ES2188667T3 - 2',5'-oligoadenilatos de fosforotioato/fosfodiester y sus usos antivirales. - Google Patents

2',5'-oligoadenilatos de fosforotioato/fosfodiester y sus usos antivirales.

Info

Publication number
ES2188667T3
ES2188667T3 ES95929637T ES95929637T ES2188667T3 ES 2188667 T3 ES2188667 T3 ES 2188667T3 ES 95929637 T ES95929637 T ES 95929637T ES 95929637 T ES95929637 T ES 95929637T ES 2188667 T3 ES2188667 T3 ES 2188667T3
Authority
ES
Spain
Prior art keywords
sub
phosfodiester
phosphorotioate
oligoadenylates
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95929637T
Other languages
English (en)
Inventor
Robert F Suhadolnik
Wolfgang Pfleiderer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Original Assignee
Temple Univ School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine
Application granted granted Critical
Publication of ES2188667T3 publication Critical patent/ES2188667T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/605—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the macromolecule containing phosphorus in the main chain, e.g. poly-phosphazene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

COMPUESTOS ANTIVIRALES ACTIVOS OPTICAMENTE QUE TIENEN LA FORMULA (I), EN LA QUE M ES 0,1,2,3; N Y Q SE SELECCIONAN A PARTIR DEL GRUPO DE 0 Y 1, DE FORMA QUE N Y Q NO PUEDEN SER AMBOS CERO; R, R{SUB,1} Y R{SUB,2} SON INDEPENDIENTEMENTE SELECCIONADOS A PARTIR DEL GRUPO INTEGRADO POR OXIGENO Y SULFURO, DE FORMA QUE R,R{SUB,1} Y R{SUB,2} NO PUEDEN SER TODOS OXIGENO, Y TAMPOCO SER TODOS SULFURO. LOS COMPUESTOS POSEEN UNA ACTIVIDAD ANTIVIRAL AUMENTADA Y/O ESTABILIDAD METABOLICA.
ES95929637T 1994-09-14 1995-08-22 2',5'-oligoadenilatos de fosforotioato/fosfodiester y sus usos antivirales. Expired - Lifetime ES2188667T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30627394A 1994-09-14 1994-09-14

Publications (1)

Publication Number Publication Date
ES2188667T3 true ES2188667T3 (es) 2003-07-01

Family

ID=23184567

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95929637T Expired - Lifetime ES2188667T3 (es) 1994-09-14 1995-08-22 2',5'-oligoadenilatos de fosforotioato/fosfodiester y sus usos antivirales.

Country Status (10)

Country Link
US (1) US5863905A (es)
EP (1) EP0777485B1 (es)
JP (2) JP3142574B2 (es)
AT (1) ATE232732T1 (es)
AU (1) AU686005B2 (es)
CA (1) CA2199747C (es)
DE (1) DE69529680T2 (es)
ES (1) ES2188667T3 (es)
NZ (1) NZ291713A (es)
WO (1) WO1996008256A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127446A1 (en) * 1992-05-14 2004-07-01 Lawrence Blatt Oligonucleotide mediated inhibition of hepatitis B virus and hepatitis C virus replication
US5587514A (en) * 1993-11-08 1996-12-24 Emory University Diastereoselective synthesis of hydroxyethylene dipeptide isosteres
WO1998056384A1 (en) 1997-06-12 1998-12-17 Temple University - Of The Commonwealth System Of Higher Education Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof
WO1998056385A1 (en) 1997-06-12 1998-12-17 Temple University - Of The Commonwealth System Of Higher Education Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof
US7186797B2 (en) * 2001-08-10 2007-03-06 Epix Pharmaceuticals, Inc. Polypeptide conjugates with extended circulating half-lives
US7057062B2 (en) * 2002-04-11 2006-06-06 Isis Pharmaceuticals, Inc. Process for manufacturing purified phosphorodiamidite
US7034177B2 (en) * 2002-06-13 2006-04-25 Rhodia Inc Process of making phosphordiamidite compounds
AU2003208084A1 (en) * 2002-07-30 2004-02-16 Sankyo Co., Ltd Phosmidosine derivative and process for producing the same
EP3366772A1 (en) 2013-02-22 2018-08-29 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58421A (en) * 1979-10-09 1984-01-31 Yeda Res & Dev Production of(2'-5')oligoisoadenylate and pharmaceutical compositions containing it
US4464359A (en) * 1981-04-10 1984-08-07 Research Corporation (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
GB2136435A (en) * 1983-03-10 1984-09-19 Julian Gordon Specific anti-oligo (a) antibodies
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4859768A (en) * 1984-07-11 1989-08-22 Temple University Of The Commonwealth System Of Higher Education Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
IL76233A (en) * 1985-08-28 1994-05-30 Yeda Res & Dev DNA molecules coding for an enyzme having (2'-5') oligo a synthetase activity, expression vectors comprising them, microorganisms transfected by thevectors, and amino acid sequences corresponding to the DNA molecules
DE3683335D1 (de) * 1985-08-28 1992-02-20 Yeda Res & Dev Interferon-induziertes (2'-5')-oligo-a-synthetase-gen, mrna, cdna und enzyme mit (2'-5')-oligo-a-synthetase-aktivitaet.
US4924624A (en) * 1987-10-22 1990-05-15 Temple University-Of The Commonwealth System Of Higher Education 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
US5188897A (en) * 1987-10-22 1993-02-23 Temple University Of The Commonwealth System Of Higher Education Encapsulated 2',5'-phosphorothioate oligoadenylates
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides

Also Published As

Publication number Publication date
AU686005B2 (en) 1998-01-29
DE69529680T2 (de) 2003-08-14
EP0777485B1 (en) 2003-02-19
EP0777485A4 (en) 1998-12-02
JPH10502666A (ja) 1998-03-10
JP3142574B2 (ja) 2001-03-07
EP0777485A1 (en) 1997-06-11
AU3332995A (en) 1996-03-29
ATE232732T1 (de) 2003-03-15
US5863905A (en) 1999-01-26
DE69529680D1 (de) 2003-03-27
NZ291713A (en) 1998-01-26
WO1996008256A1 (en) 1996-03-21
CA2199747A1 (en) 1996-03-21
CA2199747C (en) 2003-05-27
JP2001172185A (ja) 2001-06-26

Similar Documents

Publication Publication Date Title
DE69534502D1 (de) Arylthioverbindungen als antibakterielle und antivirale mittel
ES2159714T3 (es) Hidroximetil-imidazodiazepinas y sus esteres.
ES2172580T3 (es) 1,3-oxatiolanos sustituidos con propiedades antiviricas.
DE69116705D1 (de) Antiglancoma-Zusammensetzungen enthaltend 3-Arylcarbonyl-1-aminoalkyl-1H-indol
ES2188667T3 (es) 2',5'-oligoadenilatos de fosforotioato/fosfodiester y sus usos antivirales.
UY24010A1 (es) Nuevos pirrolocarbazoles
FI852806A0 (fi) 2-substituerade -1,3-propylidendifosfonatderivat och deras framstaellning.
NO931534L (no) Sulfonylbenzylsubstituerte benzo- og pyridopyridoner
DE3577433D1 (de) Herstellung optisch aktiver 1,3-dioxolan-4-methanol-verbindungen.
ATE79622T1 (de) 1,4-diazepine.
DE69130497D1 (de) Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
FI851261A0 (fi) Substituerade bensopyraner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
ATE224358T1 (de) Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung
ES2125537T3 (es) Arilbenzoilguanidinas.
ES2167510T3 (es) Agentes para mejorar el sueño.
FI812804L (fi) 2-(1,4-bensodioxan-2-ylalkyl)-imidazoler anvaendbara som antidepressiva laekemedel
ATE76405T1 (de) 2-trifluormethyl-benzimidazole.
GT199500039A (es) Compuestos ariltios
FR2424250A1 (fr) Esters methyl tetrahalogenobenzyliques, ainsi que leurs homo et copolymeres, et application de ceux-ci a l'ignifugation des matieres plastiques
DK671087A (da) Anvendelse af 5-aryl-3h-1,2,4-triazol-3-oner som antikonvulsiva
ES2135384T3 (es) Derivados de 1,4-dihidropiridina opticamente activos y procedimientos para producirlos.
IT1216931B (it) Elemento di fissaggio per trattenere l'elemento di applicazione del liquido di un applicatore di liquido come uno strumento per scrivere, uno strumento cosmetico e simili.
DK138388D0 (da) Isoquinolinderivater
ES2043778T3 (es) Procedimiento para preparar oxiindanos y tetrahidronaftalenos herbicidas.
DK702288D0 (da) Dihydropyranderivater