HRP20020926B1 - Derivati arilmetilamina i njihova upotreba kao inhibitora triptaze - Google Patents

Derivati arilmetilamina i njihova upotreba kao inhibitora triptaze

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Publication number
HRP20020926B1
HRP20020926B1 HR20020926A HRP20020926A HRP20020926B1 HR P20020926 B1 HRP20020926 B1 HR P20020926B1 HR 20020926 A HR20020926 A HR 20020926A HR P20020926 A HRP20020926 A HR P20020926A HR P20020926 B1 HRP20020926 B1 HR P20020926B1
Authority
HR
Croatia
Prior art keywords
compound
aryl
alkyl
heteroaryl
alkoxy
Prior art date
Application number
HR20020926A
Other languages
English (en)
Inventor
C. Astles Peter
R. Eastwood Paul
Houille Oliver
Levell Julian
Pauls Heinz
Czekaj Mark
Liang Guyan
Gong Yong
Pribsh James
Neuenschwander Kent
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0012362.0A external-priority patent/GB0012362D0/en
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of HRP20020926A2 publication Critical patent/HRP20020926A2/hr
Publication of HRP20020926B1 publication Critical patent/HRP20020926B1/hr

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

Spoj formule (I): ,naznacen time, daAr je aril ili heteroaril, te je beta prema na arilu, je jednostruka ili dvostruka veza; R1 i R2 su medusobno neovisno vodik ili C1-C4-alkil; R3 je aril ili heteroaril; R4 je vodik, acil, alkoksi, alkiloksikarbonil, karboksi, cijano, halogen, hidroksi, -C(=O)-NY1Y2 ili alkil po izboru supstituiran s alkoksi, alkilkarbonilamino, alkilsulfonilamino, hidroksi, -S(O)m-alkil ili -NY1Y2;Y1 i Y2 su svaki neovisno vodik, alkenil, alkil, aril, arilalkil, cikloalkil, heteroaril, heteroarilalkil ili heterocikloalkil; ili skupina -NY1Y2 moze formirati ciklicki amin; m je nula ili cijeli broj 1 do 2; n je 2; iliN-oksid spomenutog spoja, ester predlijek spomenutog spoja, farmaceutski prihvatljiva sol spomenutog spoja, solvat spomenutog spoja ili hidrat spomenutog spoja. Patent sadrzi jos 42 patentna zahtjeva.
HR20020926A 2000-05-22 2002-11-21 Derivati arilmetilamina i njihova upotreba kao inhibitora triptaze HRP20020926B1 (hr)

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PCT/US2001/013811 WO2001090101A1 (en) 2000-05-22 2001-04-27 Arylmethylamine derivatives for use as tryptase inhibitors

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