HK1247215A1 - 包含dr5-结合结构域的多价分子 - Google Patents

包含dr5-结合结构域的多价分子 Download PDF

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Publication number
HK1247215A1
HK1247215A1 HK18106692.8A HK18106692A HK1247215A1 HK 1247215 A1 HK1247215 A1 HK 1247215A1 HK 18106692 A HK18106692 A HK 18106692A HK 1247215 A1 HK1247215 A1 HK 1247215A1
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HK
Hong Kong
Prior art keywords
binding
antibodies
multivalent
molecules
binding domains
Prior art date
Application number
HK18106692.8A
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English (en)
Chinese (zh)
Inventor
Paul A Moore
Leslie S Johnson
Jonathan C Li
Kalpana Shah
Original Assignee
Macrogenics, Inc.
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Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of HK1247215A1 publication Critical patent/HK1247215A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18106692.8A 2015-01-26 2015-05-29 包含dr5-结合结构域的多价分子 HK1247215A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562107871P 2015-01-26 2015-01-26
US201562107871P 2015-01-26
US201562149139P 2015-04-17 2015-04-17
US201562149139P 2015-04-17
PCT/US2015/033099 WO2016122702A1 (en) 2015-01-26 2015-05-29 Multivalent molecules comprising dr5-binding domains

Publications (1)

Publication Number Publication Date
HK1247215A1 true HK1247215A1 (zh) 2018-09-21

Family

ID=56544108

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18106692.8A HK1247215A1 (zh) 2015-01-26 2015-05-29 包含dr5-结合结构域的多价分子

Country Status (13)

Country Link
US (1) US10501552B2 (enExample)
EP (1) EP3250601A4 (enExample)
JP (1) JP6602875B2 (enExample)
KR (1) KR20170105622A (enExample)
CN (1) CN107250161A (enExample)
AU (1) AU2015380455A1 (enExample)
CA (1) CA2974807A1 (enExample)
HK (1) HK1247215A1 (enExample)
IL (1) IL253668A0 (enExample)
RU (1) RU2017129236A (enExample)
SG (1) SG11201706024YA (enExample)
TW (1) TWI688572B (enExample)
WO (1) WO2016122702A1 (enExample)

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CN112243444A (zh) * 2018-06-08 2021-01-19 豪夫迈·罗氏有限公司 具有减少的翻译后修饰的肽接头
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US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US20230312737A1 (en) * 2020-03-04 2023-10-05 Regents Of The University Of Minnesota Anti-dr5 polypeptides and methods of use thereof
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JP2018507188A (ja) 2018-03-15
CA2974807A1 (en) 2016-08-04
RU2017129236A (ru) 2019-03-07
IL253668A0 (en) 2017-09-28
RU2017129236A3 (enExample) 2019-03-07
KR20170105622A (ko) 2017-09-19
US20180016344A1 (en) 2018-01-18
AU2015380455A1 (en) 2017-08-03
WO2016122702A1 (en) 2016-08-04
TWI688572B (zh) 2020-03-21
SG11201706024YA (en) 2017-08-30
CN107250161A (zh) 2017-10-13
TW201627323A (zh) 2016-08-01

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