HK88897A - Polyazamacrocyclic compounds for complexation of metal ions - Google Patents
Polyazamacrocyclic compounds for complexation of metal ionsInfo
- Publication number
- HK88897A HK88897A HK88897A HK88897A HK88897A HK 88897 A HK88897 A HK 88897A HK 88897 A HK88897 A HK 88897A HK 88897 A HK88897 A HK 88897A HK 88897 A HK88897 A HK 88897A
- Authority
- HK
- Hong Kong
- Prior art keywords
- complexation
- metal ions
- polyazamacrocyclic
- compound
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229910021645 metal ion Inorganic materials 0.000 title abstract 2
- 238000010668 complexation reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Laminated Bodies (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/662,075 US4639365A (en) | 1984-10-18 | 1984-10-18 | Gadolinium chelates as NMR contrast agents |
| US07/615,619 US5342606A (en) | 1984-10-18 | 1990-11-19 | Polyazamacrocyclic compounds for complexation of metal ions |
| PCT/US1991/008438 WO1992008725A1 (en) | 1984-10-18 | 1991-11-12 | Polyazamacrocyclic compounds for complexation of metal ions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK88897A true HK88897A (en) | 1997-06-27 |
Family
ID=34922814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK88897A HK88897A (en) | 1984-10-18 | 1997-06-26 | Polyazamacrocyclic compounds for complexation of metal ions |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5342606A (xx) |
| JP (1) | JP3334717B2 (xx) |
| CN (2) | CN1036717C (xx) |
| AT (1) | ATE144522T1 (xx) |
| AU (1) | AU654987B2 (xx) |
| CA (1) | CA2095615C (xx) |
| DE (1) | DE69122881T2 (xx) |
| ES (1) | ES2093816T3 (xx) |
| FI (1) | FI932231A (xx) |
| HK (1) | HK88897A (xx) |
| HU (1) | HUT64768A (xx) |
| IE (1) | IE914001A1 (xx) |
| IL (1) | IL100073A (xx) |
| MX (1) | MX9102116A (xx) |
| NO (1) | NO307380B1 (xx) |
| NZ (1) | NZ240626A (xx) |
| PT (1) | PT99556B (xx) |
| SG (1) | SG48154A1 (xx) |
| WO (1) | WO1992008725A1 (xx) |
| ZA (1) | ZA919127B (xx) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| ATE147635T1 (de) * | 1990-04-18 | 1997-02-15 | Celltech Therapeutics Ltd | Tetra-aza-makrozyklen, verfahren zu ihrer herstellung und ihre anwendung in nmr-bildformung |
| US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
| US5393892A (en) * | 1993-05-07 | 1995-02-28 | Ibc Advanced Technologies, Inc. | Processes for removing, separating and concentrating lead, thallium, alkali metals, alkaline earth metals from concentrated matrices using macrocyclic polyether cryptand ligands bonded to inorganic supports |
| US5554749A (en) * | 1994-01-14 | 1996-09-10 | Mallinckrodt Medical, Inc. | Functionalized macrocyclic ligands for imaging applications |
| DE4403039A1 (de) * | 1994-01-28 | 1995-08-03 | Schering Ag | Oktaazamakrocyclen, deren Metallkomplexe, Verfahren zu deren Herstellung, diese Komplexe enthaltende Mittel sowie deren Verwendung in Diagnostik und Therapie |
| US5622687A (en) * | 1994-11-15 | 1997-04-22 | Molecular Biosystems, Inc. | Calixarene conjugates useful as MRI and CT diagnostic imaging agents |
| ES2094101B1 (es) * | 1995-06-13 | 1997-08-01 | Univ Madrid Nac Educacion | Complexonas de naturaleza de acidos n-2-(azol-1(2)-il)etiliminodiaceticos, sintesis, estudio analitico y aplicaciones biologicas. |
| JP3356289B2 (ja) | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| US6093382A (en) * | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
| US20050112066A1 (en) * | 2003-11-26 | 2005-05-26 | Concat Lp, A California Limited Partnership | Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| EP2446904B1 (en) | 2006-05-30 | 2015-04-29 | Genentech, Inc. | Anti-CD22 antibodies, their immunoconjugates and uses thereof |
| ES2636089T3 (es) | 2006-10-27 | 2017-10-05 | Genentech, Inc. | Anticuerpos e inmunoconjugados y usos para los mismos |
| WO2008100805A2 (en) | 2007-02-09 | 2008-08-21 | Genentech, Inc. | Anti-robo4 antibodies and uses therefor |
| PE20090481A1 (es) | 2007-07-16 | 2009-05-18 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso |
| CN111499748A (zh) | 2007-07-16 | 2020-08-07 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| EP3269737B1 (en) | 2008-01-31 | 2024-06-19 | Genentech, Inc. | Anti-cd79b antibodies and immunoconjugates and methods of use |
| JP6132548B2 (ja) | 2009-04-01 | 2017-05-24 | ジェネンテック， インコーポレイテッド | 抗ＦｃＲＨ５抗体および免疫接合体および使用方法 |
| KR20180056805A (ko) | 2009-06-04 | 2018-05-29 | 노파르티스 아게 | ＩｇＧ 콘쥬게이션을 위한 자리의 확인 방법 |
| JP5690733B2 (ja) * | 2009-08-20 | 2015-03-25 | 富士フイルムＲｉファーマ株式会社 | ビスホスホン酸誘導体及びその放射性金属核種標識体 |
| US10584181B2 (en) | 2009-12-04 | 2020-03-10 | Genentech, Inc. | Methods of making and using multispecific antibody panels and antibody analog panels |
| WO2011153346A1 (en) | 2010-06-03 | 2011-12-08 | Genentech, Inc. | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
| EP2579897A1 (en) | 2010-06-08 | 2013-04-17 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CN104428006B (zh) | 2012-07-04 | 2017-09-08 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原‑抗体缀合物 |
| WO2014006118A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Anti-theophylline antibodies and methods of use |
| WO2014006123A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Anti-biotin antibodies and methods of use |
| JP6521464B2 (ja) | 2014-01-03 | 2019-05-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 共有結合で連結されたポリペプチド毒素−抗体コンジュゲート |
| RU2694981C2 (ru) | 2014-01-03 | 2019-07-18 | Ф. Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения |
| EP3960768A1 (en) | 2014-01-03 | 2022-03-02 | F. Hoffmann-La Roche AG | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
| AR101844A1 (es) | 2014-09-12 | 2017-01-18 | Genentech Inc | Anticuerpos y conjugados modificados genéticamente con cisteína |
| RU2714963C2 (ru) | 2014-12-17 | 2020-02-21 | Ф. Хоффманн-Ля Рош Аг | Новые способы опосредованного ферментами конъюгирования полипептидов с использованием сортазы |
| WO2017050866A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Novel soluble sortase a |
| JP6895953B2 (ja) | 2015-09-25 | 2021-06-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ソルターゼａを利用してチオエステルを作製するための方法 |
| BR112018003594A2 (pt) | 2015-09-25 | 2018-09-25 | Hoffmann La Roche | cadeia pesada de imunoglobulina recombinante, anticorpos, método de produção de conjugado e conjugados |
| CN108026560A (zh) | 2015-09-25 | 2018-05-11 | 豪夫迈·罗氏有限公司 | 在低共熔溶剂中使用分选酶的转酰胺反应 |
| EP3436578B1 (en) | 2016-03-30 | 2022-01-19 | F. Hoffmann-La Roche AG | Improved sortase |
| US10072032B2 (en) * | 2016-09-19 | 2018-09-11 | Afton Chemical Corporation | AminoBisPhosphonate antiwear additives |
| CN110709523B (zh) | 2017-04-12 | 2023-07-11 | 豪夫迈·罗氏有限公司 | 使用经pictet spengler反应获得的加标签的核苷的测序反应方法 |
| EP3652214A1 (en) | 2017-07-13 | 2020-05-20 | H. Hoffnabb-La Roche Ag | New binding agent and assay for pivka |
| JP7403444B2 (ja) | 2017-10-20 | 2023-12-22 | エフ． ホフマン－ラ ロシュ アーゲー | 抗体の複写保護措置 |
| WO2019108755A1 (en) | 2017-11-30 | 2019-06-06 | Genentech, Inc. | Anti-pd-l1 antibodies and methods of using the same for detection of pd-l1 |
| BR112020017941A2 (pt) | 2018-03-14 | 2021-02-17 | F. Hoffmann-La Roche Ag | anticorpos, moléculas de ácido nucleico, vetor, composição e método de determinação da troponina t cardíaca humana |
| WO2019175131A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
| EP3781600A1 (en) | 2018-04-18 | 2021-02-24 | F. Hoffmann-La Roche AG | Novel anti-thymidine kinase antibodies |
| WO2020043868A1 (en) | 2018-08-31 | 2020-03-05 | F. Hoffmann-La Roche Ag | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
| CA3113080A1 (en) | 2018-09-28 | 2020-04-02 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| WO2021013784A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis |
| KR20220016210A (ko) | 2019-07-22 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9 |
| JP7315780B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスｐ |
| EP4004555A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN114144671A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a12作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物 |
| JP2023502360A (ja) | 2019-11-15 | 2023-01-24 | エフ．ホフマン－ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化 |
| KR20230092930A (ko) | 2020-10-30 | 2023-06-26 | 에프. 호프만-라 로슈 아게 | 담관암종의 표지자로서의 timp1 |
| WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| EP4314838A1 (en) | 2021-04-01 | 2024-02-07 | F. Hoffmann-La Roche AG | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN117337394A (zh) | 2021-05-17 | 2024-01-02 | 豪夫迈·罗氏有限公司 | sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断 |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| CN118382636A (zh) | 2021-12-17 | 2024-07-23 | 豪夫迈·罗氏有限公司 | 一种用于检测淀粉样蛋白β42(Aβ42)的新抗体 |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932451A (en) * | 1973-11-27 | 1976-01-13 | E. I. Du Pont De Nemours & Company | 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids |
| US3930867A (en) * | 1974-01-07 | 1976-01-06 | E. I. Du Pont De Nemours And Company | Macrocyclic polyamines as sensitizers for silver halide emulsions |
| US4038312A (en) * | 1975-08-22 | 1977-07-26 | E. I. Du Pont De Nemours And Company | Tricyclic phosphorous triamides |
| US3996276A (en) * | 1975-08-22 | 1976-12-07 | E. I. Du Pont De Nemours And Company | Bicyclic and tricyclic phosphorous triamides |
| US3987128A (en) * | 1975-08-22 | 1976-10-19 | E. I. Du Pont De Nemours And Company | Tetracyclic tetraamino phosphoranes and method of preparation |
| US4085106A (en) * | 1976-01-07 | 1978-04-18 | E. I. Du Pont De Nemours And Company | Bicyclic and tricyclic trisaminomethanes |
| GB1529150A (en) * | 1977-05-17 | 1978-10-18 | Tabushi I | Alkyl substituted cyclic alkyltetramines |
| US4337154A (en) * | 1979-04-04 | 1982-06-29 | Nippon Shokubai Kagaku Kogyo Co., Ltd. | Crosslinked composite semipermeable membrane |
| US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
| US4432907A (en) * | 1979-09-10 | 1984-02-21 | Analytical Radiation Corporation | Diamine acid fluorescent chelates |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4421671A (en) * | 1982-06-18 | 1983-12-20 | General Electric Company | Rare-earth-doped yttria-gadolinia ceramic scintillators |
| SU1081169A1 (ru) * | 1982-12-13 | 1984-03-23 | Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова | @ , @ , @ -Трис(диоксифосфорилметил)-1,4,7-триазациклононан в качестве комплексона дл селективного св зывани катионов магни ,цинка,меди,никел |
| US4731239A (en) * | 1983-01-10 | 1988-03-15 | Gordon Robert T | Method for enhancing NMR imaging; and diagnostic use |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| US4735796A (en) * | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
| CA1317937C (en) * | 1984-10-18 | 1993-05-18 | A. Dean Sherry | Gadolinium chelates with carboxymethyl derivatives of polyazamacrocycles as nmr contrast agents |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| GB8903023D0 (en) * | 1989-02-10 | 1989-03-30 | Parker David | Chemical compounds |
| GB8914543D0 (en) * | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
| ATE147635T1 (de) * | 1990-04-18 | 1997-02-15 | Celltech Therapeutics Ltd | Tetra-aza-makrozyklen, verfahren zu ihrer herstellung und ihre anwendung in nmr-bildformung |
-
1990
- 1990-11-19 US US07/615,619 patent/US5342606A/en not_active Expired - Fee Related
-
1991
- 1991-11-12 AT AT92901960T patent/ATE144522T1/de not_active IP Right Cessation
- 1991-11-12 DE DE69122881T patent/DE69122881T2/de not_active Expired - Fee Related
- 1991-11-12 CA CA002095615A patent/CA2095615C/en not_active Expired - Fee Related
- 1991-11-12 WO PCT/US1991/008438 patent/WO1992008725A1/en active IP Right Grant
- 1991-11-12 SG SG1996007416A patent/SG48154A1/en unknown
- 1991-11-12 JP JP50107392A patent/JP3334717B2/ja not_active Expired - Fee Related
- 1991-11-12 ES ES92901960T patent/ES2093816T3/es not_active Expired - Lifetime
- 1991-11-12 HU HU9301431A patent/HUT64768A/hu unknown
- 1991-11-12 AU AU90770/91A patent/AU654987B2/en not_active Ceased
- 1991-11-18 MX MX9102116A patent/MX9102116A/es not_active IP Right Cessation
- 1991-11-18 NZ NZ240626A patent/NZ240626A/en not_active IP Right Cessation
- 1991-11-18 ZA ZA919127A patent/ZA919127B/xx unknown
- 1991-11-18 IE IE400191A patent/IE914001A1/en not_active IP Right Cessation
- 1991-11-18 IL IL100073A patent/IL100073A/xx not_active IP Right Cessation
- 1991-11-19 CN CN91107597A patent/CN1036717C/zh not_active Expired - Fee Related
- 1991-11-19 PT PT99556A patent/PT99556B/pt not_active IP Right Cessation
-
1993
- 1993-05-17 FI FI932231A patent/FI932231A/fi unknown
- 1993-05-18 NO NO931793A patent/NO307380B1/no unknown
-
1996
- 1996-10-31 CN CN96122080A patent/CN1193625A/zh active Pending
-
1997
- 1997-06-26 HK HK88897A patent/HK88897A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1193625A (zh) | 1998-09-23 |
| IL100073A0 (en) | 1992-08-18 |
| PT99556A (pt) | 1992-10-30 |
| MX9102116A (es) | 1992-06-01 |
| AU9077091A (en) | 1992-06-11 |
| IL100073A (en) | 1997-11-20 |
| NZ240626A (en) | 1994-11-25 |
| SG48154A1 (en) | 1998-04-17 |
| AU654987B2 (en) | 1994-12-01 |
| NO307380B1 (no) | 2000-03-27 |
| IE914001A1 (en) | 1992-05-20 |
| CA2095615C (en) | 2003-07-08 |
| FI932231A0 (fi) | 1993-05-17 |
| CA2095615A1 (en) | 1992-05-20 |
| HU9301431D0 (en) | 1993-12-28 |
| CN1066073A (zh) | 1992-11-11 |
| CN1036717C (zh) | 1997-12-17 |
| US5342606A (en) | 1994-08-30 |
| WO1992008725A1 (en) | 1992-05-29 |
| ZA919127B (en) | 1993-05-18 |
| ATE144522T1 (de) | 1996-11-15 |
| PT99556B (pt) | 1999-04-30 |
| DE69122881T2 (de) | 1997-04-03 |
| NO931793D0 (no) | 1993-05-18 |
| DE69122881D1 (de) | 1996-11-28 |
| FI932231A (fi) | 1993-05-17 |
| ES2093816T3 (es) | 1997-01-01 |
| HUT64768A (en) | 1994-02-28 |
| JPH06502645A (ja) | 1994-03-24 |
| JP3334717B2 (ja) | 2002-10-15 |
| NO931793L (no) | 1993-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK88897A (en) | Polyazamacrocyclic compounds for complexation of metal ions | |
| IE791895L (en) | Alkanoyl prolines. | |
| YU142188A (en) | Process for preparing polyethylenglycolcarbaminates | |
| AU4654893A (en) | Polyazamacrocyclic compounds for complexation of metal ions | |
| WO1987003478A3 (fr) | Medicaments | |
| GR3023130T3 (en) | Phosphotriester-type biologically active compounds. | |
| IE781619L (en) | Phosphonoacyl proline compounds. | |
| IE812460L (en) | Substituted azabicyclo-octane-carboxylic acids | |
| UA41904C2 (uk) | Спосіб одержання бензопіранових сполук, проміжні сполуки, спосіб одержання проміжних сполук | |
| ES8402581A1 (es) | Un procedimiento para preparar derivados de imidazol y triazol. | |
| ES8702378A1 (es) | Un derivado de triazol n-sustituido | |
| TW343229B (en) | Magnetic recording binder containing aminoalkyphosphonate salt | |
| ES8106510A1 (es) | Procedimiento para la obtencion de 1,1-dioxido de 5,6-dihi- dro-1,2,4,6-tiatriazin(5)ona | |
| ES463734A1 (es) | Un metodo para tratar un sistema acuoso y flocular de este selectivamente los iones de hierro. | |
| AU551489B2 (en) | 3-alkyl-4,5-dichlorobenzotriazole-1-n-oxides | |
| MY109377A (en) | Polyazamacrocyclic compounds for complexation of metal ions | |
| IL110646A0 (en) | Process for the preparation of azoxycyanide compounds | |
| ES465568A1 (es) | Procedimiento para la preparacion de acidos 2-amino-ciclo- pent-1-en-1-carboxilicos en n |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20031112 |
|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |