US3935223A
(en)
*
|
1972-03-06 |
1976-01-27 |
Bayer Aktiengesellschaft |
2-Amino-1,4-dihydropyridine derivatives
|
DD106832A5
(xx)
*
|
1972-03-06 |
1974-07-05 |
|
|
US3919246A
(en)
*
|
1972-03-06 |
1975-11-11 |
Bayer Ag |
Process for preparing 2-amino-1,4-dihydropyridine derivates
|
US3917619A
(en)
*
|
1972-03-06 |
1975-11-04 |
Bayer Ag |
2-Amino-4,5-dihydropyridine derivatives
|
US3917622A
(en)
*
|
1972-03-06 |
1975-11-04 |
Bayer Ag |
2-Amino-1,4-dihydropyridine derivatives
|
DE2210674C3
(de)
*
|
1972-03-06 |
1981-09-24 |
Bayer Ag, 5090 Leverkusen |
2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
|
US4001258A
(en)
*
|
1972-03-06 |
1977-01-04 |
Bayer Aktiengesellschaft |
2-amino-1,4-dihydropyridine derivatives
|
DE2218644C3
(de)
*
|
1972-04-18 |
1982-08-19 |
Bayer Ag, 5090 Leverkusen |
Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
|
DE2242786A1
(de)
*
|
1972-08-31 |
1974-03-14 |
Bayer Ag |
Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
|
US3989708A
(en)
*
|
1972-08-31 |
1976-11-02 |
Bayer Aktiengesellschaft |
2-Amino-1,4-dihydropyridine derivatives
|
DE2248150A1
(de)
*
|
1972-09-30 |
1974-04-04 |
Bayer Ag |
Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
GB1409865A
(en)
*
|
1973-02-13 |
1975-10-15 |
Science Union & Cie |
Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
|
CH607848A5
(xx)
*
|
1974-06-04 |
1978-11-30 |
Bayer Ag |
|
DE2508181A1
(de)
*
|
1975-02-26 |
1976-09-09 |
Bayer Ag |
1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
FR2320750A1
(fr)
*
|
1975-08-12 |
1977-03-11 |
Hexachimie |
Dihydro-1,4 pyridines et leur application therapeutique
|
US4154839A
(en)
*
|
1975-11-05 |
1979-05-15 |
Bayer Aktiengesellschaft |
2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
|
DE2549568C3
(de)
*
|
1975-11-05 |
1981-10-29 |
Bayer Ag, 5090 Leverkusen |
2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
|
DE2650013C3
(de)
*
|
1976-10-30 |
1981-04-02 |
Bayer Ag, 5090 Leverkusen |
1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
|
DE2658183A1
(de)
*
|
1976-12-22 |
1978-07-06 |
Bayer Ag |
In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
GB1579818A
(en)
*
|
1977-06-07 |
1980-11-26 |
Yamanouchi Pharma Co Ltd |
Nifedipine-containing solid preparation composition
|
JPS55301A
(en)
*
|
1978-02-14 |
1980-01-05 |
Yamanouchi Pharmaceut Co Ltd |
1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
|
DE2815578C2
(de)
*
|
1978-04-11 |
1986-01-16 |
Bayer Ag, 5090 Leverkusen |
Neue pharmazeutische Verwendung von Nimodipin
|
SE429652B
(sv)
*
|
1978-06-30 |
1983-09-19 |
Haessle Ab |
2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
|
DE2837477A1
(de)
*
|
1978-08-28 |
1980-03-13 |
Bayer Ag |
Sila-substituierte 1,4-dihydropyridin- derivate
|
DE2841667A1
(de)
*
|
1978-09-25 |
1980-04-10 |
Bayer Ag |
Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
DE2949464A1
(de)
*
|
1978-12-18 |
1980-06-26 |
Sandoz Ag |
Benzoxadiazole und benzothiadiazole, ihre herstellung und verwendung
|
DE2927933A1
(de)
*
|
1979-07-11 |
1981-02-05 |
Hoechst Ag |
Acetylacetoxyalkyl-allyl-ether, ihre herstellung und verwendung
|
DE2935451A1
(de)
*
|
1979-09-01 |
1981-03-19 |
Bayer Ag, 5090 Leverkusen |
Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
|
DE3023820A1
(de)
*
|
1980-06-25 |
1982-01-14 |
Bayer Ag, 5090 Leverkusen |
4,4-disubstituierte spiro-1,4-dihydropyridine, ein verfahren zu ihrer herstellung, sowie ihre verwendung als zwischenprodukt
|
DE3042769A1
(de)
*
|
1980-11-13 |
1982-06-09 |
Bayer Ag, 5090 Leverkusen |
C-3 verknuepfte 1,4-dihydropyridine, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
|
US4365063A
(en)
*
|
1981-08-31 |
1982-12-21 |
American Home Products Corporation |
Antihypertensive agents
|
US4321384A
(en)
*
|
1981-02-27 |
1982-03-23 |
American Home Products Corporation |
Antihypertensive agents
|
DE3130041A1
(de)
*
|
1981-07-30 |
1983-02-17 |
Bayer Ag, 5090 Leverkusen |
Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
|
NZ201395A
(en)
*
|
1981-07-30 |
1987-02-20 |
Bayer Ag |
Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
|
MX7567E
(es)
*
|
1981-12-23 |
1989-10-27 |
Yamanouchi Pharma Co Ltd |
Procedimiento para recubrir nicardipina de accion prolongada
|
JPS58159490A
(ja)
*
|
1982-02-23 |
1983-09-21 |
Nikken Kagaku Kk |
1,4−ジヒドロピリジン化合物
|
DE3208628A1
(de)
*
|
1982-03-10 |
1983-09-22 |
Bayer Ag, 5090 Leverkusen |
Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
DE3212736A1
(de)
*
|
1982-04-06 |
1983-10-13 |
Bayer Ag, 5090 Leverkusen |
Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
|
DE3222367A1
(de)
*
|
1982-06-15 |
1983-12-15 |
Bayer Ag, 5090 Leverkusen |
Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
|
US4656181A
(en)
*
|
1982-11-24 |
1987-04-07 |
Cermol S.A. |
Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
|
DE3248548A1
(de)
*
|
1982-12-29 |
1984-07-05 |
Heinrich Mack Nachf., 7918 Illertissen |
Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
|
DE3316510A1
(de)
*
|
1983-05-06 |
1984-11-08 |
Bayer Ag |
Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
|
GB8314744D0
(en)
*
|
1983-05-27 |
1983-07-06 |
Fujisawa Pharmaceutical Co |
2 6-disubstituted-1 4-dihydropyridine derivative
|
IE57810B1
(en)
*
|
1984-03-27 |
1993-04-21 |
Delagrange Lab |
1,4-dihydropyridine derivatives,their preparation and their use
|
US4794111A
(en)
*
|
1984-05-23 |
1988-12-27 |
Bayer Aktiengesellschaft |
Dihydropyridine preparations containing β-blockers
|
DE3419128A1
(de)
*
|
1984-05-23 |
1985-11-28 |
Bayer Ag, 5090 Leverkusen |
Dihydropyridinpraeparate und verfahren zu ihrer herstellung
|
DE3419131A1
(de)
*
|
1984-05-23 |
1985-11-28 |
Bayer Ag, 5090 Leverkusen |
Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung
|
US4757071A
(en)
*
|
1984-12-14 |
1988-07-12 |
Nisshin Flour Milling Co., Ltd. |
1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
|
DE3542794A1
(de)
*
|
1985-12-04 |
1987-06-11 |
Bayer Ag |
Antihypertensives kombinationspraeparat
|
US4771057A
(en)
*
|
1986-02-03 |
1988-09-13 |
University Of Alberta |
Reduced pyridyl derivatives with cardiovascular regulating properties
|
US4758669A
(en)
*
|
1986-05-05 |
1988-07-19 |
Radiation Oncology Center Research And Development Corporation |
4-(nitrone aryl) dihydropyridines
|
EP0311053A3
(en)
*
|
1987-10-06 |
1991-05-08 |
Banyu Pharmaceutical Co., Ltd. |
Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
|
DE3741540A1
(de)
*
|
1987-12-08 |
1989-06-22 |
Bayer Ag |
Verfahren zur herstellung von unsymmetrischen dihydropyridinen
|
US5571827A
(en)
*
|
1990-03-13 |
1996-11-05 |
Sepracor Inc. |
Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
|
US5204472A
(en)
*
|
1990-04-06 |
1993-04-20 |
Bayer Aktiengesellschaft |
Quinoline and isoquinoline intermediates
|
DE4011105A1
(de)
*
|
1990-04-06 |
1991-10-10 |
Bayer Ag |
Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
|
JPH0458703A
(ja)
*
|
1990-06-25 |
1992-02-25 |
Mitsubishi Electric Corp |
引出形遮断器の導体固定装置
|
DE4134760A1
(de)
*
|
1991-10-22 |
1993-07-08 |
Bayer Ag |
Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
|
US6735990B1
(en)
*
|
1992-01-24 |
2004-05-18 |
Acco Brands, Inc. |
Computer physical security device
|
WO1994007476A1
(en)
*
|
1992-10-06 |
1994-04-14 |
Sepracor, Inc. |
Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
|
US6001857A
(en)
*
|
1992-10-30 |
1999-12-14 |
Bayer Aktiengesellschaft |
Heterocyclyl substituted dihydropyridines
|
DE4236707A1
(de)
*
|
1992-10-30 |
1994-05-05 |
Bayer Ag |
4-Heterocyclyl substituierte Dihydropyridine
|
SE9303657D0
(sv)
*
|
1993-11-05 |
1993-11-05 |
Astra Ab |
Short-acting dihydropyridines
|
DE59410255D1
(de)
*
|
1993-12-10 |
2003-04-17 |
Bayer Ag |
Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität
|
TW483763B
(en)
*
|
1994-09-02 |
2002-04-21 |
Astra Ab |
Pharmaceutical composition comprising of ramipril and dihydropyridine compound
|
WO1997027177A2
(en)
*
|
1996-01-29 |
1997-07-31 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists
|
DE19727350C1
(de)
*
|
1997-06-27 |
1999-01-21 |
Bayer Ag |
Verfahren zur Herstellung von Nifedipin
|
WO1999025347A2
(en)
|
1997-11-14 |
1999-05-27 |
Neurosearch A/S |
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
|
KR100756565B1
(ko)
*
|
2000-04-11 |
2007-09-07 |
상꾜 가부시키가이샤 |
칼슘 채널 블록커를 함유하는 안정화된 약제 조성물
|
US6653481B2
(en)
*
|
2000-12-29 |
2003-11-25 |
Synthon Bv |
Process for making amlodipine
|
MXPA05001958A
(es)
|
2002-08-19 |
2005-04-28 |
Pfizer Prod Inc |
Terapia de combinacion para enfermedades hiperproliferativas.
|
US20050037063A1
(en)
*
|
2003-07-21 |
2005-02-17 |
Bolton Anthony E. |
Combined therapies
|
CN101090714A
(zh)
*
|
2004-07-26 |
2007-12-19 |
康泽里克斯公司 |
通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
|
US20060063803A1
(en)
*
|
2004-09-23 |
2006-03-23 |
Pfizer Inc |
4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
ATE551059T1
(de)
|
2005-10-26 |
2012-04-15 |
Asahi Kasei Pharma Corp |
Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
|
EP2351569B1
(en)
|
2005-10-26 |
2012-08-22 |
Asahi Kasei Pharma Corporation |
Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
TW200736245A
(en)
*
|
2005-11-29 |
2007-10-01 |
Sankyo Co |
Acid addition salts of optically active dihydropyridine derivatives
|
TW200806648A
(en)
*
|
2005-11-29 |
2008-02-01 |
Sankyo Co |
Acid addition salts of dihydropyridine derivatives
|
CN101663262B
(zh)
|
2006-12-01 |
2014-03-26 |
百时美施贵宝公司 |
用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
|
DK2170930T3
(da)
|
2007-06-04 |
2012-11-05 |
Synergy Pharmaceuticals Inc |
Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
JP2011522828A
(ja)
|
2008-06-04 |
2011-08-04 |
シナジー ファーマシューティカルズ インコーポレイテッド |
胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
WO2012037665A1
(en)
|
2010-09-24 |
2012-03-29 |
Oral Delivery Technology Ltd. |
Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
|
US9399019B2
(en)
|
2012-05-09 |
2016-07-26 |
Evonik Corporation |
Polymorph compositions, methods of making, and uses thereof
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
CN105143203A
(zh)
|
2013-04-17 |
2015-12-09 |
辉瑞大药厂 |
用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
|
KR102272746B1
(ko)
|
2013-06-05 |
2021-07-08 |
보슈 헬스 아일랜드 리미티드 |
구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
CA3040914A1
(en)
|
2016-11-03 |
2018-05-24 |
Juno Therapeutics, Inc. |
Combination therapy of a cell based therapy and a microglia inhibitor
|
US11413310B2
(en)
|
2017-06-02 |
2022-08-16 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods for treatment using adoptive cell therapy
|
EP3631468A1
(en)
|
2017-06-02 |
2020-04-08 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods related to toxicity associated with cell therapy
|
MA50057A
(fr)
|
2017-09-01 |
2020-07-08 |
Juno Therapeutics Inc |
Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire
|
US11564946B2
(en)
|
2017-11-01 |
2023-01-31 |
Juno Therapeutics, Inc. |
Methods associated with tumor burden for assessing response to a cell therapy
|
US20220088070A1
(en)
|
2018-11-30 |
2022-03-24 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
EP3886894B1
(en)
|
2018-11-30 |
2024-03-13 |
Juno Therapeutics, Inc. |
Methods for dosing and treatment of b cell malignancies in adoptive cell therapy
|
CN113574055B
(zh)
|
2019-01-18 |
2024-07-23 |
阿斯利康(瑞典)有限公司 |
Pcsk9抑制剂及其使用方法
|
MX2022006715A
(es)
|
2019-12-06 |
2022-09-23 |
Juno Therapeutics Inc |
Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b.
|