HK48590A - NOVEL 8α-ACYLAMINOERGOLINES - Google Patents

NOVEL 8α-ACYLAMINOERGOLINES Download PDF

Info

Publication number
HK48590A
HK48590A HK485/90A HK48590A HK48590A HK 48590 A HK48590 A HK 48590A HK 485/90 A HK485/90 A HK 485/90A HK 48590 A HK48590 A HK 48590A HK 48590 A HK48590 A HK 48590A
Authority
HK
Hong Kong
Prior art keywords
hydrogen
acylaminoergolines
novel
5alkenyl
7alkyl
Prior art date
Application number
HK485/90A
Other languages
English (en)
Inventor
Haefliger Walter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK48590A publication Critical patent/HK48590A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK485/90A 1984-01-12 1990-06-21 NOVEL 8α-ACYLAMINOERGOLINES HK48590A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (1)

Publication Number Publication Date
HK48590A true HK48590A (en) 1990-06-29

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
HK485/90A HK48590A (en) 1984-01-12 1990-06-21 NOVEL 8α-ACYLAMINOERGOLINES

Country Status (28)

Country Link
US (2) US4950672A (instruction)
JP (1) JPH0655739B2 (instruction)
AT (1) AT391317B (instruction)
AU (3) AU583489B2 (instruction)
BE (1) BE901456A (instruction)
CA (1) CA1245640A (instruction)
CH (1) CH664568A5 (instruction)
CY (1) CY1542A (instruction)
DE (1) DE3500251C2 (instruction)
DK (1) DK169891B1 (instruction)
ES (1) ES8605514A1 (instruction)
FI (1) FI82466C (instruction)
FR (1) FR2560196B1 (instruction)
GB (1) GB2152507B (instruction)
GR (1) GR850065B (instruction)
HK (1) HK48590A (instruction)
HU (1) HU197569B (instruction)
IE (1) IE58228B1 (instruction)
IL (1) IL74043A (instruction)
IT (1) IT1214648B (instruction)
LU (1) LU85725A1 (instruction)
NL (1) NL193541C (instruction)
NZ (1) NZ210818A (instruction)
PH (1) PH23286A (instruction)
PT (1) PT79818B (instruction)
SE (1) SE460420B (instruction)
SG (1) SG32390G (instruction)
ZA (1) ZA85276B (instruction)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
EP0160842B1 (de) * 1984-04-09 1994-06-22 Schering Aktiengesellschaft 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US9676776B2 (en) * 2015-01-20 2017-06-13 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
HK1248215A1 (zh) 2015-01-20 2018-10-12 Xoc Pharmaceuticals, Inc 麦角灵化合物及其用途
EP3630758A1 (en) 2017-06-01 2020-04-08 Xoc Pharmaceuticals, Inc Ergoline derivatives for use in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
PT79818A (en) 1985-02-01
FI850130A0 (fi) 1985-01-11
AU2506788A (en) 1989-03-02
DE3500251A1 (de) 1985-07-18
ES8605514A1 (es) 1986-03-16
CA1245640A (en) 1988-11-29
SG32390G (en) 1990-08-03
IE58228B1 (en) 1993-08-11
US5077298A (en) 1991-12-31
DK169891B1 (da) 1995-03-27
IT8547538A0 (it) 1985-01-11
GR850065B (instruction) 1985-05-03
FR2560196B1 (fr) 1986-07-18
GB2152507A (en) 1985-08-07
IL74043A (en) 1988-10-31
JPS60174783A (ja) 1985-09-09
AU2506688A (en) 1989-02-23
ATA5985A (de) 1990-03-15
AT391317B (de) 1990-09-25
AU583489B2 (en) 1989-05-04
AU3760985A (en) 1985-07-18
GB8500454D0 (en) 1985-02-13
SE8500107L (sv) 1985-07-13
NL193541B (nl) 1999-09-01
IE850064L (en) 1985-07-12
BE901456A (fr) 1985-07-08
NZ210818A (en) 1989-02-24
ES539511A0 (es) 1986-03-16
DK12685A (da) 1985-07-13
SE460420B (sv) 1989-10-09
LU85725A1 (fr) 1985-10-22
IL74043A0 (en) 1985-04-30
FR2560196A1 (fr) 1985-08-30
CY1542A (en) 1991-03-22
SE8500107D0 (sv) 1985-01-10
NL8500008A (nl) 1985-08-01
JPH0655739B2 (ja) 1994-07-27
GB2152507B (en) 1987-07-15
DK12685D0 (da) 1985-01-10
DE3500251C2 (de) 1995-01-26
HUT37148A (en) 1985-11-28
AU609539B2 (en) 1991-05-02
HU197569B (en) 1989-04-28
AU618290B2 (en) 1991-12-19
PT79818B (en) 1987-01-07
IT1214648B (it) 1990-01-18
CH664568A5 (de) 1988-03-15
FI850130L (fi) 1985-07-13
NL193541C (nl) 2000-01-04
FI82466B (fi) 1990-11-30
ZA85276B (en) 1986-08-27
FI82466C (fi) 1991-03-11
PH23286A (en) 1989-06-30
US4950672A (en) 1990-08-21

Similar Documents

Publication Publication Date Title
BG103485A (en) Ketobanzamides as calpain inhibitors
GR3007513T3 (instruction)
HK48590A (en) NOVEL 8α-ACYLAMINOERGOLINES
ES8207169A1 (es) Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.
IT8521213A0 (it) Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica.
IE851734L (en) Isoindolinyl-alkyl-piperazines
ES8605509A1 (es) Procedimiento para preparar derivados de bencilftalazinona sustituidos
IT8521867A0 (it) Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica.
CA2024162A1 (en) Benzazabicyclo carbamates as novel cholinesterase inhibitors
ATE30429T1 (de) Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine.
MX9500228A (es) N-oxidos de 4-arilpiperazinas y 4-arilpiperidinas.
ATE232732T1 (de) 2',5'-phosphorthioat/phosphodiester- oligoadenylate und ihre antiviralen verwendungen
IE791552L (en) 1,2-disubstituted imidazolines
SE8506125D0 (sv) 8alfa-acylaminoergolines, their production and pharmaceutical compositions containing them
EP0207606A3 (en) Use of pinacidil as an antiasthma agent
DE59109029D1 (de) 3-substituierte Cephalosporine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IE780262L (en) Carbocyclic fused thiophen-2-oxaminic acid derivatives
AU553493B2 (en) 3,7alpha-diazacyclohepta(j,k)fluoriene derivatives
DE59405727D1 (de) Thiocarbamoylverbindungen als mikrobizide
ES8702387A1 (es) Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas
AU9084091A (en) 3-{2-chloro-4-(trifluoromethyl)phenoxy}-1-azetidine carboxamides having anticonvulsant activity
AU6103790A (en) New 1,3-oxazines
UA46181A1 (uk) Похідні 4-метил-5-нітроакридину, який має антимікробну та жовчогонну активність
IL76936A (en) 3-amino-2,3-dihydro-1-benzoxepine compounds,their preparation and pharmaceutical compositions containing them
ITMI931728A1 (it) Composti eterociclici ad attivita' cardiovascolare

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)