ES8702387A1 - Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas - Google Patents
Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidasInfo
- Publication number
- ES8702387A1 ES8702387A1 ES544708A ES544708A ES8702387A1 ES 8702387 A1 ES8702387 A1 ES 8702387A1 ES 544708 A ES544708 A ES 544708A ES 544708 A ES544708 A ES 544708A ES 8702387 A1 ES8702387 A1 ES 8702387A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- thiazines
- substituted dihydro
- aroyl substituted
- alkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PREPARACION DE DIHIDRO-1,4-TIAZINAS AROIL SUSTITUIDAS, DE FORMULA (I), DONDE AR ES PIRIDILO, FENILO SUSTITUIDO O NO CON HALOGENOS, HALO-ALQUILO DE 1-4C, ALCOXI DE 1-4C O CARBOXI-ALQUILO DE 1-4C, N ES 0, 1 O 2, R1 ES H, ALQUILO O AMINOALQUILO DE 2-4C Y R2 ES H, CARBOXI-ALQUILO DE 1-4C O ALCOXI-(1-4C)-CARBONILO-ALQUILO DE 1-4C, Y SUS SALES. SE PREPARAN POR CICLACION DE UN COMPUESTO DE FORMULA (II), DONDE AR ESTA YA DEFINIDO, RA Y RB SON ALQUILOS DE 1-4C, R2K Y R2L SON H O H Y CARBOXI-ALQUILO DE 1-4C O ALCOXI-(1-4C)CARBONIL-ALQUILO DE 1-4C, O POR CONDENSACION DE UN COMPUESTO (III), DONDE AR, RA Y RB YA SE HAN DEFINIDO, CON UN COMPUESTO (IV), DONDE HAL ES CL, BR O I Y R2K Y R2L YA ESTAN DEFINIDOS. SE EMPLEAN COMO ANTIRREUMATICOS DE ADMINISTRACION ENTERAL, PARENTERAL O LOCAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/625,946 US4622322A (en) | 1984-06-29 | 1984-06-29 | Aroyl substituted dihydro-1,4-thiazines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES544708A0 ES544708A0 (es) | 1986-12-01 |
ES8702387A1 true ES8702387A1 (es) | 1986-12-01 |
Family
ID=24508300
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544708A Expired ES8702387A1 (es) | 1984-06-29 | 1985-06-28 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555463A Expired ES8707213A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555464A Expired ES8707214A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555462A Expired ES8707212A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555461A Expired ES8802452A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555465A Expired ES8707215A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555463A Expired ES8707213A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555464A Expired ES8707214A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555462A Expired ES8707212A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555461A Expired ES8802452A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
ES555465A Expired ES8707215A1 (es) | 1984-06-29 | 1986-05-29 | Procedimiento para preparar dihidro-1,4-tiazinas aroil-sustituidas |
Country Status (14)
Country | Link |
---|---|
US (1) | US4622322A (es) |
EP (1) | EP0166697B1 (es) |
JP (1) | JPS6118776A (es) |
AT (1) | ATE52504T1 (es) |
AU (1) | AU590200B2 (es) |
CA (1) | CA1279870C (es) |
DE (1) | DE3577556D1 (es) |
DK (1) | DK293885A (es) |
ES (6) | ES8702387A1 (es) |
FI (1) | FI84177C (es) |
NO (1) | NO166125C (es) |
NZ (1) | NZ212585A (es) |
PT (1) | PT80720B (es) |
ZA (1) | ZA854904B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5349108A (en) * | 1989-08-09 | 1994-09-20 | Sumitomo Chemical Company, Limited | 5-substituted-2,4-diphenylpyrimidine derivatives, their production and use |
US5403948A (en) * | 1989-08-09 | 1995-04-04 | Sumitomo Chemical Company, Limited | 5-substituted-2,4-diphenylpyrimidine derivatives, their production and use |
US5216130A (en) * | 1990-05-17 | 1993-06-01 | Albany Medical College | Complex for in-vivo target localization |
JP3497726B2 (ja) | 1998-03-26 | 2004-02-16 | 本田技研工業株式会社 | シートベルトのタング掛け機構 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL146026B (nl) * | 1963-08-22 | 1975-06-16 | Monsanto Co | Werkwijze voor het bereiden van een preparaat met herbicide werking, gevormde preparaten en werkwijze voor het bereiden van een verbinding met herbicide werking. |
BE792042A (fr) * | 1971-11-30 | 1973-05-29 | Ciba Geigy | Procede de preparation de nouvelles alcenylene-amines substituees en 3 |
GB2089796B (en) * | 1980-12-19 | 1984-07-18 | Wyeth John & Brother Ltd | Thiomorpholine derivatives |
US4427676A (en) * | 1980-12-19 | 1984-01-24 | John Wyeth & Brother Ltd. | Thiomorpholine derivatives |
FR2525106B1 (fr) * | 1982-04-15 | 1985-06-07 | Oreal | Composition cosmetique contenant en tant qu'agent actif sur l'elasticite et la souplesse de la peau, de la thiamorpholinone ou l'un de ses derives |
-
1984
- 1984-06-29 US US06/625,946 patent/US4622322A/en not_active Expired - Fee Related
-
1985
- 1985-01-28 NZ NZ212585A patent/NZ212585A/xx unknown
- 1985-06-24 DE DE8585810293T patent/DE3577556D1/de not_active Expired - Lifetime
- 1985-06-24 AT AT85810293T patent/ATE52504T1/de not_active IP Right Cessation
- 1985-06-24 EP EP85810293A patent/EP0166697B1/en not_active Expired - Lifetime
- 1985-06-26 FI FI852528A patent/FI84177C/fi not_active IP Right Cessation
- 1985-06-27 PT PT80720A patent/PT80720B/pt not_active IP Right Cessation
- 1985-06-27 CA CA000485478A patent/CA1279870C/en not_active Expired - Lifetime
- 1985-06-28 JP JP60140650A patent/JPS6118776A/ja active Pending
- 1985-06-28 DK DK293885A patent/DK293885A/da not_active Application Discontinuation
- 1985-06-28 NO NO852618A patent/NO166125C/no unknown
- 1985-06-28 AU AU44409/85A patent/AU590200B2/en not_active Ceased
- 1985-06-28 ES ES544708A patent/ES8702387A1/es not_active Expired
- 1985-06-28 ZA ZA854904A patent/ZA854904B/xx unknown
-
1986
- 1986-05-29 ES ES555463A patent/ES8707213A1/es not_active Expired
- 1986-05-29 ES ES555464A patent/ES8707214A1/es not_active Expired
- 1986-05-29 ES ES555462A patent/ES8707212A1/es not_active Expired
- 1986-05-29 ES ES555461A patent/ES8802452A1/es not_active Expired
- 1986-05-29 ES ES555465A patent/ES8707215A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0166697A3 (en) | 1986-03-26 |
ES555465A0 (es) | 1987-07-16 |
ES544708A0 (es) | 1986-12-01 |
ES555461A0 (es) | 1988-06-01 |
ES555463A0 (es) | 1987-07-16 |
ES8707212A1 (es) | 1987-07-16 |
FI84177B (fi) | 1991-07-15 |
AU590200B2 (en) | 1989-11-02 |
ES555464A0 (es) | 1987-07-16 |
ES8802452A1 (es) | 1988-06-01 |
EP0166697B1 (en) | 1990-05-09 |
NO166125C (no) | 1991-06-12 |
ES8707213A1 (es) | 1987-07-16 |
NZ212585A (en) | 1988-09-29 |
PT80720B (en) | 1987-04-23 |
FI852528A0 (fi) | 1985-06-26 |
ATE52504T1 (de) | 1990-05-15 |
US4622322A (en) | 1986-11-11 |
ES8707215A1 (es) | 1987-07-16 |
DE3577556D1 (de) | 1990-06-13 |
ES8707214A1 (es) | 1987-07-16 |
PT80720A (en) | 1985-07-01 |
ZA854904B (en) | 1986-02-26 |
FI852528L (fi) | 1985-12-30 |
NO166125B (no) | 1991-02-25 |
DK293885A (da) | 1985-12-30 |
NO852618L (no) | 1985-12-30 |
DK293885D0 (da) | 1985-06-28 |
EP0166697A2 (en) | 1986-01-02 |
FI84177C (fi) | 1991-10-25 |
JPS6118776A (ja) | 1986-01-27 |
AU4440985A (en) | 1986-01-30 |
CA1279870C (en) | 1991-02-05 |
ES555462A0 (es) | 1987-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |