HRP20030030A2 - 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3- beta - Google Patents

Info

Publication number

HRP20030030A2

HRP20030030A2 HR20030030A HRP20030030A HRP20030030A2 HR P20030030 A2 HRP20030030 A2 HR P20030030A2 HR 20030030 A HR20030030 A HR 20030030A HR P20030030 A HRP20030030 A HR P20030030A HR P20030030 A2 HRP20030030 A2 HR P20030030A2

Authority

HR

Croatia

Prior art keywords

heteroalkyl

compound according

hydrogen

compound

alkyl

Prior art date

2000-07-27

Links

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• Global Dossier
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• 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 title claims description 47
• 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 title claims description 47
• 239000003112 inhibitor Substances 0.000 title claims description 19
• LKDTVSJUXXGXKE-UHFFFAOYSA-N 3-(1h-indol-2-yl)-4-phenylpyrrole-2,5-dione Chemical class C=1C2=CC=CC=C2NC=1C=1C(=O)NC(=O)C=1C1=CC=CC=C1 LKDTVSJUXXGXKE-UHFFFAOYSA-N 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims description 247
• -1 cyano, nitro, amino Chemical group 0.000 claims description 213
• 229910052739 hydrogen Inorganic materials 0.000 claims description 83
• 239000001257 hydrogen Substances 0.000 claims description 79
• 238000000034 method Methods 0.000 claims description 72
• 125000004404 heteroalkyl group Chemical group 0.000 claims description 69
• 239000000203 mixture Substances 0.000 claims description 64
• 125000000217 alkyl group Chemical group 0.000 claims description 63
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 57
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 53
• 125000000623 heterocyclic group Chemical group 0.000 claims description 50
• 150000002431 hydrogen Chemical class 0.000 claims description 38
• 201000010099 disease Diseases 0.000 claims description 35
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 35
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 33
• 208000006673 asthma Diseases 0.000 claims description 30
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
• 238000006243 chemical reaction Methods 0.000 claims description 24
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
• 229910052736 halogen Inorganic materials 0.000 claims description 20
• 150000002367 halogens Chemical class 0.000 claims description 20
• 102000004127 Cytokines Human genes 0.000 claims description 19
• 108090000695 Cytokines Proteins 0.000 claims description 19
• 229940079593 drug Drugs 0.000 claims description 18
• 125000004475 heteroaralkyl group Chemical group 0.000 claims description 17
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
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• 125000003545 alkoxy group Chemical group 0.000 claims description 15
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• 125000001153 fluoro group Chemical group F* 0.000 claims description 13
• 125000004442 acylamino group Chemical group 0.000 claims description 12
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
• 238000004519 manufacturing process Methods 0.000 claims description 12
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 11
• 241000124008 Mammalia Species 0.000 claims description 11
• 125000001188 haloalkyl group Chemical group 0.000 claims description 11
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