ES8605509A1 - Procedimiento para preparar derivados de bencilftalazinona sustituidos - Google Patents

Procedimiento para preparar derivados de bencilftalazinona sustituidos

Info

Publication number
ES8605509A1
ES8605509A1 ES546959A ES546959A ES8605509A1 ES 8605509 A1 ES8605509 A1 ES 8605509A1 ES 546959 A ES546959 A ES 546959A ES 546959 A ES546959 A ES 546959A ES 8605509 A1 ES8605509 A1 ES 8605509A1
Authority
ES
Spain
Prior art keywords
substituted benzyl
phthalazinone derivatives
group
phthalazinone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546959A
Other languages
English (en)
Other versions
ES546959A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke AG Chemische Fabrik filed Critical Asta Werke AG Chemische Fabrik
Publication of ES8605509A1 publication Critical patent/ES8605509A1/es
Publication of ES546959A0 publication Critical patent/ES546959A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE BENCILFTALAZINONA SUSTITUIDOS. CONSISTE EN: HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (RX), EN DISOLVENTES O DISPERSANTES COMO BENCENO, TOLUENO O DIMETILFUSLFOXIDOS, EN PRESENCIA DE KOH, NAOH O ACETATOS DE METALES ALCALINOS, Y ENTRE 20J Y 200JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE INOCUOS. SIENDO: R, BENCILO, FENILETILO, METOXIETILO O ALILO; Y X, UN GRUPO HIDROXI ESTERIFICADO POR CLH O ACIDO ARIL- O ALQUIL C 1 A 6 SULFONICO EN MEZCLAS DIMETILFORMAMIDA/AGUA O DIOXANO/AGUA. SE UTILIZAN COMO ANTIALERGICOS Y PROFILACTICOS CONTRA EL ASMA.
ES546959A 1984-09-14 1985-09-13 Procedimiento para preparar derivados de bencilftalazinona sustituidos Expired ES8605509A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3433776 1984-09-14

Publications (2)

Publication Number Publication Date
ES8605509A1 true ES8605509A1 (es) 1986-03-16
ES546959A0 ES546959A0 (es) 1986-03-16

Family

ID=6245402

Family Applications (2)

Application Number Title Priority Date Filing Date
ES546959A Expired ES8605509A1 (es) 1984-09-14 1985-09-13 Procedimiento para preparar derivados de bencilftalazinona sustituidos
ES546971A Expired ES8605510A1 (es) 1984-09-14 1985-09-13 Procedimiento para preparar derivados de bencilftalazinona sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES546971A Expired ES8605510A1 (es) 1984-09-14 1985-09-13 Procedimiento para preparar derivados de bencilftalazinona sustituidos

Country Status (16)

Country Link
US (1) US4704387A (es)
EP (1) EP0174464B1 (es)
JP (1) JPH0699425B2 (es)
AT (1) ATE49205T1 (es)
CA (1) CA1263652A (es)
DD (1) DD240205A5 (es)
DE (1) DE3575135D1 (es)
DK (1) DK167118B1 (es)
ES (2) ES8605509A1 (es)
GR (1) GR852219B (es)
HU (1) HU197740B (es)
IE (1) IE64839B1 (es)
IL (1) IL75989A0 (es)
MX (1) MX159034A (es)
PT (1) PT81122B (es)
ZA (1) ZA856524B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222191B1 (de) * 1985-11-11 1991-01-30 ASTA Pharma AG 4-Benzyl-1-(2H)-phthalazinon-Derivate
EP0289939A1 (de) * 1987-05-08 1988-11-09 ASTA Pharma AG Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
ES2053678T3 (es) * 1987-11-13 1994-08-01 Asta Medica Ag Procedimiento para preparar un medicamento con contenido de azelastina para la aplicacion nasal y/u ocular.
US5232919A (en) * 1987-11-13 1993-08-03 Asta Pharma Aktiengesellschaft Azelastine embonate and compositions which contain it
MC2025A1 (fr) * 1988-04-20 1990-04-25 Asta Pharma Ag Medicament contenant de l'azelastine et capable de liberer celle-ci de facon controlee
US5271946A (en) * 1988-04-20 1993-12-21 Asta Pharma Aktiengesellschaft Controlled release azelastine-containing pharmaceutical compositions
DE59006184D1 (de) * 1989-05-05 1994-07-28 Asta Medica Ag Salze des Azelastins mit verbesserter Löslichkeit.
JPH04198180A (ja) * 1990-11-28 1992-07-17 Eezai Kagaku Kk ベンジルフタラゾン誘導体の製造方法
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
ES2704482T3 (es) 2004-11-24 2019-03-18 Meda Pharmaceuticals Inc Composiciones que comprenden azelastina y sus métodos de uso
TW200811116A (en) * 2006-04-20 2008-03-01 Glaxo Group Ltd Compounds
US20100216799A1 (en) * 2007-10-11 2010-08-26 Glaxo Group Limited Phthalazine and pyrido[3,4-d]pyridazine compounds as h1 receptor antagonists
EP3061501A1 (en) 2015-02-27 2016-08-31 Rottapharm Ltd. Composition for the treatment of acne
EP3117825A1 (en) 2015-07-16 2017-01-18 Rottapharm S.p.A. Oral formulation comprising berberine and morus alba extract

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
CH572914A5 (es) * 1971-01-22 1976-02-27 Asta Werke Ag Chem Fab
DE2114884A1 (de) * 1971-03-27 1972-10-12 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Basisch substituierte Derivate des 1(2H)-Phthalazinons
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
US4665181A (en) * 1984-05-17 1987-05-12 Pennwalt Corporation Anti-inflammatory phthalazinones

Also Published As

Publication number Publication date
CA1263652A (en) 1989-12-05
DD240205A5 (de) 1986-10-22
EP0174464B1 (de) 1990-01-03
JPH0699425B2 (ja) 1994-12-07
DK167118B1 (da) 1993-08-30
JPS6172782A (ja) 1986-04-14
IE64839B1 (en) 1995-09-06
DK416585D0 (da) 1985-09-13
HUT38340A (en) 1986-05-28
EP0174464A3 (en) 1986-12-30
DK416585A (da) 1986-03-15
DE3575135D1 (de) 1990-02-08
IL75989A0 (en) 1985-12-31
HU197740B (en) 1989-05-29
ZA856524B (en) 1986-04-30
PT81122B (pt) 1988-01-22
GR852219B (es) 1986-01-14
ES8605510A1 (es) 1986-03-16
ES546971A0 (es) 1986-03-16
ATE49205T1 (de) 1990-01-15
EP0174464A2 (de) 1986-03-19
US4704387A (en) 1987-11-03
ES546959A0 (es) 1986-03-16
PT81122A (de) 1985-10-01
IE852270L (en) 1986-03-14
MX159034A (es) 1989-04-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301