ATE232732T1 - 2',5'-phosphorthioat/phosphodiester- oligoadenylate und ihre antiviralen verwendungen - Google Patents
2',5'-phosphorthioat/phosphodiester- oligoadenylate und ihre antiviralen verwendungenInfo
- Publication number
- ATE232732T1 ATE232732T1 AT95929637T AT95929637T ATE232732T1 AT E232732 T1 ATE232732 T1 AT E232732T1 AT 95929637 T AT95929637 T AT 95929637T AT 95929637 T AT95929637 T AT 95929637T AT E232732 T1 ATE232732 T1 AT E232732T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphorthioate
- oligoadenylate
- phosphodiester
- antiviral
- antiviral uses
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 3
- SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Polymers C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 title 1
- 150000004713 phosphodiesters Chemical class 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 230000002503 metabolic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/605—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the macromolecule containing phosphorus in the main chain, e.g. poly-phosphazene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30627394A | 1994-09-14 | 1994-09-14 | |
| PCT/US1995/010683 WO1996008256A1 (en) | 1994-09-14 | 1995-08-22 | 2',5' phosphorothioate/phosphodiester oligoadenylates and antiviral uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232732T1 true ATE232732T1 (de) | 2003-03-15 |
Family
ID=23184567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95929637T ATE232732T1 (de) | 1994-09-14 | 1995-08-22 | 2',5'-phosphorthioat/phosphodiester- oligoadenylate und ihre antiviralen verwendungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5863905A (de) |
| EP (1) | EP0777485B1 (de) |
| JP (2) | JP3142574B2 (de) |
| AT (1) | ATE232732T1 (de) |
| AU (1) | AU686005B2 (de) |
| CA (1) | CA2199747C (de) |
| DE (1) | DE69529680T2 (de) |
| ES (1) | ES2188667T3 (de) |
| NZ (1) | NZ291713A (de) |
| WO (1) | WO1996008256A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127446A1 (en) * | 1992-05-14 | 2004-07-01 | Lawrence Blatt | Oligonucleotide mediated inhibition of hepatitis B virus and hepatitis C virus replication |
| US5587514A (en) * | 1993-11-08 | 1996-12-24 | Emory University | Diastereoselective synthesis of hydroxyethylene dipeptide isosteres |
| WO1998056384A1 (en) | 1997-06-12 | 1998-12-17 | Temple University - Of The Commonwealth System Of Higher Education | Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof |
| WO1998056385A1 (en) | 1997-06-12 | 1998-12-17 | Temple University - Of The Commonwealth System Of Higher Education | Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof |
| US7186797B2 (en) * | 2001-08-10 | 2007-03-06 | Epix Pharmaceuticals, Inc. | Polypeptide conjugates with extended circulating half-lives |
| US7057062B2 (en) * | 2002-04-11 | 2006-06-06 | Isis Pharmaceuticals, Inc. | Process for manufacturing purified phosphorodiamidite |
| US7034177B2 (en) * | 2002-06-13 | 2006-04-25 | Rhodia Inc | Process of making phosphordiamidite compounds |
| AU2003208084A1 (en) * | 2002-07-30 | 2004-02-16 | Sankyo Co., Ltd | Phosmidosine derivative and process for producing the same |
| EP3366772A1 (de) | 2013-02-22 | 2018-08-29 | Sirna Therapeutics, Inc. | Moleküle von kurzer eingreifender nukleinsäure (sina) mit einer 2'-internukleosid-verbindung |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58421A (en) * | 1979-10-09 | 1984-01-31 | Yeda Res & Dev | Production of(2'-5')oligoisoadenylate and pharmaceutical compositions containing it |
| US4464359A (en) * | 1981-04-10 | 1984-08-07 | Research Corporation | (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof |
| GB2136435A (en) * | 1983-03-10 | 1984-09-19 | Julian Gordon | Specific anti-oligo (a) antibodies |
| US4824941A (en) * | 1983-03-10 | 1989-04-25 | Julian Gordon | Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems |
| US4859768A (en) * | 1984-07-11 | 1989-08-22 | Temple University Of The Commonwealth System Of Higher Education | Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof |
| US5550111A (en) * | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| FR2567892B1 (fr) * | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| IL76233A (en) * | 1985-08-28 | 1994-05-30 | Yeda Res & Dev | DNA molecules coding for an enyzme having (2'-5') oligo a synthetase activity, expression vectors comprising them, microorganisms transfected by thevectors, and amino acid sequences corresponding to the DNA molecules |
| DE3683335D1 (de) * | 1985-08-28 | 1992-02-20 | Yeda Res & Dev | Interferon-induziertes (2'-5')-oligo-a-synthetase-gen, mrna, cdna und enzyme mit (2'-5')-oligo-a-synthetase-aktivitaet. |
| US4924624A (en) * | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
| US5188897A (en) * | 1987-10-22 | 1993-02-23 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated 2',5'-phosphorothioate oligoadenylates |
| US5532130A (en) * | 1993-07-20 | 1996-07-02 | Dyad Pharmaceutical Corporation | Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides |
-
1995
- 1995-08-22 CA CA002199747A patent/CA2199747C/en not_active Expired - Fee Related
- 1995-08-22 NZ NZ291713A patent/NZ291713A/en unknown
- 1995-08-22 AU AU33329/95A patent/AU686005B2/en not_active Ceased
- 1995-08-22 AT AT95929637T patent/ATE232732T1/de not_active IP Right Cessation
- 1995-08-22 DE DE69529680T patent/DE69529680T2/de not_active Expired - Fee Related
- 1995-08-22 EP EP95929637A patent/EP0777485B1/de not_active Expired - Lifetime
- 1995-08-22 JP JP08510198A patent/JP3142574B2/ja not_active Expired - Fee Related
- 1995-08-22 WO PCT/US1995/010683 patent/WO1996008256A1/en not_active Ceased
- 1995-08-22 ES ES95929637T patent/ES2188667T3/es not_active Expired - Lifetime
-
1997
- 1997-01-08 US US08/780,244 patent/US5863905A/en not_active Expired - Lifetime
-
2000
- 2000-10-13 JP JP2000314512A patent/JP2001172185A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU686005B2 (en) | 1998-01-29 |
| DE69529680T2 (de) | 2003-08-14 |
| EP0777485B1 (de) | 2003-02-19 |
| ES2188667T3 (es) | 2003-07-01 |
| EP0777485A4 (de) | 1998-12-02 |
| JPH10502666A (ja) | 1998-03-10 |
| JP3142574B2 (ja) | 2001-03-07 |
| EP0777485A1 (de) | 1997-06-11 |
| AU3332995A (en) | 1996-03-29 |
| US5863905A (en) | 1999-01-26 |
| DE69529680D1 (de) | 2003-03-27 |
| NZ291713A (en) | 1998-01-26 |
| WO1996008256A1 (en) | 1996-03-21 |
| CA2199747A1 (en) | 1996-03-21 |
| CA2199747C (en) | 2003-05-27 |
| JP2001172185A (ja) | 2001-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |