carboxamida y triazolopirimidina carboxamida, su preparacion y su aplicacion terapeutica. | |
| PT1202957E (pt) | Aminobenzofenonas como inibidoras de il-1beta e tnf-alpha | |
| AP1705A (en) | Heterocyclic compounds for use in the treatment of disorders of the urinary tract | |
| MX2009012377A (es) | Compuestos de arilamida pirimidona. | |
| ES482700A1 (es) | Procedimiento para la obtencion de alfa-azolil-beta-hidroxi-cetonas. | |
| AP9901578A0 (en) | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents. | |
| DE3866175D1 (de) | Therapeutisches mittel. | |
| EA200700891A1 (ru) | Производные пиридина, их получение и их применение в терапии | |
| TW200420292A (en) | Benzofuran derivative | |
| ATE172454T1 (de) | Pyridazinon derivate mit pharmazeutischer wirkung | |
| BG104471A (en) | Benzylidene pyrazolones, their preparation and use as herbicides | |
| NZ337749A (en) | Benzimidazole derivative and their use in allergy-related disease | |
| CY1113458T1 (el) | Σπειρο (πιπεριδιν-4, 2'-πυρρολιδιν)-1-(3,5 τριφθορομεθυλ φαινυλ) μεθυλκαρβοξαμιδια ως ανταγωνιστες του υποδοχεα ταχυκινινης νκ1 | |
| PT934278E (pt) | Bis(acridinocarboxamida) e bis(fenazinocarboxamida) como agentes antitumorais | |
| PT1068200E (pt) | Antifungicos 1,3-dioxolano 2,4,4-tir-substituidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20070403 Year of fee payment: 2 |
|
| B1PR | Patent granted | ||
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20080328 |