CA2974807A1 - Multivalent molecules comprising dr5-binding domains - Google Patents
Multivalent molecules comprising dr5-binding domains Download PDFInfo
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- CA2974807A1 CA2974807A1 CA2974807A CA2974807A CA2974807A1 CA 2974807 A1 CA2974807 A1 CA 2974807A1 CA 2974807 A CA2974807 A CA 2974807A CA 2974807 A CA2974807 A CA 2974807A CA 2974807 A1 CA2974807 A1 CA 2974807A1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- General Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US201562107871P | 2015-01-26 | 2015-01-26 | |
| US62/107,871 | 2015-01-26 | ||
| US201562149139P | 2015-04-17 | 2015-04-17 | |
| US62/149,139 | 2015-04-17 | ||
| PCT/US2015/033099 WO2016122702A1 (en) | 2015-01-26 | 2015-05-29 | Multivalent molecules comprising dr5-binding domains |
Publications (1)
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| CA2974807A1 true CA2974807A1 (en) | 2016-08-04 |
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| CA2974807A Abandoned CA2974807A1 (en) | 2015-01-26 | 2015-05-29 | Multivalent molecules comprising dr5-binding domains |
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| EP (1) | EP3250601A4 (enExample) |
| JP (1) | JP6602875B2 (enExample) |
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| IL (1) | IL253668A0 (enExample) |
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| SG (1) | SG11201706024YA (enExample) |
| TW (1) | TWI688572B (enExample) |
| WO (1) | WO2016122702A1 (enExample) |
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| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| TN2016000525A1 (en) * | 2014-05-29 | 2018-04-04 | Macrogenics Inc | Tri-specific binding molecules and methods of use thereof |
| CU20170041A7 (es) * | 2014-09-26 | 2017-09-06 | Macrogenics Inc | Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3 |
| DK3247728T3 (da) | 2015-01-20 | 2020-07-13 | Igm Biosciences Inc | Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf |
| EP3112381A1 (en) * | 2015-07-01 | 2017-01-04 | FONDAZIONE IRCCS Istituto Nazionale dei Tumori | Bispecific antibodies for use in cancer immunotherapy |
| IL295423B2 (en) * | 2015-10-01 | 2023-11-01 | Heat Biologics Inc | Compounds and methods for joining extracellular complexes of type 1 and 2 as heterologous chimeric proteins |
| KR102791773B1 (ko) * | 2015-10-30 | 2025-04-03 | 갤럭시 바이오테크, 엘엘씨 | 사멸 수용체 4 및 사멸 수용체 5에 결합하는 매우 강력한 항체 |
| EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
| RU2766582C2 (ru) | 2016-12-23 | 2022-03-15 | Ремд Биотерапьютикс, Инк. | Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1) |
| KR101926834B1 (ko) | 2017-03-21 | 2018-12-07 | 동아에스티 주식회사 | 항-dr5 항체 및 그의 용도 |
| CN111164101B (zh) * | 2017-10-04 | 2025-04-25 | 安进公司 | 甲状腺素视黄质运载蛋白免疫球蛋白融合体 |
| KR102194026B1 (ko) * | 2017-12-15 | 2020-12-22 | 경북대학교 산학협력단 | Trail 수용체에 결합하는 펩타이드 및 이의 용도 |
| JP2021526026A (ja) * | 2018-06-08 | 2021-09-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 翻訳後修飾が低減したペプチドリンカー |
| CA3106829A1 (en) | 2018-08-03 | 2020-02-06 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing two antigen-binding domains that are linked to each other |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2021178569A2 (en) * | 2020-03-04 | 2021-09-10 | Regents Of The University Of Minnesota | Anti-dr5 polypeptides and methods of use thereof |
| WO2022241034A1 (en) * | 2021-05-12 | 2022-11-17 | BioLegend, Inc. | Anti-ccr8 antibodies, antigen-binding fragments thereof, and agents and compositions and methods for making and using the same |
| AU2024207355A1 (en) * | 2023-01-13 | 2025-08-21 | Chimagen Biosciences, Ltd | Multi-specific polypeptide complexes |
| WO2025098480A1 (zh) * | 2023-11-10 | 2025-05-15 | 信达生物制药(苏州)有限公司 | 抗dr5和ceacam5的双特异性抗体及其用途 |
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-
2015
- 2015-05-29 SG SG11201706024YA patent/SG11201706024YA/en unknown
- 2015-05-29 AU AU2015380455A patent/AU2015380455A1/en not_active Abandoned
- 2015-05-29 HK HK18106692.8A patent/HK1247215A1/zh unknown
- 2015-05-29 US US15/545,871 patent/US10501552B2/en not_active Expired - Fee Related
- 2015-05-29 RU RU2017129236A patent/RU2017129236A/ru not_active Application Discontinuation
- 2015-05-29 JP JP2017539274A patent/JP6602875B2/ja not_active Expired - Fee Related
- 2015-05-29 CN CN201580074115.8A patent/CN107250161A/zh active Pending
- 2015-05-29 EP EP15880591.1A patent/EP3250601A4/en not_active Withdrawn
- 2015-05-29 TW TW104117566A patent/TWI688572B/zh not_active IP Right Cessation
- 2015-05-29 WO PCT/US2015/033099 patent/WO2016122702A1/en not_active Ceased
- 2015-05-29 KR KR1020177023834A patent/KR20170105622A/ko not_active Withdrawn
- 2015-05-29 CA CA2974807A patent/CA2974807A1/en not_active Abandoned
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2017
- 2017-07-26 IL IL253668A patent/IL253668A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017129236A3 (enExample) | 2019-03-07 |
| KR20170105622A (ko) | 2017-09-19 |
| AU2015380455A1 (en) | 2017-08-03 |
| EP3250601A4 (en) | 2018-07-11 |
| SG11201706024YA (en) | 2017-08-30 |
| WO2016122702A1 (en) | 2016-08-04 |
| TW201627323A (zh) | 2016-08-01 |
| EP3250601A1 (en) | 2017-12-06 |
| TWI688572B (zh) | 2020-03-21 |
| CN107250161A (zh) | 2017-10-13 |
| RU2017129236A (ru) | 2019-03-07 |
| JP2018507188A (ja) | 2018-03-15 |
| US10501552B2 (en) | 2019-12-10 |
| IL253668A0 (en) | 2017-09-28 |
| HK1247215A1 (zh) | 2018-09-21 |
| US20180016344A1 (en) | 2018-01-18 |
| JP6602875B2 (ja) | 2019-11-06 |
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