HK1254358A1 - 用於治療突觸核蛋白病的藥劑、用途和方法 - Google Patents

用於治療突觸核蛋白病的藥劑、用途和方法

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Publication number
HK1254358A1
HK1254358A1 HK18113434.7A HK18113434A HK1254358A1 HK 1254358 A1 HK1254358 A1 HK 1254358A1 HK 18113434 A HK18113434 A HK 18113434A HK 1254358 A1 HK1254358 A1 HK 1254358A1
Authority
HK
Hong Kong
Prior art keywords
synucleinopathy
agents
treatment
methods
Prior art date
Application number
HK18113434.7A
Other languages
English (en)
Inventor
P‧卡爾倫基
K‧福
L‧B‧韋斯特拉格
A-L‧貝里斯特倫
F‧索蒂
D‧薩蒂恩
E‧范登布林克
P‧帕倫
R‧拉德馬克
T‧溫克
I‧J‧馬里克
L‧C‧P‧蒙特西尼奧
Original Assignee
H‧隆德貝克有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H‧隆德貝克有限公司 filed Critical H‧隆德貝克有限公司
Publication of HK1254358A1 publication Critical patent/HK1254358A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
HK18113434.7A 2015-07-13 2018-10-19 用於治療突觸核蛋白病的藥劑、用途和方法 HK1254358A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1512203.9A GB201512203D0 (en) 2015-07-13 2015-07-13 Agents,uses and methods
PCT/EP2016/066476 WO2017009312A1 (en) 2015-07-13 2016-07-12 Agents, uses and methods for the treatment of synucleinopathy

Publications (1)

Publication Number Publication Date
HK1254358A1 true HK1254358A1 (zh) 2019-07-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HK18113434.7A HK1254358A1 (zh) 2015-07-13 2018-10-19 用於治療突觸核蛋白病的藥劑、用途和方法

Country Status (33)

Country Link
US (12) US10800836B2 (zh)
EP (1) EP3322722A1 (zh)
JP (3) JP7012004B2 (zh)
KR (1) KR20180029205A (zh)
CN (2) CN115925921A (zh)
AR (1) AR105336A1 (zh)
AU (1) AU2016292896B2 (zh)
BR (1) BR112017027506A2 (zh)
CA (1) CA2989735A1 (zh)
CL (1) CL2018000075A1 (zh)
CO (1) CO2017012941A2 (zh)
CR (2) CR20180021A (zh)
DO (1) DOP2018000013A (zh)
EA (1) EA036499B1 (zh)
EC (1) ECSP18002645A (zh)
GB (1) GB201512203D0 (zh)
GE (1) GEP20207151B (zh)
HK (1) HK1254358A1 (zh)
IL (1) IL256501B (zh)
JO (1) JO3692B1 (zh)
MA (1) MA42439A (zh)
MX (1) MX2018000504A (zh)
MY (1) MY194944A (zh)
NI (1) NI201800006A (zh)
PE (1) PE20181049A1 (zh)
PH (1) PH12018500016A1 (zh)
RU (1) RU2765303C2 (zh)
SV (1) SV2018005612A (zh)
TN (1) TN2018000005A1 (zh)
TW (1) TWI729992B (zh)
UA (1) UA125501C2 (zh)
WO (1) WO2017009312A1 (zh)
ZA (1) ZA201708607B (zh)

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KR20200115590A (ko) * 2018-01-26 2020-10-07 퀀텀-에스아이 인코포레이티드 서열화 디바이스들을 위한 머신 학습 가능형 펄스 및 염기 호출
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JP2021534381A (ja) * 2018-08-09 2021-12-09 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft パーキンソン病の判定
TWI734279B (zh) * 2018-12-14 2021-07-21 美商美國禮來大藥廠 抗α-突觸核蛋白抗體及其用途
WO2020212593A1 (en) * 2019-04-18 2020-10-22 Ac Immune Sa Novel molecules for therapy and diagnosis
KR102466943B1 (ko) * 2020-04-02 2022-11-14 한국과학기술연구원 갭을 갖는 바이오 센서를 이용한 파킨슨병 모니터링 방법 및 시스템
CN111537738A (zh) * 2020-05-18 2020-08-14 南通大学附属医院 用于超早期帕金森病检测的试剂盒
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Publication number Publication date
MX2018000504A (es) 2018-04-30
US20180127492A1 (en) 2018-05-10
JP7138322B2 (ja) 2022-09-16
US10364285B2 (en) 2019-07-30
US20180179271A1 (en) 2018-06-28
US10358483B2 (en) 2019-07-23
US20190382473A1 (en) 2019-12-19
DOP2018000013A (es) 2018-04-15
EP3322722A1 (en) 2018-05-23
AR105336A1 (es) 2017-09-27
TWI729992B (zh) 2021-06-11
TN2018000005A1 (en) 2019-07-08
JP2022174131A (ja) 2022-11-22
EA201792616A1 (ru) 2018-06-29
RU2765303C2 (ru) 2022-01-28
JP2018529634A (ja) 2018-10-11
US20190367594A1 (en) 2019-12-05
SV2018005612A (es) 2018-07-20
NI201800006A (es) 2018-10-18
US10647764B2 (en) 2020-05-12
EA036499B1 (ru) 2020-11-17
US11421024B2 (en) 2022-08-23
US20210147522A1 (en) 2021-05-20
ZA201708607B (en) 2019-05-29
US11542323B2 (en) 2023-01-03
PH12018500016A1 (en) 2018-07-09
JP7012004B2 (ja) 2022-02-10
UA125501C2 (uk) 2022-04-13
ECSP18002645A (es) 2018-03-31
CR20180021A (es) 2018-03-13
US10358484B2 (en) 2019-07-23
US10800836B2 (en) 2020-10-13
CL2018000075A1 (es) 2018-05-11
US10647763B2 (en) 2020-05-12
RU2017145653A3 (zh) 2019-11-21
US20210054057A1 (en) 2021-02-25
AU2016292896A1 (en) 2018-01-18
US20190367595A1 (en) 2019-12-05
US20210061892A1 (en) 2021-03-04
TW201716440A (zh) 2017-05-16
US20180127491A1 (en) 2018-05-10
US20230312693A1 (en) 2023-10-05
JP2021191763A (ja) 2021-12-16
WO2017009312A1 (en) 2017-01-19
MA42439A (fr) 2018-05-23
US10358482B2 (en) 2019-07-23
BR112017027506A2 (pt) 2018-09-11
US11524995B2 (en) 2022-12-13
PE20181049A1 (es) 2018-07-03
US10640554B2 (en) 2020-05-05
CA2989735A1 (en) 2017-01-19
US20170015739A1 (en) 2017-01-19
MY194944A (en) 2022-12-27
CR20230300A (es) 2023-08-25
KR20180029205A (ko) 2018-03-20
GEP20207151B (en) 2020-09-25
CO2017012941A2 (es) 2018-03-09
CN115925921A (zh) 2023-04-07
IL256501B (en) 2021-10-31
AU2016292896B2 (en) 2022-02-24
IL256501A (en) 2018-02-28
CN107709361A (zh) 2018-02-16
RU2017145653A (ru) 2019-08-13
US20180179270A1 (en) 2018-06-28
GB201512203D0 (en) 2015-08-19
JO3692B1 (ar) 2020-08-27

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