WO1994004494A1
(en)
*
|
1992-08-13 |
1994-03-03 |
Warner-Lambert Company |
Tachykinin antagonists
|
US5420297A
(en)
*
|
1990-10-24 |
1995-05-30 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptides having substance P antagonistic activity
|
US5610140A
(en)
*
|
1991-04-01 |
1997-03-11 |
Cortech, Inc. |
Bradykinin receptor antagonists with neurokinin receptor blocking activity
|
US5472978A
(en)
*
|
1991-07-05 |
1995-12-05 |
Merck Sharp & Dohme Ltd. |
Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
|
US5654400A
(en)
*
|
1991-10-04 |
1997-08-05 |
Fujisawa Pharmaceutical Co., Ltd. |
Process for making peptide compounds having tachykinin antagonistic activity
|
ATE161821T1
(de)
*
|
1991-11-12 |
1998-01-15 |
Pfizer |
Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten
|
GB9200535D0
(en)
*
|
1992-01-10 |
1992-02-26 |
Fujisawa Pharmaceutical Co |
New compound
|
HUT70475A
(en)
*
|
1992-09-03 |
1995-10-30 |
Boehringer Ingelheim Kg |
New aminoacid derivates, process for producing the same and pharmaceutical compositions containing these compounds
|
DE4243496A1
(de)
*
|
1992-09-03 |
1994-03-10 |
Boehringer Ingelheim Kg |
Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
|
FR2700472B1
(fr)
|
1993-01-19 |
1995-02-17 |
Rhone Poulenc Rorer Sa |
Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
|
WO1994020126A1
(en)
*
|
1993-03-03 |
1994-09-15 |
Fujisawa Pharmaceutical Co., Ltd. |
Use of peptides for the manufacture of a medicament
|
WO1995000536A1
(en)
*
|
1993-06-22 |
1995-01-05 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compounds
|
KR960703621A
(ko)
*
|
1993-08-10 |
1996-08-31 |
후지야마 아키라 |
경피흡수 제제(Percutaneously absorbable preparation)
|
JP3971454B2
(ja)
*
|
1993-10-29 |
2007-09-05 |
ザ トラスティーズ オブ ボストン ユニバーシティ |
抗新生物剤としての酪酸、酪酸塩、および誘導体の生理学的に安定な組成物
|
US6403577B1
(en)
|
1993-11-17 |
2002-06-11 |
Eli Lilly And Company |
Hexamethyleneiminyl tachykinin receptor antagonists
|
ITFI940009A1
(it)
*
|
1994-01-19 |
1995-07-19 |
Menarini Farma Ind |
Antagonisti delle tachichinine, loro preparazione e formulazioni farmaceutiche che li contengono.
|
DE69519182T2
(de)
*
|
1994-03-17 |
2001-05-17 |
Fujirebio Inc., Tokio/Tokyo |
Azapeptid-Derivate
|
FR2719312B1
(fr)
*
|
1994-04-28 |
1996-06-14 |
Adir |
Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
|
CA2189764A1
(en)
*
|
1994-05-07 |
1995-11-16 |
Gerd Schnorrenberg |
Neurokinine (tachykinine) antagonists
|
FR2728169A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
|
FR2728165A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
|
FR2728166A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Composition topique contenant un antagoniste de substance p
|
US5966295A
(en)
*
|
1994-12-27 |
1999-10-12 |
Autonics Corporation |
Convertible flush or exposure type terminal board of control device
|
FR2741262B1
(fr)
|
1995-11-20 |
1999-03-05 |
Oreal |
Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
|
GB9700597D0
(en)
*
|
1997-01-14 |
1997-03-05 |
Sandoz Pharma Uk |
Organic compounds
|
CA2287487A1
(en)
*
|
1997-04-24 |
1998-10-29 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating eating disorders
|
US6903075B1
(en)
|
1997-05-29 |
2005-06-07 |
Merck & Co., Inc. |
Heterocyclic amide compounds as cell adhesion inhibitors
|
CA2291778A1
(en)
*
|
1997-05-29 |
1998-12-03 |
Merck & Co., Inc. |
Heterocyclic amide compounds as cell adhesion inhibitors
|
WO1999007375A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
AU738047B2
(en)
*
|
1997-08-04 |
2001-09-06 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating mania
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6441131B1
(en)
*
|
1997-12-22 |
2002-08-27 |
Ono Pharmaceutical Co., Ltd. |
Peptides, method for assaying human pepsinogen II or human pepsin II, and assaying kit
|
CA2324426A1
(en)
*
|
1998-02-11 |
1999-08-19 |
Douglas V. Faller |
Compositions and methods for the treatment of cystic fibrosis
|
WO1999064395A1
(en)
*
|
1998-06-11 |
1999-12-16 |
Merck & Co., Inc. |
Heterocyclic amide compounds as cell adhesion inhibitors
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
US6307049B1
(en)
|
1998-09-30 |
2001-10-23 |
The Procter & Gamble Co. |
Heterocyclic 2-substituted ketoamides
|
US6300341B1
(en)
|
1998-09-30 |
2001-10-09 |
The Procter & Gamble Co. |
2-substituted heterocyclic sulfonamides
|
AU2180600A
(en)
*
|
1998-12-18 |
2000-07-12 |
Warner-Lambert Company |
Non-peptide nk1 receptors antagonists
|
EP1158996A4
(en)
|
1999-02-18 |
2005-01-12 |
Kaken Pharma Co Ltd |
NEW AMID DERIVATIVES AS GROWTH HORMONE SECRETION CONVEYORS
|
AU781179B2
(en)
|
1999-11-03 |
2005-05-12 |
Albany Molecular Research, Inc. |
Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
US7084152B2
(en)
|
2000-07-11 |
2006-08-01 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
|
KR100960802B1
(ko)
|
2003-03-08 |
2010-06-01 |
주식회사유한양행 |
씨형 간염바이러스 감염 치료용 엔에스3 프로테아제 억제제
|
AR047793A1
(es)
*
|
2004-01-30 |
2006-02-22 |
Medivir Ab |
Inhibidores de la serina proteasa ns-3 del vhc
|
EP1778639B1
(en)
|
2004-07-15 |
2015-09-02 |
Albany Molecular Research, Inc. |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
KR20080044840A
(ko)
|
2005-07-15 |
2008-05-21 |
에이엠알 테크놀로지, 인크. |
아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
AU2008204380B2
(en)
|
2007-01-10 |
2013-08-15 |
Msd Italia S.R.L. |
Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
|
WO2008090114A1
(en)
|
2007-01-24 |
2008-07-31 |
Glaxo Group Limited |
Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
|
EP2170076B1
(en)
|
2007-06-27 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
AR071997A1
(es)
|
2008-06-04 |
2010-07-28 |
Bristol Myers Squibb Co |
Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
UA105182C2
(ru)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
|
WO2010105112A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Hemaquest Pharmaceuticals, Inc. |
Detection of short-chain fatty acids in biological samples
|
RU2011141794A
(ru)
|
2009-03-17 |
2013-04-27 |
Дайити Санкио Компани, Лимитед |
Амидное производное
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
KR101830447B1
(ko)
|
2009-05-12 |
2018-02-20 |
알바니 몰레큘라 리써치, 인크. |
7-([1,2,4]트리아졸로[1,5-α]피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
|
CN102638982B
(zh)
|
2009-05-12 |
2015-07-08 |
百时美施贵宝公司 |
(S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
|
MX2011011901A
(es)
|
2009-05-12 |
2012-01-20 |
Albany Molecular Res Inc |
Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
|
WO2011038224A1
(en)
|
2009-09-24 |
2011-03-31 |
Trustees Of Boston University |
Methods for treating viral disorders
|
MX2012004377A
(es)
|
2009-10-14 |
2012-06-01 |
Merck Sharp & Dohme |
Piperidinas sustituidas que aumentan la actividad de p53 y sus usos.
|
CN102802412A
(zh)
|
2009-12-08 |
2012-11-28 |
海玛奎斯特医药公司 |
用于治疗红细胞病症的方法及低剂量方案
|
US20110245154A1
(en)
|
2010-03-11 |
2011-10-06 |
Hemaquest Pharmaceuticals, Inc. |
Methods and Compositions for Treating Viral or Virally-Induced Conditions
|
EP3330377A1
(en)
|
2010-08-02 |
2018-06-06 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
|
EP2606134B1
(en)
|
2010-08-17 |
2019-04-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
EP2613782B1
(en)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
EP2615916B1
(en)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel erk inhibitors
|
ES2663009T3
(es)
|
2010-10-29 |
2018-04-10 |
Sirna Therapeutics, Inc. |
Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
CN103732592A
(zh)
|
2011-04-21 |
2014-04-16 |
默沙东公司 |
胰岛素样生长因子-1受体抑制剂
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
EP3919620A1
(en)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
RU2660429C2
(ru)
|
2012-09-28 |
2018-07-06 |
Мерк Шарп И Доум Корп. |
Новые соединения, которые являются ингибиторами erk
|
JP6290237B2
(ja)
|
2012-11-28 |
2018-03-07 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
癌を処置するための組成物および方法
|
AR094116A1
(es)
|
2012-12-20 |
2015-07-08 |
Merck Sharp & Dohme |
Imidazopiridinas sustituidas como inhibidores de hdm2
|
EP2951180B1
(en)
|
2013-01-30 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2018071283A1
(en)
|
2016-10-12 |
2018-04-19 |
Merck Sharp & Dohme Corp. |
Kdm5 inhibitors
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
US11981701B2
(en)
|
2018-08-07 |
2024-05-14 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
CN114206447A
(zh)
|
2019-05-31 |
2022-03-18 |
维拉克塔附属公司 |
用组蛋白脱乙酰基酶抑制剂治疗病毒相关的癌症的方法
|