HRP20020988B1 - Compounds for treating impaired fundic relaxation - Google Patents
Compounds for treating impaired fundic relaxationInfo
- Publication number
- HRP20020988B1 HRP20020988B1 HR20020988A HRP20020988A HRP20020988B1 HR P20020988 B1 HRP20020988 B1 HR P20020988B1 HR 20020988 A HR20020988 A HR 20020988A HR P20020988 A HRP20020988 A HR P20020988A HR P20020988 B1 HRP20020988 B1 HR P20020988B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- alkyloxy
- hydroxy
- alkyloxycarbonyloxy
- aminocarbonyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000001771 impaired effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 9
- -1 trihaomethyl Chemical group 0.000 abstract 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 6
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00202180 | 2000-06-22 | ||
PCT/EP2001/006749 WO2001098306A1 (en) | 2000-06-22 | 2001-06-13 | Compounds for treating impaired fundic relaxation |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20020988A2 HRP20020988A2 (en) | 2005-02-28 |
HRP20020988B1 true HRP20020988B1 (en) | 2011-06-30 |
Family
ID=8171674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20020988A HRP20020988B1 (en) | 2000-06-22 | 2002-12-12 | Compounds for treating impaired fundic relaxation |
Country Status (34)
Country | Link |
---|---|
US (2) | US7081453B2 (ru) |
EP (1) | EP1296987B1 (ru) |
JP (1) | JP4911860B2 (ru) |
KR (1) | KR100821107B1 (ru) |
CN (2) | CN100516066C (ru) |
AR (1) | AR032158A1 (ru) |
AT (1) | ATE312104T1 (ru) |
AU (1) | AU783292B2 (ru) |
BG (1) | BG65895B1 (ru) |
BR (1) | BR0111859B1 (ru) |
CA (1) | CA2410233C (ru) |
CZ (1) | CZ305005B6 (ru) |
DE (1) | DE60115647T2 (ru) |
EA (1) | EA005760B1 (ru) |
EE (1) | EE04878B1 (ru) |
EG (1) | EG24462A (ru) |
ES (1) | ES2254467T3 (ru) |
HK (1) | HK1057896A1 (ru) |
HR (1) | HRP20020988B1 (ru) |
HU (1) | HU227398B1 (ru) |
IL (2) | IL153559A0 (ru) |
IS (1) | IS2618B (ru) |
JO (1) | JO2352B1 (ru) |
MX (1) | MXPA02012844A (ru) |
MY (1) | MY155267A (ru) |
NO (1) | NO328547B1 (ru) |
NZ (1) | NZ522519A (ru) |
PA (1) | PA8519601A1 (ru) |
PL (1) | PL201656B1 (ru) |
SA (1) | SA01220442B1 (ru) |
SK (1) | SK287730B6 (ru) |
UA (1) | UA74576C2 (ru) |
WO (1) | WO2001098306A1 (ru) |
ZA (1) | ZA200210303B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1187829T3 (da) | 1999-06-02 | 2004-04-13 | Janssen Pharmaceutica Nv | Aminoalkylsubstituerede (benzodioxan, benzofuran eller benzopyran) derivater |
PL198532B1 (pl) | 1999-06-02 | 2008-06-30 | Janssen Pharmaceutica Nv | Pochodna benzopiranu podstawiona pirolidynylem, piperydynylem lub homopiperydynylem i sposób jej otrzymywania oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
HUP0501182A3 (en) | 2003-04-24 | 2011-08-29 | Incyte Corp | Aza spiro alkane derivatives as inhibitors of metallproteases and pharmaceutical compositions containing them |
JP4896476B2 (ja) * | 2005-09-16 | 2012-03-14 | 広栄化学工業株式会社 | メチルオキシメチルアミノピリジン誘導体及びその製造方法 |
US7999107B2 (en) | 2007-01-31 | 2011-08-16 | Merck Sharp & Dohme Corp. | Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators |
WO2008141081A1 (en) * | 2007-05-10 | 2008-11-20 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
JP5731718B2 (ja) | 2011-11-11 | 2015-06-10 | ファイザー・インク | 2−チオピリミジノン |
MA42035A (fr) | 2015-05-05 | 2018-03-14 | Pfizer | 2-thiopyrimidinones |
CN105481839B (zh) * | 2015-11-23 | 2018-05-11 | 安徽千和新材料科技发展有限公司 | 一种光活性环氧啉对映体的制备方法 |
EP3229193A1 (en) | 2016-04-07 | 2017-10-11 | The Boeing Company | A computer-implemented method and system for sharing information between passengers and air traffic management stakeholders |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910930A (en) * | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
EP0004358A1 (de) * | 1978-03-20 | 1979-10-03 | Ciba-Geigy Ag | N-Oxacyclyl-alkyl-piperidine, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen |
WO1993017017A1 (en) * | 1992-02-27 | 1993-09-02 | Janssen Pharmaceutica N.V. | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
WO1997028157A1 (fr) * | 1996-02-01 | 1997-08-07 | Pierre Fabre Medicament | Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques |
WO1999029687A1 (en) * | 1997-12-05 | 1999-06-17 | Janssen Pharmaceutica N.V. | (benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
WO2000075136A1 (en) * | 1999-06-02 | 2000-12-14 | Janssen Pharmaceutica N.V. | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
WO2000075137A1 (en) * | 1999-06-02 | 2000-12-14 | Janssen Pharmaceutica N.V. | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2400049A1 (de) * | 1974-01-02 | 1975-07-10 | Spumalit Anstalt | Transportkasten aus kunststoff, insbesondere fuer flaschen |
US4329348A (en) * | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
EP0144101B1 (en) * | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines |
CA2090767A1 (en) | 1992-03-06 | 1993-09-07 | Gerald Guillaumet | 1,4-dioxino[2,3-b]pyridine derivatives |
US6403103B1 (en) * | 1994-08-12 | 2002-06-11 | Bio Merieux | Trypanosoma cruzi antigen, gene encoding therefore, and methods of detecting and treating chagas disease |
TWI225488B (en) * | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
-
2001
- 2001-05-29 JO JO200184A patent/JO2352B1/en active
- 2001-06-13 CA CA2410233A patent/CA2410233C/en not_active Expired - Fee Related
- 2001-06-13 DE DE60115647T patent/DE60115647T2/de not_active Expired - Lifetime
- 2001-06-13 ES ES01962742T patent/ES2254467T3/es not_active Expired - Lifetime
- 2001-06-13 IL IL15355901A patent/IL153559A0/xx active IP Right Grant
- 2001-06-13 PL PL358886A patent/PL201656B1/pl unknown
- 2001-06-13 CN CNB200510113576XA patent/CN100516066C/zh not_active Expired - Fee Related
- 2001-06-13 EP EP01962742A patent/EP1296987B1/en not_active Expired - Lifetime
- 2001-06-13 WO PCT/EP2001/006749 patent/WO2001098306A1/en active IP Right Grant
- 2001-06-13 NZ NZ522519A patent/NZ522519A/en not_active IP Right Cessation
- 2001-06-13 MX MXPA02012844A patent/MXPA02012844A/es active IP Right Grant
- 2001-06-13 AU AU83864/01A patent/AU783292B2/en not_active Ceased
- 2001-06-13 EA EA200300049A patent/EA005760B1/ru not_active IP Right Cessation
- 2001-06-13 UA UA20021210045A patent/UA74576C2/uk unknown
- 2001-06-13 US US10/311,612 patent/US7081453B2/en not_active Expired - Lifetime
- 2001-06-13 AT AT01962742T patent/ATE312104T1/de not_active IP Right Cessation
- 2001-06-13 EE EEP200200694A patent/EE04878B1/xx not_active IP Right Cessation
- 2001-06-13 BR BRPI0111859-5A patent/BR0111859B1/pt not_active IP Right Cessation
- 2001-06-13 HU HU0301185A patent/HU227398B1/hu not_active IP Right Cessation
- 2001-06-13 JP JP2002504262A patent/JP4911860B2/ja not_active Expired - Fee Related
- 2001-06-13 SK SK49-2003A patent/SK287730B6/sk not_active IP Right Cessation
- 2001-06-13 CZ CZ2003-115A patent/CZ305005B6/cs not_active IP Right Cessation
- 2001-06-13 CN CNB018116108A patent/CN1288157C/zh not_active Expired - Fee Related
- 2001-06-13 KR KR1020027014679A patent/KR100821107B1/ko not_active IP Right Cessation
- 2001-06-14 PA PA20018519601A patent/PA8519601A1/es unknown
- 2001-06-20 MY MYPI20012913A patent/MY155267A/en unknown
- 2001-06-20 EG EG20010661A patent/EG24462A/xx active
- 2001-06-21 AR ARP010102955A patent/AR032158A1/es active IP Right Grant
- 2001-10-10 SA SA1220442A patent/SA01220442B1/ar unknown
-
2002
- 2002-10-25 IS IS6591A patent/IS2618B/is unknown
- 2002-11-25 BG BG107313A patent/BG65895B1/bg unknown
- 2002-12-12 HR HR20020988A patent/HRP20020988B1/xx not_active IP Right Cessation
- 2002-12-19 IL IL153559A patent/IL153559A/en not_active IP Right Cessation
- 2002-12-19 ZA ZA200210303A patent/ZA200210303B/en unknown
- 2002-12-23 NO NO20026219A patent/NO328547B1/no not_active IP Right Cessation
-
2004
- 2004-02-04 HK HK04100726A patent/HK1057896A1/xx not_active IP Right Cessation
-
2006
- 2006-02-16 US US11/355,402 patent/US7423048B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910930A (en) * | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
EP0004358A1 (de) * | 1978-03-20 | 1979-10-03 | Ciba-Geigy Ag | N-Oxacyclyl-alkyl-piperidine, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen |
WO1993017017A1 (en) * | 1992-02-27 | 1993-09-02 | Janssen Pharmaceutica N.V. | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
WO1997028157A1 (fr) * | 1996-02-01 | 1997-08-07 | Pierre Fabre Medicament | Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques |
WO1999029687A1 (en) * | 1997-12-05 | 1999-06-17 | Janssen Pharmaceutica N.V. | (benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
WO2000075136A1 (en) * | 1999-06-02 | 2000-12-14 | Janssen Pharmaceutica N.V. | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
WO2000075137A1 (en) * | 1999-06-02 | 2000-12-14 | Janssen Pharmaceutica N.V. | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20180524 Year of fee payment: 18 |
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