HRP20020926B1 - Derivati arilmetilamina i njihova upotreba kao inhibitora triptaze - Google Patents
Derivati arilmetilamina i njihova upotreba kao inhibitora triptazeInfo
- Publication number
- HRP20020926B1 HRP20020926B1 HR20020926A HRP20020926A HRP20020926B1 HR P20020926 B1 HRP20020926 B1 HR P20020926B1 HR 20020926 A HR20020926 A HR 20020926A HR P20020926 A HRP20020926 A HR P20020926A HR P20020926 B1 HRP20020926 B1 HR P20020926B1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- aryl
- alkyl
- heteroaryl
- alkoxy
- Prior art date
Links
- 239000002750 tryptase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract
Spoj formule (I): ,naznacen time, daAr je aril ili heteroaril, te je beta prema na arilu, je jednostruka ili dvostruka veza; R1 i R2 su medusobno neovisno vodik ili C1-C4-alkil; R3 je aril ili heteroaril; R4 je vodik, acil, alkoksi, alkiloksikarbonil, karboksi, cijano, halogen, hidroksi, -C(=O)-NY1Y2 ili alkil po izboru supstituiran s alkoksi, alkilkarbonilamino, alkilsulfonilamino, hidroksi, -S(O)m-alkil ili -NY1Y2;Y1 i Y2 su svaki neovisno vodik, alkenil, alkil, aril, arilalkil, cikloalkil, heteroaril, heteroarilalkil ili heterocikloalkil; ili skupina -NY1Y2 moze formirati ciklicki amin; m je nula ili cijeli broj 1 do 2; n je 2; iliN-oksid spomenutog spoja, ester predlijek spomenutog spoja, farmaceutski prihvatljiva sol spomenutog spoja, solvat spomenutog spoja ili hidrat spomenutog spoja. Patent sadrzi jos 42 patentna zahtjeva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0012362.0A GB0012362D0 (en) | 2000-05-22 | 2000-05-22 | Chemical compounds |
US09/843,126 US6977263B2 (en) | 2000-05-22 | 2001-04-26 | Chemical compounds |
PCT/US2001/013811 WO2001090101A1 (en) | 2000-05-22 | 2001-04-27 | Arylmethylamine derivatives for use as tryptase inhibitors |
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HRP20020926A2 HRP20020926A2 (en) | 2005-02-28 |
HRP20020926B1 true HRP20020926B1 (hr) | 2011-01-31 |
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US (1) | US20050228018A1 (hr) |
EP (1) | EP1296972B1 (hr) |
KR (1) | KR100858642B1 (hr) |
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AU (2) | AU5741301A (hr) |
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HK (1) | HK1057899A1 (hr) |
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MA (1) | MA25809A1 (hr) |
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OA (1) | OA12274A (hr) |
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DE4407139A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryl-1-azacycloalkane und deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
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PL360495A1 (en) | 2004-09-06 |
HK1057899A1 (en) | 2004-04-23 |
KR100858642B1 (ko) | 2008-09-17 |
HRP20020926A2 (en) | 2005-02-28 |
NO20025601D0 (no) | 2002-11-21 |
IL152830A0 (en) | 2003-06-24 |
HUP0302485A2 (hu) | 2003-12-29 |
CA2409827A1 (en) | 2001-11-29 |
CA2409827C (en) | 2010-06-01 |
NO327378B1 (no) | 2009-06-22 |
HUP0302485A3 (en) | 2007-09-28 |
EP1296972B1 (en) | 2009-12-23 |
AR033525A1 (es) | 2003-12-26 |
NO20025601L (no) | 2003-01-06 |
AU2001257413B2 (en) | 2007-01-18 |
CN1230431C (zh) | 2005-12-07 |
MXPA02011400A (es) | 2003-05-23 |
KR20030003294A (ko) | 2003-01-09 |
AU5741301A (en) | 2001-12-03 |
US20050228018A1 (en) | 2005-10-13 |
EP1296972A1 (en) | 2003-04-02 |
OA12274A (en) | 2006-05-09 |
WO2001090101A1 (en) | 2001-11-29 |
BR0111206A (pt) | 2003-04-15 |
DZ3347A1 (fr) | 2001-11-29 |
HU227630B1 (hu) | 2011-10-28 |
CN1439003A (zh) | 2003-08-27 |
MA25809A1 (fr) | 2003-07-01 |
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