HRP20020926B1 - Arylmethylamine derivatives for use as tryptase inhibitors - Google Patents
Arylmethylamine derivatives for use as tryptase inhibitorsInfo
- Publication number
- HRP20020926B1 HRP20020926B1 HR20020926A HRP20020926A HRP20020926B1 HR P20020926 B1 HRP20020926 B1 HR P20020926B1 HR 20020926 A HR20020926 A HR 20020926A HR P20020926 A HRP20020926 A HR P20020926A HR P20020926 B1 HRP20020926 B1 HR P20020926B1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- aryl
- alkyl
- heteroaryl
- alkoxy
- Prior art date
Links
- 239000002750 tryptase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0012362.0A GB0012362D0 (en) | 2000-05-22 | 2000-05-22 | Chemical compounds |
US09/843,126 US6977263B2 (en) | 2000-05-22 | 2001-04-26 | Chemical compounds |
PCT/US2001/013811 WO2001090101A1 (en) | 2000-05-22 | 2001-04-27 | Arylmethylamine derivatives for use as tryptase inhibitors |
Publications (2)
Publication Number | Publication Date |
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HRP20020926A2 HRP20020926A2 (en) | 2005-02-28 |
HRP20020926B1 true HRP20020926B1 (en) | 2011-01-31 |
Family
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HR20020926A HRP20020926B1 (en) | 2000-05-22 | 2002-11-21 | Arylmethylamine derivatives for use as tryptase inhibitors |
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US (1) | US20050228018A1 (pl) |
EP (1) | EP1296972B1 (pl) |
KR (1) | KR100858642B1 (pl) |
CN (1) | CN1230431C (pl) |
AR (1) | AR033525A1 (pl) |
AU (2) | AU2001257413B2 (pl) |
BR (1) | BR0111206A (pl) |
CA (1) | CA2409827C (pl) |
DZ (1) | DZ3347A1 (pl) |
HK (1) | HK1057899A1 (pl) |
HR (1) | HRP20020926B1 (pl) |
HU (1) | HU227630B1 (pl) |
IL (1) | IL152830A0 (pl) |
MA (1) | MA25809A1 (pl) |
MX (1) | MXPA02011400A (pl) |
NO (1) | NO327378B1 (pl) |
OA (1) | OA12274A (pl) |
PL (1) | PL360495A1 (pl) |
WO (1) | WO2001090101A1 (pl) |
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MXPA05005583A (es) | 2002-11-26 | 2005-07-27 | Pfizer Prod Inc | Activadores de ppar. |
GB0308613D0 (en) * | 2002-12-26 | 2003-05-21 | Aventis Pharma Inc | 4-(3-Aminomethylphenyl) piperidin-1-yl- 5-(2-fluorophenylethynyl) furan-2-yl- methanone as an inhibitor of mast cell tryptase |
SI2910551T1 (sl) | 2003-04-11 | 2017-07-31 | Ptc Therapeutics, Inc. | Spojine 1,2,4-oksadiazol benzojske kisline in njihova uporaba za zatiranje nesmiselne ter zdravljenje bolezni |
JP2006525355A (ja) * | 2003-05-01 | 2006-11-09 | アボット・ラボラトリーズ | ナトリウムチャンネルモジュレーターとしてのピラゾール−アミドおよびスルホンアミド |
MXPA06000940A (es) | 2003-07-24 | 2006-03-30 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento de dolor. |
EP1571150A1 (en) * | 2004-03-02 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Process for the preparation of tryptase inhibitors |
DE602005017471D1 (pl) * | 2004-03-02 | 2009-12-17 | Aventis Pharma Inc | |
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EP1775298B1 (en) | 2004-07-01 | 2013-03-20 | Daiichi Sankyo Company, Limited | Thienopyrazole derivative having pde7 inhibitory activity |
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US7880007B2 (en) | 2004-11-29 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Bicyclic substituted phenyl piperidine modulators of muscarinic receptors |
US20080039442A1 (en) * | 2004-12-21 | 2008-02-14 | Devgen Nv | Compounds With Kv4 Ion Channel Activity |
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KR101157004B1 (ko) | 2005-12-05 | 2012-07-09 | 오쓰까 세이야꾸 가부시키가이샤 | 항종양제로서의 디아릴에테르 유도체 |
EP2387995A1 (en) | 2006-03-30 | 2011-11-23 | PTC Therapeutics, Inc. | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith |
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UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
WO2008075077A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
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JP2011504499A (ja) | 2007-11-21 | 2011-02-10 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリプターゼ阻害剤として使用するためのスピロピペリジン |
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EA020548B1 (ru) | 2008-12-19 | 2014-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл |
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AU2010333892A1 (en) * | 2009-12-23 | 2012-07-19 | Sanofi | Treatment for inflammatory bowel disease |
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EP3002008B8 (en) * | 2010-03-11 | 2018-10-24 | New York University | Amido compounds as roryt modulators and uses thereof |
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JP5647339B2 (ja) | 2010-05-17 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2アンタゴニスト及びこれらの使用 |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
EP2694707B1 (en) | 2011-04-07 | 2018-08-15 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
SG11201504231PA (en) * | 2012-11-30 | 2015-07-30 | Kyowa Hakko Kirin Co Ltd | Nitrogen-containing heterocyclic compound |
TW201441193A (zh) | 2012-12-06 | 2014-11-01 | Kyowa Hakko Kirin Co Ltd | 吡啶酮化合物 |
AU2014348422B2 (en) | 2013-11-15 | 2019-02-14 | The Wistar Institute Of Anatomy And Biology | EBNA1 inhibitors and their method of use |
JP6946001B2 (ja) | 2014-03-06 | 2021-10-06 | ピーティーシー セラピューティクス, インコーポレイテッド | 薬学的組成物、および1,2,4−オキサジアゾール安息香酸の塩 |
CN113149885A (zh) | 2015-05-14 | 2021-07-23 | 威斯塔解剖学和生物学研究所 | Ebna1抑制剂和使用其的方法 |
JP6917910B2 (ja) | 2015-07-02 | 2021-08-11 | セントレクシオン セラピューティクス コーポレイション | (4−((3r,4r)−3−メトキシテトラヒドロ−ピラン−4−イルアミノ)ピペリジン−1−イル)(5−メチル−6−(((2r,6s)−6−(p−トリル)テトラヒドロ−2h−ピラン−2−イル)メチルアミノ)ピリミジン−4イル)メタノンクエン酸塩 |
BR112018008838A8 (pt) | 2015-10-30 | 2019-02-26 | Ptc Therapeutics Inc | método para tratar, prevenir, melhorar ou administrar uma doença epiléptica |
WO2019222470A1 (en) | 2018-05-17 | 2019-11-21 | The Wistar Institute | Ebna1 inhibitor crystalline forms, and methods of preparing and using same |
CN110357833B (zh) * | 2019-06-03 | 2022-05-24 | 杭州维坦医药科技有限公司 | 芳杂乙酰胺类衍生物及其制备和应用 |
TW202115086A (zh) * | 2019-06-28 | 2021-04-16 | 美商輝瑞大藥廠 | Bckdk抑制劑 |
IL298672A (en) * | 2020-06-04 | 2023-01-01 | Pillai Universal Llc | Novel small molecules for targeted unloading of untargetable kras in cancer therapy |
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DE4407139A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryl-1-azacycloalkane und deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
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US6673908B1 (en) * | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
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- 2001-04-27 KR KR1020027015683A patent/KR100858642B1/ko not_active IP Right Cessation
- 2001-04-27 AU AU2001257413A patent/AU2001257413B2/en not_active Ceased
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- 2001-04-27 WO PCT/US2001/013811 patent/WO2001090101A1/en active IP Right Grant
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- 2001-04-27 AU AU5741301A patent/AU5741301A/xx active Pending
- 2001-04-27 PL PL36049501A patent/PL360495A1/pl not_active Application Discontinuation
- 2001-04-27 CN CNB018119522A patent/CN1230431C/zh not_active Expired - Lifetime
- 2001-04-27 AR ARP010102009A patent/AR033525A1/es active IP Right Grant
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2002
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- 2002-11-21 HR HR20020926A patent/HRP20020926B1/xx not_active IP Right Cessation
- 2002-11-21 MA MA26919A patent/MA25809A1/fr unknown
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2004
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4407139A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryl-1-azacycloalkane und deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
Also Published As
Publication number | Publication date |
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PL360495A1 (pl) | 2004-09-06 |
CA2409827C (en) | 2010-06-01 |
CN1230431C (zh) | 2005-12-07 |
KR100858642B1 (ko) | 2008-09-17 |
EP1296972A1 (en) | 2003-04-02 |
AU2001257413B2 (en) | 2007-01-18 |
HRP20020926A2 (en) | 2005-02-28 |
AR033525A1 (es) | 2003-12-26 |
HU227630B1 (hu) | 2011-10-28 |
KR20030003294A (ko) | 2003-01-09 |
AU5741301A (en) | 2001-12-03 |
CN1439003A (zh) | 2003-08-27 |
BR0111206A (pt) | 2003-04-15 |
CA2409827A1 (en) | 2001-11-29 |
HUP0302485A2 (hu) | 2003-12-29 |
NO20025601L (no) | 2003-01-06 |
DZ3347A1 (fr) | 2001-11-29 |
OA12274A (en) | 2006-05-09 |
MA25809A1 (fr) | 2003-07-01 |
WO2001090101A1 (en) | 2001-11-29 |
HUP0302485A3 (en) | 2007-09-28 |
US20050228018A1 (en) | 2005-10-13 |
HK1057899A1 (en) | 2004-04-23 |
IL152830A0 (en) | 2003-06-24 |
MXPA02011400A (es) | 2003-05-23 |
EP1296972B1 (en) | 2009-12-23 |
NO327378B1 (no) | 2009-06-22 |
NO20025601D0 (no) | 2002-11-21 |
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